• 1.

  Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer.

  • Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF.
  • Nutr Cancer. Author manuscript. 2011 Sep 2;63(7):1085-94. doi: 10.1080/01635581.2011.601845.
  • PMCID: PMC3201987

  Martínez-Montemayor MM, et al.

  Nutr Cancer. Author manuscript. 2011.

  PMCID: PMC3201987

  Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for anti-IBC therapy. Reishi contains biological compounds that are cytotoxic against cancer cells. ...These findings suggest that Reish …

  Herein we describe the potential of the medicinal mushroom Ganoderma lucidum (Reishi) as an attractive candidate for an …
• 2.

  Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States.

  • Wu DT, Deng Y, Chen LX, Zhao J, Bzhelyansky A, Li SP.
  • Sci Rep. 2017 Aug 10;7(1):7792. doi: 10.1038/s41598-017-06336-3.
  • PMCID: PMC5552695

  Wu DT, et al.

  Sci Rep. 2017.

  PMCID: PMC5552695

  Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. ...In this study, 19 batches of products of G. lucidum (Red …

  Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form …
• 3.

  Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models.

  • Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM.
  • PLoS One. 2013 Feb 28;8(2):e57431. doi: 10.1371/journal.pone.0057431.
  • PMCID: PMC3585368

  Suarez-Arroyo IJ, et al.

  PLoS One. 2013.

  PMCID: PMC3585368

  The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer (IBC) using in vivo and in vitro IBC models. ...Our results provide evidence that Reishi suppresses protein synthesis and tumor growt …

  The medicinal mushroom Ganoderma lucidum (Reishi) was tested as a potential therapeutic for Inflammatory Breast Cancer …
• 4.

  The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk.

  • Chan SW, Tomlinson B, Chan P, Lam CWK.
  • Pharm Biol. 2021 Dec;59(1):1161-1171. doi: 10.1080/13880209.2021.1969413.
  • PMCID: PMC8409941

  Chan SW, et al.

  Pharm Biol. 2021.

  PMCID: PMC8409941

  The search terms used were Ganoderma lucidum, Lingzhi, Reishi, cardiovascular, hypoglycaemic, diabetes, dyslipidaemia, antihypertensive, and anti-inflammatory. ...CONCLUSIONS: The inconsistent evidence about the potential health benefits of G. lucidum …

  The search terms used were Ganoderma lucidum, Lingzhi, Reishi, cardiovascular, hypoglycaemic, diabetes, dyslipidaemia, …
• 5.

  A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum).

  • Younger J, Donovan EK, Hodgin KS, Ness TJ.
  • Int J Environ Res Public Health. 2021 Apr 1;18(7):3671. doi: 10.3390/ijerph18073671.
  • PMCID: PMC8037868

  Younger J, et al.

  Int J Environ Res Public Health. 2021.

  PMCID: PMC8037868

  We used a placebo-controlled, pseudo-randomized, crossover design to test the effects of reishi mushroom (Ganoderma lucidum), stinging nettle (Uritca dioica), and epimedium (Epimedium sagittatum) in 29 men with GWI. ...GWI symptom severity was unchanged from …

  We used a placebo-controlled, pseudo-randomized, crossover design to test the effects of reishi mushroom (Ganoderma lucidum …
• 6.

  Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst (Reishi Mushroom) cultivation and their FT-IR assessments.

  • Akcay C, Arslan R, Ceylan F.
  • PLoS One. 2025 Jul 22;20(7):e0328732. doi: 10.1371/journal.pone.0328732.
  • PMCID: PMC12282901

  Akcay C, et al.

  PLoS One. 2025.

  PMCID: PMC12282901

  Ganoderma lucidum (Curtis) P. Karst (Reishi) has significant pharmacological benefits, and optimizing its cultivation on diverse substrates enhances its commercial viability. ...FT-IR spectra indicated that this method could effectively elucidate the biodegra …

  Ganoderma lucidum (Curtis) P. Karst (Reishi) has significant pharmacological benefits, and optimizing its cultivation o …
• 7.

  Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector.

  • González A, Atienza V, Montoro A, Soriano JM.
  • Nutrients. 2020 Apr 19;12(4):1143. doi: 10.3390/nu12041143.
  • PMCID: PMC7230513

  González A, et al.

  Nutrients. 2020.

  PMCID: PMC7230513

  For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic properties, as recorded in the oldest Chinese herbal encyclopedia. ...In vivo studies reveal the efficiency of G. lucidum aqueous extrac …

  For millennia, naturopaths and physicians have used Ganoderma lucidum (reishi mushroom) for its diverse therapeutic pro …
• 8.

  Self-Medication with Ganoderma lucidum ("Reishi") to Combat Parkinson's Disease Symptoms: A Single Case Study.

  • Kuypers KPC.
  • J Med Food. 2020 Nov 9;24(7):766-773. doi: 10.1089/jmf.2020.0137.
  • PMCID: PMC8311956

  Kuypers KPC.

  J Med Food. 2020.

  PMCID: PMC8311956

  Preclinical research suggests that the Traditional Chinese Medicine Ganoderma lucidum ("Reishi") can alleviate symptoms in neurological disorders like PD. However, no clinical research to date has addressed this. An (unmedicated) patient, 50 years of age and …

  Preclinical research suggests that the Traditional Chinese Medicine Ganoderma lucidum ("Reishi") can alleviate symptoms …
• 9.

  Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.

  • Hajjaj H, Macé C, Roberts M, Niederberger P, Fay LB.
  • Appl Environ Microbiol. 2005 Jul;71(7):3653-8. doi: 10.1128/AEM.71.7.3653-3658.2005.
  • PMCID: PMC1168986

  Hajjaj H, et al.

  Appl Environ Microbiol. 2005.

  PMCID: PMC1168986

  Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine. ...We found that these oxygenated sterols from G. lucidum inhibited …

  Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi …
• 10.

  The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected].

  • Liu D, Gong J, Dai W, Kang X, Huang Z, Zhang HM, Liu W, Liu L, Ma J, Xia Z, Chen Y, Chen Y, Wang D, Ni P, Guo AY, Xiong X.
  • PLoS One. 2012 May 2;7(5):e36146. doi: 10.1371/journal.pone.0036146.
  • PMCID: PMC3342255

  Liu D, et al.

  PLoS One. 2012.

  PMCID: PMC3342255

  BACKGROUND: Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries. ...We performed comprehensive annotation for G. lucidum ge …

  BACKGROUND: Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been …

• 11.

  Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China.

  • Zeng P, Guo Z, Zeng X, Hao C, Zhang Y, Zhang M, Liu Y, Li H, Li J, Zhang L.
  • J Cell Mol Med. 2018 Apr 24;22(7):3278-3297. doi: 10.1111/jcmm.13613.
  • PMCID: PMC6010762

  Zeng P, et al.

  J Cell Mol Med. 2018.

  PMCID: PMC6010762

  Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. ...The large-scale production of the drug began in 1985 and approved by the Chinese FDA as "Polysaccharidum of G. lucidum Karst Injection" …

  Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. ...The …
• 12.

  Identifying the "Mushroom of Immortality": Assessing the Ganoderma Species Composition in Commercial Reishi Products.

  • Loyd AL, Richter BS, Jusino MA, Truong C, Smith ME, Blanchette RA, Smith JA.
  • Front Microbiol. 2018 Jul 16;9:1557. doi: 10.3389/fmicb.2018.01557.
  • PMCID: PMC6055023

  Loyd AL, et al.

  Front Microbiol. 2018.

  PMCID: PMC6055023

  Species of Ganoderma, commonly called reishi (in Japan) or lingzhi (in China), have been used in traditional medicine for thousands of years, and their use has gained interest from pharmaceutical industries in recent years. Globally, the taxonomy of Ganoderma …

  Species of Ganoderma, commonly called reishi (in Japan) or lingzhi (in China), have been used in traditional medicine for thou …
• 13.

  Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR.

  • Kühnel H, Seiler M, Feldhofer B, Ebrahimian A, Maurer M.
  • Curr Issues Mol Biol. 2025 Feb 18;47(2):130. doi: 10.3390/cimb47020130.
  • PMCID: PMC11854148

  Kühnel H, et al.

  Curr Issues Mol Biol. 2025.

  PMCID: PMC11854148

  This study investigated the potential of Ganoderma lucidum (Reishi) ethanol extract to modulate the senescent phenotype of human dermal fibroblasts. Reishi powder of two different vendors was used. The extract was produced by extracting the Reishi …

  This study investigated the potential of Ganoderma lucidum (Reishi) ethanol extract to modulate the senescent phenotype …
• 14.

  Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion's Mane Extracts.

  • Ziemlewska A, Wójciak M, Mroziak-Lal K, Zagórska-Dziok M, Bujak T, Nizioł-Łukaszewska Z, Szczepanek D, Sowa I.
  • Molecules. 2022 Aug 10;27(16):5090. doi: 10.3390/molecules27165090.
  • PMCID: PMC9412612

  Ziemlewska A, et al.

  Molecules. 2022.

  PMCID: PMC9412612

  Water extracts of Grifolafrondosa (Maitake), Hericiumerinaceus (Lion's Mane) and Ganoderma lucidum (Reishi) were tested for their antioxidant properties, bioactive substances content, skin cell toxicity, ability to limit TEWL, effect on skin hydration and pH, …

  Water extracts of Grifolafrondosa (Maitake), Hericiumerinaceus (Lion's Mane) and Ganoderma lucidum (Reishi) were tested …
• 15.

  Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom).

  • Saylam Kurtipek G, Ataseven A, Kurtipek E, Kucukosmanoglu İ, Toksoz MR.
  • Dermatol Ther (Heidelb). 2016 Feb 11;6(1):105-9. doi: 10.1007/s13555-016-0099-4.
  • PMCID: PMC4799037

  Saylam Kurtipek G, et al.

  Dermatol Ther (Heidelb). 2016.

  PMCID: PMC4799037

  Ganoderma lucidum (reishi mushroom) has been used in traditional Chinese and Japanese medicine as a herbal remedy for over 2000 years. Studies have shown that G. lucidum has anti-allergic, anti-oxidant, anti-tumor, anti-viral, and anti-inflammatory pro …

  Ganoderma lucidum (reishi mushroom) has been used in traditional Chinese and Japanese medicine as a herbal remedy for o …
• 16.

  Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

  • Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, Khoo KH, Lin CH, Hsu HY, Wu CY, Wong CH.
  • Proc Natl Acad Sci U S A. 2013 Aug 1;110(34):13809-14. doi: 10.1073/pnas.1312457110.
  • PMCID: PMC3752246

  Liao SF, et al.

  Proc Natl Acad Sci U S A. 2013.

  PMCID: PMC3752246

  Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides has been used as antitumor supplement, but the mechanism of immune response has rarely be …

  Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum …
• 17.

  Emerging Roles of Ganoderma Lucidum in Anti-Aging.

  • Wang J, Cao B, Zhao H, Feng J.
  • Aging Dis. 2017 Dec 1;8(6):691-707. doi: 10.14336/AD.2017.0410.
  • PMCID: PMC5758346

  Wang J, et al.

  Aging Dis. 2017.

  PMCID: PMC5758346

  Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extr …

  Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity …
• 18.

  The Impact of Ganoderma lucidum (Curtis) P. Karst. Supplementation on the Technological, Chemical, and Quality Parameters of Wheat Bread.

  • Łysakowska P, Sobota A, Wirkijowska A, Zarzycki P, Blicharz-Kania A.
  • Foods. 2024 Sep 28;13(19):3101. doi: 10.3390/foods13193101.
  • PMCID: PMC11475047

  Łysakowska P, et al.

  Foods. 2024.

  PMCID: PMC11475047

  This study explores the incorporation of Ganoderma lucidum (Curtis) P. Karst. (Reishi mushroom) into wheat bread to develop a functional food with enhanced nutritional value. ...However, higher Reishi levels negatively impacted bread volume, possibly d …

  This study explores the incorporation of Ganoderma lucidum (Curtis) P. Karst. (Reishi mushroom) into wheat bread to dev …
• 19.

  Hypotensive effects and angiotensin-converting enzyme inhibitory peptides of reishi (Ganoderma lingzhi) auto-digested extract.

  • Tran HB, Yamamoto A, Matsumoto S, Ito H, Igami K, Miyazaki T, Kondo R, Shimizu K.
  • Molecules. 2014 Aug 29;19(9):13473-85. doi: 10.3390/molecules190913473.
  • PMCID: PMC6271714

  Tran HB, et al.

  Molecules. 2014.

  PMCID: PMC6271714

  Reishi (Ganoderma lingzhi) has been used as a traditional medicine for millennia. However, relatively little is known about this mushroom's proteins and their bioactivities. In this study, we used reishi's own proteases to hydrolyze its protein and obtained a …

  Reishi (Ganoderma lingzhi) has been used as a traditional medicine for millennia. However, relatively little is known about th …
• 20.

  Incorporating Ganoderma lucidum extract and powder with probiotic cultures (Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis) enhanced the functional, textural, and sensory qualities of yogurt.

  • Atik A, Atik İ, Akarca G, Denizkara AJ.
  • J Food Sci Technol. 2024 Aug 21;62(4):787-798. doi: 10.1007/s13197-024-06068-z.
  • PMCID: PMC11914407
  • Currently Embargoed: Full text in PMC on April 1, 2026 PubMed Abstract

  Atik A, et al.

  J Food Sci Technol. 2024.

  PMCID: PMC11914407

  Currently Embargoed.

  In this study, the extract and powder obtained from the Reishi mushroom (Ganoderma lucidum) were used in the production of yogurt, and also Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis bacteria were also inoculated. ...The count of pro …

  In this study, the extract and powder obtained from the Reishi mushroom (Ganoderma lucidum) were used in the production …

• 21.

  Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.

  • Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C.
  • Nutrients. 2017 Feb 28;9(3):210. doi: 10.3390/nu9030210.
  • PMCID: PMC5372873

  Barbieri A, et al.

  Nutrients. 2017.

  PMCID: PMC5372873

  Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for the treatment of numerous diseases, including cancer, in Oriental countries. ...Taken together, these results indicate the possible use of Ganoderma …

  Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for the treatment …
• 22.

  Deep insight into the Ganoderma lucidum by comprehensive analysis of its transcriptome.

  • Yu GJ, Wang M, Huang J, Yin YL, Chen YJ, Jiang S, Jin YX, Lan XQ, Wong BH, Liang Y, Sun H.
  • PLoS One. 2012 Aug 27;7(8):e44031. doi: 10.1371/journal.pone.0044031.
  • PMCID: PMC3428325

  Yu GJ, et al.

  PLoS One. 2012.

  PMCID: PMC3428325

  BACKGROUND: Ganoderma lucidum is a basidiomycete white rot fungus and is of medicinal importance in China, Japan and other countries in the Asiatic region. To date, much research has been performed in identifying the medicinal ingredients in Ganoderma luci …

  BACKGROUND: Ganoderma lucidum is a basidiomycete white rot fungus and is of medicinal importance in China, Japan and other cou …
• 23.

  Ganoderma lucidum (Reishi mushroom) for cancer treatment.

  • Jin X, Ruiz Beguerie J, Sze DM, Chan GC.
  • Cochrane Database Syst Rev. 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3.
  • PMCID: PMC6353236

  Jin X, et al.

  Cochrane Database Syst Rev. 2016.

  PMCID: PMC6353236

  BACKGROUND: Ganoderma lucidum is a natural medicine that is widely used and recommended by Asian physicians and naturopaths for its supporting effects on immune system. ...AUTHORS' CONCLUSIONS: Our review did not find sufficient evidence to justify the use of G. …

  BACKGROUND: Ganoderma lucidum is a natural medicine that is widely used and recommended by Asian physicians and naturopaths fo …
• 24.

  The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites.

  • Ji W, Zhang N, Su W, Wang X, Liu X, Wang Y, Chen K, Ren L.
  • Sci Rep. 2024 May 2;14(1):10097. doi: 10.1038/s41598-024-60750-y.
  • PMCID: PMC11066026

  Ji W, et al.

  Sci Rep. 2024.

  PMCID: PMC11066026

  To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecutive years of cultivation on the same plo …

  To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and …
• 25.

  Intraspecific Variation and Phylogenetic Relationships Are Revealed by ITS1 Secondary Structure Analysis and Single-Nucleotide Polymorphism in Ganoderma lucidum.

  • Zhang X, Xu Z, Pei H, Chen Z, Tan X, Hu J, Yang B, Sun J.
  • PLoS One. 2017 Jan 5;12(1):e0169042. doi: 10.1371/journal.pone.0169042.
  • PMCID: PMC5215925

  Zhang X, et al.

  PLoS One. 2017.

  PMCID: PMC5215925

  Ganoderma lucidum is a typical polypore fungus used for traditional Chinese medical purposes. The taxonomic delimitation of Ganoderma lucidum is still debated. In this study, we sequenced seven internal transcribed spacer (ITS) sequences of Ganoderm …

  Ganoderma lucidum is a typical polypore fungus used for traditional Chinese medical purposes. The taxonomic delimitation of …
• 26.

  Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.

  • Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A.
  • Cochrane Database Syst Rev. 2015 Feb 17;2015(2):CD007259. doi: 10.1002/14651858.CD007259.pub2.
  • PMCID: PMC6486141

  Klupp NL, et al.

  Cochrane Database Syst Rev. 2015.

  PMCID: PMC6486141

  BACKGROUND: Ganoderma lucidum (also known as lingzhi or reishi) is a mushroom that has been consumed for its broad medicinal properties in Asia for over 2000 years. G lucidum is becoming increasingly popular in western countries as a complementary medi …

  BACKGROUND: Ganoderma lucidum (also known as lingzhi or reishi) is a mushroom that has been consumed for its broad medi …
• 27.

  Ganoderma lucidum Polysaccharides as An Anti-cancer Agent.

  • Sohretoglu D, Huang S.
  • Anticancer Agents Med Chem. Author manuscript. 2018;18(5):667-674. doi: 10.2174/1871520617666171113121246.
  • PMCID: PMC6624854

  Sohretoglu D, et al.

  Anticancer Agents Med Chem. Author manuscript. 2018.

  PMCID: PMC6624854

  The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. ...G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts …

  The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases an …
• 28.

  Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum.

  • Seweryn E, Ziała A, Gamian A.
  • Nutrients. 2021 Aug 7;13(8):2725. doi: 10.3390/nu13082725.
  • PMCID: PMC8400705

  Seweryn E, et al.

  Nutrients. 2021.

  PMCID: PMC8400705

  Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccharides has antioxidant, immunomodulatory, antineurodegenerative and antidiabetic activities. In this review, we summarize the activity of …

  Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccha …
• 29.

  Efficient expression of heterologous genes by the introduction of the endogenous glyceraldehyde-3-phosphate dehydrogenase gene intron 1 in Ganoderma lucidum.

  • You H, Sun B, Li N, Xu JW.
  • Microb Cell Fact. 2021 Aug 21;20(1):164. doi: 10.1186/s12934-021-01654-8.
  • PMCID: PMC8379801

  You H, et al.

  Microb Cell Fact. 2021.

  PMCID: PMC8379801

  BACKGROUND: Ganoderma lucidum, a well-known medicinal mushroom, has received wide attention as a promising cell factory for producing bioactive compounds. ...Moreover, the insertion of the gpd intron 1 in the beta-glucuronidase gene (gus) elevates its mRNA accumulat …

  BACKGROUND: Ganoderma lucidum, a well-known medicinal mushroom, has received wide attention as a promising cell factory for pr …
• 30.

  Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum).

  • He X, Chen Y, Li Z, Fang L, Chen H, Liang Z, Abozeid A, Yang Z, Yang D.
  • Chin Herb Med. 2023 Jun 10;15(3):376-382. doi: 10.1016/j.chmed.2023.01.005.
  • PMCID: PMC10394326

  He X, et al.

  Chin Herb Med. 2023.

  PMCID: PMC10394326

  Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are the major constituents. ...Also we overviewed G. lucidum in the components, the biological activities and biosynthetic pathways of g …

  Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are …

• 31.

  Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids.

  • Xu JW, Zhong JJ.
  • Bioengineered. 2015;6(6):357-60. doi: 10.1080/21655979.2015.1119341.
  • PMCID: PMC4825833

  Xu JW, et al.

  Bioengineered. 2015.

  PMCID: PMC4825833

  Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioactivities. ...In this report, the genetic transformation systems of G. lucidum are described; current trends are also presented to imp …

  Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioac …
• 32.

  Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.

  • Mallard B, Leach DN, Wohlmuth H, Tiralongo J.
  • PLoS One. 2019 Nov 7;14(11):e0224740. doi: 10.1371/journal.pone.0224740.
  • PMCID: PMC6837746

  Mallard B, et al.

  PLoS One. 2019.

  PMCID: PMC6837746

  In this study we analysed nine commercially available preparations from three mushroom species, Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes) and Maitake (Grifola frondosa), for beta- and alpha-glucan content. ...

  In this study we analysed nine commercially available preparations from three mushroom species, Reishi (Ganoderma lucidum …
• 33.

  Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review.

  • Cör D, Knez Ž, Knez Hrnčič M.
  • Molecules. 2018 Mar 13;23(3):649. doi: 10.3390/molecules23030649.
  • PMCID: PMC6017764

  Cör D, et al.

  Molecules. 2018.

  PMCID: PMC6017764

  Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promoting effects on health and life expectancy. G. lucidum contains various compounds with a high grade of biological activty, which incre …

  Ganoderma lucidum (Reishi) is a popular medicinal mushroom and has been used in oriental medicine because of its promot …
• 34.

  Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi, or Mannentake" as Functional Foods: Current Scenario and Future Perspectives.

  • El Sheikha AF.
  • Foods. 2022 Apr 1;11(7):1030. doi: 10.3390/foods11071030.
  • PMCID: PMC8998036

  El Sheikha AF.

  Foods. 2022.

  PMCID: PMC8998036

  Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing properties. ...Still, more research studies on the biotherapeutic components of G. lucidum are needed to ensure the safety and efficien …

  Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing pr …
• 35.

  A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.

  • Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH.
  • Sci Rep. 2016 Aug 11;6:29540. doi: 10.1038/srep29540.
  • PMCID: PMC4980683

  Klupp NL, et al.

  Sci Rep. 2016.

  PMCID: PMC4980683

  Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganoderma lucidum, Ganoderma lucidum with Cordyceps sinensis, or placebo. The dosage was 3 g/day of Ganoderma l …

  Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganode …
• 36.

  Evaluation of Immune Modulation by beta-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial.

  • Chen SN, Nan FH, Liu MW, Yang MF, Chang YC, Chen S.
  • Foods. 2023 Feb 3;12(3):659. doi: 10.3390/foods12030659.
  • PMCID: PMC9914031

  Chen SN, et al.

  Foods. 2023.

  PMCID: PMC9914031

  Studies have indicated that beta-glucan derived from Ganoderma lucidum (commonly known as Reishi) holds particular promise in this regard, both in laboratory and in vivo settings. ...Overall, the study provides evidence for the ability of Reishi beta-g …

  Studies have indicated that beta-glucan derived from Ganoderma lucidum (commonly known as Reishi) holds particular prom …
• 37.

  The species identity of the widely cultivated Ganoderma, 'G. lucidum' (Ling-zhi), in China.

  • Wang XC, Xi RJ, Li Y, Wang DM, Yao YJ.
  • PLoS One. 2012 Jul 20;7(7):e40857. doi: 10.1371/journal.pone.0040857.
  • PMCID: PMC3401198

  Wang XC, et al.

  PLoS One. 2012.

  PMCID: PMC3401198

  Ling-zhi, a widely cultivated fungus in China, has a long history in traditional Chinese medicine. Although the name 'Ganoderma lucidum', a species originally described from England, has been applied to the fungus, their identities are not the same. ...Specimens of …

  Ling-zhi, a widely cultivated fungus in China, has a long history in traditional Chinese medicine. Although the name 'Ganoderma lu …
• 38.

  Physiological changes and gene responses during Ganoderma lucidum growth with selenium supplementation.

  • Zhang B, Tan W, Zhou J, Ye L, Jia D, Li X.
  • PeerJ. 2022 Dec 20;10:e14488. doi: 10.7717/peerj.14488.
  • PMCID: PMC9784338

  Zhang B, et al.

  PeerJ. 2022.

  PMCID: PMC9784338

  Ganoderma lucidum basidiomycota is highly appreciated for its health and nutrition value. In the present study, Ganoderma lucidum was cultivated as selenium transformation carrier, and the physiological changes and gene responses by selenium supplement …

  Ganoderma lucidum basidiomycota is highly appreciated for its health and nutrition value. In the present study, Ganoderma …
• 39.

  The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks.

  • Lian W, Yang X, Duan Q, Li J, Zhao Y, Yu C, He T, Sun T, Zhao Y, Wang W.
  • Molecules. 2024 May 26;29(11):2516. doi: 10.3390/molecules29112516.
  • PMCID: PMC11173733

  Lian W, et al.

  Molecules. 2024.

  PMCID: PMC11173733

  This literature review collates and examines the existing research on the bioactivity of active compounds and extracts from Ganoderma lucidum in modulating the pathological hallmarks of neurodegenerative diseases. ...It is clearly presented from the patterns that mo …

  This literature review collates and examines the existing research on the bioactivity of active compounds and extracts from Ganoderma …
• 40.

  Genetic and metabolic intraspecific biodiversity of Ganoderma lucidum.

  • Pawlik A, Janusz G, Dębska I, Siwulski M, Frąc M, Rogalski J.
  • Biomed Res Int. 2015 Mar 1;2015:726149. doi: 10.1155/2015/726149.
  • PMCID: PMC4359883

  Pawlik A, et al.

  Biomed Res Int. 2015.

  PMCID: PMC4359883

  Fourteen Ganoderma lucidum strains from different geographic regions were identified using ITS region sequencing. Based on the sequences obtained, the genomic relationship between the analyzed strains was determined. All G. lucidum strains were also genetical …

  Fourteen Ganoderma lucidum strains from different geographic regions were identified using ITS region sequencing. Based on the …

• 41.

  Targeted Gene Insertion and Replacement in the Basidiomycete Ganoderma lucidum by Inactivation of Nonhomologous End Joining Using CRISPR/Cas9.

  • Tu JL, Bai XY, Xu YL, Li N, Xu JW.
  • Appl Environ Microbiol. 2021 Sep 15;87(23):e0151021. doi: 10.1128/AEM.01510-21.
  • PMCID: PMC8579997

  Tu JL, et al.

  Appl Environ Microbiol. 2021.

  PMCID: PMC8579997

  Although CRISPR/Cas9 works well for gene disruption and deletion in Ganoderma lucidum, targeted gene insertion and replacement remain a serious challenge due to the low efficiency of homologous recombination (HR) in this species. ...This tool will advance our unders …

  Although CRISPR/Cas9 works well for gene disruption and deletion in Ganoderma lucidum, targeted gene insertion and replacement …
• 42.

  Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.

  • Plosca MP, Chiș MS, Fărcaș AC, Păucean A.
  • Antioxidants (Basel). 2025 Apr 25;14(5):513. doi: 10.3390/antiox14050513.
  • PMCID: PMC12108272

  Plosca MP, et al.

  Antioxidants (Basel). 2025.

  PMCID: PMC12108272

  Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine. ...Advances in extraction technologies, such as ultrasound and microwave-assisted methods, have improved the …

  Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history …
• 43.

  Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.

  • El-Khashab IH.
  • Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1095-1104. doi: 10.31557/APJCP.2021.22.4.1095.
  • PMCID: PMC8325138

  El-Khashab IH.

  Asian Pac J Cancer Prev. 2021.

  PMCID: PMC8325138

  OBJECTIVE: The present study was designed to evaluate the apoptotic and antiangiogenic effects of Atorvastatin and/or Ganoderma lucidum against Ehrlich solid tumor inoculated in female mice. MATERIALS AND METHODS: Atorvastatin (AT) or/and Ganoderma lucidum …

  OBJECTIVE: The present study was designed to evaluate the apoptotic and antiangiogenic effects of Atorvastatin and/or Ganoderma lu …
• 44.

  Comparison of extraction methods of chitin from Ganoderma lucidum mushroom obtained in submerged culture.

  • Ospina Álvarez SP, Ramírez Cadavid DA, Escobar Sierra DM, Ossa Orozco CP, Rojas Vahos DF, Zapata Ocampo P, Atehortúa L.
  • Biomed Res Int. 2014 Jan 15;2014:169071. doi: 10.1155/2014/169071.
  • PMCID: PMC3914579

  Ospina Álvarez SP, et al.

  Biomed Res Int. 2014.

  PMCID: PMC3914579

  The chitin was isolated from the Ganoderma lucidum submerged cultures mycelium as potential source of chitin under biotechnological processes. ...Obtained chitin was characterized by X-Ray Diffraction (XRD), by Fourier transform infrared spectroscopy (FTIR), and by …

  The chitin was isolated from the Ganoderma lucidum submerged cultures mycelium as potential source of chitin under biotechnolo …
• 45.

  Structure determination of beta-glucans from Ganoderma lucidum with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.

  • Hung WT, Wang SH, Chen CH, Yang WB.
  • Molecules. 2008 Aug 3;13(8):1538-50. doi: 10.3390/molecules13081538.
  • PMCID: PMC6245394

  Hung WT, et al.

  Molecules. 2008.

  PMCID: PMC6245394

  A novel method that uses matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to analyze molecular weight and sequencing of glucan in Ganoderma lucidum is presented. Thus, beta-glucan, which was isolated from fruiting bodies of G. lucidum, wa …

  A novel method that uses matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to analyze molecular weight and sequencing of …
• 46.

  Enhancement of ganoderic acid accumulation by overexpression of an N-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum.

  • Xu JW, Xu YN, Zhong JJ.
  • Appl Environ Microbiol. 2012 Aug 31;78(22):7968-76. doi: 10.1128/AEM.01263-12.
  • PMCID: PMC3485969

  Xu JW, et al.

  Appl Environ Microbiol. 2012.

  PMCID: PMC3485969

  Ganoderic acids produced by Ganoderma lucidum, a well-known traditional Chinese medicinal mushroom, exhibit antitumor and antimetastasis activities. Genetic modification of G. lucidum is difficult but critical for the enhancement of cellular accumulation of g …

  Ganoderic acids produced by Ganoderma lucidum, a well-known traditional Chinese medicinal mushroom, exhibit antitumor and anti …
• 47.

  Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars.

  • Zou P, Guo Y, Ding S, Song Z, Cui H, Zhang Y, Zhang Z, Chen X.
  • Molecules. 2022 Oct 9;27(19):6734. doi: 10.3390/molecules27196734.
  • PMCID: PMC9570943

  Zou P, et al.

  Molecules. 2022.

  PMCID: PMC9570943

  Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. ...Here, we aimed to study the metabolite profile of G. lucidum via nontargeted metabonomic technology. Metabonomic data revealed that o …

  Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. ... …
• 48.

  Isolation and Physicochemical Characterization of Laccase from Ganoderma lucidum-CDBT1 Isolated from Its Native Habitat in Nepal.

  • Shrestha P, Joshi B, Joshi J, Malla R, Sreerama L.
  • Biomed Res Int. 2016 Oct 16;2016:3238909. doi: 10.1155/2016/3238909.
  • PMCID: PMC5086383

  Shrestha P, et al.

  Biomed Res Int. 2016.

  PMCID: PMC5086383

  In the present study, three fungal species, namely, Ganoderma lucidum-CDBT1, Ganoderma japonicum, and Lentinula edodes, isolated from their native habitat in Nepal were screened for laccase production, and G. lucidum-CDBT1 was found to express highest …

  In the present study, three fungal species, namely, Ganoderma lucidum-CDBT1, Ganoderma japonicum, and Lentinula edodes, …
• 49.

  Structural characteristics, sugar metabolizing enzyme activity and biological activity of Ganoderma lucidum polysaccharides at different growth stages.

  • Ma S, Chen Y, Huang H, Pu X, Liang H, Kuang Y, Liu Y.
  • Sci Rep. 2025 Feb 9;15(1):4834. doi: 10.1038/s41598-025-89559-z.
  • PMCID: PMC11808097

  Ma S, et al.

  Sci Rep. 2025.

  PMCID: PMC11808097

  The Ganoderma lucidum polysaccharides (GLPs) content, monosaccharide composition, molecular weight, sugar metabolism-related enzyme activities and in vitro antioxidant activities of Ganoderma lucidum fruiting body (GLFB) from cassava stalk cultivation …

  The Ganoderma lucidum polysaccharides (GLPs) content, monosaccharide composition, molecular weight, sugar metabolism-related e …
• 50.

  Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum.

  • Fei Y, Li N, Zhang DH, Xu JW.
  • Microb Cell Fact. 2019 Jun 28;18(1):115. doi: 10.1186/s12934-019-1164-3.
  • PMCID: PMC6599323

  Fei Y, et al.

  Microb Cell Fact. 2019.

  PMCID: PMC6599323

  BACKGROUND: Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities. To improve production of GAs, a homologous farnesyl diphosphate synthase (FPS) gene was overexpressed in G. < …

  BACKGROUND: Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other importa …

• 51.

  Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.

  • Gao X, Huo H, Bao H, Wang J, Gao D.
  • Molecules. 2024 May 31;29(11):2591. doi: 10.3390/molecules29112591.
  • PMCID: PMC11173900

  Gao X, et al.

  Molecules. 2024.

  PMCID: PMC11173900

  Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding concerning the intrinsic mechanisms governing the accumulation of active components and potential protein expression across its diverse deve …

  Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding …
• 52.

  Anti-angiotensin converting enzyme (ACE) proteins from mycelia of Ganoderma lucidum (Curtis) P. Karst.

  • Mohamad Ansor N, Abdullah N, Aminudin N.
  • BMC Complement Altern Med. 2013 Oct 4;13:256. doi: 10.1186/1472-6882-13-256.
  • PMCID: PMC3852974

  Mohamad Ansor N, et al.

  BMC Complement Altern Med. 2013.

  PMCID: PMC3852974

  BACKGROUND: Ganoderma lucidum has been purported as a potent remedy in the treatment and prevention of several ailments, including hypertension. This study aimed to explore the anti-ACE potential of protein fractions from the mycelia of G. lucidum. METHODS: < …

  BACKGROUND: Ganoderma lucidum has been purported as a potent remedy in the treatment and prevention of several ailments, inclu …
• 53.

  PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum.

  • Li Y, Wang Z, Li Z, Tang X, Ji T, Liu R, Zhao M.
  • Microb Cell Fact. 2025 Aug 19;24(1):191. doi: 10.1186/s12934-025-02814-w.
  • PMCID: PMC12363083

  Li Y, et al.

  Microb Cell Fact. 2025.

  PMCID: PMC12363083

  Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in environmental protection and bioenergy development. Ganoderma lucidum, as a white rot fungus, secret a large amount of cellulase …

  Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in env …
• 54.

  The APSES transcription factor Swi6B upregulates CATALASE 1 transcription to enhance oxidative stress tolerance of Ganoderma lucidum.

  • Wang L, Shi L, Zhang S, Ma J, Zhang C, Chen H, Zhao M.
  • Appl Environ Microbiol. 2025 Jun 18;91(7):e0067925. doi: 10.1128/aem.00679-25.
  • PMCID: PMC12285235

  Wang L, et al.

  Appl Environ Microbiol. 2025.

  PMCID: PMC12285235

  Previously, we revealed that the Swi6B transcription factor is involved in the stress tolerance of Ganoderma lucidum. However, the underlying molecular mechanism is unclear. The present study demonstrated that oxidative stress increased the levels of Swi6B. ...Here, …

  Previously, we revealed that the Swi6B transcription factor is involved in the stress tolerance of Ganoderma lucidum. However, …
• 55.

  Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease.

  • Bharadwaj S, Lee KE, Dwivedi VD, Yadava U, Panwar A, Lucas SJ, Pandey A, Kang SG.
  • Sci Rep. 2019 Dec 13;9(1):19059. doi: 10.1038/s41598-019-55723-5.
  • PMCID: PMC6911040

  Bharadwaj S, et al.

  Sci Rep. 2019.

  PMCID: PMC6911040

  Triterpenoids from the medicinal fungus Ganoderma lucidum have been suggested as pharmacologically bioactive compounds and tested as anti-viral agents against various viral pathogens including human immunodeficiency virus. However, no reports are available concernin …

  Triterpenoids from the medicinal fungus Ganoderma lucidum have been suggested as pharmacologically bioactive compounds and tes …
• 56.

  Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.

  • Lin WC, Lin WL.
  • World J Gastroenterol. 2006 Jan 14;12(2):265-70. doi: 10.3748/wjg.v12.i2.265.
  • PMCID: PMC4066037

  Lin WC, et al.

  World J Gastroenterol. 2006.

  PMCID: PMC4066037

  AIM: To investigate the effects of Reishi mushroom, Ganoderma lucidum extract (GLE), on liver fibrosis induced by carbon tetrachloride (CCl4) in rats. ...

  AIM: To investigate the effects of Reishi mushroom, Ganoderma lucidum extract (GLE), on liver fibrosis induced by carbo …
• 57.

  Phytochemical analysis and antimicrobial activity of Ganoderma lucidum against selected bacteria and fungi of medical importance.

  • Solomon S, Oyekale AO, Ayanyinka A, Adeniyi I, Adedolapo OB, Ojeniyi FD, Oyelayo I, Olayinka O, Opaleye OO, Ojurongbe O, Olowe OA.
  • Sci Rep. 2025 Aug 25;15(1):31272. doi: 10.1038/s41598-025-06068-9.
  • PMCID: PMC12379213

  Solomon S, et al.

  Sci Rep. 2025.

  PMCID: PMC12379213

  Ganoderma lucidum is a rapidly growing mushroom, wood-colonizing fungus belonging to the phylum Basidiomycota. ...However, Aspergillus flavus, Aspergillus niger and Penicillium showed resistance against Ganoderma lucidum. Overall, this findings show th …

  Ganoderma lucidum is a rapidly growing mushroom, wood-colonizing fungus belonging to the phylum Basidiomycota. ...However, Asp …
• 58.

  Dual sgRNA-directed gene deletion in basidiomycete Ganoderma lucidum using the CRISPR/Cas9 system.

  • Liu K, Sun B, You H, Tu JL, Yu X, Zhao P, Xu JW.
  • Microb Biotechnol. 2020 Jan 20;13(2):386-396. doi: 10.1111/1751-7915.13534.
  • PMCID: PMC7017817

  Liu K, et al.

  Microb Biotechnol. 2020.

  PMCID: PMC7017817

  Ganoderma lucidum is an important medicinal mushroom in traditional Chinese medicine. However, the lack of adequate genetic tools has hindered molecular genetic research in and the genetic modification of this species. ...Furthermore, genomic fragment deletions in t …

  Ganoderma lucidum is an important medicinal mushroom in traditional Chinese medicine. However, the lack of adequate genetic to …
• 59.

  PRMT5 regulates the polysaccharide content by controlling the splicing of thaumatin-like protein in Ganoderma lucidum.

  • Liu R, Yang Z, Yang T, Wang Z, Chen X, Zhu J, Ren A, Shi L, Yu H, Zhao M.
  • Microbiol Spectr. 2023 Oct 26;11(6):e0290623. doi: 10.1128/spectrum.02906-23.
  • PMCID: PMC10715077

  Liu R, et al.

  Microbiol Spectr. 2023.

  PMCID: PMC10715077

  PRMT5 contributes to secondary metabolite biosynthesis in Ganoderma lucidum. However, the mechanism through which PRMT5 regulates the biosynthesis of secondary metabolites remains unclear. In the current study, PRMT5 silencing led to a significant decrease in the bi …

  PRMT5 contributes to secondary metabolite biosynthesis in Ganoderma lucidum. However, the mechanism through which PRMT5 regula …
• 60.

  Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum.

  • Shangguan J, Wu T, Tian L, Liu Y, Zhu L, Liu R, Zhu J, Shi L, Zhao M, Ren A.
  • Redox Biol. 2024 Jun 6;74:103227. doi: 10.1016/j.redox.2024.103227.
  • PMCID: PMC11215418

  Shangguan J, et al.

  Redox Biol. 2024.

  PMCID: PMC11215418

  Previous studies have shown that H(2)S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of Ganoderma lucidum. However, a comprehensive understanding of the physiological effects and molecular mechanisms of H(2)S in G. lucidum …

  Previous studies have shown that H(2)S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of Ganoderm …

• 61.

  The Possible Role of PD-1 Protein in Ganoderma lucidum-Mediated Immunomodulation and Cancer Treatment.

  • Wang G, Wang L, Zhou J, Xu X.
  • Integr Cancer Ther. 2019 Jan-Dec;18:1534735419880275. doi: 10.1177/1534735419880275.
  • PMCID: PMC6876169

  Wang G, et al.

  Integr Cancer Ther. 2019.

  PMCID: PMC6876169

  Background:Ganoderma lucidum has been used in Chinese medicine for thousands years to improve health and to promote longevity. ...Conclusions: PD-1 protein is an important target of G lucidum-mediated immunomodulation. G lucidum and its bioactive compo …

  Background:Ganoderma lucidum has been used in Chinese medicine for thousands years to improve health and to promote longevity. …
• 62.

  Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action.

  • Ahmad MF, Ahmad FA, Zeyaullah M, Alsayegh AA, Mahmood SE, AlShahrani AM, Khan MS, Shama E, Hamouda A, Elbendary EY, Attia KAHA.
  • Nutrients. 2023 Apr 13;15(8):1874. doi: 10.3390/nu15081874.
  • PMCID: PMC10146730

  Ahmad MF, et al.

  Nutrients. 2023.

  PMCID: PMC10146730

  Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. ...This review summarizes the hepatoprotective properties of G. lucidum with its vari …

  Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mush …
• 63.

  Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.

  • Łysakowska P, Sobota A, Wirkijowska A.
  • Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393.
  • PMCID: PMC10384337

  Łysakowska P, et al.

  Molecules. 2023.

  PMCID: PMC10384337

  Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach. ex Pers.) ...

  Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst. …
• 64.

  Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress.

  • Zhu Q, Ren A, Ding J, He J, Zhao M, Jiang A, Zhou X, Wang J, He Q.
  • Microbiol Spectr. 2022 Nov 2;10(6):e0129722. doi: 10.1128/spectrum.01297-22.
  • PMCID: PMC9784773

  Zhu Q, et al.

  Microbiol Spectr. 2022.

  PMCID: PMC9784773

  In this study, water stress was found to increase intracellular reactive oxygen species (ROS) level, ganoderic acid (GA) content, and NADPH oxidase (NOX) activity of Ganoderma lucidum by 148.45%, 75.32%, and 161.61%, respectively. Water stress induced the expression …

  In this study, water stress was found to increase intracellular reactive oxygen species (ROS) level, ganoderic acid (GA) content, and NADPH …
• 65.

  The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study.

  • Rahimnia R, Akbari MR, Yasseri AF, Taheri D, Mirzaei A, Ghajar HA, Farashah PD, Baghdadabad LZ, Aghamir SMK.
  • Sci Rep. 2023 Nov 2;13(1):18940. doi: 10.1038/s41598-023-46118-8.
  • PMCID: PMC10622576

  Rahimnia R, et al.

  Sci Rep. 2023.

  PMCID: PMC10622576

  Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. ...Ganoderma lucidum polysaccharide synergistically increased the effect of Docetaxel and Flutamide and increased the sensitivity of the prostate cancer cell line …

  Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. ...Ganoderma lucidum p …
• 66.

  Expression and characteristics of manganese peroxidase from Ganoderma lucidum in Pichia pastoris and its application in the degradation of four dyes and phenol.

  • Xu H, Guo MY, Gao YH, Bai XH, Zhou XW.
  • BMC Biotechnol. 2017 Feb 23;17(1):19. doi: 10.1186/s12896-017-0338-5.
  • PMCID: PMC5324234

  Xu H, et al.

  BMC Biotechnol. 2017.

  PMCID: PMC5324234

  BACKGROUND: Manganese peroxidase (MnP) of white rot basidiomycetes, an extracellular heme enzyme, is part of a peroxidase superfamily that is capable of degrading the different phenolic compounds. Ganoderma, a white rot basidiomycete widely distributed worldwide, could sec …

  BACKGROUND: Manganese peroxidase (MnP) of white rot basidiomycetes, an extracellular heme enzyme, is part of a peroxidase superfamily that i …
• 67.

  A toxicological assessment of Ganoderma lucidum and Cordyceps militaris mushroom powders.

  • Chrysostomou PP, Freeman E, Murphy MM, Chaudhary A, Siddiqui N, Daoust J.
  • Front Toxicol. 2024 Oct 30;6:1469348. doi: 10.3389/ftox.2024.1469348.
  • PMCID: PMC11558339

  Chrysostomou PP, et al.

  Front Toxicol. 2024.

  PMCID: PMC11558339

  Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C. militaris) are among the many mushrooms known for their long history of use in traditional medicine. ...The purpose of this study was to assess the potential for acute toxicity, subchronic toxicity, and geno …

  Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C. militaris) are among the many mushrooms known for their long histor …
• 68.

  GCN4 Regulates Secondary Metabolism through Activation of Antioxidant Gene Expression under Nitrogen Limitation Conditions in Ganoderma lucidum.

  • Lian L, Wang L, Song S, Zhu J, Liu R, Shi L, Ren A, Zhao M.
  • Appl Environ Microbiol. 2021 Jun 25;87(14):e0015621. doi: 10.1128/AEM.00156-21.
  • PMCID: PMC8231712

  Lian L, et al.

  Appl Environ Microbiol. 2021.

  PMCID: PMC8231712

  Here, we found that nitrogen limitation highly induced the expression of GCN4 and promoted the synthesis of ganoderic acid (GA), an important secondary metabolite in Ganoderma lucidum. The activated GCN4 is involved in regulating GA biosynthesis. In addition, the ac …

  Here, we found that nitrogen limitation highly induced the expression of GCN4 and promoted the synthesis of ganoderic acid (GA), an importan …
• 69.

  Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells.

  • Cheng AY, Chien YC, Lee HC, Hsieh YH, Yu YL.
  • Molecules. 2020 Aug 6;25(16):3585. doi: 10.3390/molecules25163585.
  • PMCID: PMC7464863

  Cheng AY, et al.

  Molecules. 2020.

  PMCID: PMC7464863

  The current treatment is mainly surgery, chemotherapy, and radiation therapy, but the results are not satisfactory. Ganoderma lucidum (G. lucidum), also called "Lingzhi", is a medicinal mushroom that has been used as a therapeutic agent for the treatment of n …

  The current treatment is mainly surgery, chemotherapy, and radiation therapy, but the results are not satisfactory. Ganoderma luci …
• 70.

  Ganoderma lucidum cultivation affect microbial community structure of soil, wood segments and tree roots.

  • Ren F, Zhang Y, Yu H, Zhang YA.
  • Sci Rep. 2020 Feb 26;10(1):3435. doi: 10.1038/s41598-020-60362-2.
  • PMCID: PMC7044327

  Ren F, et al.

  Sci Rep. 2020.

  PMCID: PMC7044327

  The popular medicinal mushroom Ganoderma lucidum (Fr.) Karst. [Ling Zhi] has been widely used for the general promotion of health and longevity in Asian countries. ...The study will provide useful information for G. lucidum cultivation and under-forest econom …

  The popular medicinal mushroom Ganoderma lucidum (Fr.) Karst. [Ling Zhi] has been widely used for the general promotion of hea …

• 71.

  Heat Stress Modulates Mycelium Growth, Heat Shock Protein Expression, Ganoderic Acid Biosynthesis, and Hyphal Branching of Ganoderma lucidum via Cytosolic Ca2.

  • Zhang X, Ren A, Li MJ, Cao PF, Chen TX, Zhang G, Shi L, Jiang AL, Zhao MW.
  • Appl Environ Microbiol. 2016 Jun 30;82(14):4112-4125. doi: 10.1128/AEM.01036-16.
  • PMCID: PMC4959220

  Zhang X, et al.

  Appl Environ Microbiol. 2016.

  PMCID: PMC4959220

  Thus, a comprehensive understanding of how organisms sense HS and respond to it is required. Ganoderma lucidum, a higher basidiomycete with bioactive secondary metabolites, has become a potential model system due to the complete sequencing of its genome, transgenic …

  Thus, a comprehensive understanding of how organisms sense HS and respond to it is required. Ganoderma lucidum, a higher basid …
• 72.

  Submerged fermentation production and characterization of intracellular triterpenoids from Ganoderma lucidum using HPLC-ESI-MS.

  • Cui ML, Yang HY, He GQ.
  • J Zhejiang Univ Sci B. 2015 Dec;16(12):998-1010. doi: 10.1631/jzus.B1500147.
  • PMCID: PMC4678043

  Cui ML, et al.

  J Zhejiang Univ Sci B. 2015.

  PMCID: PMC4678043

  As the main bioactive metabolites of Ganoderma lucidum, triterpenoids have various pharmacological effects. In this paper, the nutritional requirements and culture conditions of a submerged culture of G. lucidum were optimized using the response surface metho …

  As the main bioactive metabolites of Ganoderma lucidum, triterpenoids have various pharmacological effects. In this paper, the …
• 73.

  Optimization of Culture Condition for Ganoderic Acid Production in Ganoderma lucidum Liquid Static Culture and Design of a Suitable Bioreactor.

  • Hu G, Zhai M, Niu R, Xu X, Liu Q, Jia J.
  • Molecules. 2018 Oct 8;23(10):2563. doi: 10.3390/molecules23102563.
  • PMCID: PMC6222601

  Hu G, et al.

  Molecules. 2018.

  PMCID: PMC6222601

  Ganoderma lucidum, a famous medicinal mushroom used worldwide, is a rich source of triterpenoids which, together with polysaccharides, are believed to be the main effective constituents of G. lucidum. ...Our results demonstrate the potential of industrial app …

  Ganoderma lucidum, a famous medicinal mushroom used worldwide, is a rich source of triterpenoids which, together with polysacc …
• 74.

  Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.

  • Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF.
  • BMC Genomics. 2007 Nov 9;8:411. doi: 10.1186/1471-2164-8-411.
  • PMCID: PMC2211495

  Cheng KC, et al.

  BMC Genomics. 2007.

  PMCID: PMC2211495

  BACKGROUND: Ganoderma lucidum has been widely used as a herbal medicine for promoting health and longevity in China and other Asian countries. Polysaccharide extracts from Ganoderma lucidum have been reported to exhibit immuno-modulating and anti-tumor …

  BACKGROUND: Ganoderma lucidum has been widely used as a herbal medicine for promoting health and longevity in China and other …
• 75.

  Integrative Analysis of Selected Metabolites and the Fungal Transcriptome during the Developmental Cycle of Ganoderma lucidum Strain G0119 Correlates Lignocellulose Degradation with Carbohydrate and Triterpenoid Metabolism.

  • Zhou S, Zhang X, Ma F, Xie S, Tang C, Tang Q, Zhang J.
  • Appl Environ Microbiol. 2021 Jun 11;87(13):e0053321. doi: 10.1128/AEM.00533-21.
  • PMCID: PMC8315967

  Zhou S, et al.

  Appl Environ Microbiol. 2021.

  PMCID: PMC8315967

  To systemically understand the biosynthetic pathways of bioactive substances, including triterpenoids and polysaccharides, in Ganoderma lucidum, the correlation between substrate degradation and carbohydrate and triterpenoid metabolism during growth was analyzed by …

  To systemically understand the biosynthetic pathways of bioactive substances, including triterpenoids and polysaccharides, in Ganoderma …
• 76.

  Genome-wide identification and characterization of long intergenic non-coding RNAs in Ganoderma lucidum.

  • Li J, Wu B, Xu J, Liu C.
  • PLoS One. 2014 Jun 16;9(6):e99442. doi: 10.1371/journal.pone.0099442.
  • PMCID: PMC4059649

  Li J, et al.

  PLoS One. 2014.

  PMCID: PMC4059649

  Ganoderma lucidum is a white-rot fungus best-known for its medicinal activities. We have previously sequenced its genome and annotated the protein coding genes. However, long non-coding RNAs in G. lucidum genome have not been analyzed. In this study, we have …

  Ganoderma lucidum is a white-rot fungus best-known for its medicinal activities. We have previously sequenced its genome and a …
• 77.

  The ITS region provides a reliable DNA barcode for identifying reishi/lingzhi (Ganoderma) from herbal supplements.

  • Gunnels T, Creswell M, McFerrin J, Whittall JB.
  • PLoS One. 2020 Nov 12;15(11):e0236774. doi: 10.1371/journal.pone.0236774.
  • PMCID: PMC7660467

  Gunnels T, et al.

  PLoS One. 2020.

  PMCID: PMC7660467

  We employed a molecular phylogenetic analysis for species authentication of the commonly used fungal supplement, reishi (Ganoderma lingzhi), by amplifying and sequencing the nuclear ribosomal internal transcribed spacer regions (ITS) with genus-specific primers. PCR …

  We employed a molecular phylogenetic analysis for species authentication of the commonly used fungal supplement, reishi (Ganoderma …
• 78.

  Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships.

  • Chen S, Li X, Yong T, Wang Z, Su J, Jiao C, Xie Y, Yang BB.
  • Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336.
  • PMCID: PMC5354642

  Chen S, et al.

  Oncotarget. 2017.

  PMCID: PMC5354642

  We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). ...These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a the …

  We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols …
• 79.

  Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.

  • Kong M, Yao Y, Zhang H.
  • Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869489. doi: 10.1177/2058738419869489.
  • PMCID: PMC6716173

  Kong M, et al.

  Int J Immunopathol Pharmacol. 2019.

  PMCID: PMC6716173

  Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studies on the biological activities of Ganoderma lucidum polysaccharide (GLP), little is known regarding the medicinal potential of …

  Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studie …
• 80.

  Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/beta-Catenin Signaling Pathway.

  • Zhang QH, Hu QX, Xie D, Chang B, Miao HG, Wang YG, Liu DZ, Li XD.
  • Integr Cancer Ther. 2019 Jan-Dec;18:1534735419890917. doi: 10.1177/1534735419890917.
  • PMCID: PMC6923688

  Zhang QH, et al.

  Integr Cancer Ther. 2019.

  PMCID: PMC6923688

  Background: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with traditional Chinese medicine. Ganoderma lucidum, a traditional Chinese medicine with antitumor effects, offers a potential alternat …

  Background: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with tradi …

• 81.

  Proteome exploration to provide a resource for the investigation of Ganoderma lucidum.

  • Yu GJ, Yin YL, Yu WH, Liu W, Jin YX, Shrestha A, Yang Q, Ye XD, Sun H.
  • PLoS One. 2015 Mar 10;10(3):e0119439. doi: 10.1371/journal.pone.0119439.
  • PMCID: PMC4355618

  Yu GJ, et al.

  PLoS One. 2015.

  PMCID: PMC4355618

  Ganoderma lucidum is a basidiomycete white rot fungus that has been used for medicinal purposes worldwide. Although information concerning its genome and transcriptome has recently been reported, relatively little information is available for G. lucidum at th …

  Ganoderma lucidum is a basidiomycete white rot fungus that has been used for medicinal purposes worldwide. Although informatio …
• 82.

  Heme Oxygenase/Carbon Monoxide Participates in the Regulation of Ganoderma lucidum Heat-Stress Response, Ganoderic Acid Biosynthesis, and Cell-Wall Integrity.

  • Wu T, Liu X, Wang T, Tian L, Qiu H, Ge F, Zhu J, Shi L, Jiang A, Yu H, Ren A.
  • Int J Mol Sci. 2022 Oct 29;23(21):13147. doi: 10.3390/ijms232113147.
  • PMCID: PMC9659044

  Wu T, et al.

  Int J Mol Sci. 2022.

  PMCID: PMC9659044

  However, whether HO/CO is involved in the regulation of the heat-stress (HS) response of Ganoderma lucidum (G. lucidum) is still poorly understood. In this paper, we reported that under heat stress, the HMX1 transcription level, HO enzyme activity, and CO con …

  However, whether HO/CO is involved in the regulation of the heat-stress (HS) response of Ganoderma lucidum (G. lucidum) …
• 83.

  A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.

  • You BJ, Lee MH, Tien N, Lee MS, Hsieh HC, Tseng LH, Chung YL, Lee HZ.
  • PLoS One. 2013 Jan 10;8(1):e53616. doi: 10.1371/journal.pone.0053616.
  • PMCID: PMC3542374

  You BJ, et al.

  PLoS One. 2013.

  PMCID: PMC3542374

  Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, …

  Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its ac …
• 84.

  Profiling and quantifying differential gene transcription provide insights into ganoderic acid biosynthesis in Ganoderma lucidum in response to methyl jasmonate.

  • Ren A, Li MJ, Shi L, Mu DS, Jiang AL, Han Q, Zhao MW.
  • PLoS One. 2013 Jun 7;8(6):e65027. doi: 10.1371/journal.pone.0065027.
  • PMCID: PMC3676390

  Ren A, et al.

  PLoS One. 2013.

  PMCID: PMC3676390

  Ganoderma lucidum is a mushroom with traditional medicinal properties that has been widely used in China and other countries in Eastern Asia. Ganoderic acids (GA) produced by G. lucidum exhibit important pharmacological activities. Previous studies have demon …

  Ganoderma lucidum is a mushroom with traditional medicinal properties that has been widely used in China and other countries i …
• 85.

  Enhanced production of polysaccharides and triterpenoids in Ganoderma lucidum fruit bodies on induction with signal transduction during the fruiting stage.

  • Ye L, Liu S, Xie F, Zhao L, Wu X.
  • PLoS One. 2018 Apr 25;13(4):e0196287. doi: 10.1371/journal.pone.0196287.
  • PMCID: PMC5919040

  Ye L, et al.

  PLoS One. 2018.

  PMCID: PMC5919040

  Ganoderma lucidum is a medicinal mushroom that has been widely used in East Asia for the treatment of various diseases. ...The present study provides a useful approach to producing G. lucidum fruit bodies with high polysaccharide and triterpenoid content. Thi …

  Ganoderma lucidum is a medicinal mushroom that has been widely used in East Asia for the treatment of various diseases. ...The …
• 86.

  Generation and analysis of the expressed sequence tags from the mycelium of Ganoderma lucidum.

  • Huang YH, Wu HY, Wu KM, Liu TT, Liou RF, Tsai SF, Shiao MS, Ho LT, Tzean SS, Yang UC.
  • PLoS One. 2013 May 2;8(5):e61127. doi: 10.1371/journal.pone.0061127.
  • PMCID: PMC3642047

  Huang YH, et al.

  PLoS One. 2013.

  PMCID: PMC3642047

  Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To enable a systematic exploration of the genes associated with the various phenotypes of the fungus, the genome consortium of G. lucidum …

  Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To e …
• 87.

  Proteome study of dikaryotic and monokaryotic mycelia reveals the transfer between biological processes contributing to dikaryon growth advantage of the medicinal fungus Ganoderma lucidum.

  • Yu H, Dong L, Zhao Q.
  • BMC Genomics. 2025 Aug 1;26(1):711. doi: 10.1186/s12864-025-11905-2.
  • PMCID: PMC12315474

  Yu H, et al.

  BMC Genomics. 2025.

  PMCID: PMC12315474

  BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate in its dikaryotic mycelia compared to monokaryons, and this is essential for its fruiting body formation and medicinal utilization. ...This …

  BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate …
• 88.

  A Summary of a Cochrane Review: Ganoderma lucidum (Reishi mushroom) for the treatment of cancer.

  • Santesso N, Wieland LS.
  • Eur J Integr Med. Author manuscript. 2016 Jul 20;8(5):619-620. doi: 10.1016/j.eujim.2016.07.025.
  • PMCID: PMC5222619

  Santesso N, et al.

  Eur J Integr Med. Author manuscript. 2016.

  PMCID: PMC5222619
• 89.

  Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms.

  • Ewunkem AJ, Priester T, Williams D, Ariyon B, Tshimanga I, Justice B, Singh DK.
  • J Biomater Nanobiotechnol. Author manuscript. 2024 Jul 12;15(3):51-63. doi: 10.4236/jbnb.2024.153004.
  • PMCID: PMC12393771

  Ewunkem AJ, et al.

  J Biomater Nanobiotechnol. Author manuscript. 2024.

  PMCID: PMC12393771

  Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract of medicinal mushroom Ganoderma lucidum (also known as reishi). The structural and dimensional dispersion of the biosyn …

  Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract …
• 90.

  Ganoderma lucidum stimulates autophagy-dependent longevity pathways in Caenorhabditis elegans and human cells.

  • Peng HH, Wu CY, Hsiao YC, Martel J, Ke PY, Chiu CY, Liau JC, Chang IT, Su YH, Ko YF, Young JD, Ojcius DM.
  • Aging (Albany NY). 2021 May 20;13(10):13474-13495. doi: 10.18632/aging.203068.
  • PMCID: PMC8202889

  Peng HH, et al.

  Aging (Albany NY). 2021.

  PMCID: PMC8202889

  The medicinal fungus Ganoderma lucidum is used as a dietary supplement and health tonic, but whether it affects longevity remains unclear. ...These results suggest that G. lucidum can increase longevity by inducing autophagy and stress resistance....

  The medicinal fungus Ganoderma lucidum is used as a dietary supplement and health tonic, but whether it affects longevity rema …

• 91.

  Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum.

  • You BJ, Tien N, Lee MH, Bao BY, Wu YS, Hu TC, Lee HZ.
  • Sci Rep. 2017 Mar 23;7(1):318. doi: 10.1038/s41598-017-00281-x.
  • PMCID: PMC5428012

  You BJ, et al.

  Sci Rep. 2017.

  PMCID: PMC5428012

  However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungus Ganoderma lucidum is a popular herbal medicine worldwide, but the biosynthetic regulation of its active ingredients (ganoderic acids, GAs) …

  However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungus Ganoderma …
• 92.

  Abundant and selective RNA-editing events in the medicinal mushroom Ganoderma lucidum.

  • Zhu Y, Luo H, Zhang X, Song J, Sun C, Ji A, Xu J, Chen S.
  • Genetics. 2014 Feb 4;196(4):1047-57. doi: 10.1534/genetics.114.161414.
  • PMCID: PMC3982681

  Zhu Y, et al.

  Genetics. 2014.

  PMCID: PMC3982681

  In this study, we screened for fungal RNA editing sites at the genomic level in Ganoderma lucidum, a valuable medicinal fungus. On the basis of our pipeline that predicted the editing sites from genomic and transcriptomic data, a total of 8906 possible RNA-editing s …

  In this study, we screened for fungal RNA editing sites at the genomic level in Ganoderma lucidum, a valuable medicinal fungus …
• 93.

  Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum.

  • Li C, Cui Y, Lu J, Liu C, Chen S, Ma C, Liu Z, Wang J, Kang W.
  • Molecules. 2020 Mar 13;25(6):1309. doi: 10.3390/molecules25061309.
  • PMCID: PMC7144108

  Li C, et al.

  Molecules. 2020.

  PMCID: PMC7144108

  Ganoderma lucidum is widely used in traditional Chinese medicine (TCM). Ganoderic acid A and D are the main bioactive components with anticancer effects in G. lucidum. To obtain the maximum content of two compounds from G. lucidum, a novel extraction m …

  Ganoderma lucidum is widely used in traditional Chinese medicine (TCM). Ganoderic acid A and D are the main bioactive componen …
• 94.

  Purification, crystallization and preliminary X-ray structure analysis of the laccase from Ganoderma lucidum.

  • Lyashenko AV, Belova O, Gabdulkhakov AG, Lashkov AA, Lisov AV, Leontievsky AA, Mikhailov AM.
  • Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 20;67(Pt 8):926-9. doi: 10.1107/S1744309111021129.
  • PMCID: PMC3151130

  Lyashenko AV, et al.

  Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011.

  PMCID: PMC3151130

  This paper presents the purification, crystallization and preliminary X-ray analysis of the laccase from the ligninolytic basidiomycete Ganoderma lucidum....

  This paper presents the purification, crystallization and preliminary X-ray analysis of the laccase from the ligninolytic basidiomycete G …
• 95.

  The Anti-Melanogenic Effects of Ganodermanontriol from the Medicinal Mushroom Ganoderma lucidum through the Regulation of the CREB and MAPK Signaling Pathways in B16F10 Cells.

  • Park CH, Oh YL, Shin JH, Park YJ.
  • Molecules. 2024 Aug 22;29(16):3976. doi: 10.3390/molecules29163976.
  • PMCID: PMC11357533

  Park CH, et al.

  Molecules. 2024.

  PMCID: PMC11357533

  Ganoderma lucidum, a member of the Basidiomycetes family, is attracting attention for its medicinal potential due to its biological activity and the presence of numerous bioactive compounds. ...Finally, the biosynthesis of GT and other substances by G. lucidum …

  Ganoderma lucidum, a member of the Basidiomycetes family, is attracting attention for its medicinal potential due to its biolo …
• 96.

  Genome sequence of the model medicinal mushroom Ganoderma lucidum.

  • Chen S, Xu J, Liu C, Zhu Y, Nelson DR, Zhou S, Li C, Wang L, Guo X, Sun Y, Luo H, Li Y, Song J, Henrissat B, Levasseur A, Qian J, Li J, Luo X, Shi L, He L, Xiang L, Xu X, Niu Y, Li Q, Han MV, Yan H, Zhang J, Chen H, Lv A, Wang Z, Liu M, Schwartz DC, Sun C.
  • Nat Commun. 2012 Jun 26;3:913. doi: 10.1038/ncomms1923.
  • PMCID: PMC3621433

  Chen S, et al.

  Nat Commun. 2012.

  PMCID: PMC3621433

  Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. ...Moreover, 78 CYP genes are coexpressed with lanosterol synthase, and 16 of these show high similarity to fungal CYPs that s …

  Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioacti …
• 97.

  Screening and Analysis of the Marker Components in Ganoderma lucidum by HPLC and HPLC-MS(n) with the Aid of Chemometrics.

  • Wu L, Liang W, Chen W, Li S, Cui Y, Qi Q, Zhang L.
  • Molecules. 2017 Apr 6;22(4):584. doi: 10.3390/molecules22040584.
  • PMCID: PMC6154496

  Wu L, et al.

  Molecules. 2017.

  PMCID: PMC6154496

  Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. ...This study provides helpful chemical information for further research on the anti …

  Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditi …
• 98.

  GlPRMT5 inhibits GlPP2C1 via symmetric dimethylation and regulates the biosynthesis of secondary metabolites in Ganoderma lucidum.

  • Wang Z, Qiu H, Li Y, Zhao M, Liu R.
  • Commun Biol. 2024 Feb 28;7(1):241. doi: 10.1038/s42003-024-05942-y.
  • PMCID: PMC10902306

  Wang Z, et al.

  Commun Biol. 2024.

  PMCID: PMC10902306

  Secondary metabolites are vital pharmacological compounds in Ganoderma lucidum, and their content is an important indicator for evaluating the quality of G. lucidum. ...In addition, silencing GlPP2C1 clearly reduced GA content, indicating that GlPP2C1 positiv …

  Secondary metabolites are vital pharmacological compounds in Ganoderma lucidum, and their content is an important indicator fo …
• 99.

  A Systematic Review of in-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment (P14-021-19).

  • Nkodo A.
  • Curr Dev Nutr. 2019 Jun 13;3(Suppl 1):nzz052.P14-021-19. doi: 10.1093/cdn/nzz052.P14-021-19.
  • PMCID: PMC6574952

  Nkodo A.

  Curr Dev Nutr. 2019.

  PMCID: PMC6574952

  OBJECTIVES: A systematic review was undertaken of the evidence on the use of Hericium erinaceus (Reishi), Ganoderma lucidum (Lion's Mane), Ophiocordyceps sinensis (Cordyceps) and Cordyceps militaris (Cordyceps), dietary supplementation on cognitive impairment …

  OBJECTIVES: A systematic review was undertaken of the evidence on the use of Hericium erinaceus (Reishi), Ganoderma lucidum …
• 100.

  Determination of volatile aroma compounds of Ganoderma lucidum by gas chromatography mass spectrometry (HS-GC/MS).

  • Taşkın H, Kafkas E, Çakıroğlu Ö, Büyükalaca S.
  • Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):353-5.
  • PMCID: PMC3746584

  Taşkın H, et al.

  Afr J Tradit Complement Altern Med. 2012.

  PMCID: PMC3746584

  This study was conducted at Horticulture Department of Cukurova University, Adana, Turkey during 2010-2011. Fresh sample of Ganoderma lucidum collected from Mersin province of Turkey was used as material. Volatile aroma compounds were performed by Headspace Gas Chro …

  This study was conducted at Horticulture Department of Cukurova University, Adana, Turkey during 2010-2011. Fresh sample of Ganoderma …

• 101.

  Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial-static culture of Ganoderma lucidum.

  • Wang Q, Xu M, Zhao L, Wang F, Li Y, Shi G, Ding Z.
  • Microb Biotechnol. 2020 Sep 25;14(2):600-613. doi: 10.1111/1751-7915.13670.
  • PMCID: PMC7936306

  Wang Q, et al.

  Microb Biotechnol. 2020.

  PMCID: PMC7936306

  Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited many significant pharmacological activities. In this study, the biosynthetic mechanism of GAs was investigated by comparing metabolites and transcriptome dynamics during liquid su …

  Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited many significant pharmacological activi …
• 102.

  Production Ganoderma lucidum extract nanoparticles by expansion of supercritical fluid solution and evaluation of the antioxidant ability.

  • Karimi M, Raofie F, Karimi M.
  • Sci Rep. 2022 Jun 14;12(1):9904. doi: 10.1038/s41598-022-13727-8.
  • PMCID: PMC9198024

  Karimi M, et al.

  Sci Rep. 2022.

  PMCID: PMC9198024

  Due to the growing human tendency to treat with natural substances, fungi such as Ganoderma lucidum can be a good source to meet this need. Effectiveness, ease of use and a rich source of active ingredients such as ganoderic acids have caused G. lucidum to be …

  Due to the growing human tendency to treat with natural substances, fungi such as Ganoderma lucidum can be a good source to me …
• 103.

  Ganoderma lucidum-Derived Meroterpenoids Show Anti-Inflammatory Activity In Vitro.

  • Liu YY, Cai D, Tang XP, Cheng YX.
  • Molecules. 2024 Mar 5;29(5):1149. doi: 10.3390/molecules29051149.
  • PMCID: PMC10935275

  Liu YY, et al.

  Molecules. 2024.

  PMCID: PMC10935275

  Ganoderma lucidum, known as the "herb of spiritual potency", is used for the treatment and prevention of various diseases, but the responsible constituents for its therapeutic effects are largely unknown. ...The current study will aid in enriching the structural and …

  Ganoderma lucidum, known as the "herb of spiritual potency", is used for the treatment and prevention of various diseases, but …
• 104.

  Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum.

  • Dai J, Miller MA, Everetts NJ, Wang X, Li P, Li Y, Xu JH, Yao G.
  • Oncotarget. 2017 Feb 21;8(8):13770-13781. doi: 10.18632/oncotarget.14634.
  • PMCID: PMC5355137

  Dai J, et al.

  Oncotarget. 2017.

  PMCID: PMC5355137

  The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment of many diseases including cancer. Here we studied the cytotoxic effects of two natural compounds purified from Ganoderma lucidum …

  The medical mushroom Ganoderma lucidum has long been used in traditional Chinese medicine and shown effective in the treatment …
• 105.

  Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats.

  • Laçin N, İzol SB, İpek F, Tuncer MC.
  • Acta Cir Bras. 2019 Nov 25;34(9):e201900904. doi: 10.1590/s0102-865020190090000004.
  • PMCID: PMC6887096

  Laçin N, et al.

  Acta Cir Bras. 2019.

  PMCID: PMC6887096

  PURPOSE: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. METHODS: Wistar male rats (n = 3 …

  PURPOSE: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, w …
• 106.

  Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum.

  • Wang G, Xu L, Yu H, Gao J, Guo L.
  • BMC Genomics. 2019 Jul 16;20(1):585. doi: 10.1186/s12864-019-5962-0.
  • PMCID: PMC6636155

  Wang G, et al.

  BMC Genomics. 2019.

  PMCID: PMC6636155

  BACKGROUND: Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioactive compounds. ...Although it has been studied for a long time, its function is still unclear in G. lucidum. In this study, a global …

  BACKGROUND: Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioact …
• 107.

  Utilization of Response Surface Methodology in Optimization of Polysaccharides Extraction from Vietnamese Red Ganoderma lucidum by Ultrasound-Assisted Enzymatic Method and Examination of Bioactivities of the Extract.

  • Do DT, Lam DH, Nguyen T, Phuong Mai TT, Phan LTM, Vuong HT, Nguyen DV, Linh NTT, Hoang MN, Mai TP, Nguyen HH.
  • ScientificWorldJournal. 2021 Feb 11;2021:7594092. doi: 10.1155/2021/7594092.
  • PMCID: PMC7892253

  Do DT, et al.

  ScientificWorldJournal. 2021.

  PMCID: PMC7892253

  Red Ganoderma lucidum (G. lucidum) is a popular medicinal herb commonly used in Vietnamese traditional remedies due to its potential value for health. ...This result suggested that UAEE could be considered as an appropriate and effective extraction method for …

  Red Ganoderma lucidum (G. lucidum) is a popular medicinal herb commonly used in Vietnamese traditional remedies due to …
• 108.

  Selected strains of the Ganoderma lucidum complex from Finnish forests have excellent broadly acting antiviral properties.

  • Reshamwala D, Shroff S, Liimatainen J, Tienaho J, Kuukkanen I, Laajala M, Civra A, Francese R, Veteli P, Cortina-Escribano M, Sarjala T, Karonen M, Lembo D, Linnakoski R, Marjomäki V.
  • Sci Rep. 2025 Jul 2;15(1):23565. doi: 10.1038/s41598-025-08377-5.
  • PMCID: PMC12223054

  Reshamwala D, et al.

  Sci Rep. 2025.

  PMCID: PMC12223054

  Thus, the current study aims to investigate the broad-spectrum antiviral activity of ferments of selected strains belonging to the Ganoderma lucidum complex isolated from Finland and investigate their mechanism of action. ...The results show great promise for the fu …

  Thus, the current study aims to investigate the broad-spectrum antiviral activity of ferments of selected strains belonging to the Ganode …
• 109.

  Complete mitochondrial genome of the medicinal mushroom Ganoderma lucidum.

  • Li J, Zhang J, Chen H, Chen X, Lan J, Liu C.
  • PLoS One. 2013 Aug 26;8(8):e72038. doi: 10.1371/journal.pone.0072038.
  • PMCID: PMC3753355

  Li J, et al.

  PLoS One. 2013.

  PMCID: PMC3753355

  Ganoderma lucidum is one of the well-known medicinal basidiomycetes worldwide. The mitochondrion, referred to as the second genome, is an organelle found in most eukaryotic cells and participates in critical cellular functions. Elucidating the structure and function …

  Ganoderma lucidum is one of the well-known medicinal basidiomycetes worldwide. The mitochondrion, referred to as the second ge …
• 110.

  Optimization of Laccase from Ganoderma lucidum Decolorizing Remazol Brilliant Blue R and Glac1 as Main Laccase-Contributing Gene.

  • Qin P, Wu Y, Adil B, Wang J, Gu Y, Yu X, Zhao K, Zhang X, Ma M, Chen Q, Chen X, Zhang Z, Xiang Q.
  • Molecules. 2019 Oct 30;24(21):3914. doi: 10.3390/molecules24213914.
  • PMCID: PMC6864837

  Qin P, et al.

  Molecules. 2019.

  PMCID: PMC6864837

  In this work, the influence of reaction time, pH, temperature, dye concentration, metal ions, and mediators on laccase-catalyzed Remazol Brilliant Blue R dye (RBBR) decolorization were investigated in vitro using crude laccase from the white-rot fungus Ganoderma lucidum …

  In this work, the influence of reaction time, pH, temperature, dye concentration, metal ions, and mediators on laccase-catalyzed Remazol Bri …

• 111.

  GlMPC activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum.

  • Wang Z, Chen J, Ding J, Han J, Shi L.
  • mBio. 2023 Sep 21;14(5):e0135623. doi: 10.1128/mbio.01356-23.
  • PMCID: PMC10653791

  Wang Z, et al.

  mBio. 2023.

  PMCID: PMC10653791

  In this study, we report that GCN4 can directly bind to the promoter region and activate the expression of GlMPC, thereby regulating the tricarboxylic acid cycle and secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum. These findings provi …

  In this study, we report that GCN4 can directly bind to the promoter region and activate the expression of GlMPC, thereby regulating the tri …
• 112.

  Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation.

  • Meng L, Bai X, Zhang S, Zhang M, Zhou S, Mukhtar I, Wang L, Li Z, Wang W.
  • Int J Mol Sci. 2019 Jun 10;20(11):2830. doi: 10.3390/ijms20112830.
  • PMCID: PMC6600565

  Meng L, et al.

  Int J Mol Sci. 2019.

  PMCID: PMC6600565

  Ganoderic acids (GAs) are a type of highly oxygenated lanostane-type triterpenoids that are responsible for the pharmacological activities of Ganoderma lucidum. They have been investigated for their biological activities, including antibacterial, antiviral, antitumo …

  Ganoderic acids (GAs) are a type of highly oxygenated lanostane-type triterpenoids that are responsible for the pharmacological activities o …
• 113.

  Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum.

  • Sadiq NB, Ryu DH, Cho JY, Lee AH, Song DG, Dorjsembe B, Kim JC, Jung JH, Nho CW, Hamayun M, Yang SH, Kim HY.
  • Molecules. 2021 Jul 25;26(15):4484. doi: 10.3390/molecules26154484.
  • PMCID: PMC8347575

  Sadiq NB, et al.

  Molecules. 2021.

  PMCID: PMC8347575

  Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest step during the processing of Ganoderma lucidum. ...We investigated the effects of different postharvest drying protocols on …

  Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest …
• 114.

  Transcriptional Dynamics of Genes Purportedly Involved in the Control of Meiosis, Carbohydrate, and Secondary Metabolism during Sporulation in Ganoderma lucidum.

  • Cai M, Liang X, Liu Y, Hu H, Xie Y, Chen S, Gao X, Li X, Xiao C, Chen D, Wu Q.
  • Genes (Basel). 2021 Mar 29;12(4):504. doi: 10.3390/genes12040504.
  • PMCID: PMC8066989

  Cai M, et al.

  Genes (Basel). 2021.

  PMCID: PMC8066989

  Ganoderma lucidum spores (GLS), the mature germ cells ejected from the abaxial side of the pileus, have diverse pharmacological effects. ...Our results provide a dataset of dynamic gene expression during sporulation in G. lucidum. They also shed light on gene …

  Ganoderma lucidum spores (GLS), the mature germ cells ejected from the abaxial side of the pileus, have diverse pharmacologica …
• 115.

  Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats.

  • Matsuzaki H, Shimizu Y, Iwata N, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y, Okazaki M.
  • BMC Complement Altern Med. 2013 Dec 26;13:370. doi: 10.1186/1472-6882-13-370.
  • PMCID: PMC3879659

  Matsuzaki H, et al.

  BMC Complement Altern Med. 2013.

  PMCID: PMC3879659

  BACKGROUND: Ganoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Previously, we reported that a water-soluble extract from a culture medium of Ganoderma lucidum mycelia (MAK) exerts antioxidative …

  BACKGROUND: Ganoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Prev …
• 116.

  Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum.

  • Kim JW, Kim HI, Kim JH, Kwon OC, Son ES, Lee CS, Park YJ.
  • Int J Mol Sci. 2016 Oct 27;17(11):1798. doi: 10.3390/ijms17111798.
  • PMCID: PMC5133799

  Kim JW, et al.

  Int J Mol Sci. 2016.

  PMCID: PMC5133799

  Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variety of biological activities and great potential as an ingredient in skin care cosmetics including "skin-whitening" products. ...Therefore, th …

  Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variet …
• 117.

  Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43.

  • Dai S, Liu J, Sun X, Wang N.
  • BMC Complement Altern Med. 2014 Nov 5;14:434. doi: 10.1186/1472-6882-14-434.
  • PMCID: PMC4232730

  Dai S, et al.

  BMC Complement Altern Med. 2014.

  PMCID: PMC4232730

  BACKGROUND: Ganoderma lucidum (G. lucidum, Reishimax) is an herbal mushroom known to have inhibitory effect on tumor cell growth. ...METHODS: Human ovarian cancer cells HO 8910 (HOCC) and human primary ovarian cells (HPOC) were treated with G. lucidum. …

  BACKGROUND: Ganoderma lucidum (G. lucidum, Reishimax) is an herbal mushroom known to have inhibitory effect on tumor ce …
• 118.

  Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells.

  • Reis FS, Lima RT, Morales P, Ferreira IC, Vasconcelos MH.
  • Molecules. 2015 Sep 29;20(10):17872-82. doi: 10.3390/molecules201017872.
  • PMCID: PMC6332321

  Reis FS, et al.

  Molecules. 2015.

  PMCID: PMC6332321

  Ganoderma lucidum is one of the most widely studied mushroom species, particularly in what concerns its medicinal properties. ...The results obtained proved that, in AGS cells, the methanolic extract of G. lucidum causes an induction of autophagy, rather than …

  Ganoderma lucidum is one of the most widely studied mushroom species, particularly in what concerns its medicinal properties. …
• 119.

  The development and application of a multiple gene co-silencing system using endogenous URA3 as a reporter gene in Ganoderma lucidum.

  • Mu D, Shi L, Ren A, Li M, Wu F, Jiang A, Zhao M.
  • PLoS One. 2012 Aug 24;7(8):e43737. doi: 10.1371/journal.pone.0043737.
  • PMCID: PMC3427163

  Mu D, et al.

  PLoS One. 2012.

  PMCID: PMC3427163

  Ganoderma lucidum is one of the most important medicinal mushrooms; however, molecular genetics research on this species has been limited due to a lack of reliable reverse genetic tools. ...To highlight the advantages of the dual promoter system, we constructed a co …

  Ganoderma lucidum is one of the most important medicinal mushrooms; however, molecular genetics research on this species has b …
• 120.

  The CBS/H(2)S signalling pathway regulated by the carbon repressor CreA promotes cellulose utilization in Ganoderma lucidum.

  • Shangguan J, Qiao J, Liu H, Zhu L, Han X, Shi L, Zhu J, Liu R, Ren A, Zhao M.
  • Commun Biol. 2024 Apr 17;7(1):466. doi: 10.1038/s42003-024-06180-y.
  • PMCID: PMC11024145

  Shangguan J, et al.

  Commun Biol. 2024.

  PMCID: PMC11024145

  In this paper, we found that the hydrogen sulfide (H(2)S) concentration under cellulose culture condition increased to approximately 2.3-fold compared with that under glucose culture condition in Ganoderma lucidum. Further evidence shown that cellulase activities of …

  In this paper, we found that the hydrogen sulfide (H(2)S) concentration under cellulose culture condition increased to approximately 2.3-fol …

• 121.

  Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum.

  • Jiang AL, Liu YN, Liu R, Ren A, Ma HY, Shu LB, Shi L, Zhu J, Zhao MW.
  • Int J Mol Sci. 2019 Dec 4;20(24):6116. doi: 10.3390/ijms20246116.
  • PMCID: PMC6941157

  Jiang AL, et al.

  Int J Mol Sci. 2019.

  PMCID: PMC6941157

  Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of ganoderic acids (GAs), which are the main active ingredients of G. lucidum. ...In c …

  Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl …
• 122.

  Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodies.

  • Kao PF, Wang SH, Hung WT, Liao YH, Lin CM, Yang WB.
  • J Biomed Biotechnol. 2011 Dec 6;2012:673764. doi: 10.1155/2012/673764.
  • PMCID: PMC3236510

  Kao PF, et al.

  J Biomed Biotechnol. 2011.

  PMCID: PMC3236510

  The major cell wall constituent of Ganoderma lucidum (G. lucidum) is beta-1,3-glucan. This study examined the polysaccharide from the residues of alkaline-extracted fruiting bodies using high-performance anion-exchange chromatography (HPAEC), and it employed …

  The major cell wall constituent of Ganoderma lucidum (G. lucidum) is beta-1,3-glucan. This study examined the polysacch …
• 123.

  Ganoderma lucidum aqueous extract inducing PHGPx to inhibite membrane lipid hydroperoxides and regulate oxidative stress based on single-cell animal transcriptome.

  • Ding W, Zhang X, Yin X, Zhang Q, Wang Y, Guo C, Chen Y.
  • Sci Rep. 2022 Feb 24;12(1):3139. doi: 10.1038/s41598-022-06985-z.
  • PMCID: PMC8873301

  Ding W, et al.

  Sci Rep. 2022.

  PMCID: PMC8873301

  In this study, the single-cell eukaryotic model organism Tetrahymena thermophila was used as an experimental material to reveal the anti-aging mechanism of Ganoderma lucidum aqueous extract. After treatment with the G. lucidum aqueous extract, the logarithmic …

  In this study, the single-cell eukaryotic model organism Tetrahymena thermophila was used as an experimental material to reveal the anti-agi …
• 124.

  Spermidine enhances the heat tolerance of Ganoderma lucidum by promoting mitochondrial respiration driven by fatty acid beta-oxidation.

  • Han X, Wang Z, Shi L, Wei Z, Shangguan J, Shi L, Zhao M.
  • Appl Environ Microbiol. 2025 Jan 29;91(2):e0097924. doi: 10.1128/aem.00979-24.
  • PMCID: PMC11837530

  Han X, et al.

  Appl Environ Microbiol. 2025.

  PMCID: PMC11837530

  In conclusion, spermidine enhances key TCA cycle and ETC enzyme activities and is involved in heat stress-induced fatty acid beta-oxidation by promoting the translation of LCAD and HADH, thereby improving the heat tolerance of Ganoderma lucidum. IMPORTANCE: Polyamin …

  In conclusion, spermidine enhances key TCA cycle and ETC enzyme activities and is involved in heat stress-induced fatty acid beta-oxidation …
• 125.

  The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.

  • Doğan G, İpek H.
  • Acta Cir Bras. 2020 Mar 20;35(1):e202000103. doi: 10.1590/s0102-865020200010000003.
  • PMCID: PMC7092665

  Doğan G, et al.

  Acta Cir Bras. 2020.

  PMCID: PMC7092665

  PURPOSE: To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury. METHODS: Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 ho …

  PURPOSE: To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-repe …
• 126.

  Structure and bioactivities of a polysaccharide isolated from Ganoderma lucidum in submerged fermentation.

  • Ai-Lati A, Liu S, Ji Z, Zhang H, Mao J.
  • Bioengineered. 2017 Jan 31;8(5):565-571. doi: 10.1080/21655979.2017.1283459.
  • PMCID: PMC5639833

  Ai-Lati A, et al.

  Bioengineered. 2017.

  PMCID: PMC5639833

  In this study, a Ganoderma lucidum polysaccharide GLP-1-1 was isolated from a culture broth with Mw of 22014 Da. ...

  In this study, a Ganoderma lucidum polysaccharide GLP-1-1 was isolated from a culture broth with Mw of 22014 Da. ...
• 127.

  Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities.

  • Zheng S, Zhang W, Liu S.
  • PLoS One. 2020 Dec 31;15(12):e0244749. doi: 10.1371/journal.pone.0244749.
  • PMCID: PMC7774858

  Zheng S, et al.

  PLoS One. 2020.

  PMCID: PMC7774858

  Ganoderma lucidum (Fr.) Krast, commonly known as "Lingzhi" in Chinese, is a medicinal mushroom that is rich in biologically active substances. ...The present study is the first report on the simultaneous extraction of polysaccharides and triterpenoids from G. luc …

  Ganoderma lucidum (Fr.) Krast, commonly known as "Lingzhi" in Chinese, is a medicinal mushroom that is rich in biologically ac …
• 128.

  Purification and Characterization of Antibacterial Activity against Phytopathogenic Bacteria in Culture Fluids from Ganoderma lucidum.

  • Robles-Hernández L, Salas-Salazar NA, Gonzalez-Franco AC.
  • Molecules. 2021 Sep 13;26(18):5553. doi: 10.3390/molecules26185553.
  • PMCID: PMC8465007

  Robles-Hernández L, et al.

  Molecules. 2021.

  PMCID: PMC8465007

  Previous studies of Ganoderma lucidum have focused on its medicinal applications. Limited information is available about its antibacterial activity against plant pathogens. ...This is the first report of small polysaccharides produced by G. lucidum with activ …

  Previous studies of Ganoderma lucidum have focused on its medicinal applications. Limited information is available about its a …
• 129.

  Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum.

  • Shao Y, Qiao L, Wu L, Sun X, Zhu D, Yang G, Zhang X, Mao X, Chen W, Liang W, Zhang Y, Zhang L.
  • Molecules. 2016 May 21;21(5):678. doi: 10.3390/molecules21050678.
  • PMCID: PMC6273610

  Shao Y, et al.

  Molecules. 2016.

  PMCID: PMC6273610

  Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. In the present study, systematic isolation, and in silico pharmacological prediction …

  Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditi …
• 130.

  In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.

  • Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH.
  • World J Gastroenterol. 2006 Mar 7;12(9):1379-85. doi: 10.3748/wjg.v12.i9.1379.
  • PMCID: PMC4124314

  Yang XJ, et al.

  World J Gastroenterol. 2006.

  PMCID: PMC4124314

  AIM: To investigate the possible mechanism of the protective effects of a bioactive fraction,Ganoderma lucidum proteoglycan (GLPG) isolated from Ganoderma lucidum mycelia, against carbon tetrachloride-induced liver injury. ...

  AIM: To investigate the possible mechanism of the protective effects of a bioactive fraction,Ganoderma lucidum proteoglycan (G …

• 131.

  Comparison of polysaccharides from two species of Ganoderma.

  • Xie J, Zhao J, Hu DJ, Duan JA, Tang YP, Li SP.
  • Molecules. 2012 Jan 13;17(1):740-52. doi: 10.3390/molecules17010740.
  • PMCID: PMC6268238

  Xie J, et al.

  Molecules. 2012.

  PMCID: PMC6268238

  Ganoderma lucidum and Ganoderma sinense, known as Lingzhi in Chinese, are commonly used Chinese medicines with excellent beneficial health effects. ...However, the content of triterpenes differs significantly between the two species of Ganoderma. To da …

  Ganoderma lucidum and Ganoderma sinense, known as Lingzhi in Chinese, are commonly used Chinese medicines with excellen …
• 132.

  Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.

  • Wang C, Shi S, Chen Q, Lin S, Wang R, Wang S, Chen C.
  • Integr Cancer Ther. 2018 Apr 2;17(3):674-683. doi: 10.1177/1534735418762537.
  • PMCID: PMC6142075

  Wang C, et al.

  Integr Cancer Ther. 2018.

  PMCID: PMC6142075

  Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. ...

  Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive co …
• 133.

  Identification and characterization of circular RNAs in Ganoderma lucidum.

  • Shao J, Wang L, Liu X, Yang M, Chen H, Wu B, Liu C.
  • Sci Rep. 2019 Nov 11;9(1):16522. doi: 10.1038/s41598-019-52932-w.
  • PMCID: PMC6848116

  Shao J, et al.

  Sci Rep. 2019.

  PMCID: PMC6848116

  However, no circRNAs have been reported in Ganoderma lucidum. Here, we carried out a genome-wide identification of the circRNAs in G.lucidum using RNA-Seq data, and analyzed their features. ...Our results indicated that circRNAs are present in G. lucidum …

  However, no circRNAs have been reported in Ganoderma lucidum. Here, we carried out a genome-wide identification of the circRNA …
• 134.

  A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs.

  • Kashimoto N, Ishii S, Myojin Y, Ushijima M, Hayama M, Watanabe H.
  • Oncol Lett. 2010 Jan 1;1(1):63-68. doi: 10.3892/ol_00000011.
  • PMCID: PMC3436462

  Kashimoto N, et al.

  Oncol Lett. 2010.

  PMCID: PMC3436462

  The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum (Reishi) mycelia (MAK) is able to protect the small intestine against damage induced by anti-cancer drugs. ...

  The present study investigated whether a water-soluble extract from the culture medium of Ganoderma lucidum (Reishi) my …
• 135.

  Structure Identification of Ganoderma lucidum Spore Polysaccharides and Their Antitumor Activity In Vivo.

  • Liu HM, Cheng J, Wang XY, Jiang Y, Ni J, Zhang Y, Wang W.
  • Molecules. 2024 May 16;29(10):2348. doi: 10.3390/molecules29102348.
  • PMCID: PMC11124482

  Liu HM, et al.

  Molecules. 2024.

  PMCID: PMC11124482

  Ganoderma lucidum spore powder, valued for its nutritional and medicinal properties, contains polysaccharides crucial for its efficacy. ...This study aimed to investigate the effects of acid heat treatment on Ganoderma lucidum spore polysaccharides (GL …

  Ganoderma lucidum spore powder, valued for its nutritional and medicinal properties, contains polysaccharides crucial for its …
• 136.

  Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds.

  • Kolniak-Ostek J, Oszmiański J, Szyjka A, Moreira H, Barg E.
  • Int J Mol Sci. 2022 Aug 19;23(16):9359. doi: 10.3390/ijms23169359.
  • PMCID: PMC9408863

  Kolniak-Ostek J, et al.

  Int J Mol Sci. 2022.

  PMCID: PMC9408863

  The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to identify bioactive compounds found in their extracts. ...Resveratrol was the most abundant phenolic in the extract (5155.7 mg/100 g DM). Th …

  The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to …
• 137.

  Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.

  • Grienke U, Mihály-Bison J, Schuster D, Afonyushkin T, Binder M, Guan SH, Cheng CR, Wolber G, Stuppner H, Guo DA, Bochkov VN, Rollinger JM.
  • Bioorg Med Chem. 2011 Sep 29;19(22):6779-91. doi: 10.1016/j.bmc.2011.09.039.
  • PMCID: PMC3254236

  Grienke U, et al.

  Bioorg Med Chem. 2011.

  PMCID: PMC3254236

  Virtual screening experiments of our in-house Chinese Herbal Medicine database with structure-based pharmacophore models, previously generated and validated, revealed mainly lanostane-type triterpenes of the TCM fungus Ganoderma lucidum Karst. as putative FXR ligand …

  Virtual screening experiments of our in-house Chinese Herbal Medicine database with structure-based pharmacophore models, previously generat …
• 138.

  Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection.

  • Chen BK, Chan CH, Tsao A, Wang CK.
  • Molecules. 2024 Jul 30;29(15):3609. doi: 10.3390/molecules29153609.
  • PMCID: PMC11314549

  Chen BK, et al.

  Molecules. 2024.

  PMCID: PMC11314549

  This study investigated the inhibitory effects of extracts of Echinacea purpurea (EP) and Ganoderma lucidum (G. lucidum) and the advanced G. lucidum drink (AG) on influenza A/B viruses. To determine whether EP and G. lucidum extracts enhance cel …

  This study investigated the inhibitory effects of extracts of Echinacea purpurea (EP) and Ganoderma lucidum (G. lucidum …
• 139.

  Amelioration of CCl(4)-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.

  • Johra FT, Hossain S, Jain P, Bristy AT, Emran T, Ahmed R, Sharker SM, Bepari AK, Reza HM.
  • Sci Rep. 2023 Jun 19;13(1):9909. doi: 10.1038/s41598-023-35228-y.
  • PMCID: PMC10279652

  Johra FT, et al.

  Sci Rep. 2023.

  PMCID: PMC10279652

  The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl(4)-induced liver toxicity in rats. The experimental Long Evans rats were divided into five groups, of which four groups were treated with carbon tetrachloride (CCl(4)). .. …

  The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl(4)-induced liver toxicity in ra …
• 140.

  Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.

  • Wu QP, Xie YZ, Deng Z, Li XM, Yang W, Jiao CW, Fang L, Li SZ, Pan HH, Yee AJ, Lee DY, Li C, Zhang Z, Guo J, Yang BB.
  • PLoS One. 2012 Aug 30;7(8):e44579. doi: 10.1371/journal.pone.0044579.
  • PMCID: PMC3431381

  Wu QP, et al.

  PLoS One. 2012.

  PMCID: PMC3431381

  We found that the biologically active component isolated from Ganoderma lucidum could overcome the drug-resistance conferred by miR-378. We purified and identified the biologically active component of Ganoderma lucidum as ergosterol peroxide. ...

  We found that the biologically active component isolated from Ganoderma lucidum could overcome the drug-resistance conferred b …

• 141.

  Optimization of ultrasonic-assisted debittering of Ganoderma lucidum using response surface methodology, characterization, and evaluation of antioxidant activity.

  • Chen S, Song S, Tan Y, He S, Ren X, Li Z, Liu Y.
  • PeerJ. 2024 Oct 14;12:e17943. doi: 10.7717/peerj.17943.
  • PMCID: PMC11485051

  Chen S, et al.

  PeerJ. 2024.

  PMCID: PMC11485051

  BACKGROUND: Ganoderma lucidum (G. lucidum) has gained increasing attention as a potential health care product and food source. However, the bitter taste of G. lucidum has limited its development and utilization for the food industry. METHONDS: The resp …

  BACKGROUND: Ganoderma lucidum (G. lucidum) has gained increasing attention as a potential health care product and food …
• 142.

  Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.

  • Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY.
  • J Immunol Res. 2021 Mar 5;2021:6696606. doi: 10.1155/2021/6696606.
  • PMCID: PMC7954632

  Song M, et al.

  J Immunol Res. 2021.

  PMCID: PMC7954632

  BACKGROUND: Ganoderma lucidum has certain components with known pharmacological effects, including strengthening immunity and anti-inflammatory activity. G. lucidum seeds inherit all its biological characteristics. G. lucidum spore polysaccharide (GLSP …

  BACKGROUND: Ganoderma lucidum has certain components with known pharmacological effects, including strengthening immunity and …
• 143.

  Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer.

  • Naseri M, Movagharnejad K, Nanvakenari S.
  • Sci Rep. 2023 Aug 3;13(1):12636. doi: 10.1038/s41598-023-39883-z.
  • PMCID: PMC10400541

  Naseri M, et al.

  Sci Rep. 2023.

  PMCID: PMC10400541

  Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. ...This study aimed to investigate the effects of air velocity and temperature in the convective dryer, sample distance, and infrared power in infrared dryers on the drying kin …

  Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. ...This study aimed to investigate t …
• 144.

  Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides.

  • Meng M, Yao J, Zhang Y, Sun H, Liu M.
  • Molecules. 2023 Mar 8;28(6):2483. doi: 10.3390/molecules28062483.
  • PMCID: PMC10052150

  Meng M, et al.

  Molecules. 2023.

  PMCID: PMC10052150

  In this review, we summarized the available reports on the protective effects of Ganoderma lucidum polysaccharides (GLP) on RA in terms of anti-inflammatory, immunomodulatory, anti-angiogenic and osteoprotective effects. ...

  In this review, we summarized the available reports on the protective effects of Ganoderma lucidum polysaccharides (GLP) on RA …
• 145.

  Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis.

  • Bai JH, Xu J, Zhao J, Zhang R.
  • Cell Transplant. 2020 Jan-Dec;29:963689720931435. doi: 10.1177/0963689720931435.
  • PMCID: PMC7563825

  Bai JH, et al.

  Cell Transplant. 2020.

  PMCID: PMC7563825

  Ganoderma lucidum is a popular traditional Chinese medicine used in China to improve health. Previous researches have revealed that the polysaccharide from G. lucidum could exert diversity activities, including immunomodulation, antioxidant, and antitumor eff …

  Ganoderma lucidum is a popular traditional Chinese medicine used in China to improve health. Previous researches have revealed …
• 146.

  Unlocking the therapeutic potential of bioactive compounds in Ganoderma lucidum: a new frontier in natural medicine.

  • Khanal S, Thakur P, Sharma A, Kumar A, Pillai M, Kumar D, Kumar A, Verma R, Tapwal A, Kumar D, Kumar V, Bala A.
  • 3 Biotech. 2025 Jun 7;15(7):203. doi: 10.1007/s13205-025-04353-y.
  • PMCID: PMC12144018
  • Currently Embargoed: Full text in PMC on July 1, 2026 PubMed Abstract

  Khanal S, et al.

  3 Biotech. 2025.

  PMCID: PMC12144018

  Currently Embargoed.

  Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. ...It subsequen …

  Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked wid …
• 147.

  The Cas9-gRNA ribonucleoprotein complex-mediated editing of pyrG in Ganoderma lucidum and unexpected insertion of contaminated DNA fragments.

  • Eom H, Choi YJ, Nandre R, Han HG, Kim S, Kim M, Oh YL, Nakazawa T, Honda Y, Ro HS.
  • Sci Rep. 2023 Jul 10;13(1):11133. doi: 10.1038/s41598-023-38331-2.
  • PMCID: PMC10333205

  Eom H, et al.

  Sci Rep. 2023.

  PMCID: PMC10333205

  In this study, we successfully edited pyrG of Ganoderma lucidum using a preassembled Cas9-gRNA ribonucleoprotein complex, which primarily induced a double-strand break (DSB) at the fourth position prior to the protospacer adjacent motif. ...Despite this unexpected f …

  In this study, we successfully edited pyrG of Ganoderma lucidum using a preassembled Cas9-gRNA ribonucleoprotein complex, whic …
• 148.

  Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.

  • Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA.
  • Nutrients. 2020 Oct 30;12(11):3338. doi: 10.3390/nu12113338.
  • PMCID: PMC7693844

  Lee HA, et al.

  Nutrients. 2020.

  PMCID: PMC7693844

  Ganoderma lucidum is used widely in oriental medicine to treat obesity and metabolic diseases. Bioactive substances extracted from G. lucidum have been shown to ameliorate dyslipidemia, insulin resistance, and type 2 diabetes in mice via multiple 5' AMP-activ …

  Ganoderma lucidum is used widely in oriental medicine to treat obesity and metabolic diseases. Bioactive substances extracted …
• 149.

  Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging.

  • Zeng Q, Zhou F, Lei L, Chen J, Lu J, Zhou J, Cao K, Gao L, Xia F, Ding S, Huang L, Xiang H, Wang J, Xiao Y, Xiao R, Huang J.
  • Mol Med Rep. 2016 Dec 12;15(1):111-116. doi: 10.3892/mmr.2016.6026.
  • PMCID: PMC5355704

  Zeng Q, et al.

  Mol Med Rep. 2016.

  PMCID: PMC5355704

  Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. Ganoderma polysaccharides (GL-PS), a major active ingredient in Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. ...

  Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. Ganoderma polysaccharides (GL-PS), …
• 150.

  The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo.

  • Li K, Na K, Sang T, Wu K, Wang Y, Wang X.
  • Oncol Rep. 2017 Sep 27;38(5):2803-2813. doi: 10.3892/or.2017.6010.
  • PMCID: PMC5780033

  Li K, et al.

  Oncol Rep. 2017.

  PMCID: PMC5780033

  The medicinal mushroom Ganoderma lucidum (G. lucidum) has been reported to possess a variety of pharmacological activities including anticancer effects. ...Our results suggest that triterpenoids of sporoderm-broken spores of G. lucidum ethanol extracts …

  The medicinal mushroom Ganoderma lucidum (G. lucidum) has been reported to possess a variety of pharmacological activit …

• 151.

  Cross Talk between Nitric Oxide and Calcium-Calmodulin Regulates Ganoderic Acid Biosynthesis in Ganoderma lucidum under Heat Stress.

  • Liu R, Shi L, Zhu T, Yang T, Ren A, Zhu J, Zhao MW.
  • Appl Environ Microbiol. 2018 May 1;84(10):e00043-18. doi: 10.1128/AEM.00043-18.
  • PMCID: PMC5930367

  Liu R, et al.

  Appl Environ Microbiol. 2018.

  PMCID: PMC5930367

  We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum via Ca(2+) Therefore, to further understand the signal-regulating network of the organism's response to heat stress (HS), we examined the role of nitric oxide …

  We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum via Ca(2+) Therefor …
• 152.

  Abscisic acid-mediated cytosolic Ca(2+) modulates triterpenoid accumulation of Ganoderma lucidum.

  • Cui M, Zhao Y, Zhang X, Zhao W.
  • J Zhejiang Univ Sci B. 2023 Dec 15;24(12):1174-1179. doi: 10.1631/jzus.B2300279.
  • PMCID: PMC10710909

  Cui M, et al.

  J Zhejiang Univ Sci B. 2023.

  PMCID: PMC10710909

  Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. lucidum are ganoderic triterpenoids (GTs), which exhibit important pharmacological activity. ...

  Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. l …
• 153.

  Enhancing in vitro ruminal digestibility of oil palm empty fruit bunch by biological pre-treatment with Ganoderma lucidum fungal culture.

  • Nur-Nazratul FMY, Rakib MRM, Zailan MZ, Yaakub H.
  • PLoS One. 2021 Sep 30;16(9):e0258065. doi: 10.1371/journal.pone.0258065.
  • PMCID: PMC8483372

  Nur-Nazratul FMY, et al.

  PLoS One. 2021.

  PMCID: PMC8483372

  The changes in lignocellulosic biomass composition and in vitro rumen digestibility of oil palm empty fruit bunch (OPEFB) after pre-treatment with the fungus Ganoderma lucidum were evaluated. The results demonstrated that the pre-treatment for 2-12 weeks has gradual …

  The changes in lignocellulosic biomass composition and in vitro rumen digestibility of oil palm empty fruit bunch (OPEFB) after pre-treatmen …
• 154.

  Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress.

  • Zhong D, Wang H, Liu M, Li X, Huang M, Zhou H, Lin S, Lin Z, Yang B.
  • Sci Rep. 2015 Nov 25;5:16910. doi: 10.1038/srep16910.
  • PMCID: PMC4658483

  Zhong D, et al.

  Sci Rep. 2015.

  PMCID: PMC4658483

  Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of renal ischemia reperfusion injury (RIRI). ...

  Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of re …
• 155.

  Hypereosinophilia with Hepatic Nodule Formation Caused by Ganoderma lucidum.

  • Kogure T, Koiwai A, Fukushi D, Satoh M, Murakami K, Hirota M, Endo K, Murakami K, Satoh K.
  • Intern Med. 2021 Dec 15;60(24):3897-3903. doi: 10.2169/internalmedicine.7431-21.
  • PMCID: PMC8758446

  Kogure T, et al.

  Intern Med. 2021.

  PMCID: PMC8758446

  He had been taking the commercial herbal medicine Ganoderma lucidum for his liver function. After discontinuing G. lucidum, the eosinophil counts and liver enzyme levels rapidly resolved, and the nodules disappeared completely. ...

  He had been taking the commercial herbal medicine Ganoderma lucidum for his liver function. After discontinuing G. lucidum< …
• 156.

  In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts.

  • Ahmadi M, Salimi M, Saraei M, Nezhad NS, Javadi A, Mohammadi F, Heydarian P, Ali E, Hajialilo E.
  • BMC Res Notes. 2023 May 18;16(1):82. doi: 10.1186/s13104-023-06355-6.
  • PMCID: PMC10197208

  Ahmadi M, et al.

  BMC Res Notes. 2023.

  PMCID: PMC10197208

  This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma lucidum on Toxoplasma gondii RH strain tachyzoites, in vitro. RESULTS: All three types of extracts showed toxoplasmacidal effects. ... …

  This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma < …
• 157.

  Improving the fermentation production of the individual key triterpene ganoderic acid me by the medicinal fungus Ganoderma lucidum in submerged culture.

  • Liu GQ, Wang XL, Han WJ, Lin QL.
  • Molecules. 2012 Oct 24;17(11):12575-86. doi: 10.3390/molecules171112575.
  • PMCID: PMC6269005

  Liu GQ, et al.

  Molecules. 2012.

  PMCID: PMC6269005

  Enhanced ganoderic acid Me (GA-Me, an important anti-tumor triterpene) yield was attained with the medicinal fungus Ganoderma lucidum using response surface methodology (RSM). Interactions were studied with three variables, viz. glucose, peptone and culture time usi …

  Enhanced ganoderic acid Me (GA-Me, an important anti-tumor triterpene) yield was attained with the medicinal fungus Ganoderma luci …
• 158.

  Acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice.

  • Hasnat A, Pervin M, Lim BO.
  • Molecules. 2013 Jun 7;18(6):6663-78. doi: 10.3390/molecules18066663.
  • PMCID: PMC6269759

  Hasnat A, et al.

  Molecules. 2013.

  PMCID: PMC6269759

  In this study, the acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice (GLBR) were evaluated. In antioxidant assays in vitro, GLBR was found to have strong metal chelating activity, DPPH …

  In this study, the acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown …
• 159.

  Triterpenes and Aromatic Meroterpenoids with Antioxidant Activity and Neuroprotective Effects from Ganoderma lucidum.

  • Wang C, Liu X, Lian C, Ke J, Liu J.
  • Molecules. 2019 Nov 28;24(23):4353. doi: 10.3390/molecules24234353.
  • PMCID: PMC6930543

  Wang C, et al.

  Molecules. 2019.

  PMCID: PMC6930543

  There is a great interest in developing new antioxidants from Ganoderma fungus due to its low toxicity. As part of our ongoing search for antioxidative constituents from the fruiting bodies of Ganoderma lucidum, the chemical constituents were investigated and …

  There is a great interest in developing new antioxidants from Ganoderma fungus due to its low toxicity. As part of our ongoing search …
• 160.

  Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking.

  • Nascimento CP, Luz DA, da Silva CCS, Malcher CMR, Fernandes LMP, Dalla Santa HS, Gomes ARQ, Monteiro MC, Ribeiro CHMA, Fontes-Júnior EA, Maia CSF.
  • Oxid Med Cell Longev. 2020 Jul 30;2020:2497845. doi: 10.1155/2020/2497845.
  • PMCID: PMC7415090

  Nascimento CP, et al.

  Oxid Med Cell Longev. 2020.

  PMCID: PMC7415090

  Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. ...In this study, we investigated whether the Aqueous Extract of G. lucidum (AEGl) …

  Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological acti …

• 161.

  Cross Talk between Calcium and Reactive Oxygen Species Regulates Hyphal Branching and Ganoderic Acid Biosynthesis in Ganoderma lucidum under Copper Stress.

  • Gao T, Shi L, Zhang T, Ren A, Jiang A, Yu H, Zhao M.
  • Appl Environ Microbiol. 2018 Jun 18;84(13):e00438-18. doi: 10.1128/AEM.00438-18.
  • PMCID: PMC6007119

  Gao T, et al.

  Appl Environ Microbiol. 2018.

  PMCID: PMC6007119

  Ganoderma lucidum is among the best known medicinal basidiomycetes due to its production of many pharmacologically active compounds. ...These results indicated that cytosolic ROS and Ca(2+) levels exert important cross talk in the regulation of hyphal growth and GA …

  Ganoderma lucidum is among the best known medicinal basidiomycetes due to its production of many pharmacologically active comp …
• 162.

  Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.

  • Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G.
  • Stem Cell Reports. 2017 Jan 10;8(1):84-94. doi: 10.1016/j.stemcr.2016.12.007.
  • PMCID: PMC5233449

  Huang S, et al.

  Stem Cell Reports. 2017.

  PMCID: PMC5233449

  Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration …

  Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganode …
• 163.

  Effect of common foods as supplements for the mycelium growth of Ganoderma lucidum and Pleurotus ostreatus on solid substrates.

  • Soh E, Saeidi N, Javadian A, Hebel DE, Le Ferrand H.
  • PLoS One. 2021 Nov 30;16(11):e0260170. doi: 10.1371/journal.pone.0260170.
  • PMCID: PMC8631619

  Soh E, et al.

  PLoS One. 2021.

  PMCID: PMC8631619

  In this paper, we study the effects of the addition of food supplements on the growth of two fungal species, Ganoderma lucidum and Pleurotus ostreatus. The substrates, the food supplements, and the mycelia are characterized using Fourier-transform infrared spectrosc …

  In this paper, we study the effects of the addition of food supplements on the growth of two fungal species, Ganoderma lucidum …
• 164.

  Optimization of alkaline extraction of polysaccharides from Ganoderma lucidum and their effect on immune function in mice.

  • Huang SQ, Li JW, Wang Z, Pan HX, Chen JX, Ning ZX.
  • Molecules. 2010 May 25;15(5):3694-708. doi: 10.3390/molecules15053694.
  • PMCID: PMC6263365

  Huang SQ, et al.

  Molecules. 2010.

  PMCID: PMC6263365

  Response surface methodology was employed to optimize the conditions for alkaline extraction of polysaccharides from Ganoderma lucidum. The results indicated that the optimum conditions were an extraction temperature of 60.1 degrees C, an extraction time of 77.3 min …

  Response surface methodology was employed to optimize the conditions for alkaline extraction of polysaccharides from Ganoderma luc …
• 165.

  Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids of Ganoderma lucidum.

  • Cui M, Ma Y, Yu Y.
  • J Zhejiang Univ Sci B. 2021 Nov 15;22(11):941-953. [Article in English] doi: 10.1631/jzus.B2000818.
  • PMCID: PMC8593529

  Cui M, et al.

  J Zhejiang Univ Sci B. 2021. [Article in English]

  PMCID: PMC8593529

  Ganoderic triterpenoids (GTs) are the primary bioactive constituents of the Basidiomycotina fungus, Ganoderma lucidum. These compounds exhibit antitumor, anti-hyperlipidemic, and immune-modulatory pharmacological activities. This study focused on GT accumulation in …

  Ganoderic triterpenoids (GTs) are the primary bioactive constituents of the Basidiomycotina fungus, Ganoderma lucidum. These c …
• 166.

  A retrospective study of Ganoderma Lucidum Spore Powder for patients with epilepsy.

  • Wang GH, Li X, Cao WH, Li J, Wang LH.
  • Medicine (Baltimore). 2018 Jun;97(23):e10941. doi: 10.1097/MD.0000000000010941.
  • PMCID: PMC5999473

  Wang GH, et al.

  Medicine (Baltimore). 2018.

  PMCID: PMC5999473

  This study firstly investigated the feasibility effect and safety of Ganoderma Lucidum Spore Powder (GLSP) for treating patients with epilepsy.Eighteen eligible patients with epilepsy were included. ...

  This study firstly investigated the feasibility effect and safety of Ganoderma Lucidum Spore Powder (GLSP) for treating patien …
• 167.

  Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells.

  • Liang C, Li H, Zhou H, Zhang S, Liu Z, Zhou Q, Sun F.
  • Oncol Rep. 2011 Dec 14;27(4):1079-89. doi: 10.3892/or.2011.1593.
  • PMCID: PMC3583434

  Liang C, et al.

  Oncol Rep. 2011.

  PMCID: PMC3583434

  In Asia, the mushroom of the fungus Ganoderma lucidum has been widely used as a traditional medicine for the past two millennia. ...

  In Asia, the mushroom of the fungus Ganoderma lucidum has been widely used as a traditional medicine for the past two millenni …
• 168.

  Ganoderma lucidum total triterpenes prevent gamma-radiation induced oxidative stress in Swiss albino mice in vivo.

  • Smina TP, Joseph J, Janardhanan KK.
  • Redox Rep. 2016 Feb 5;21(6):254-61. doi: 10.1080/13510002.2015.1126098.
  • PMCID: PMC6837450

  Smina TP, et al.

  Redox Rep. 2016.

  PMCID: PMC6837450

  OBJECTIVES: The in vivo radio-protective effect of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst was evaluated using Swiss albino mice, by pre-treatment with total triterpenes for 14 days, followed by a whole body exposure to gamma-radiation. ...D …

  OBJECTIVES: The in vivo radio-protective effect of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst was evalua …
• 169.

  The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients.

  • Sargowo D, Ovianti N, Susilowati E, Ubaidillah N, Widya Nugraha A, Vitriyaturrida, Siwi Proboretno K, Failasufi M, Ramadhan F, Wulandari H, Waranugraha Y, Hayuning Putri D.
  • Indian Heart J. 2017 Dec 14;70(5):608-614. doi: 10.1016/j.ihj.2017.12.007.
  • PMCID: PMC6204443

  Sargowo D, et al.

  Indian Heart J. 2017.

  PMCID: PMC6204443

  Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of beta-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in anima …

  Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of beta-glucan. Previous studi …
• 170.

  Targeted insertion of heterogenous DNA using Cas9-gRNA ribonucleoprotein-mediated gene editing in Ganoderma lucidum.

  • Eom H, Choi YJ, Nandre R, Kim M, Oh YL, Kim S, Nakazawa T, Honda Y, Ro HS.
  • Bioengineered. 2025 Jan 29;16(1):2458376. doi: 10.1080/21655979.2025.2458376.
  • PMCID: PMC11781247

  Eom H, et al.

  Bioengineered. 2025.

  PMCID: PMC11781247

  Co-transformation of donor DNAs with RNP targeting the pyrG gene in Ganoderma lucidum yielded 184 transformants without homologous arms and 781 with 300-bp homologous arms (HR_donor DNAs). ...

  Co-transformation of donor DNAs with RNP targeting the pyrG gene in Ganoderma lucidum yielded 184 transformants without homolo …

• 171.

  Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.

  • Li HN, Zhao LL, Zhou DY, Chen DQ.
  • Med Sci Monit. 2020 Apr 4;26:e921905. doi: 10.12659/MSM.921905.
  • PMCID: PMC7154563

  Li HN, et al.

  Med Sci Monit. 2020.

  PMCID: PMC7154563

  BACKGROUND Type 2 diabetes mellitus (T2DM) and its comorbidities, including obesity, hypertension, and hyperlipidemia, are commonly associated with non-alcoholic fatty liver disease (NAFLD). Ganoderma lucidum polysaccharide (GDLP) is one of the central bioactive com …

  BACKGROUND Type 2 diabetes mellitus (T2DM) and its comorbidities, including obesity, hypertension, and hyperlipidemia, are commonly associat …
• 172.

  Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS.

  • Hilliard A, Mendonca P, Soliman KFA.
  • J Neuroimmunol. Author manuscript. 2020 May 26;345:577269. doi: 10.1016/j.jneuroim.2020.577269.
  • PMCID: PMC7382303

  Hilliard A, et al.

  J Neuroimmunol. Author manuscript. 2020.

  PMCID: PMC7382303

  Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. ...

  Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. ...
• 173.

  Sporoderm-Removed Ganoderma lucidum Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway.

  • Liu J, Zeng T.
  • Integr Cancer Ther. 2021 Jan-Dec;20:15347354211062157. doi: 10.1177/15347354211062157.
  • PMCID: PMC8649442

  Liu J, et al.

  Integr Cancer Ther. 2021.

  PMCID: PMC8649442

  Emerging evidence suggests that sporoderm-removed Ganoderma lucidum spore powder can suppress tumor growth and metastasis. However, the molecular mechanisms of action remain elusive. ...Finally, we found that sporoderm-removed Ganoderma lucidum spore p …

  Emerging evidence suggests that sporoderm-removed Ganoderma lucidum spore powder can suppress tumor growth and metastasis. How …
• 174.

  Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation.

  • Zhang X, Wu D, Tian Y, Chen X, Lan J, Wei F, Li Y, Luo Y, Sun X.
  • Pharm Biol. 2022 Dec;60(1):2201-2209. doi: 10.1080/13880209.2022.2142615.
  • PMCID: PMC9665083

  Zhang X, et al.

  Pharm Biol. 2022.

  PMCID: PMC9665083

  CONTEXT: Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Ganodermataceae), are reported to have anti-inflammatory effects, including anti-neuroinflammation and anti-colitis. ...

  CONTEXT: Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Ganodermataceae …
• 175.

  Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo.

  • Na K, Li K, Sang T, Wu K, Wang Y, Wang X.
  • Int J Oncol. 2017 Mar 29;50(5):1541-1554. doi: 10.3892/ijo.2017.3939.
  • PMCID: PMC5403400

  Na K, et al.

  Int J Oncol. 2017.

  PMCID: PMC5403400

  Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention for many years. ...In addition, it is unclear whether sporoderm-broken spores of G. lucidum water extract (BSGLWE), which contain …

  Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevent …
• 176.

  Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA.

  • Ahmad F, Singh G, Soni H, Tandon S.
  • Aging Med (Milton). 2022 Dec 12;6(2):144-154. doi: 10.1002/agm2.12232.
  • PMCID: PMC10242270

  Ahmad F, et al.

  Aging Med (Milton). 2022.

  PMCID: PMC10242270

  According to a recent study, microtubule affinity regulation kinase 4 (MARK4) is attributed as one of the most promising drug targets for AD, thus, being selected for this study. Compounds from Ganoderma lucidum (Reishi mushroom) extracts were selected to be …

  According to a recent study, microtubule affinity regulation kinase 4 (MARK4) is attributed as one of the most promising drug targets for AD …
• 177.

  The GCN4-Swi6B module mediates low nitrogen-induced cell wall remodeling in Ganoderma lucidum.

  • Shi L, Wang L, Liu R, Zhu J, Shi L, Ren A, Chen H, Zhao M.
  • Appl Environ Microbiol. 2025 Mar 27;91(4):e0016425. doi: 10.1128/aem.00164-25.
  • PMCID: PMC12016525

  Shi L, et al.

  Appl Environ Microbiol. 2025.

  PMCID: PMC12016525

  Here, we found that compared with those under normal nitrogen conditions, both the cell wall thickness and polysaccharide content of Ganoderma lucidum are increased under low nitrogen conditions. Furthermore, the abundance of SWI6B, a transcription factor that parti …

  Here, we found that compared with those under normal nitrogen conditions, both the cell wall thickness and polysaccharide content of Gano …
• 178.

  A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.

  • Zheng C, Rangsinth P, Shiu PHT, Wang W, Li R, Li J, Kwan YW, Leung GPH.
  • Molecules. 2023 Feb 12;28(4):1756. doi: 10.3390/molecules28041756.
  • PMCID: PMC9962123

  Zheng C, et al.

  Molecules. 2023.

  PMCID: PMC9962123

  Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. lucidum are primarily attributed to its polysaccharides and triterpenoids. Ganoderic and lucidenic acids are the two major triterpenoids gr …

  Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. luc …
• 179.

  SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum.

  • Liu R, Cao P, Ren A, Wang S, Yang T, Zhu T, Shi L, Zhu J, Jiang AL, Zhao MW.
  • Redox Biol. 2018 Mar 31;16:388-400. doi: 10.1016/j.redox.2018.03.018.
  • PMCID: PMC5953243

  Liu R, et al.

  Redox Biol. 2018.

  PMCID: PMC5953243

  Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosyn …

  Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicyli …
• 180.

  Genome-wide Identification and Characterization of Natural Antisense Transcripts by Strand-specific RNA Sequencing in Ganoderma lucidum.

  • Shao J, Chen H, Yang D, Jiang M, Zhang H, Wu B, Li J, Yuan L, Liu C.
  • Sci Rep. 2017 Jul 18;7(1):5711. doi: 10.1038/s41598-017-04303-6.
  • PMCID: PMC5515960

  Shao J, et al.

  Sci Rep. 2017.

  PMCID: PMC5515960

  Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. ...

  Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. ...

• 181.

  Decolorization applicability of sol-gel matrix immobilized manganese peroxidase produced from an indigenous white rot fungal strain Ganoderma lucidum.

  • Muhammad Nasir Iqbal H, Asgher M.
  • BMC Biotechnol. 2013 Jul 13;13:56. doi: 10.1186/1472-6750-13-56.
  • PMCID: PMC3717284

  Muhammad Nasir Iqbal H, et al.

  BMC Biotechnol. 2013.

  PMCID: PMC3717284

  By keeping in mind the extensive industrial applications of ligninolytic enzymes, this study was performed to purify, and immobilize the manganese peroxidase (MnP) produced from an indigenous strain of Ganoderma lucidum. The present study was also focused on investi …

  By keeping in mind the extensive industrial applications of ligninolytic enzymes, this study was performed to purify, and immobilize the man …
• 182.

  Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.

  • Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X.
  • Int J Mol Sci. 2014 May 22;15(5):9103-16. doi: 10.3390/ijms15059103.
  • PMCID: PMC4057777

  Liang Z, et al.

  Int J Mol Sci. 2014.

  PMCID: PMC4057777

  Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to possess anti-tumor ability. ...

  Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to possess anti-tumor ability. ...
• 183.

  Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-kappaB Signaling.

  • Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM.
  • Inflamm Bowel Dis. Author manuscript. 2015 Aug;21(8):1918-25. doi: 10.1097/MIB.0000000000000439.
  • PMCID: PMC4509964

  Liu C, et al.

  Inflamm Bowel Dis. Author manuscript. 2015.

  PMCID: PMC4509964

  Here, we investigated the anti-inflammatory effects of a bioactive compound isolated from Ganoderma lucidum (G. lucidum), a key herbal constituent of Food Allergy Herbal Formula-2, in CD in vitro. ...GAC1 is a key beneficial constituent in G. lucidum a …

  Here, we investigated the anti-inflammatory effects of a bioactive compound isolated from Ganoderma lucidum (G. lucidum …
• 184.

  ATP deficiency triggers ganoderic acids accumulation via fatty acid beta-oxidation pathway in Ganoderma lucidum.

  • Liu W, Sun Y, Yue S, Kong Y, Cong Q, Lan Y, Zhao M, Shi L.
  • Microb Cell Fact. 2025 Mar 11;24(1):62. doi: 10.1186/s12934-025-02668-2.
  • PMCID: PMC11900599

  Liu W, et al.

  Microb Cell Fact. 2025.

  PMCID: PMC11900599

  BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties. ...However, the specific …

  BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a …
• 185.

  Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.

  • Lai P, Cao X, Xu Q, Liu Y, Li R, Zhang J, Zhang M.
  • Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471.
  • PMCID: PMC7470073

  Lai P, et al.

  Pharm Biol. 2020.

  PMCID: PMC7470073

  CONTEXT: Ganoderma lucidum (Leyss.ex Fr.) Karst (Ganodermataceae) is a fungus that has been used in traditional Chinese medicine. OBJECTIVE: This is the first investigation of the lipid-lowering and anti-atherosclerotic effects of Ganoderma lucidum spo …

  CONTEXT: Ganoderma lucidum (Leyss.ex Fr.) Karst (Ganodermataceae) is a fungus that has been used in traditional Chinese medici …
• 186.

  Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review.

  • Shaher F, Qiu H, Wang S, Hu Y, Wang W, Zhang Y, Wei Y, Al-Ward H, Abdulghani MAM, Alenezi SK, Baldi S, Zhou S.
  • Biomed Res Int. 2020 Jul 25;2020:7136075. doi: 10.1155/2020/7136075.
  • PMCID: PMC7397440

  Shaher F, et al.

  Biomed Res Int. 2020.

  PMCID: PMC7397440

  This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. ...Among the 1731 studies of indexed PubMed arti …

  This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lu …
• 187.

  Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice.

  • Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L.
  • Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6.
  • PMCID: PMC8249598

  Yao C, et al.

  Sci Rep. 2021.

  PMCID: PMC8249598

  Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative tranquilizing effects. However, the component of G. lucidum that promotes sleep has not been clearly identified. Here, the effect and mechanism of the acidic part of …

  Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative tranquilizing effects. However, t …
• 188.

  Accessing biological actions of Ganoderma secondary metabolites by in silico profiling.

  • Grienke U, Kaserer T, Pfluger F, Mair CE, Langer T, Schuster D, Rollinger JM.
  • Phytochemistry. Author manuscript. 2014 Nov 6;114:114-24. doi: 10.1016/j.phytochem.2014.10.010.
  • PMCID: PMC4948669

  Grienke U, et al.

  Phytochemistry. Author manuscript. 2014.

  PMCID: PMC4948669

  The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medicines, as well as in modern applications such as functional food or nutraceuticals. ...Accordingly, this study discloses putative ligand tar …

  The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medi …
• 189.

  Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice.

  • Zhang Y, Feng Y, Wang W, Jia L, Zhang J.
  • Oxid Med Cell Longev. 2021 Feb 3;2021:9703682. doi: 10.1155/2021/9703682.
  • PMCID: PMC7876828

  Zhang Y, et al.

  Oxid Med Cell Longev. 2021.

  PMCID: PMC7876828

  In recent years, there have been many studies on Ganoderma lucidum polysaccharides (GLP), but the role of GLP in MODS is still unclear. The purpose of this work was to explore the antioxidant, anti-inflammatory, and protective effects of GLP on the liver in MODS mod …

  In recent years, there have been many studies on Ganoderma lucidum polysaccharides (GLP), but the role of GLP in MODS is still …
• 190.

  The transcription factor GCN4 contributes to maintaining intracellular amino acid contents under nitrogen-limiting conditions in the mushroom Ganoderma lucidum.

  • Lian L, Qiao J, Guo X, Xing Z, Ren A, Zhao M, Zhu J.
  • Microb Cell Fact. 2023 Oct 10;22(1):205. doi: 10.1186/s12934-023-02213-z.
  • PMCID: PMC10563202

  Lian L, et al.

  Microb Cell Fact. 2023.

  PMCID: PMC10563202

  A previous study revealed that GCN4 plays a pivotal role in nitrogen utilization and growth in Ganoderma lucidum. However, its regulation is nearly unknown in mushrooms. RESULTS: In this study, we found that the amino acid contents reached 120.51 mg per gram of myce …

  A previous study revealed that GCN4 plays a pivotal role in nitrogen utilization and growth in Ganoderma lucidum. However, its …

• 191.

  The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach.

  • Shi M.
  • Reprod Sci. 2024 Mar 6;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3.
  • PMCID: PMC11217070

  Shi M.

  Reprod Sci. 2024.

  PMCID: PMC11217070

  Ganoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor properties. ...

  Ganoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor prope …
• 192.

  The effect of Ganodermalucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation.

  • Jiao C, Xie Y, Yun H, Liang H, He C, Jiang A, Wu Q, Yang BB.
  • Aging (Albany NY). 2020 Jul 21;12(14):14125-14140. doi: 10.18632/aging.103412.
  • PMCID: PMC7425473

  Jiao C, et al.

  Aging (Albany NY). 2020.

  PMCID: PMC7425473

  The mushroom Ganoderma lucidum (G. lucidum Leyss. ex Fr.) Karst has been a traditional Chinese medicine for millennia. In this study, we isolated the Ganoderma lucidum spore oil (GLSO) and evaluated the effect of GLSO on skin burn wound healing …

  The mushroom Ganoderma lucidum (G. lucidum Leyss. ex Fr.) Karst has been a traditional Chinese medicine for millennia. …
• 193.

  Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats.

  • Wang F, Zhou Z, Ren X, Wang Y, Yang R, Luo J, Strappe P.
  • Lipids Health Dis. 2015 May 22;14:49. doi: 10.1186/s12944-015-0045-y.
  • PMCID: PMC4443549

  Wang F, et al.

  Lipids Health Dis. 2015.

  PMCID: PMC4443549

  BACKGROUND: The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to the date, there is no detailed study for describing the effect of G. lucidum spores on oxidative stress, blood glucose level and lipi …

  BACKGROUND: The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to …
• 194.

  Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties.

  • Li LF, Liu HB, Zhang QW, Li ZP, Wong TL, Fung HY, Zhang JX, Bai SP, Lu AP, Han QB.
  • Sci Rep. 2018 Apr 18;8(1):6172. doi: 10.1038/s41598-018-22885-7.
  • PMCID: PMC5906605

  Li LF, et al.

  Sci Rep. 2018.

  PMCID: PMC5906605

  Both Ganoderma lucidum (GL) and G. sinense (GS) are used as Lingzhi in China. Their functions are assumed to mainly derive from triterpenes and polysaccharides; however, the two species have very different triterpenes profiles, if this was the case, then the bioacti …

  Both Ganoderma lucidum (GL) and G. sinense (GS) are used as Lingzhi in China. Their functions are assumed to mainly derive fro …
• 195.

  Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.

  • Risoli S, Nali C, Sarrocco S, Cicero AFG, Colletti A, Bosco F, Venturella G, Gadaleta A, Gargano ML, Marcotuli I.
  • Nutrients. 2023 Feb 2;15(3):776. doi: 10.3390/nu15030776.
  • PMCID: PMC9919834

  Risoli S, et al.

  Nutrients. 2023.

  PMCID: PMC9919834

  The molecular identification of the sequences with those deposited in GenBank allowed for identifying 6 out of 19 samples, matching with those deposited belonging to the species indicated in the label, i.e., Lentinula edodes (samples 1, 4, 12 and 18) and Ganoderma lucid …

  The molecular identification of the sequences with those deposited in GenBank allowed for identifying 6 out of 19 samples, matching with tho …
• 196.

  Computational analysis and low-scale constitutive expression of laccases synthetic genes GlLCC1 from Ganoderma lucidum and POXA 1B from Pleurotus ostreatus in Pichia pastoris.

  • Rivera-Hoyos CM, Morales-Álvarez ED, Poveda-Cuevas SA, Reyes-Guzmán EA, Poutou-Piñales RA, Reyes-Montaño EA, Pedroza-Rodríguez AM, Rodríguez-Vázquez R, Cardozo-Bernal ÁM.
  • PLoS One. 2015 Jan 22;10(1):e0116524. doi: 10.1371/journal.pone.0116524.
  • PMCID: PMC4303304

  Rivera-Hoyos CM, et al.

  PLoS One. 2015.

  PMCID: PMC4303304

  In this work we selected fungal genes encoding for laccase enzymes GlLCC1 in Ganoderma lucidum and POXA 1B in Pleurotus ostreatus. These genes were optimized for codon use, GC content, and regions generating secondary structures. ...Interaction analysis of the 3D mo …

  In this work we selected fungal genes encoding for laccase enzymes GlLCC1 in Ganoderma lucidum and POXA 1B in Pleurotus ostrea …
• 197.

  Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity.

  • Shen R, Ge Y, Qin Y, Gao H, Yu H, Wu H, Song H.
  • J Cell Mol Med. 2024 Mar;28(6):e18223. doi: 10.1111/jcmm.18223.
  • PMCID: PMC10919157

  Shen R, et al.

  J Cell Mol Med. 2024.

  PMCID: PMC10919157

  Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum, an edible mushroom species utilized in traditional Chinese medicine for addressing various tumour types, presents an intriguing avenue …

  Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum< …
• 198.

  Ganoderma lucidum methanolic extract as a potent phytoconstituent: characterization, in-vitro antimicrobial and cytotoxic activity.

  • Mousavi SM, Hashemi SA, Gholami A, Omidifar N, Chiang WH, Neralla VR, Yousefi K, Shokripour M.
  • Sci Rep. 2023 Oct 13;13(1):17326. doi: 10.1038/s41598-023-44135-1.
  • PMCID: PMC10576041

  Mousavi SM, et al.

  Sci Rep. 2023.

  PMCID: PMC10576041

  Ganoderma lucidum methanolic extract (GLME) has attracted tremendous attention due to its exceptional antimicrobial and anticancer properties that can be delicately tuned by controlling the initial extraction's content and concentration. ...

  Ganoderma lucidum methanolic extract (GLME) has attracted tremendous attention due to its exceptional antimicrobial and antica …
• 199.

  Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum.

  • Wu T, Xia J, Ge F, Qiu H, Tian L, Liu X, Liu R, Jiang A, Zhu J, Shi L, Yu H, Zhao M, Ren A.
  • Microbiol Spectr. 2022 Sep 20;10(5):e0163322. doi: 10.1128/spectrum.01633-22.
  • PMCID: PMC9604110

  Wu T, et al.

  Microbiol Spectr. 2022.

  PMCID: PMC9604110

  In addition, GlAZ upregulated the metabolic pathway of ganoderic acid (GA) biosynthesis in Ganoderma lucidum by modulating the intracellular Put content. However, a target of rapamycin (TOR) was found to promote the accumulation of intracellular Put after the GlTOR …

  In addition, GlAZ upregulated the metabolic pathway of ganoderic acid (GA) biosynthesis in Ganoderma lucidum by modulating the …
• 200.

  An active ingredient isolated from Ganoderma lucidum promotes burn wound healing via TRPV1/SMAD signaling.

  • Jiao C, Yun H, Liang H, Lian X, Li S, Chen J, Qadir J, Yang BB, Xie Y.
  • Aging (Albany NY). 2022 Jun 13;14(13):5376-5389. doi: 10.18632/aging.204119.
  • PMCID: PMC9320545

  Jiao C, et al.

  Aging (Albany NY). 2022.

  PMCID: PMC9320545

  The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction isolated from Ganoderma spores. ...

  The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction …

• 201.

  Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.

  • Wang GH, Wang LH, Wang C, Qin LH.
  • Medicine (Baltimore). 2018 May;97(19):e0636. doi: 10.1097/MD.0000000000010636.
  • PMCID: PMC5959386

  Wang GH, et al.

  Medicine (Baltimore). 2018.

  PMCID: PMC5959386

  BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating patients with Alzheimer disease (AD). METHODS: Forty-two eligible patients with AD were recruited. ...

  BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating …
• 202.

  Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.

  • Mahgoub SM, Alawam AS, Rudayni HA, Allam AA, Shaban A, Khaled E, Mokhtar AM, Aleem Abdel Aziz SA, Mahmoud R.
  • RSC Adv. 2025 Jun 20;15(24):19392-19416. doi: 10.1039/d5ra02368h.
  • PMCID: PMC12179686

  Mahgoub SM, et al.

  RSC Adv. 2025.

  PMCID: PMC12179686

  To address these issues, this study develops an innovative progesterone-reishi mushroom (Ganoderma lucidum) composite, leveraging the natural bioactive properties of reishi mushrooms to enhance therapeutic efficacy. The composite was prepared by encaps …

  To address these issues, this study develops an innovative progesterone-reishi mushroom (Ganoderma lucidum) composite, …
• 203.

  GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus Umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice.

  • Huang Q, Li L, Chen H, Liu Q, Wang Z.
  • Nutrients. 2019 Jun 28;11(7):1480. doi: 10.3390/nu11071480.
  • PMCID: PMC6682870

  Huang Q, et al.

  Nutrients. 2019.

  PMCID: PMC6682870

  Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly exhibit immunoregulation. ...

  Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly e …
• 204.

  Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury.

  • Abate M, Pepe G, Randino R, Pisanti S, Basilicata MG, Covelli V, Bifulco M, Cabri W, D'Ursi AM, Campiglia P, Rodriquez M.
  • Pharmaceuticals (Basel). 2020 Aug 29;13(9):224. doi: 10.3390/ph13090224.
  • PMCID: PMC7557611

  Abate M, et al.

  Pharmaceuticals (Basel). 2020.

  PMCID: PMC7557611

  Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer activities are well known. Moreover, lately, there has been an increasing interest from pharmaceu …

  Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, an …
• 205.

  Performance of wild-Serbian Ganoderma lucidum mycelium in treating synthetic sewage loading using batch bioreactor.

  • Mohd Hanafiah Z, Wan Mohtar WHM, Abu Hasan H, Jensen HS, Klaus A, Wan-Mohtar WAAQI.
  • Sci Rep. 2019 Nov 6;9(1):16109. doi: 10.1038/s41598-019-52493-y.
  • PMCID: PMC6834664

  Mohd Hanafiah Z, et al.

  Sci Rep. 2019.

  PMCID: PMC6834664

  Thus, the performance of pre-grown wild-Serbian Ganoderma lucidum mycelial pellets (GLMPs) was evaluated on four different synthetic domestic wastewaters under different conditions of initial pH (pH 4, 5, and 7) and chemical oxygen demand (COD) to nitrogen (COD/N) r …

  Thus, the performance of pre-grown wild-Serbian Ganoderma lucidum mycelial pellets (GLMPs) was evaluated on four different syn …
• 206.

  Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.

  • Guo J, Yuan C, Huang M, Liu Y, Chen Y, Liu C, Chen Y.
  • Drug Deliv. 2018 Nov;25(1):1802-1810. doi: 10.1080/10717544.2018.1516006.
  • PMCID: PMC6201799

  Guo J, et al.

  Drug Deliv. 2018.

  PMCID: PMC6201799

  The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microemulsion on pharmaceutical performance and anti-lung cancer treatment. ...

  The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microem …
• 207.

  Ganoderma lucidum Extract Reduces the Motility of Breast Cancer Cells Mediated by the RAC-Lamellipodin Axis.

  • Acevedo-Díaz A, Ortiz-Soto G, Suárez-Arroyo IJ, Zayas-Santiago A, Martínez Montemayor MM.
  • Nutrients. 2019 May 19;11(5):1116. doi: 10.3390/nu11051116.
  • PMCID: PMC6567024

  Acevedo-Díaz A, et al.

  Nutrients. 2019.

  PMCID: PMC6567024

  Here, we aimed to investigate the therapeutic efficacy of Ganoderma lucidum extract (GLE)-a medicinal mushroom with anticancer properties-on BC motility via the Rac/Lamellipodin pathway. ...

  Here, we aimed to investigate the therapeutic efficacy of Ganoderma lucidum extract (GLE)-a medicinal mushroom with anticancer …
• 208.

  Combination of Spirulina platensis, Ganoderma lucidum and Moringa oleifera Improves Cardiac Functions and Reduces Pro-Inflammatory Biomarkers in Preclinical Models of Short-Term Doxorubicin-Mediated Cardiotoxicity: New Frontiers in Cardioncology?

  • Quagliariello V, Basilicata MG, Pepe G, De Anseris R, Di Mauro A, Scognamiglio G, Palma G, Vestuto V, Buccolo S, Luciano A, Barbieri M, Bruzzese F, Maurea C, Pumpo R, Ostacolo C, Campiglia P, Berretta M, Maurea N.
  • J Cardiovasc Dev Dis. 2022 Nov 28;9(12):423. doi: 10.3390/jcdd9120423.
  • PMCID: PMC9780956

  Quagliariello V, et al.

  J Cardiovasc Dev Dis. 2022.

  PMCID: PMC9780956

  Whilst prolonging cancer-related survival, these agents can induce drug-related cardiotoxicity. Spirulina, Reishi (Ganoderma lucidum) and Moringa are three nutraceuticals with anti-inflammatory effects that are currently used in cancer patients as complementa …

  Whilst prolonging cancer-related survival, these agents can induce drug-related cardiotoxicity. Spirulina, Reishi (Ganoderma < …
• 209.

  Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice.

  • Li F, Zhang Y, Zhong Z.
  • Int J Mol Sci. 2011 Sep 20;12(9):6135-45. doi: 10.3390/ijms12096135.
  • PMCID: PMC3189773

  Li F, et al.

  Int J Mol Sci. 2011.

  PMCID: PMC3189773

  The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. ...

  The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-i …
• 210.

  The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes.

  • Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H, Sliva D.
  • Int J Oncol. 2014 Apr 9;44(6):2009-15. doi: 10.3892/ijo.2014.2375.
  • PMCID: PMC4735696

  Loganathan J, et al.

  Int J Oncol. 2014.

  PMCID: PMC4735696

  In the present study, we evaluated a well-characterized extract from the medicinal mushroom Ganoderma lucidum (GLE) for its affects on tumor growth and breast-to-lung cancer metastasis. ...

  In the present study, we evaluated a well-characterized extract from the medicinal mushroom Ganoderma lucidum (GLE) for its af …

• 211.

  Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast.

  • Yuan W, Jiang C, Wang Q, Fang Y, Wang J, Wang M, Xiao H.
  • Nat Commun. 2022 Dec 14;13(1):7740. doi: 10.1038/s41467-022-35500-1.
  • PMCID: PMC9748899

  Yuan W, et al.

  Nat Commun. 2022.

  PMCID: PMC9748899

  Type II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior biological activities. However, challenges in the genetic manipulation of the native producer, low level of accumulation in the farmed mushroom …

  Type II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior bio …
• 212.

  Ganoderma lucidum Mycelia Mass and Bioactive Compounds Production through Grape Pomace and Cheese Whey Valorization.

  • Kachrimanidou V, Papadaki A, Papapostolou H, Alexandri M, Gonou-Zagou Z, Kopsahelis N.
  • Molecules. 2023 Aug 30;28(17):6331. doi: 10.3390/molecules28176331.
  • PMCID: PMC10489755

  Kachrimanidou V, et al.

  Molecules. 2023.

  PMCID: PMC10489755

  Numerous compounds obtained from the medicinal mushroom Ganoderma lucidum have evidenced renowned bioactive characteristics. Controlled fermentation to generate fungal mycelia confers several advantages, specifically when the valorization of agro-industrial streams …

  Numerous compounds obtained from the medicinal mushroom Ganoderma lucidum have evidenced renowned bioactive characteristics. C …
• 213.

  Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1 beta Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice.

  • Liang CJ, Lee CW, Sung HC, Chen YH, Chiang YC, Hsu HY, Tseng YC, Li CY, Wang SH, Chen YL.
  • Evid Based Complement Alternat Med. 2014 Mar 4;2014:305149. doi: 10.1155/2014/305149.
  • PMCID: PMC3960732

  Liang CJ, et al.

  Evid Based Complement Alternat Med. 2014.

  PMCID: PMC3960732

  The aim of the present study was to examine the effects of an extract of Ganoderma lucidum (Reishi) polysaccharides (EORPs), which is effective against immunological disorders, on interleukin- (IL-) 1 beta expression by human aortic smooth muscle cells (HASMC …

  The aim of the present study was to examine the effects of an extract of Ganoderma lucidum (Reishi) polysaccharides (EO …
• 214.

  Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii.

  • Saha TK, Mariom, Rahman T, Moniruzzaman M, Min T, Hossain Z.
  • Sci Rep. 2023 Sep 5;13(1):14652. doi: 10.1038/s41598-023-41557-9.
  • PMCID: PMC10480226

  Saha TK, et al.

  Sci Rep. 2023.

  PMCID: PMC10480226

  We studied how supplementing Labeo rohita's diet with reishi mushroom powder containing beta-glucan influenced immunological function. A supplemented diet containing 10% reishi mushroom powder was administered for 120 days. ...Therefore, the results indicated that a …

  We studied how supplementing Labeo rohita's diet with reishi mushroom powder containing beta-glucan influenced immunological function …
• 215.

  Ganoderma lucidum Modulates Inflammatory Responses following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice.

  • Ren Z, Ding H, Zhou M, Chan P.
  • Nutrients. 2022 Sep 19;14(18):3872. doi: 10.3390/nu14183872.
  • PMCID: PMC9505693

  Ren Z, et al.

  Nutrients. 2022.

  PMCID: PMC9505693

  Ganoderma lucidum, one of the most valued medicinal mushrooms, has been used for health supplements and medicine in China. Our previous studies have proved that Ganoderma lucidum extract (GLE) could inhibit activation of microglia and protect dopaminer …

  Ganoderma lucidum, one of the most valued medicinal mushrooms, has been used for health supplements and medicine in China. Our …
• 216.

  Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders.

  • Zhang XT, Ji CL, Fu YJ, Yang Y, Xu GY.
  • Biosci Rep. 2024 Jul 31;44(7):BSR20232068. doi: 10.1042/BSR20232068.
  • PMCID: PMC11292473

  Zhang XT, et al.

  Biosci Rep. 2024.

  PMCID: PMC11292473

  Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI. The active ingredients in GL and their corresponding targets were screened through TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis …

  Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI. The active ingredients …
• 217.

  Peroxidase-Like Platinum Clusters Synthesized by Ganoderma lucidum Polysaccharide for Sensitively Colorimetric Detection of Dopamine.

  • Lai X, Han Y, Zhang J, Zhang J, Lin W, Liu Z, Wang L.
  • Molecules. 2021 May 6;26(9):2738. doi: 10.3390/molecules26092738.
  • PMCID: PMC8125108

  Lai X, et al.

  Molecules. 2021.

  PMCID: PMC8125108

  In this study, we reported the colorimetric detection of DA using Ganoderma lucidum polysaccharide (GLP) stabilized platinum nanoclusters (Pt(n)-GLP NCs). ...

  In this study, we reported the colorimetric detection of DA using Ganoderma lucidum polysaccharide (GLP) stabilized platinum n …
• 218.

  Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers.

  • Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK.
  • Pharm Biol. 2017 Dec;55(1):1041-1046. doi: 10.1080/13880209.2017.1288750.
  • PMCID: PMC6130508

  Chiu HF, et al.

  Pharm Biol. 2017.

  PMCID: PMC6130508

  CONTEXT: Ganoderma lucidum (Leyss: Fr) Karst. (Polyporaceae) is an oriental medicinal fungus, commonly used in traditional Chinese medicine (TCM) for treating various condition or diseases such as hypertension, hyperglycaemia, hepatitis and cancer. OBJECTIVE: The cu …

  CONTEXT: Ganoderma lucidum (Leyss: Fr) Karst. (Polyporaceae) is an oriental medicinal fungus, commonly used in traditional Chi …
• 219.

  Antidiabetic, antihyperlipidemic and antioxidant activities of a novel proteoglycan from ganoderma lucidum fruiting bodies on db/db mice and the possible mechanism.

  • Pan D, Zhang D, Wu J, Chen C, Xu Z, Yang H, Zhou P.
  • PLoS One. 2013 Jul 11;8(7):e68332. doi: 10.1371/journal.pone.0068332.
  • PMCID: PMC3708940

  Pan D, et al.

  PLoS One. 2013.

  PMCID: PMC3708940

  Previously, we screened a proteoglycan for anti-hyperglycemic, named FYGL, from Ganoderma Lucidum. For further research of the antidiabetic mechanisms of FYGL in vivo, the glucose homeostasis, activities of insulin-sensitive enzymes, glucose transporter expression a …

  Previously, we screened a proteoglycan for anti-hyperglycemic, named FYGL, from Ganoderma Lucidum. For further research of the …
• 220.

  Innovative eco-sustainable reishi mushroom-based adsorbents for progesterone removal and agricultural sustainability.

  • Abdelwahab A, Alenezi KM, Humaidi JR, Haque A, Mahgoub SM, Mokhtar AM, Shaban A, Mansour M M M, Mahmoud R.
  • RSC Adv. 2025 May 20;15(21):16690-16707. doi: 10.1039/d5ra01906k.
  • PMCID: PMC12089978

  Abdelwahab A, et al.

  RSC Adv. 2025.

  PMCID: PMC12089978

  This study introduces an innovative, eco-friendly approach utilizing non-edible reishi mushroom (Ganoderma lucidum) and its calcined form as natural adsorbents for progesterone removal while simultaneously exploring the potential of the formed composites as s …

  This study introduces an innovative, eco-friendly approach utilizing non-edible reishi mushroom (Ganoderma lucidum) and …

• 221.

  Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

  • Wang X, Wang X, Zhao L, Zhou F.
  • Nutrients. 2025 Feb 28;17(5):844. doi: 10.3390/nu17050844.
  • PMCID: PMC11901880

  Wang X, et al.

  Nutrients. 2025.

  PMCID: PMC11901880

  Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. ...

  Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. ...
• 222.

  Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.

  • Romero-Córdoba SL, Salido-Guadarrama I, Meneses ME, Cosentino G, Iorio MV, Tagliabue E, Torres N, Sánchez-Tapia M, Bonilla M, Castillo I, Petlacalco B, Tovar AR, Martínez-Carrera D.
  • Nutrients. 2020 Dec 24;13(1):38. doi: 10.3390/nu13010038.
  • PMCID: PMC7823885

  Romero-Córdoba SL, et al.

  Nutrients. 2020.

  PMCID: PMC7823885

  Natural products, such as the medicinal mushroom Ganoderma lucidum (Gl), have demonstrated hypocholesterolemic, prebiotic and antidiabetic properties. ...

  Natural products, such as the medicinal mushroom Ganoderma lucidum (Gl), have demonstrated hypocholesterolemic, prebiotic and …
• 223.

  Ganoderma lucidum Rhodiola compound preparation prevent D-galactose-induced immune impairment and oxidative stress in aging rat model.

  • Yuan S, Yang Y, Li J, Tan X, Cao Y, Li S, Hong HD, Liu L, Zhang Q.
  • Sci Rep. 2020 Nov 6;10(1):19244. doi: 10.1038/s41598-020-76249-1.
  • PMCID: PMC7648061

  Yuan S, et al.

  Sci Rep. 2020.

  PMCID: PMC7648061

  This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rosen, in aging rats. Rats were subcutaneously injected with 400 mg/kg of D-galactose daily, and aging could be induced after 8 weeks. ...

  This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rose …
• 224.

  Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.

  • Cai Q, Li Y, Pei G.
  • J Neuroinflammation. 2017 Mar 24;14(1):63. doi: 10.1186/s12974-017-0839-0.
  • PMCID: PMC5364682

  Cai Q, et al.

  J Neuroinflammation. 2017.

  PMCID: PMC5364682

  BACKGROUND: Ganoderma lucidum (GL) has been widely used in Asian countries for hundreds of years to promote health and longevity. The pharmacological functions of which had been classified, including the activation of innate immune responses, suppression of tumour a …

  BACKGROUND: Ganoderma lucidum (GL) has been widely used in Asian countries for hundreds of years to promote health and longevi …
• 225.

  Unlocking Reishi's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.

  • Shady RM, El-Gayar MH, El-Gebaly E, Abbass HS, Yassein MA.
  • AMB Express. 2025 Jul 12;15(1):104. doi: 10.1186/s13568-025-01905-6.
  • PMCID: PMC12255602

  Shady RM, et al.

  AMB Express. 2025.

  PMCID: PMC12255602

  Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assessed the in-vitro antimicrobial, antitumor, antiviral as well as antioxidant capacity of Ganoderma lucidum water extract (GLWE). …

  Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assesse …
• 226.

  Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts.

  • Huh S, Lee S, Choi SJ, Wu Z, Cho JH, Kim L, Shin YS, Kang BW, Kim JG, Liu K, Cho H, Kang H.
  • Molecules. 2019 Oct 24;24(21):3834. doi: 10.3390/molecules24213834.
  • PMCID: PMC6864608

  Huh S, et al.

  Molecules. 2019.

  PMCID: PMC6864608

  Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse events. Ganoderma lucidum is a traditional mushroom used for pharmaceutical purposes. G. lucidum extracts (GLE) showed potenti …

  Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse events. …
• 227.

  Antitumor Activity of Extract From the Sporoderm-Breaking Spore of Ganoderma lucidum: Restoration on Exhausted Cytotoxic T Cell With Gut Microbiota Remodeling.

  • Su J, Su L, Li D, Shuai O, Zhang Y, Liang H, Jiao C, Xu Z, Lai Y, Xie Y.
  • Front Immunol. 2018 Jul 31;9:1765. doi: 10.3389/fimmu.2018.01765.
  • PMCID: PMC6079217

  Su J, et al.

  Front Immunol. 2018.

  PMCID: PMC6079217

  Recently, active components from the spores of Ganoderma lucidum have attracted much attention for their versatile biological activities owing to the advance in sporoderm-breaking technology. Here, anticancer potential of an extract derived from the sporoderm-breaki …

  Recently, active components from the spores of Ganoderma lucidum have attracted much attention for their versatile biological …
• 228.

  GCN4 Enhances the Transcriptional Regulation of AreA by Interacting with SKO1 To Mediate Nitrogen Utilization in Ganoderma lucidum.

  • Lian L, Shi L, Zhu J, Shi L, Ren A, You H, Liu R, Zhao M.
  • Appl Environ Microbiol. 2022 Nov 7;88(22):e0132222. doi: 10.1128/aem.01322-22.
  • PMCID: PMC9680636

  Lian L, et al.

  Appl Environ Microbiol. 2022.

  PMCID: PMC9680636

  However, the mechanism by which GCN4 regulates nitrogen utilization in Ganoderma lucidum is not well understood. In this study, we found that GCN4 physically interacts with SKO1, a bZIP (basic leucine zipper) transcription factor. ...

  However, the mechanism by which GCN4 regulates nitrogen utilization in Ganoderma lucidum is not well understood. In this study …
• 229.

  Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography-Tandem Mass Spectrometry.

  • Zhang Q, Huang L, Wu Y, Huang L, Xu X, Lin R.
  • Molecules. 2022 Jun 27;27(13):4130. doi: 10.3390/molecules27134130.
  • PMCID: PMC9268268

  Zhang Q, et al.

  Molecules. 2022.

  PMCID: PMC9268268

  (A. roxburghii) oral liquid (CAROL) is a hospital preparation of A. roxburghii and Ganoderma lucidum (G. lucidum), which have hepatoprotective effects. Eight active components (five nucleosides/nucleobases and three triterpenoid acids) in CAROL, A. roxburghii …

  (A. roxburghii) oral liquid (CAROL) is a hospital preparation of A. roxburghii and Ganoderma lucidum (G. lucidum), whic …
• 230.

  Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma-bearing mice.

  • Zhu J, Xu J, Jiang LL, Huang JQ, Yan JY, Chen YW, Yang Q.
  • Kaohsiung J Med Sci. 2019 Apr 8;35(4):222-229. doi: 10.1002/kjm2.12020.
  • PMCID: PMC11900711

  Zhu J, et al.

  Kaohsiung J Med Sci. 2019.

  PMCID: PMC11900711

  Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS-induced antitumor effect of in U14 cervical carcinoma-bearing mice. ...

  Our main goal of this study is to investigate the improvement of Ganoderma lucidum polysaccharides (GPS) on CIS-induced antitu …

• 231.

  Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.

  • Pan H, Li C, Wang M, Ye K, Fan X, Fu Y, Yang J, Li Z.
  • Sci Rep. 2025 Jul 1;15(1):22111. doi: 10.1038/s41598-025-05890-5.
  • PMCID: PMC12219779

  Pan H, et al.

  Sci Rep. 2025.

  PMCID: PMC12219779

  This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action. ...

  This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS …
• 232.

  Multiple Fingerprint-Activity Relationship Assessment of Immunomodulatory Polysaccharides from Ganoderma lucidum Based on Chemometric Methods.

  • Liu J, Zhang J, Feng J, Tang C, Yan M, Zhou S, Chen W, Wang W, Liu Y.
  • Molecules. 2023 Mar 24;28(7):2913. doi: 10.3390/molecules28072913.
  • PMCID: PMC10096448

  Liu J, et al.

  Molecules. 2023.

  PMCID: PMC10096448

  Polysaccharides with molecular weights ranging from 1.75 10(3) to 1.14 10(4) g/mol were obtained from the fruit bodies of Ganoderma lucidum. The multiple fingerprints and macrophage immunostimulatory activity of these fractions were analyzed as well as the fingerpri …

  Polysaccharides with molecular weights ranging from 1.75 10(3) to 1.14 10(4) g/mol were obtained from the fruit bodies of Ganoderma < …
• 233.

  Ganoderma lucidum Polysaccharides Ameliorate Acetaminophen-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Apoptosis along the Nrf2 Pathway.

  • Zhang N, Han Z, Zhang R, Liu L, Gao Y, Li J, Yan M.
  • Nutrients. 2024 Jun 13;16(12):1859. doi: 10.3390/nu16121859.
  • PMCID: PMC11206445

  Zhang N, et al.

  Nutrients. 2024.

  PMCID: PMC11206445

  The excessive employment of acetaminophen (APAP) is capable of generating oxidative stress and apoptosis, which ultimately result in acute liver injury (ALI). Ganoderma lucidum polysaccharides (GLPs) exhibit hepatoprotective activity, yet the protective impact and p …

  The excessive employment of acetaminophen (APAP) is capable of generating oxidative stress and apoptosis, which ultimately result in acute l …
• 234.

  The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network.

  • Zhao R, Chen Q, He YM.
  • Sci Rep. 2018 Aug 23;8(1):12680. doi: 10.1038/s41598-018-30881-0.
  • PMCID: PMC6107651

  Zhao R, et al.

  Sci Rep. 2018.

  PMCID: PMC6107651

  Ganoderma lucidum extract (GLE) has shown positive effects for tumor treatment. However, the molecular mechanism of GLE treatment is unknown. ...

  Ganoderma lucidum extract (GLE) has shown positive effects for tumor treatment. However, the molecular mechanism of GLE treatm …
• 235.

  Synthesis and Evaluation of Herbal Chitosan from Ganoderma Lucidum Spore Powder for Biomedical Applications.

  • Zhu LF, Yao ZC, Ahmad Z, Li JS, Chang MW.
  • Sci Rep. 2018 Oct 2;8(1):14608. doi: 10.1038/s41598-018-33088-5.
  • PMCID: PMC6168458

  Zhu LF, et al.

  Sci Rep. 2018.

  PMCID: PMC6168458

  In the current work, chitosan is obtained from an herbal source (Ganoderma lucidum spore powder (GLSP)) for the first time. To show this, both standard (thermochemical deacetylation, (TCD)) and emerging (ultrasound-assisted deacetylation (USAD)) methods of chitosan …

  In the current work, chitosan is obtained from an herbal source (Ganoderma lucidum spore powder (GLSP)) for the first time. To …
• 236.

  Hypocholesterolemic Properties and Prebiotic Effects of Mexican Ganoderma lucidum in C57BL/6 Mice.

  • Meneses ME, Martínez-Carrera D, Torres N, Sánchez-Tapia M, Aguilar-López M, Morales P, Sobal M, Bernabé T, Escudero H, Granados-Portillo O, Tovar AR.
  • PLoS One. 2016 Jul 20;11(7):e0159631. doi: 10.1371/journal.pone.0159631.
  • PMCID: PMC4954724

  Meneses ME, et al.

  PLoS One. 2016.

  PMCID: PMC4954724

  Edible and medicinal mushrooms contain bioactive compounds with promising effects on several cardiovascular risk biomarkers. However, strains of Ganoderma lucidum of Mexican origin have not yet been studied. Standardized extracts of G. lucidum (Gl) were given …

  Edible and medicinal mushrooms contain bioactive compounds with promising effects on several cardiovascular risk biomarkers. However, strain …
• 237.

  Hepatoprotective effects of mushrooms.

  • Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM.
  • Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609.
  • PMCID: PMC6270077

  Soares AA, et al.

  Molecules. 2013.

  PMCID: PMC6270077

  The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this rev …

  The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage …
• 238.

  Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances.

  • Eira A, Gonçalves MBS, Fongang YSF, Domingues C, Jarak I, Mascarenhas-Melo F, Figueiras A.
  • Pharmaceutics. 2025 Mar 26;17(4):422. doi: 10.3390/pharmaceutics17040422.
  • PMCID: PMC12030363

  Eira A, et al.

  Pharmaceutics. 2025.

  PMCID: PMC12030363

  Background:Ganoderma lucidum (GL), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. ...

  Background:Ganoderma lucidum (GL), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for i …
• 239.

  Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen.

  • Jan RH, Lin TY, Hsu YC, Lee SS, Lo SY, Chang M, Chen LK, Lin YL.
  • BMC Immunol. 2011 May 25;12:31. doi: 10.1186/1471-2172-12-31.
  • PMCID: PMC3127845

  Jan RH, et al.

  BMC Immunol. 2011.

  PMCID: PMC3127845

  BACKGROUND: Ganoderma lucidum-derived polysaccharide (PS-G) can rapidly and effectively promote the activation and maturation of immature dendritic cells (DCs), suggesting that PS-G possesses the capacity to regulate immune responses. ...

  BACKGROUND: Ganoderma lucidum-derived polysaccharide (PS-G) can rapidly and effectively promote the activation and maturation …
• 240.

  The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and immunosuppression.

  • Shahid A, Huang M, Liu M, Shamim MA, Parsa C, Orlando R, Huang Y.
  • PLoS One. 2022 Mar 21;17(3):e0265615. doi: 10.1371/journal.pone.0265615.
  • PMCID: PMC8936451

  Shahid A, et al.

  PLoS One. 2022.

  PMCID: PMC8936451

  The medicinal mushroom Ganoderma lucidum is traditionally used for treating multiple diseases, including cancer. ...

  The medicinal mushroom Ganoderma lucidum is traditionally used for treating multiple diseases, including cancer. ...

• 241.

  Ultrasonic-assisted supercritical fluid separation removing plasticizers from ganoderma lucidum spores' oil.

  • Li C, Ma Y, Shen X, Chen W, Zhou Y, Zhi X.
  • Ultrason Sonochem. 2023 Sep 23;100:106622. doi: 10.1016/j.ultsonch.2023.106622.
  • PMCID: PMC10550761

  Li C, et al.

  Ultrason Sonochem. 2023.

  PMCID: PMC10550761

  Ultrasonic-assisted supercritical fluid separation (USFS) was firstly applied to regulate solubility and remove plasticizers from ganoderma lucidum spores' oil to improve product safety. Separation efficiency was related with four variables, including temperature, p …

  Ultrasonic-assisted supercritical fluid separation (USFS) was firstly applied to regulate solubility and remove plasticizers from ganoder …
• 242.

  Triterpenoids and Polysaccharides from Ganoderma lucidum Improve the Histomorphology and Function of Testes in Middle-Aged Male Mice by Alleviating Oxidative Stress and Cellular Apoptosis.

  • Li Y, Liang W, Han Y, Zhao W, Wang S, Qin C.
  • Nutrients. 2022 Nov 9;14(22):4733. doi: 10.3390/nu14224733.
  • PMCID: PMC9696538

  Li Y, et al.

  Nutrients. 2022.

  PMCID: PMC9696538

  Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ganoderma lucidum (GL) containing triterpenes and polysaccharides has been shown to have anti-aging properties. ...

  Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ga …
• 243.

  Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis.

  • Ren ZL, Wang CD, Wang T, Ding H, Zhou M, Yang N, Liu YY, Chan P.
  • Acta Pharmacol Sin. 2018 Jul 10;40(4):441-450. doi: 10.1038/s41401-018-0077-8.
  • PMCID: PMC6461997

  Ren ZL, et al.

  Acta Pharmacol Sin. 2018.

  PMCID: PMC6461997

  Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson's disease. Ganoderma lucidum (GL) has emerged as a novel agent that protects neurons from oxidative stress. ...

  Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson's disease. Ganod …
• 244.

  Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice.

  • Yu N, Huang Y, Jiang Y, Zou L, Liu X, Liu S, Chen F, Luo J, Zhu Y.
  • Oxid Med Cell Longev. 2020 Jan 28;2020:9894037. doi: 10.1155/2020/9894037.
  • PMCID: PMC7008260

  Yu N, et al.

  Oxid Med Cell Longev. 2020.

  PMCID: PMC7008260

  Alzheimer's disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) have nutritional health benefits and has been shown to promote health and longevity, but a protective effect of GLTs on AD damage has not yet b …

  Alzheimer's disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) hav …
• 245.

  Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migration.

  • Chen LH, Lin ZB, Li WD.
  • Acta Pharmacol Sin. 2011 Oct 24;32(12):1505-12. doi: 10.1038/aps.2011.126.
  • PMCID: PMC4010208

  Chen LH, et al.

  Acta Pharmacol Sin. 2011.

  PMCID: PMC4010208

  AIM: To study the effects of Ganoderma lucidum polysaccharides (Gl-PS) on methotrexate (MTX)-induced small intestinal damage in mice and the underlying mechanisms. ...

  AIM: To study the effects of Ganoderma lucidum polysaccharides (Gl-PS) on methotrexate (MTX)-induced small intestinal damage i …
• 246.

  Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis.

  • Sharma P, Tulsawani R.
  • Sci Rep. 2020 Jun 2;10(1):8944. doi: 10.1038/s41598-020-65812-5.
  • PMCID: PMC7265456

  Sharma P, et al.

  Sci Rep. 2020.

  PMCID: PMC7265456

  Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprotective mechanism using rat hypobaric hypoxia test model. ...

  Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract …
• 247.

  Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.

  • Chan WK, Cheung CC, Law HK, Lau YL, Chan GC.
  • J Hematol Oncol. 2008 Jul 21;1:9. doi: 10.1186/1756-8722-1-9.
  • PMCID: PMC2517069

  Chan WK, et al.

  J Hematol Oncol. 2008.

  PMCID: PMC2517069

  BACKGROUND: Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive beta-glucan can stimulate the maturation of monocyte-derived dendritic cells (DC). ...

  BACKGROUND: Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive beta-glucan can stimu …
• 248.

  Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review.

  • Cadar E, Negreanu-Pirjol T, Pascale C, Sirbu R, Prasacu I, Negreanu-Pirjol BS, Tomescu CL, Ionescu AM.
  • Antioxidants (Basel). 2023 Oct 25;12(11):1907. doi: 10.3390/antiox12111907.
  • PMCID: PMC10669212

  Cadar E, et al.

  Antioxidants (Basel). 2023.

  PMCID: PMC10669212

  Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depending on the country. ...The potential health benefits of G. lucidum are systematized based on biological actions. The findings prese …

  Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depe …
• 249.

  Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model.

  • Heriansyah T, Nurwidyaningtyas W, Sargowo D, Tjahjono CT, Wihastuti TA.
  • Vasc Health Risk Manag. 2019 Oct 3;15:419-427. doi: 10.2147/VHRM.S205996.
  • PMCID: PMC6781740

  Heriansyah T, et al.

  Vasc Health Risk Manag. 2019.

  PMCID: PMC6781740

  This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through an increase of circulating endothelial cells and circulating endothelial cells (CEC) ratio, decreased H2O2, triglyceride (TG), total choles …

  This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through …
• 250.

  Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer.

  • Cancemi G, Caserta S, Gangemi S, Pioggia G, Allegra A.
  • J Clin Med. 2024 Feb 18;13(4):1153. doi: 10.3390/jcm13041153.
  • PMCID: PMC10889924

  Cancemi G, et al.

  J Clin Med. 2024.

  PMCID: PMC10889924

  Moreover, research clarified the capability of molecules from Ganoderma lucidum to induce mitochondrial damage in acute promyelocytic leukemia cells, without cytotoxic effects in normal mononuclear cells. ...Our review presents data revealing the possibility of empl …

  Moreover, research clarified the capability of molecules from Ganoderma lucidum to induce mitochondrial damage in acute promye …

• 251.

  Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs via a CARD9-NF-kappaB-IDO pathway.

  • Wang Y, Fan X, Wu X.
  • Biosci Rep. 2020 Jun 26;40(6):BSR20201170. doi: 10.1042/BSR20201170.
  • PMCID: PMC7313449

  Wang Y, et al.

  Biosci Rep. 2020.

  PMCID: PMC7313449

  A homogeneous polysaccharide (GLP), with an average molecular weight of 4.44 104 Da, was isolated and purified from the fruiting bodies of Ganoderma lucidum. In this work, we examined the antitumor activities of GLP using a mouse Lewis lung cancer (LLC) model and ex …

  A homogeneous polysaccharide (GLP), with an average molecular weight of 4.44 104 Da, was isolated and purified from the fruiting bodies of < …
• 252.

  Gastroprotective Effects of Ganoderma lucidum Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats.

  • Tian B, Zhao Q, Xing H, Xu J, Li Z, Zhu H, Yang K, Sun P, Cai M.
  • Nutrients. 2022 Apr 1;14(7):1476. doi: 10.3390/nu14071476.
  • PMCID: PMC9002462

  Tian B, et al.

  Nutrients. 2022.

  PMCID: PMC9002462

  Ganoderma lucidum is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different Ganoderma lucidum polysaccharides (GLPs), GLP was separated into three parts with different mole …

  Ganoderma lucidum is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastropr …
• 253.

  A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies.

  • Wu Y, Wang D.
  • J Proteome Res. Author manuscript. 2009 Feb;8(2):436-42. doi: 10.1021/pr800554w.
  • PMCID: PMC2656399

  Wu Y, et al.

  J Proteome Res. Author manuscript. 2009.

  PMCID: PMC2656399

  A water-soluble glycopeptide (PGY), fractionated and purified from the aqueous extract of the fruiting bodies of Ganoderma lucidum via two-step dialysis, anion exchange, and gel permeation chromatography, was constituted of two moieties of carbohydrate and peptide. …

  A water-soluble glycopeptide (PGY), fractionated and purified from the aqueous extract of the fruiting bodies of Ganoderma lucidum …
• 254.

  Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.

  • Fijałkowska A, Jędrejko K, Sułkowska-Ziaja K, Ziaja M, Kała K, Muszyńska B.
  • Foods. 2022 May 20;11(10):1489. doi: 10.3390/foods11101489.
  • PMCID: PMC9141008

  Fijałkowska A, et al.

  Foods. 2022.

  PMCID: PMC9141008

  We specifically highlight the results of preclinical and clinical studies on dietary supplementation with three selected mushroom species: Lion's mane (Hericium erinaceus), Caterpillar mushroom (Cordyceps militaris), and Lingzhi/Reishi (Ganoderma lucidum). Pr …

  We specifically highlight the results of preclinical and clinical studies on dietary supplementation with three selected mushroom species: L …
• 255.

  Ganoderma triterpenoids attenuate tumour angiogenesis in lung cancer tumour-bearing nude mice.

  • Liu W, Yuan R, Hou A, Tan S, Liu X, Tan P, Huang X, Wang J.
  • Pharm Biol. 2020 Dec;58(1):1061-1068. doi: 10.1080/13880209.2020.1839111.
  • PMCID: PMC7655057

  Liu W, et al.

  Pharm Biol. 2020.

  PMCID: PMC7655057

  CONTEXT: Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyporaceae) triterpenoids (GLTs), the main components and bioactive metabolites of G. lucidum, have antitumour activity. ...

  CONTEXT: Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyporaceae) triterpenoids (GLTs), the main components and bioactive metab …
• 256.

  Inhibition on alpha-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum.

  • Zhang Y, Pan Y, Li J, Zhang Z, He Y, Yang H, Zhou P.
  • Molecules. 2022 Feb 22;27(5):1457. doi: 10.3390/molecules27051457.
  • PMCID: PMC8912016

  Zhang Y, et al.

  Molecules. 2022.

  PMCID: PMC8912016

  In this study, an anti-oxidative proteoglycan (named FYGL) extracted from Ganoderma lucidum was investigated in vitro for its inhibitory effect on alpha-glucosidase and non-enzymatic glycation using molecular kinetics, intrinsic fluorescence assay, and bovine serum …

  In this study, an anti-oxidative proteoglycan (named FYGL) extracted from Ganoderma lucidum was investigated in vitro for its …
• 257.

  Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation.

  • Pan H, Wang Y, Na K, Wang Y, Wang L, Li Z, Guo C, Guo D, Wang X.
  • Cell Death Dis. 2019 Jun 11;10(6):456. doi: 10.1038/s41419-019-1653-7.
  • PMCID: PMC6560101

  Pan H, et al.

  Cell Death Dis. 2019.

  PMCID: PMC6560101

  Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects. ...

  Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma lucidum polysaccharide (GLP) has been show …
• 258.

  Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.

  • Kim TH, Kim Js, Kim Zh, Huang RB, Wang RS.
  • PLoS One. 2012 Oct 8;7(10):e46208. doi: 10.1371/journal.pone.0046208.
  • PMCID: PMC3466234

  Kim TH, et al.

  PLoS One. 2012.

  PMCID: PMC3466234

  Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. ...

  Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of ca …
• 259.

  Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high-cholesterol diet.

  • Wu YS, Ho SY, Nan FH, Chen SN.
  • BMC Complement Altern Med. 2016 Dec 3;16(1):500. doi: 10.1186/s12906-016-1476-3.
  • PMCID: PMC5135828

  Wu YS, et al.

  BMC Complement Altern Med. 2016.

  PMCID: PMC5135828

  BACKGROUND: Binding of beta 1,3/1,6 glucan of Ganoderma lucidum (G. lucidum) with the receptor results in a series of signal transfers (signalling cascades), which activates the transcription factors for regulating inflammation. ...METHODS: The current study …

  BACKGROUND: Binding of beta 1,3/1,6 glucan of Ganoderma lucidum (G. lucidum) with the receptor results in a series of s …
• 260.

  Spermidine Regulates Mitochondrial Function by Enhancing eIF5A Hypusination and Contributes to Reactive Oxygen Species Production and Ganoderic Acid Biosynthesis in Ganoderma lucidum.

  • Han X, Shangguan J, Wang Z, Li Y, Fan J, Ren A, Zhao M.
  • Appl Environ Microbiol. 2022 Feb 2;88(6):e0203721. doi: 10.1128/AEM.02037-21.
  • PMCID: PMC8939328

  Han X, et al.

  Appl Environ Microbiol. 2022.

  PMCID: PMC8939328

  To explore the mechanism by which spermidine regulates ganoderic acid (GA) biosynthesis in Ganoderma lucidum, the effects of spermidine on GA and reactive oxygen species (ROS) contents were examined. ...

  To explore the mechanism by which spermidine regulates ganoderic acid (GA) biosynthesis in Ganoderma lucidum, the effects of s …

• 261.

  Improved 1-Deoxynojirimycin (DNJ) production in mulberry leaves fermented by microorganism.

  • Jiang YG, Wang CY, Jin C, Jia JQ, Guo X, Zhang GZ, Gui ZZ.
  • Braz J Microbiol. 2014 Aug 29;45(2):721-9. doi: 10.1590/s1517-83822014000200048.
  • PMCID: PMC4166305

  Jiang YG, et al.

  Braz J Microbiol. 2014.

  PMCID: PMC4166305

  In this study, we focus on screening an appropriate microorganism for performing fermentation to improve DNJ content in mulberry leaf. Results showed that Ganoderma lucidum was selected from 8 species and shown to be the most effective in improvement of DNJ producti …

  In this study, we focus on screening an appropriate microorganism for performing fermentation to improve DNJ content in mulberry leaf. Resul …
• 262.

  Heat Treatment of Reishi Medicinal Mushroom (Ganoderma lingzhi) Basidiocarp Enhanced Its beta-glucan Solubility, Antioxidant Capacity and Lactogenic Properties.

  • Kiss A, Grünvald P, Ladányi M, Papp V, Papp I, Némedi E, Mirmazloum I.
  • Foods. 2021 Aug 27;10(9):2015. doi: 10.3390/foods10092015.
  • PMCID: PMC8466132

  Kiss A, et al.

  Foods. 2021.

  PMCID: PMC8466132

  The effect of heat treatment on dried fruiting bodies of Reishi medicinal mushroom (Ganoderma lingzhi) is investigated. Control and samples treated for 20 min at temperatures of 70, 120, 150 and 180 C were subjected for their free radical scavenging capacity, differ …

  The effect of heat treatment on dried fruiting bodies of Reishi medicinal mushroom (Ganoderma lingzhi) is investigated. Contro …
• 263.

  Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice.

  • Wu SY, Ou CC, Lee ML, Hsin IL, Kang YT, Jan MS, Ko JL.
  • Microbiol Spectr. 2023 May 22;11(3):e0313022. doi: 10.1128/spectrum.03130-22.
  • PMCID: PMC10269453

  Wu SY, et al.

  Microbiol Spectr. 2023.

  PMCID: PMC10269453

  Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cachexia. Whether the Ganoderma lucidum polysaccharide Liz-H exerts protective effects on cachexia and gut microbiota dysbiosis ind …

  Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cache …
• 264.

  Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study.

  • Hassan HM, Al-Wahaibi LH, Elmorsy MA, Mahran YF.
  • Drug Des Devel Ther. 2020 Jun 11;14:2335-2353. doi: 10.2147/DDDT.S249093.
  • PMCID: PMC7296982

  Hassan HM, et al.

  Drug Des Devel Ther. 2020.

  PMCID: PMC7296982

  The aim of this study was to investigate the molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cisplatin (CP)-induced hepatotoxicity theoretically and experimentally. MATERIALS AND METHODS: Thirty-six male Sprague-Dawley (SD) rats were di …

  The aim of this study was to investigate the molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cis …
• 265.

  Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum.

  • Wang Y, Yu F, Zheng X, Li J, Zhang Z, Zhang Q, Chen J, He Y, Yang H, Zhou P.
  • Lipids Health Dis. 2023 Aug 8;22(1):120. doi: 10.1186/s12944-023-01880-6.
  • PMCID: PMC10408226

  Wang Y, et al.

  Lipids Health Dis. 2023.

  PMCID: PMC10408226

  Based on previous findings, FYGL, a natural hyperbranched proteoglycan extracted from the G. lucidum fruiting body, can decrease blood glucose and reduce body weight in diabetic mice. ...

  Based on previous findings, FYGL, a natural hyperbranched proteoglycan extracted from the G. lucidum fruiting body, can decrease bloo …
• 266.

  Benzothiazole-An Antifungal Compound Derived from Medicinal Mushroom Ganoderma lucidum against Mango Anthracnose Pathogen Colletotrichum gloeosporioides (Penz and (Sacc.)).

  • Muniyappan G, Gurudevan T, Thangaraj P, Balamurali AS, Iyadurai AP, Suppaiah R, Subbiah KA, Shanmugam H.
  • Molecules. 2023 Mar 8;28(6):2476. doi: 10.3390/molecules28062476.
  • PMCID: PMC10053814

  Muniyappan G, et al.

  Molecules. 2023.

  PMCID: PMC10053814

  The present investigation is focused on exploring the possibilities of identifying biomolecules from the fruiting body of the medicinal mushroom Ganoderma lucidum against the mango anthracnose pathogen Colletotrichum gloeosporioides. ...The research on biomolecular …

  The present investigation is focused on exploring the possibilities of identifying biomolecules from the fruiting body of the medicinal mush …
• 267.

  Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the Shanghai Breast Cancer Survival Study.

  • Bao PP, Lu W, Cui Y, Zheng Y, Gu K, Chen Z, Zheng W, Shu XO.
  • PLoS One. 2012 Jun 20;7(6):e39343. doi: 10.1371/journal.pone.0039343.
  • PMCID: PMC3379976

  Bao PP, et al.

  PLoS One. 2012.

  PMCID: PMC3379976

  OBJECTIVE: To evaluate associations between quality of life (QOL) and use of ginseng and Ganoderma lucidum (G. lucidum) among breast cancer survivors. METHODS: Included in this study were 4,149 women with breast cancer who participated in the Shanghai Breast …

  OBJECTIVE: To evaluate associations between quality of life (QOL) and use of ginseng and Ganoderma lucidum (G. lucidum) …
• 268.

  Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or beta-amyloid-induced damage in human neuronal SH-SY5Y cells.

  • Huang CH, Liao YT, Chen CL, Tsai GJ.
  • BMC Complement Med Ther. 2024 Apr 5;24(1):148. doi: 10.1186/s12906-024-04409-1.
  • PMCID: PMC10996153

  Huang CH, et al.

  BMC Complement Med Ther. 2024.

  PMCID: PMC10996153

  Although the neuroprotective effects of Ganoderma lucidum aqueous extract and G. lucidum-derived triterpenoids and polysaccharides have been reported, the influence of G. lucidum-fermented crops on AD still lacks clarity. METHODS: This study aimed to i …

  Although the neuroprotective effects of Ganoderma lucidum aqueous extract and G. lucidum-derived triterpenoids and poly …
• 269.

  Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice.

  • Hsu HY, Kuan YC, Lin TY, Tsao SM, Hsu J, Ma LJ, Sheu F.
  • Evid Based Complement Alternat Med. 2013 Jun 24;2013:513542. doi: 10.1155/2013/513542.
  • PMCID: PMC3707273

  Hsu HY, et al.

  Evid Based Complement Alternat Med. 2013.

  PMCID: PMC3707273

  LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells. ...

  LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to …
• 270.

  A Novel Strain Breeding of Ganoderma lucidum UV119 (Agaricomycetes) with High Spores Yield and Strong Resistant Ability to Other Microbes' Invasions.

  • Tang C, Tan Y, Zhang J, Zhou S, Honda Y, Zhang H.
  • Foods. 2023 Jan 19;12(3):465. doi: 10.3390/foods12030465.
  • PMCID: PMC9914782

  Tang C, et al.

  Foods. 2023.

  PMCID: PMC9914782

  The spore powder of Ganoderma lucidum (G. lucidum) has been proven to have a variety of pharmacological activities, and it has become a new resource for the development of health products and pharmaceuticals. ...In conclusion, this study suggested that ultrav …

  The spore powder of Ganoderma lucidum (G. lucidum) has been proven to have a variety of pharmacological activities, and …

• 271.

  Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells.

  • Wu K, Na K, Chen D, Wang Y, Pan H, Wang X.
  • Int J Oncol. 2018 Sep 28;53(6):2356-2368. doi: 10.3892/ijo.2018.4578.
  • PMCID: PMC6203158

  Wu K, et al.

  Int J Oncol. 2018.

  PMCID: PMC6203158

  Ganoderma lucidum polysaccharides (GLP) has been demonstrated to elicit antitumorigenic and proapoptotic activities in cancer; however, the molecular mechanisms underlying the anticancer effects of GLP have yet to be elucidated. ...

  Ganoderma lucidum polysaccharides (GLP) has been demonstrated to elicit antitumorigenic and proapoptotic activities in cancer; …
• 272.

  Interaction of ganoderic acid on HIV related target: molecular docking studies.

  • Akbar R, Yam WK.
  • Bioinformation. 2011 Dec 21;7(8):413-7. doi: 10.6026/97320630007413.
  • PMCID: PMC3280442

  Akbar R, et al.

  Bioinformation. 2011.

  PMCID: PMC3280442

  The idea of finding cure from known pharmacologically active natural occurring compounds is intriguing and practical. Ganoderma lucidum (Ling-Zhi or Reishi) is one of the most productive and pharmacologically active compounds found in Asian countries. ...This …

  The idea of finding cure from known pharmacologically active natural occurring compounds is intriguing and practical. Ganoderma lu …
• 273.

  Synergy of de-walled Ganoderma Lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study.

  • Wu TT, Chen YY, Yuan ZC, Yang GW, Zhang GL.
  • BMC Complement Med Ther. 2024 Mar 18;24(1):125. doi: 10.1186/s12906-024-04416-2.
  • PMCID: PMC10949790

  Wu TT, et al.

  BMC Complement Med Ther. 2024.

  PMCID: PMC10949790

  However the adverse effects, primarily fatigue, remain an overwhelming deficiency of Osimertinib, hindering it from achieving adequate clinical efficacy for such NSCLC. Ganoderma lucidum has been used for thousands of years in China to combat fatigue, while Ganod …

  However the adverse effects, primarily fatigue, remain an overwhelming deficiency of Osimertinib, hindering it from achieving adequate clini …
• 274.

  Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.

  • Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YY, Young JD, Lai HC.
  • Nat Commun. 2015 Jun 23;6:7489. doi: 10.1038/ncomms8489.
  • PMCID: PMC4557287

  Chang CJ, et al.

  Nat Commun. 2015.

  PMCID: PMC4557287

  Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum< …

  Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom …
• 275.

  GSNOR regulates ganoderic acid content in Ganoderma lucidum under heat stress through S-nitrosylation of catalase.

  • Liu R, Zhu T, Chen X, Wang Z, Yang Z, Ren A, Shi L, Yu H, Zhao M.
  • Commun Biol. 2022 Jan 11;5(1):32. doi: 10.1038/s42003-021-02988-0.
  • PMCID: PMC8752759

  Liu R, et al.

  Commun Biol. 2022.

  PMCID: PMC8752759
• 276.

  Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.

  • Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S.
  • PLoS One. 2012 Oct 30;7(10):e47873. doi: 10.1371/journal.pone.0047873.
  • PMCID: PMC3484149

  Sliva D, et al.

  PLoS One. 2012.

  PMCID: PMC3484149

  We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma lucidum (GLT). The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice. ...

  We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma luc …
• 277.

  Intervention effects of ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin.

  • Wang SQ, Li XJ, Zhou S, Sun DX, Wang H, Cheng PF, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM.
  • PLoS One. 2013 Apr 24;8(4):e61687. doi: 10.1371/journal.pone.0061687.
  • PMCID: PMC3634853

  Wang SQ, et al.

  PLoS One. 2013.

  PMCID: PMC3634853

  Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has shown some antiepileptic effects in our previous studies. ...

  Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has …
• 278.

  Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII alpha in epileptic hippocampal neurons.

  • Wang SQ, Li XJ, Qiu HB, Jiang ZM, Simon M, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM, Di WH, Zhou S.
  • PLoS One. 2014 Jul 10;9(7):e102161. doi: 10.1371/journal.pone.0102161.
  • PMCID: PMC4092074

  Wang SQ, et al.

  PLoS One. 2014.

  PMCID: PMC4092074

  PURPOSE: To investigate the mechanism of the anti-epileptic effect of Ganoderma lucidum polysaccharides (GLP), the changes of intracellular calcium and CaMK II alpha expression in a model of epileptic neurons were investigated. ...

  PURPOSE: To investigate the mechanism of the anti-epileptic effect of Ganoderma lucidum polysaccharides (GLP), the changes of …
• 279.

  Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: A protocol of systematic review.

  • Qin LH, Wang C, Jiang XX, Song Y, Feng Y, Qin LW, Zhang SP.
  • Medicine (Baltimore). 2020 Aug 14;99(33):e21711. doi: 10.1097/MD.0000000000021711.
  • PMCID: PMC7437730

  Qin LH, et al.

  Medicine (Baltimore). 2020.

  PMCID: PMC7437730

  BACKGROUND: This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related proteins (ARP) in hippocampus tissue of epilepsy following dementia. ...

  BACKGROUND: This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related …
• 280.

  Ganoderma lingzhi (Reishi Mushroom)-Induced Acute Liver Injury in the Setting of Alcohol Use: A Case Report and Review of the Literature.

  • Guedikian R, Kim B, Singh G, Alexander R.
  • Cureus. 2023 Sep 25;15(9):e45953. doi: 10.7759/cureus.45953.
  • PMCID: PMC10599861

  Guedikian R, et al.

  Cureus. 2023.

  PMCID: PMC10599861

  We present a case of a 47-year-old male who presented to the hospital with headache and abdominal pain after consuming Reishi Mushroom (Ganoderma lingzhi) powder and alcohol. The patient was found to have acute hepatitis with significant transaminitis, which was man …

  We present a case of a 47-year-old male who presented to the hospital with headache and abdominal pain after consuming Reishi Mushroo …

• 281.

  Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa.

  • Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA, Adebayo EA.
  • Front Pharmacol. 2022 Aug 22;13:952027. doi: 10.3389/fphar.2022.952027.
  • PMCID: PMC9441938

  Oke MA, et al.

  Front Pharmacol. 2022.

  PMCID: PMC9441938

  Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea. ...Various formulations have been developed, patented, and utilize …

  Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments …
• 282.

  Advanced mycelium materials as potential self-growing biomedical scaffolds.

  • Antinori ME, Contardi M, Suarato G, Armirotti A, Bertorelli R, Mancini G, Debellis D, Athanassiou A.
  • Sci Rep. 2021 Jun 16;11(1):12630. doi: 10.1038/s41598-021-91572-x.
  • PMCID: PMC8209158

  Antinori ME, et al.

  Sci Rep. 2021.

  PMCID: PMC8209158

  In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. . …

  In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are pres …
• 283.

  Medicinal Fungi with Antiviral Effect.

  • Zhang Y, Zhang G, Ling J.
  • Molecules. 2022 Jul 12;27(14):4457. doi: 10.3390/molecules27144457.
  • PMCID: PMC9322162

  Zhang Y, et al.

  Molecules. 2022.

  PMCID: PMC9322162

  However, drug research and development is a very difficult task, and finding new antiviral compounds is desirable. A range of medicinal fungi such as Ganoderma lucidum and Cordyceps sinensis are widely used all over the world, and they can enhance human immunity and …

  However, drug research and development is a very difficult task, and finding new antiviral compounds is desirable. A range of medicinal fung …
• 284.

  Application of 2,3-naphthalenediamine in labeling natural carbohydrates for capillary electrophoresis.

  • Kuo CY, Wang SH, Lin C, Liao SK, Hung WT, Fang JM, Yang WB.
  • Molecules. 2012 Jun 15;17(6):7387-400. doi: 10.3390/molecules17067387.
  • PMCID: PMC6269047

  Kuo CY, et al.

  Molecules. 2012.

  PMCID: PMC6269047

  Neutral and acidic monosaccharide components in Ganoderma lucidum polysaccharide are readily labeled with 2,3-naphthalenediamine, and the resulting saccharide-naphthimidazole (NAIM) derivatives are quantified by capillary electrophoresis (CE) in borate buffer. ...

  Neutral and acidic monosaccharide components in Ganoderma lucidum polysaccharide are readily labeled with 2,3-naphthalenediami …
• 285.

  Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview.

  • Cör Andrejč D, Knez Ž, Knez Marevci M.
  • Front Pharmacol. 2022 Jul 22;13:934982. doi: 10.3389/fphar.2022.934982.
  • PMCID: PMC9353308

  Cör Andrejč D, et al.

  Front Pharmacol. 2022.

  PMCID: PMC9353308

  Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. ...In addition, most of the included studies were small, and there were concerns about the methodological quality of each study. Studies have shown that Gan …

  Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. ...In addition, mos …
• 286.

  GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.

  • Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, Miao Y, Guo Y, Li L, Shi J, Dong Z, Yang S, Fan G, Ma C.
  • Theranostics. 2023 Feb 21;13(4):1325-1341. doi: 10.7150/thno.80250.
  • PMCID: PMC10008734

  Zheng G, et al.

  Theranostics. 2023.

  PMCID: PMC10008734

  Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from Ganoderma lucidum which is a Traditional Chinese Medicine with the homology of medicine and food. ...

  Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from < …
• 287.

  A Polysaccharide Purified From Ganoderma lucidum Acts as a Potent Mucosal Adjuvant That Promotes Protective Immunity Against the Lethal Challenge With Enterovirus A71.

  • Lin YL, Shih C, Cheng PY, Chin CL, Liou AT, Lee PY, Chiang BL.
  • Front Immunol. 2020 Sep 29;11:561758. doi: 10.3389/fimmu.2020.561758.
  • PMCID: PMC7550786

  Lin YL, et al.

  Front Immunol. 2020.

  PMCID: PMC7550786

  It is known that polysaccharide purified from Ganoderma lucidum (PS-G) can effectively modulate immune function. Here, we used PS-G as an adjuvant with the EV-A71 mucosal vaccine and studied its effects. ...

  It is known that polysaccharide purified from Ganoderma lucidum (PS-G) can effectively modulate immune function. Here, we used …
• 288.

  Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties.

  • Haneef M, Ceseracciu L, Canale C, Bayer IS, Heredia-Guerrero JA, Athanassiou A.
  • Sci Rep. 2017 Jan 24;7:41292. doi: 10.1038/srep41292.
  • PMCID: PMC5259796

  Haneef M, et al.

  Sci Rep. 2017.

  PMCID: PMC5259796

  Mycelia from two types of edible, medicinal fungi, Ganoderma lucidum and Pleurotus ostreatus, have been carefully cultivated, being fed by two bio-substrates: cellulose and cellulose/potato-dextrose, the second being easier to digest by mycelium due to presence of s …

  Mycelia from two types of edible, medicinal fungi, Ganoderma lucidum and Pleurotus ostreatus, have been carefully cultivated, …
• 289.

  Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.

  • Oluwafemi Adetuyi B, Olamide Okeowo T, Adefunke Adetuyi O, Abraham Adebisi O, Ogunlana OO, Janet Oretade O, Marraiki N, Beshbishy AM, N Welson N, Batiha GE.
  • Biology (Basel). 2020 Sep 27;9(10):313. doi: 10.3390/biology9100313.
  • PMCID: PMC7601706

  Oluwafemi Adetuyi B, et al.

  Biology (Basel). 2020.

  PMCID: PMC7601706

  This study, therefore, examines the protective potential of Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced (40%) liver oxido-inflammation in male rats. ...Additionally, Ganoderma lucidum reversed a large decline in proinflammatory ma …

  This study, therefore, examines the protective potential of Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced …
• 290.

  Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain.

  • Mi X, Zeng GR, Liu JQ, Luo ZS, Zhang L, Dai XM, Fang WT, Zhang J, Chen XC.
  • Nutrients. 2022 May 28;14(11):2268. doi: 10.3390/nu14112268.
  • PMCID: PMC9182879

  Mi X, et al.

  Nutrients. 2022.

  PMCID: PMC9182879

  Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response in a stressful event, targeted preventive and therapeutic drugs still remain scarce. Ganoderma lucidum triterpenoids (GLTs) ca …

  Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response …

• 291.

  Influence of Humidity on the Acoustic Properties of Mushroom Mycelium Films Used as Sensitive Layers for Acoustic Humidity Sensors.

  • Kuznetsova I, Zaitsev B, Krasnopolskaya L, Teplykh A, Semyonov A, Avtonomova A, Ziangirova M, Smirnov A, Kolesov V.
  • Sensors (Basel). 2020 May 9;20(9):2711. doi: 10.3390/s20092711.
  • PMCID: PMC7248784

  Kuznetsova I, et al.

  Sensors (Basel). 2020.

  PMCID: PMC7248784

  The influence of humidity on the density, shear elastic module, viscosity, and thickness of the mushroom Pleurotus eryngii and Ganoderma lucidum mycelium films was studied. These data were obtained by comparing the theoretical and experimental frequency dependencies …

  The influence of humidity on the density, shear elastic module, viscosity, and thickness of the mushroom Pleurotus eryngii and Ganoderma< …
• 292.

  Ganoderma lucidum spore powder alleviates rheumatoid arthritis-associated pain hypersensitivity through inhibiting accumulation, N1 polarization, and ROS production of neutrophils in mice.

  • Huang S, Zhan Z, Xu F, Liu X, Fang Z, Wu W, Liang Z, Liu G, Wang M, da Silva HS, Luo X, Mo K.
  • Front Immunol. 2025 Apr 30;16:1569295. doi: 10.3389/fimmu.2025.1569295.
  • PMCID: PMC12075414

  Huang S, et al.

  Front Immunol. 2025.

  PMCID: PMC12075414

  The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management. Ganoderma lucidum spore powder (GLSP) has demonstrated therapeutic benefits in various diseases, with no reported toxicity or …

  The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management. …
• 293.

  Spore powder of Ganoderma lucidum for Alzheimer's disease: A protocol for systematic review.

  • Qin LH, Wang C, Qin LW, Liang YF, Wang GH.
  • Medicine (Baltimore). 2019 Feb;98(5):e14382. doi: 10.1097/MD.0000000000014382.
  • PMCID: PMC6380698

  Qin LH, et al.

  Medicine (Baltimore). 2019.

  PMCID: PMC6380698

  BACKGROUND: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of Alzheimer's disease (AD). ...

  BACKGROUND: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of …
• 294.

  Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients.

  • Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, Dunkin D, Busse P, Weir D, Tversky J, Miller RL, Goldfarb J, Zhan J, Li XM.
  • Int Immunopharmacol. Author manuscript. 2015 May 21;27(2):224-31. doi: 10.1016/j.intimp.2015.05.018.
  • PMCID: PMC4635663

  Liu C, et al.

  Int Immunopharmacol. Author manuscript. 2015.

  PMCID: PMC4635663

  ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. ...The ob …

  ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens …
• 295.

  Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections.

  • Ekiz E, Oz E, Abd El-Aty AM, Proestos C, Brennan C, Zeng M, Tomasevic I, Elobeid T, Çadırcı K, Bayrak M, Oz F.
  • Foods. 2023 Apr 3;12(7):1512. doi: 10.3390/foods12071512.
  • PMCID: PMC10094145

  Ekiz E, et al.

  Foods. 2023.

  PMCID: PMC10094145

  Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. ...Therefore, it would be premature to draw any definitive conclusions about the effectiveness of G. lucidum in preventing or treating coronavirus in …

  Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. ...Therefore, it …
• 296.

  SNP and SCAR Markers for Specific Discrimination of Antler-Shaped Ganoderma lucidum.

  • Kwon OC, Lee CS, Park YJ.
  • Microorganisms. 2019 Jan 9;7(1):12. doi: 10.3390/microorganisms7010012.
  • PMCID: PMC6352128

  Kwon OC, et al.

  Microorganisms. 2019.

  PMCID: PMC6352128

  In this study we identified single nucleotide polymorphism (SNP) and sequence characteristic amplification region (SCAR) markers for specific identification of antler-shaped Ganoderma lucidum strains. When the partial mitochondrial SSU rDNA gene sequence of various …

  In this study we identified single nucleotide polymorphism (SNP) and sequence characteristic amplification region (SCAR) markers for specifi …
• 297.

  Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

  • Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS.
  • BMC Complement Altern Med. 2014 Jul 10;14:236. doi: 10.1186/1472-6882-14-236.
  • PMCID: PMC4227278

  Kim TH, et al.

  BMC Complement Altern Med. 2014.

  PMCID: PMC4227278

  BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus umbellatus mycelia (Khz). It inhibits the growth of cancer cells. ...

  BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus …
• 298.

  Dye decolorization and detoxification potential of Ca-alginate beads immobilized manganese peroxidase.

  • Bilal M, Asgher M.
  • BMC Biotechnol. 2015 Dec 10;15:111. doi: 10.1186/s12896-015-0227-8.
  • PMCID: PMC4676175

  Bilal M, et al.

  BMC Biotechnol. 2015.

  PMCID: PMC4676175

  In present study, a promising and eco-friendly entrapment approach was adopted to immobilize purified manganese peroxidase (MnP) produced from an indigenous strain of Ganoderma lucidum IBL-05 on Ca-alginate beads. The immobilized MnP was subsequently used for enhanc …

  In present study, a promising and eco-friendly entrapment approach was adopted to immobilize purified manganese peroxidase (MnP) produced fr …
• 299.

  Preliminary Efficacy and Safety of Reishi & Privet Formula on Quality of Life Among Non-Small Cell Lung Cancer Patients Undergoing Chemotherapy: A Randomized Placebo-Controlled Trial.

  • Liu J, Mao JJ, Li SQ, Lin H.
  • Integr Cancer Ther. 2020 Jan-Dec;19:1534735420944491. doi: 10.1177/1534735420944491.
  • PMCID: PMC7450289

  Liu J, et al.

  Integr Cancer Ther. 2020.

  PMCID: PMC7450289

  This study aimed to determine the preliminary efficacy and safety of Reishi & Privet Formula (RPF) for maintaining quality of life among patients with non-small cell lung cancer (NSCLC) undergoing chemotherapy. ...

  This study aimed to determine the preliminary efficacy and safety of Reishi & Privet Formula (RPF) for maintaining quality of lif …
• 300.

  Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study.

  • Meneses ME, Martínez-Carrera D, González-Ibáñez L, Torres N, Sánchez-Tapia M, Márquez-Mota CC, Rendón G, Mitzi V, Morales A, Tello-Salgado I, Tovar AR.
  • PLoS One. 2023 Apr 6;18(4):e0283605. doi: 10.1371/journal.pone.0283605.
  • PMCID: PMC10079091

  Meneses ME, et al.

  PLoS One. 2023.

  PMCID: PMC10079091

  Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum (Gl), a medicinal mushroom, cultivated on oak sawdust (Gl-1) or oak sawdust plus acetylsalicylic acid (Gl-2, ASA), have been shown to exert antioxidant, hypocholesterolemic, anti …

  Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum (Gl), a medicinal mushroom, cultivated …

• 301.

  Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B1.

  • Liu T, Ma Q, Zhao L, Jia R, Zhang J, Ji C, Wang X.
  • Toxins (Basel). 2016 Sep 24;8(10):278. doi: 10.3390/toxins8100278.
  • PMCID: PMC5086638

  Liu T, et al.

  Toxins (Basel). 2016.

  PMCID: PMC5086638

  This study was conducted to investigate the toxic effects of aflatoxin B1 (AFB1) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were …

  This study was conducted to investigate the toxic effects of aflatoxin B1 (AFB1) and evaluate the effects of sporoderm-broken spores of G …
• 302.

  Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites.

  • Ahmad MF, A Alsayegh A, Ahmad FA, Akhtar MS, Alavudeen SS, Bantun F, Wahab S, Ahmed A, Ali M, Elbendary EY, Raposo A, Kambal N, H Abdelrahman M.
  • Heliyon. 2024 Feb 4;10(3):e25607. doi: 10.1016/j.heliyon.2024.e25607.
  • PMCID: PMC10865332

  Ahmad MF, et al.

  Heliyon. 2024.

  PMCID: PMC10865332

  Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times. They are currently used as nutraceuticals and functional foods. G. lucidum …

  Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been u …
• 303.

  Functional properties of Ganoderma lucidum supplementation in canine nutrition.

  • Kayser E, Castaneda PL, Soto-Diaz K, Steelman AJ, Murphy A, Spindola M, He F, de Godoy MRC.
  • J Anim Sci. 2024 Jan 3;102:skae051. doi: 10.1093/jas/skae051.
  • PMCID: PMC11025632

  Kayser E, et al.

  J Anim Sci. 2024.

  PMCID: PMC11025632

  Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunostimulatory and anti-inflammatory capacity, which has been hypothesized to be attributed mainly to the recognition of its cell-surface patterns by cells of the immune system present …

  Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunostimulatory and anti-inflammatory capacit …
• 304.

  The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.

  • Jafari A, Mardani H, Mirzaei Fashtali Z, Arghavan B.
  • Food Sci Nutr. 2025 Jun 12;13(6):e70423. doi: 10.1002/fsn3.70423.
  • PMCID: PMC12160064

  Jafari A, et al.

  Food Sci Nutr. 2025.

  PMCID: PMC12160064

  This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals. ...Ganoderma lucidum supplementation may ha …

  This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related i …
• 305.

  Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics.

  • Guo ZJ, Liu Y, Yang JY, Jin MY, Mao PW, Zhou XW.
  • Molecules. 2023 Apr 6;28(7):3272. doi: 10.3390/molecules28073272.
  • PMCID: PMC10096787

  Guo ZJ, et al.

  Molecules. 2023.

  PMCID: PMC10096787

  The aim of this study was to evaluate the application potential of a recombinant fungal immunomodulatory protein from Ganoderma lucidum (rFIP-glu). First, a recombinant plasmid pPIC9K::FIP-glu-His was transferred into Pichia pastoris for the production of protein. . …

  The aim of this study was to evaluate the application potential of a recombinant fungal immunomodulatory protein from Ganoderma lu …
• 306.

  Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation.

  • Liu MM, Liu T, Yeung S, Wang Z, Andresen B, Parsa C, Orlando R, Zhou B, Wu W, Li X, Zhang Y, Wang C, Huang Y.
  • Precis Clin Med. 2021 Aug 28;4(4):231-245. doi: 10.1093/pcmedi/pbab023.
  • PMCID: PMC8982591

  Liu MM, et al.

  Precis Clin Med. 2021.

  PMCID: PMC8982591

  The medicinal mushroom Ganoderma lucidum (GL, Reishi or Lingzhi) exhibits an inhibitory effect on cancers. However, the underlying mechanism of the antitumor activity of GL is not fully understood. ...

  The medicinal mushroom Ganoderma lucidum (GL, Reishi or Lingzhi) exhibits an inhibitory effect on cancers. However, the …
• 307.

  Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review.

  • Liu J, Zhang B, Wang L, Li S, Long Q, Xiao X.
  • Chin Herb Med. 2024 Jan 17;16(3):375-391. doi: 10.1016/j.chmed.2023.09.007.
  • PMCID: PMC11283234

  Liu J, et al.

  Chin Herb Med. 2024.

  PMCID: PMC11283234

  Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. ...They contain all the genetic active substances of G. lucidum. G. lucidum spore oil (GLSO) is a lipid component extracted from broken-wall …

  Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. ...They contai …
• 308.

  Potential Cosmetic Applications of the Combined Extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and Several Asian Plants.

  • Wang W, Zhong M, Liu R, Zhao S, Wei X, Zheng Q, Zhong Q, Shen Y, He F.
  • J Cosmet Dermatol. 2025 Aug;24(8):e70343. doi: 10.1111/jocd.70343.
  • PMCID: PMC12322945

  Wang W, et al.

  J Cosmet Dermatol. 2025.

  PMCID: PMC12322945

  This study aimed to evaluate the stability of a combined extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and several Asian plants (PGC), and its multifunctional efficacy for acne-related skin dysfunction. ...

  This study aimed to evaluate the stability of a combined extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and …
• 309.

  Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases.

  • Qin X, Fang Z, Zhang J, Zhao W, Zheng N, Wang X.
  • Front Microbiol. 2024 Mar 18;15:1362479. doi: 10.3389/fmicb.2024.1362479.
  • PMCID: PMC10990249

  Qin X, et al.

  Front Microbiol. 2024.

  PMCID: PMC10990249

  Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal and nutritional health care values. ...The purpose of this paper is to summarize the regulatory effects of G …

  Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a preci …
• 310.

  Comparison of sterols and fatty acids in two species of Ganoderma.

  • Lv GP, Zhao J, Duan JA, Tang YP, Li SP.
  • Chem Cent J. 2012 Jan 31;6(1):10. doi: 10.1186/1752-153X-6-10.
  • PMCID: PMC3287153

  Lv GP, et al.

  Chem Cent J. 2012.

  PMCID: PMC3287153

  BACKGROUND: Two species of Ganoderma, G. sinense and G. lucidum, are used as Lingzhi in China. Howerver, the content of triterpenoids and polysaccharides, main actives compounds, are significant different, though the extracts of both G. lucidum and G. sinense …

  BACKGROUND: Two species of Ganoderma, G. sinense and G. lucidum, are used as Lingzhi in China. Howerver, the content of triter …

• 311.

  Optimization of Growth Conditions and Biological Activities of Nepalese Ganoderma lucidum Strain Philippine.

  • Subedi K, Basnet BB, Panday R, Neupane M, Tripathi GR.
  • Adv Pharmacol Pharm Sci. 2021 Oct 4;2021:4888979. doi: 10.1155/2021/4888979.
  • PMCID: PMC8505087

  Subedi K, et al.

  Adv Pharmacol Pharm Sci. 2021.

  PMCID: PMC8505087

  Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivation of G. lucidum strain Philippine in different culture media, including sawdust substrate, was performed and optimized on the Potato …

  Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivatio …
• 312.

  Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum.

  • Hsu MJ, Lee SS, Lee ST, Lin WW.
  • Br J Pharmacol. 2003 May;139(2):289-98. doi: 10.1038/sj.bjp.0705243.
  • PMCID: PMC1573843

  Hsu MJ, et al.

  Br J Pharmacol. 2003.

  PMCID: PMC1573843

  1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and to elicit antitumor effects. ...Moreover, chemotactic action of PS-G requires the activities of PI3K, p38 MAPK, Src tyrosine kinases and PKC. 6 All these results dem …

  1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and to elicit antitumor effec …
• 313.

  Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion.

  • Xu J, Yang W, Pan Y, Xu H, He L, Zheng B, Xie Y, Wu X.
  • Food Chem Toxicol. 2022 Sep 28;169:113438. doi: 10.1016/j.fct.2022.113438.
  • PMCID: PMC9526994

  Xu J, et al.

  Food Chem Toxicol. 2022.

  PMCID: PMC9526994

  High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known as a superior immunoenhancer exhibits various antiviral effects, whether it can resist SARS-CoV-2 remains unclear. ...

  High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known as a superior immu …
• 314.

  Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis.

  • Mahran YF, Hassan HM.
  • Oxid Med Cell Longev. 2020 Jul 6;2020:4932587. doi: 10.1155/2020/4932587.
  • PMCID: PMC7362286

  Mahran YF, et al.

  Oxid Med Cell Longev. 2020.

  PMCID: PMC7362286

  However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect. Ganoderma lucidum (GL), a medicinal mushroom, has antioxidant and inflammatory activities. ...

  However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect. Ganoderma lucidum (GL), …
• 315.

  Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells via inhibition of Jak-1/STAT-3 activity.

  • Wang X, Wang B, Zhou L, Wang X, Veeraraghavan VP, Mohan SK, Xin F.
  • Saudi J Biol Sci. 2020 Jun 3;27(10):2632-2637. doi: 10.1016/j.sjbs.2020.05.044.
  • PMCID: PMC7499110

  Wang X, et al.

  Saudi J Biol Sci. 2020.

  PMCID: PMC7499110

  In present study, we examined the anticancer potentials of Ganoderma lucidum against the prostate cancer (PC-3) cells by inflection of JAK-1/STAT-3 signalling pathway. ...CONCLUSION: In the end our finding concluded that Ganoderma lucidum hinder prosta …

  In present study, we examined the anticancer potentials of Ganoderma lucidum against the prostate cancer (PC-3) cells by infle …
• 316.

  Surface-Engineered Cubosomes Serve as a Novel Vaccine Adjuvant to Modulate Innate Immunity and Improve Adaptive Immunity in vivo.

  • Liu Z, Yu L, Gu P, Bo R, Xu S, Wusiman A, Liu J, Hu Y, Wang D.
  • Int J Nanomedicine. 2020 Nov 4;15:8595-8608. doi: 10.2147/IJN.S266165.
  • PMCID: PMC7650836

  Liu Z, et al.

  Int J Nanomedicine. 2020.

  PMCID: PMC7650836

  METHODS: Here, we exploit the effects of surface chemistry on the adjuvant activity of Ganoderma lucidum polysaccharide cubosomes (GLPC) by placing two kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB) and poly(diallydimethyl ammonium chloride) (PDD …

  METHODS: Here, we exploit the effects of surface chemistry on the adjuvant activity of Ganoderma lucidum polysaccharide cuboso …
• 317.

  Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum.

  • Du Y, Tian L, Wang Y, Li Z, Xu Z.
  • Chin Med. 2024 Mar 22;19(1):51. doi: 10.1186/s13020-024-00922-0.
  • PMCID: PMC10958966

  Du Y, et al.

  Chin Med. 2024.

  PMCID: PMC10958966

  Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both medicine and food. ...Furthermore, we summarized the omics data, genetic transformation system, and cultivation techniques of G. lucidum, described as medicinal model fungi. …

  Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both medicine and food. ...Furthermore, we sum …
• 318.

  A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge.

  • Lin YL, Cheng PY, Chin CL, Chuang KT, Lin JY, Chang N, Pan CK, Lin CS, Pan SC, Chiang BL.
  • J Biomed Sci. 2023 Dec 18;30(1):96. doi: 10.1186/s12929-023-00987-3.
  • PMCID: PMC10729491

  Lin YL, et al.

  J Biomed Sci. 2023.

  PMCID: PMC10729491

  METHODS: In this study, formalin-inactivated EV-A71 and EV-D68 were used as antigens, while PS-G, a polysaccharide from Ganoderma lucidum, was used as an adjuvant. Natural polysaccharides have the characteristics of intrinsic immunomodulation, biocompatibility, low …

  METHODS: In this study, formalin-inactivated EV-A71 and EV-D68 were used as antigens, while PS-G, a polysaccharide from Ganoderma …
• 319.

  Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

  • Hu Y, Wang SX, Wu FY, Wu KJ, Shi RP, Qin LH, Lu CF, Wang SQ, Wang FF, Zhou S.
  • Biomed Res Int. 2022 Mar 8;2022:4314415. doi: 10.1155/2022/4314415.
  • PMCID: PMC8923773

  Hu Y, et al.

  Biomed Res Int. 2022.

  PMCID: PMC8923773

  Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. ...

  Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. ...
• 320.

  Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.

  • Li JP, Chu CL, Chao WR, Yeh CS, Lee YJ, Chen DC, Yang SF, Chao YH.
  • Aging (Albany NY). 2023 May 5;15(9):3621-3634. doi: 10.18632/aging.204695.
  • PMCID: PMC10449289

  Li JP, et al.

  Aging (Albany NY). 2023.

  PMCID: PMC10449289

  Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in Ganoderma lucidum mycelia, has potential for drug development due to its multiple bioactivities and functions. ...

  Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in Ganoderma lucidum mycelia, has potential for drug development due to i …

• 321.

  A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.

  • Ye T, Ge Y, Jiang X, Song H, Peng C, Liu B.
  • Chin Med. 2023 Aug 28;18(1):107. doi: 10.1186/s13020-023-00811-y.
  • PMCID: PMC10463474

  Ye T, et al.

  Chin Med. 2023.

  PMCID: PMC10463474

  Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious adverse reactions and drug toxicity, bringing irreversible damage to patients and seriously affecting the quality of life. Ganoderma …

  Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious …
• 322.

  Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.

  • Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB.
  • World J Gastroenterol. 2002 Aug;8(4):728-33. doi: 10.3748/wjg.v8.i4.728.
  • PMCID: PMC4656329

  Zhang GL, et al.

  World J Gastroenterol. 2002.

  PMCID: PMC4656329

  AIM: To examine the effect of ganoderma lucidum polysaccharide (GLP) on the immune liver injury induced by BCG infection, and investigate the relationship between degrees of hepatic damage and NO production in mice. ...

  AIM: To examine the effect of ganoderma lucidum polysaccharide (GLP) on the immune liver injury induced by BCG infection, and …
• 323.

  Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms.

  • Xu J, Shen R, Jiao Z, Chen W, Peng D, Wang L, Yu N, Peng C, Cai B, Song H, Chen F, Liu B.
  • Nutrients. 2022 Jun 24;14(13):2622. doi: 10.3390/nu14132622.
  • PMCID: PMC9268676

  Xu J, et al.

  Nutrients. 2022.

  PMCID: PMC9268676

  Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma lucidum, Cordyceps sinensis, Pleurotus ostreatus, and Grifola frondosa, have been demonstrated to possess a board range of pharmaceutical pr …

  Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma luci …
• 324.

  Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.

  • Thuy NHL, Tu VL, Thu LNA, Giang TT, Huyen DTK, Loc DH, Tam DNH, Phat NT, Huynh HH, Truyen TTTT, Nguyen QH, Do U, Nguyen D, Dat TV, Minh LHN.
  • Cureus. 2023 Sep 2;15(9):e44574. doi: 10.7759/cureus.44574.
  • PMCID: PMC10545004

  Thuy NHL, et al.

  Cureus. 2023.

  PMCID: PMC10545004

  Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, diabetes, and cancer. ...G. lucidum sporoderm-broken extract demonstrated higher efficiency than unbroken spore extract. ...

  Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, di …
• 325.

  Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries.

  • Viet Hung T, Thang PNT, Hien HM, Diep VT, Thu NT, Tan DM, Pham DT, Thi Ha D, Huynh DTM.
  • Plants (Basel). 2022 Dec 6;11(23):3397. doi: 10.3390/plants11233397.
  • PMCID: PMC9738896

  Viet Hung T, et al.

  Plants (Basel). 2022.

  PMCID: PMC9738896

  Ganoderma lucidum (Fr.) P. Karst. (Ganodermataceae), commonly called Linhzhi, is traditionally employed in the treatment of human diseases, including hepatitis, liver disorders, hypercholesterolemia, arthritis, bronchitis, and tumorigenic diseases. In this study, th …

  Ganoderma lucidum (Fr.) P. Karst. (Ganodermataceae), commonly called Linhzhi, is traditionally employed in the treatment of hu …
• 326.

  Ergosterol Peroxide from the Medicinal Mushroom Ganoderma lucidum Inhibits Differentiation and Lipid Accumulation of 3T3-L1 Adipocytes.

  • Jeong YU, Park YJ.
  • Int J Mol Sci. 2020 Jan 10;21(2):460. doi: 10.3390/ijms21020460.
  • PMCID: PMC7014426

  Jeong YU, et al.

  Int J Mol Sci. 2020.

  PMCID: PMC7014426
• 327.

  Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro.

  • Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F.
  • Front Pharmacol. 2019 Feb 19;10:115. doi: 10.3389/fphar.2019.00115.
  • PMCID: PMC6389703

  Martínez-Montemayor MM, et al.

  Front Pharmacol. 2019.

  PMCID: PMC6389703

  We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-cancer activity against triple negative inflammatory breast cancer models. ...The combined studies indicate that EP from Ganoderma lucidum extract is a promising m …

  We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-cancer activity against triple negati …
• 328.

  Taxonomic Position and Species Identity of the Cultivated Yeongji 'Ganoderma lucidum' in Korea.

  • Kwon OC, Park YJ, Kim HI, Kong WS, Cho JH, Lee CS.
  • Mycobiology. 2016 Mar 31;44(1):1-6. doi: 10.5941/MYCO.2016.44.1.1.
  • PMCID: PMC4838586

  Kwon OC, et al.

  Mycobiology. 2016.

  PMCID: PMC4838586

  Ganoderma lucidum has a long history of use as a traditional medicine in Asian countries. ...Recently, it was proposed that G. lucidum from China be renamed as G. sichuanense or G. lingzhi. In the present study, phylogenetic analysis using the internal transc …

  Ganoderma lucidum has a long history of use as a traditional medicine in Asian countries. ...Recently, it was proposed that G. …
• 329.

  The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.

  • Xie YZ, Yang F, Tan W, Li X, Jiao C, Huang R, Yang BB.
  • Oncoscience. 2016 Aug 28;3(7-8):203-207. doi: 10.18632/oncoscience.316.
  • PMCID: PMC5043070

  Xie YZ, et al.

  Oncoscience. 2016.

  PMCID: PMC5043070

  Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted from Ganoderma. We found that Ganoderma treatment normalized ejection fraction and corrected the fractional shortening generated by TAC. ...We found reduced expression of …

  Our preliminary results demonstrated a potential cardioprotective role for spore oil extracted from Ganoderma. We found that Ganod …
• 330.

  Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.

  • Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL, Wong CH.
  • J Biol Chem. 2009 Oct 16;284(50):34479-89. doi: 10.1074/jbc.M109.065961.
  • PMCID: PMC2787309

  Hsu TL, et al.

  J Biol Chem. 2009.

  PMCID: PMC2787309

  Our studies indicate that the immune modulating properties of many herbal drugs, for instance, the medicinal fungus Reishi (Ganoderma lucidum) and Cordyceps sinensis, could be attributed to their polysaccharide components. ...The results show that several inn …

  Our studies indicate that the immune modulating properties of many herbal drugs, for instance, the medicinal fungus Reishi (Ganode …

• 331.

  Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years.

  • Wang S, Wang L, Shangguan J, Jiang A, Ren A.
  • Life (Basel). 2024 Oct 21;14(10):1339. doi: 10.3390/life14101339.
  • PMCID: PMC11509451

  Wang S, et al.

  Life (Basel). 2024.

  PMCID: PMC11509451

  Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China. The main bioactive components in G. lucidum include triterpenoids, polysaccharides, steroids, and sterols. Ganoderic acids (GAs) are one of the most abundant triter …

  Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China. The main bioactive components i …
• 332.

  A Review of Bioactive Components and Pharmacological Effects of Ganoderma lucidum.

  • Ren S, Liu H, Sang Q, Lu M, Gao Q, Chen W.
  • Food Sci Nutr. 2025 Jul 13;13(7):e70623. doi: 10.1002/fsn3.70623.
  • PMCID: PMC12256279

  Ren S, et al.

  Food Sci Nutr. 2025.

  PMCID: PMC12256279

  Ganoderma lucidum, a distinguished traditional medicinal herb, has long been recognized for its purported benefits in promoting physical well-being, enhancing stamina, and boosting vitality. ...Despite its established status as a functional food and potential therap …

  Ganoderma lucidum, a distinguished traditional medicinal herb, has long been recognized for its purported benefits in promotin …
• 333.

  Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning.

  • Xiao C, Huang G, Cao X, Li X.
  • Am J Transl Res. 2024 Jan 15;16(1):295-303. doi: 10.62347/ERWA6712.
  • PMCID: PMC10839386

  Xiao C, et al.

  Am J Transl Res. 2024.

  PMCID: PMC10839386

  In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom poisoning. ...CONCLUSION: Ganoderma lucidum is very effective in treating mushroom poisoning by alpha-amanita and is worth promoting.. …

  In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom poisonin …
• 334.

  Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.

  • Ghobadi R, Mohammadi R, Chabavizade J, Sami M.
  • Adv Biomed Res. 2018 Feb 16;7:24. doi: 10.4103/2277-9175.225595.
  • PMCID: PMC5840970

  Ghobadi R, et al.

  Adv Biomed Res. 2018.

  PMCID: PMC5840970

  BACKGROUND: Ganoderma lucidum from Ganodermataceae family is a kind of mushroom known to have various therapeutic properties such as lowering high blood sugar and high blood pressure, boosting the immune system as well as its antibacterial and antioxidant effects. M …

  BACKGROUND: Ganoderma lucidum from Ganodermataceae family is a kind of mushroom known to have various therapeutic properties s …
• 335.

  Supercritical fluid extraction effectively removes phthalate plasticizers in spores of Ganoderma lucidum.

  • Li P, Liang ZH, Jiang Z, Qiu Z, Du B, Liu YB, Li WZ, Tan LH.
  • Food Sci Biotechnol. 2018 Jun 8;27(6):1857-1864. doi: 10.1007/s10068-018-0404-3.
  • PMCID: PMC6233416

  Li P, et al.

  Food Sci Biotechnol. 2018.

  PMCID: PMC6233416

  Phthalate plasticizers residue in food is a serious threat to public health. Spores of Ganoderma lucidum are easy to be contaminated with phthalates during collection and processing. In this study, supercritical fluid extraction (SFE) was performed to remove phthala …

  Phthalate plasticizers residue in food is a serious threat to public health. Spores of Ganoderma lucidum are easy to be contam …
• 336.

  Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial.

  • Pakravan F, Yegdaneh A, Taymouri S, Rahimi S, Ghahremani N.
  • Front Dent. 2024 Dec 1;21:45. doi: 10.18502/fid.v21i45.17178.
  • PMCID: PMC11792735

  Pakravan F, et al.

  Front Dent. 2024.

  PMCID: PMC11792735

  Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS). ...Conclusion: No significant difference existed between the antifungal efficacy of G. lucidum …

  Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for …
• 337.

  MALDI-TOF MS analysis of native and permethylated or benzimidazole-derivatized polysaccharides.

  • Hung WT, Wang SH, Chen YT, Yu HM, Chen CH, Yang WB.
  • Molecules. 2012 Apr 30;17(5):4950-61. doi: 10.3390/molecules17054950.
  • PMCID: PMC6268202

  Hung WT, et al.

  Molecules. 2012.

  PMCID: PMC6268202

  Polysaccharides including dextran, glucomannan, arabinoxylan, arabinogalactan and beta-1,3-glucan, isolated from nutritional supplements of Ganoderma lucidum and Saccharomyces pastorianus were measured using MALDI-TOF MS with 2,5-dihydroxybenzoic acid (2,5-DHB) as t …

  Polysaccharides including dextran, glucomannan, arabinoxylan, arabinogalactan and beta-1,3-glucan, isolated from nutritional supplements of …
• 338.

  Mass Spectrometry-Based Untargeted Metabolomics and alpha-Glucosidase Inhibitory Activity of Lingzhi (Ganoderma lingzhi) During the Developmental Stages.

  • Satria D, Tamrakar S, Suhara H, Kaneko S, Shimizu K.
  • Molecules. 2019 May 29;24(11):2044. doi: 10.3390/molecules24112044.
  • PMCID: PMC6600326

  Satria D, et al.

  Molecules. 2019.

  PMCID: PMC6600326

  Lingzhi is a Ganoderma mushroom species which has a wide range of bioactivities. Analysis of the changes in metabolites during the developmental stages of lingzhi is important to understand the underlying mechanism of its biosynthesis, as well as its bioactivity. ...

  Lingzhi is a Ganoderma mushroom species which has a wide range of bioactivities. Analysis of the changes in metabolites during the de …
• 339.

  Phenolic Rich Fractions from Mycelium and Fruiting Body of Ganoderma lucidum Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line.

  • Mishra J, Joshi A, Rajput R, Singh K, Bansal A, Misra K.
  • Adv Pharmacol Sci. 2018 Dec 17;2018:6285615. doi: 10.1155/2018/6285615.
  • PMCID: PMC6311817

  Mishra J, et al.

  Adv Pharmacol Sci. 2018.

  PMCID: PMC6311817

  Ganoderma lucidum (G. lucidum) fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan, and many Asian countries on account of its numerous medicinal properties such as antioxidant, anticancer, antimicrobial, energy enhancing, …

  Ganoderma lucidum (G. lucidum) fungus (Family Ganodermataceae) is widely used as a traditional medicine in China, Japan …
• 340.

  Identification of Potential Anticancer Activities of Novel Ganoderma lucidum Extracts Using Gene Expression and Pathway Network Analysis.

  • Kao CH, Bishop KS, Xu Y, Han DY, Murray PM, Marlow GJ, Ferguson LR.
  • Genomics Insights. 2016 Feb 16;9:1-16. doi: 10.4137/GEI.S32477.
  • PMCID: PMC4778854

  Kao CH, et al.

  Genomics Insights. 2016.

  PMCID: PMC4778854

  Ganoderma lucidum (lingzhi) has been used for the general promotion of health in Asia for many centuries. ...The anticancer effect of G. lucidum, using whiskey and rice wine-based extraction methods, has not been previously reported. ...

  Ganoderma lucidum (lingzhi) has been used for the general promotion of health in Asia for many centuries. ...The anticancer ef …

• 341.

  Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats.

  • Viroel FJM, Laurino LF, Caetano ÉLA, Jozala AF, Spim SRV, Pickler TB, Sercundes MK, Gomes MC, Hataka A, Grotto D, Gerenutti M.
  • Antioxidants (Basel). 2022 May 24;11(6):1035. doi: 10.3390/antiox11061035.
  • PMCID: PMC9219838

  Viroel FJM, et al.

  Antioxidants (Basel). 2022.

  PMCID: PMC9219838

  The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. Ganoderma lucidum contains a variety of bioactive compounds, such as polysaccharides, proteins and polyph …

  The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to ma …
• 342.

  A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells.

  • Dan X, Liu W, Wong JH, Ng TB.
  • Front Pharmacol. 2016 Jul 25;7:217. doi: 10.3389/fphar.2016.00217.
  • PMCID: PMC4958627

  Dan X, et al.

  Front Pharmacol. 2016.

  PMCID: PMC4958627

  The mushroom Ganoderma lucidum (G. lucidum) has been consumed in China as a medicine for promoting health and longevity for thousands of years. ...Herein, we reported the isolation of a protein (Ganoderma lucidum ribonuclease, GLR) with anti-col …

  The mushroom Ganoderma lucidum (G. lucidum) has been consumed in China as a medicine for promoting health and longevity …
• 343.

  A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.

  • Aquino G, Viscusi G, D'Alterio MC, Covelli V, Gorrasi G, Pellecchia C, Rizzo P, D'Ursi AM, Pepe G, Amante C, Del Gaudio P, Rodriquez M.
  • Int J Mol Sci. 2024 Sep 5;25(17):9608. doi: 10.3390/ijms25179608.
  • PMCID: PMC11395607

  Aquino G, et al.

  Int J Mol Sci. 2024.

  PMCID: PMC11395607

  This study aims to create and characterize electrospun PLLA membranes loaded with spironolactone (SP), mimicking active compounds of Ganoderma lucidum (GL), to develop a biodegradable patch for topical wound-healing applications. ...

  This study aims to create and characterize electrospun PLLA membranes loaded with spironolactone (SP), mimicking active compounds of Gano …
• 344.

  Ganodermataceae-current status, research, and development in Lower Mekong Basin.

  • Karunarathna SC, Patabendige NM, Luangharn T, Hapuarachchi KK.
  • Front Cell Infect Microbiol. 2025 May 12;15:1545135. doi: 10.3389/fcimb.2025.1545135.
  • PMCID: PMC12104286

  Karunarathna SC, et al.

  Front Cell Infect Microbiol. 2025.

  PMCID: PMC12104286

  The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma, which is prominent in traditional medicine for its therapeutic properties. Species within this family, particularly Ganoderma lucidum, have been valued for centurie …

  The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma, which is prominent in traditional medi …
• 345.

  Identification of a Novel Metabolic Target for Bioactive Triterpenoids Biosynthesis in Ganoderma lucidum.

  • Xu J, Wang Y, Zhang Y, Xiong K, Yan X, Ruan S, Wu X.
  • Front Microbiol. 2022 May 9;13:878110. doi: 10.3389/fmicb.2022.878110.
  • PMCID: PMC9125208

  Xu J, et al.

  Front Microbiol. 2022.

  PMCID: PMC9125208

  Triterpenoids are crucial active ingredients of Ganoderma lucidum (G. lucidum) with various health benefits. Yet the low biosynthesis greatly restricts their industrial applications, novel metabolic engineering strategies are needed to further enhance Gano …

  Triterpenoids are crucial active ingredients of Ganoderma lucidum (G. lucidum) with various health benefits. Yet the lo …
• 346.

  Optimal Medium Conditions for the Detection of Cellulolytic Activity in Ganoderma lucidum.

  • Jo WS, Bae SH, Cho DH, Park SD, Yoo YB, Park SC.
  • Mycobiology. 2009 Dec 31;37(4):313-6. doi: 10.4489/MYCO.2009.37.4.313.
  • PMCID: PMC3749426

  Jo WS, et al.

  Mycobiology. 2009.

  PMCID: PMC3749426

  On the whole, the best protocol called for Ganoderma lucidum transfer onto media containing Congo red with pH adjusted to 7.0, followed by incubation at 25 for 5 days. Our results will be useful to researchers who aim to study extracellular enzyme activity in Gan …

  On the whole, the best protocol called for Ganoderma lucidum transfer onto media containing Congo red with pH adjusted to 7.0, …
• 347.

  Chemical Constituents and Antimicrobial Activity of a Ganoderma lucidum (Curtis.) P. Karst. Aqueous Ammonia Extract.

  • Sánchez-Hernández E, Teixeira A, Pereira C, Cruz A, Martín-Gil J, Oliveira R, Martín-Ramos P.
  • Plants (Basel). 2023 Jun 11;12(12):2271. doi: 10.3390/plants12122271.
  • PMCID: PMC10305452

  Sánchez-Hernández E, et al.

  Plants (Basel). 2023.

  PMCID: PMC10305452

  This study investigates the chemical profile of an aqueous ammonia extract obtained from the carpophores of Ganoderma lucidum, which grows on Quercus ilex trees, and explores its valorization as a biorational. ...Subsequent ex situ testing of the COS-G. lucidum …

  This study investigates the chemical profile of an aqueous ammonia extract obtained from the carpophores of Ganoderma lucidum, …
• 348.

  Chemical Characterization and Evaluation of Antimicrobial Properties of the Wild Medicinal Mushroom Ganoderma lucidum Growing in Northern Moroccan Forests.

  • Erbiai EH, Amina B, Kaoutar A, Saidi R, Lamrani Z, Pinto E, Esteves da Silva JCG, Maouni A, Pinto da Silva L.
  • Life (Basel). 2023 May 19;13(5):1217. doi: 10.3390/life13051217.
  • PMCID: PMC10223331

  Erbiai EH, et al.

  Life (Basel). 2023.

  PMCID: PMC10223331

  Ganoderma lucidum is an extensively famous medicinal mushroom distributed worldwide. Despite being widely grown in Moroccan forests, there are no studies on its nutritional, nutraceutical and pharmaceutical values. Herein, the objective of this study was to investig …

  Ganoderma lucidum is an extensively famous medicinal mushroom distributed worldwide. Despite being widely grown in Moroccan fo …
• 349.

  Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review.

  • Wu P, Zhang C, Yin Y, Zhang X, Li Q, Yuan L, Sun Y, Zhou S, Ying S, Wu J.
  • Heliyon. 2024 Aug 29;10(19):e36987. doi: 10.1016/j.heliyon.2024.e36987.
  • PMCID: PMC11492437

  Wu P, et al.

  Heliyon. 2024.

  PMCID: PMC11492437

  Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. ...

  Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. ...
• 350.

  B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.

  • Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
  • Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984.
  • PMCID: PMC5973856

  Rossi P, et al.

  Oncotarget. 2018.

  PMCID: PMC5973856

  Clinical effects of mycotherapy (specifically, the use of Ganoderma lucidum and Grifola frondosa) on long-term survival, tumor response, host immune functions, inflammation, and QoL in cancer patients were also addressed. ...Emerging data point to a potential role o …

  Clinical effects of mycotherapy (specifically, the use of Ganoderma lucidum and Grifola frondosa) on long-term survival, tumor …

• 351.

  Ganoderic Acid A targeting leucine-rich repeat kinase 2 involved in Parkinson's disease-A computational study.

  • Ahmad F.
  • Aging Med (Milton). 2022 Dec 20;6(3):272-280. doi: 10.1002/agm2.12235.
  • PMCID: PMC10498832

  Ahmad F.

  Aging Med (Milton). 2022.

  PMCID: PMC10498832

  Therefore, GAA needs further validation through in vitro and in vivo studies. CONCLUSION: Ganoderma lucidum exhibits cytotoxic, hepatoprotective, antioxidative, anticancer, and antinociceptive activities. This study predicted that Ganoderma lucidum cou …

  Therefore, GAA needs further validation through in vitro and in vivo studies. CONCLUSION: Ganoderma lucidum exhibits cytotoxic …
• 352.

  Potential Active Compounds of Ganoderma lucidum and Their Anticancer Effects: A Comprehensive Review.

  • Liu Y, Ren S, Sang Q, Cheng X, Bi Y.
  • Food Sci Nutr. 2025 Aug 1;13(8):e70741. doi: 10.1002/fsn3.70741.
  • PMCID: PMC12314313

  Liu Y, et al.

  Food Sci Nutr. 2025.

  PMCID: PMC12314313

  Chinese herbal medicine, as an alternative therapy, can effectively alleviate clinical symptoms of cancer patients by preventing or stabilizing tumor growth. Ganoderma lucidum is a medicinal fungus that contains a variety of bioactive compounds in its fruiting body …

  Chinese herbal medicine, as an alternative therapy, can effectively alleviate clinical symptoms of cancer patients by preventing or stabiliz …
• 353.

  Quality control of Ganoderma lucidum by using C, H, O, and N stable isotopes and C and N contents for geographical traceability.

  • Zhang Y, Jiang K, Chen S, Wang L, Zhang X, Xu W, Yam MF, Wu C, Xu W, Lin Y.
  • Front Plant Sci. 2023 Oct 11;14:1234729. doi: 10.3389/fpls.2023.1234729.
  • PMCID: PMC10598867

  Zhang Y, et al.

  Front Plant Sci. 2023.

  PMCID: PMC10598867

  RATIONALE: Ganoderma lucidum (G. lucidum) is a popular medicinal fungus that has been used in traditional medicine for decades, with its provenance influencing its medicinal and commercial worth. ...CONCLUSION: C, H, O, and N stable isotopes and C and N conte …

  RATIONALE: Ganoderma lucidum (G. lucidum) is a popular medicinal fungus that has been used in traditional medicine for …
• 354.

  Total Syntheses and Biological Evaluation of the Ganoderma lucidum Alkaloids Lucidimines B and C.

  • Chen Y, Lan P.
  • ACS Omega. 2018 Mar 26;3(3):3471-3481. doi: 10.1021/acsomega.8b00295.
  • PMCID: PMC6045472

  Chen Y, et al.

  ACS Omega. 2018.

  PMCID: PMC6045472

  Although a range of pharmacologically active compounds has been obtained from the mycelium and fruiting bodies of Ganoderma lucidum, the biological properties of the alkaloids present in this functional food remain unknown. ...This work thus demonstrates, for the fi …

  Although a range of pharmacologically active compounds has been obtained from the mycelium and fruiting bodies of Ganoderma lucidu …
• 355.

  Optimisation of biomass, exopolysaccharide and intracellular polysaccharide production from the mycelium of an identified Ganoderma lucidum strain QRS 5120 using response surface methodology.

  • Supramani S, Ahmad R, Ilham Z, Annuar MSM, Klaus A, Wan-Mohtar WAAQI.
  • AIMS Microbiol. 2019 Jan 22;5(1):19-38. doi: 10.3934/microbiol.2019.1.19.
  • PMCID: PMC6646932

  Supramani S, et al.

  AIMS Microbiol. 2019.

  PMCID: PMC6646932

  Wild-cultivated medicinal mushroom Ganoderma lucidum was morphologically identified and sequenced using phylogenetic software. ...Molecularly, the G. lucidum strain QRS 5120 generated 637 base pairs, which was commensurate with related Ganoderma specie …

  Wild-cultivated medicinal mushroom Ganoderma lucidum was morphologically identified and sequenced using phylogenetic software. …
• 356.

  Favorable Culture Conditions for Mycelial Growth of Korean Wild Strains in Ganoderma lucidum.

  • Jayasinghe C, Imtiaj A, Hur H, Lee GW, Lee TS, Lee UY.
  • Mycobiology. 2008 Mar 31;36(1):28-33. doi: 10.4489/MYCO.2008.36.1.028.
  • PMCID: PMC3755248

  Jayasinghe C, et al.

  Mycobiology. 2008.

  PMCID: PMC3755248

  Ganoderma lucidum (Fr.) Karst (Polyporaceae), belonging to basidiomycota, is one of the most famous medicinal mushrooms. ...Generally, Hamada, Glucose peptone, YM, Mushroom complete and Lilly media were the most suitable for the mycelial growth of G. lucidum. …

  Ganoderma lucidum (Fr.) Karst (Polyporaceae), belonging to basidiomycota, is one of the most famous medicinal mushrooms. ...Ge …
• 357.

  Application of Electronic tongue and HPLC in rapid determination of functional triterpenes and origins of Ganoderma lucidum.

  • Tian J, Wei J, Liu Y, Li C, Ma C, Kang W.
  • Front Nutr. 2024 Oct 21;11:1446956. doi: 10.3389/fnut.2024.1446956.
  • PMCID: PMC11532027

  Tian J, et al.

  Front Nutr. 2024.

  PMCID: PMC11532027

  INTRODUCTION: Ganoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Ganoderic acid D, as well as the sensory characteristics could reflect the quality of G. lucidum. METHODS: In order to find rapid methods …

  INTRODUCTION: Ganoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Gano …
• 358.

  Effect of Strain, Wood Substrate and Cold Treatment on the Yield and beta-Glucan Content of Ganoderma lucidum Fruiting Bodies.

  • Cortina-Escribano M, Pihlava JM, Miina J, Veteli P, Linnakoski R, Vanhanen H.
  • Molecules. 2020 Oct 15;25(20):4732. doi: 10.3390/molecules25204732.
  • PMCID: PMC7587577

  Cortina-Escribano M, et al.

  Molecules. 2020.

  PMCID: PMC7587577

  The aim of this study was to evaluate the suitability of wood residues for the cultivation of Ganoderma lucidum originating from boreal forests. The substrates tested included sawdust and wood chips of Betula spp., Populus tremula, Picea abies, Pinus sylvestris and …

  The aim of this study was to evaluate the suitability of wood residues for the cultivation of Ganoderma lucidum originating fr …
• 359.

  Differences in Antioxidants, Polyphenols, Protein Digestibility and Nutritional Profile between Ganoderma lingzhi from Industrial Crops in Asia and Ganoderma lucidum from Cultivation and Iberian Origin.

  • Fraile-Fabero R, Ozcariz-Fermoselle MV, Oria-de-Rueda-Salgueiro JA, Garcia-Recio V, Cordoba-Diaz D, Del P Jiménez-López M, Girbés-Juan T.
  • Foods. 2021 Jul 29;10(8):1750. doi: 10.3390/foods10081750.
  • PMCID: PMC8394434

  Fraile-Fabero R, et al.

  Foods. 2021.

  PMCID: PMC8394434

  Carpophores of Ganoderma lingzhi (GZ) from industrial crops in China were analysed and compared with carpophores of three Iberian strains of cultivated Ganoderma lucidum (GL) (Aveiro, Madrid, Palencia) previously genetically characterized. ...

  Carpophores of Ganoderma lingzhi (GZ) from industrial crops in China were analysed and compared with carpophores of three Iberian str …
• 360.

  Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.

  • Chi B, Wang S, Bi S, Qin W, Wu D, Luo Z, Gui S, Wang D, Yin X, Wang F.
  • Exp Ther Med. 2017 Nov 8;15(1):847-853. doi: 10.3892/etm.2017.5472.
  • PMCID: PMC5772755

  Chi B, et al.

  Exp Ther Med. 2017.

  PMCID: PMC5772755

  For several thousand years, Ganoderma lucidum (Ling-Zhi in Chinese and Reishi in Japanese) has been widely used as a traditional medication for the prevention and treatment of various diseases in Asia. ...

  For several thousand years, Ganoderma lucidum (Ling-Zhi in Chinese and Reishi in Japanese) has been widely used as a tr …

• 361.

  Structural characterization of polysaccharides after fermentation from Ganoderma lucidum and its antioxidant activity in HepG2 cells induced by H(2)O(2).

  • Zhao Y, Li Q, Wang M, Wang Y, Piao C, Yu H, Liu J, Li Z.
  • Food Chem X. 2023 Apr 23;18:100682. doi: 10.1016/j.fochx.2023.100682.
  • PMCID: PMC10165195

  Zhao Y, et al.

  Food Chem X. 2023.

  PMCID: PMC10165195

  In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) Ganoderma lucidum spore powder. ...This experiment is beneficial to …

  In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides …
• 362.

  Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients.

  • Li X, Sun L, Chimonas S, Li SQ, Feng P, Yang Y, Mao JJ.
  • Integr Med Res. 2024 Sep 30;13(4):101089. doi: 10.1016/j.imr.2024.101089.
  • PMCID: PMC11614793

  Li X, et al.

  Integr Med Res. 2024.

  PMCID: PMC11614793

  However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications. We thus sought to evaluate patient reported benefits and harms of using Reishi. METHODS: We conducted a cross-sectional survey among Chine …

  However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications. We th …
• 363.

  High-Pressure Supercritical CO(2) Extracts of Ganoderma lucidum Fruiting Body and Their Anti-hepatoma Effect Associated With the Ras/Raf/MEK/ERK Signaling Pathway.

  • Zhu L, Wu M, Li P, Zhou Y, Zhong J, Zhang Z, Li Y, Yao W, Xu J.
  • Front Pharmacol. 2020 Dec 14;11:602702. doi: 10.3389/fphar.2020.602702.
  • PMCID: PMC7768272

  Zhu L, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7768272

  As a noted medicinal mushroom, Ganoderma lucidum (G. lucidum) has been reported to have a number of pharmacological effects such as anti-tumor and liver protection. Compared with the common ethanol reflux method, supercritical CO(2) extraction has obvious adv …

  As a noted medicinal mushroom, Ganoderma lucidum (G. lucidum) has been reported to have a number of pharmacological eff …
• 364.

  Exploring Nutrient Profiles, Phytochemical Composition, and the Antiproliferative Activity of Ganoderma lucidum and Ganoderma leucocontextum: A Comprehensive Comparative Study.

  • Peng G, Xiong C, Zeng X, Jin Y, Huang W.
  • Foods. 2024 Feb 18;13(4):614. doi: 10.3390/foods13040614.
  • PMCID: PMC10888466

  Peng G, et al.

  Foods. 2024.

  PMCID: PMC10888466

  Ganoderma, often hailed as a holistic "health package", comprises an array of nutritional components and active compounds, contributing to its esteemed status in the realm of healthy foods. In this study, a comprehensive analysis was performed to elucidate the diverse nutr …

  Ganoderma, often hailed as a holistic "health package", comprises an array of nutritional components and active compounds, contributi …
• 365.

  Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides.

  • Zhu XL, Liu JH, Li WD, Lin ZB.
  • Front Pharmacol. 2012 Feb 24;3:20. doi: 10.3389/fphar.2012.00020.
  • PMCID: PMC3288721

  Zhu XL, et al.

  Front Pharmacol. 2012.

  PMCID: PMC3288721

  Our previous studies demonstrated that Ganoderma lucidum polysaccharides (Gl-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. ...

  Our previous studies demonstrated that Ganoderma lucidum polysaccharides (Gl-PS) exhibit potent immunomodulating effects. Immu …
• 366.

  Growth performance of Ganoderma lucidum using billet method in Garhwal Himalaya, India.

  • Bijalwan A, Bahuguna K, Vasishth A, Singh A, Chaudhary S, Dongariyal A, Kumar Thakur T, Kaushik S, Javed Ansari M, Alfarraj S, Ali Alharbi S, Skalicky M, Brestic M.
  • Saudi J Biol Sci. 2021 Mar 23;28(5):2709-2717. doi: 10.1016/j.sjbs.2021.03.030.
  • PMCID: PMC8117109

  Bijalwan A, et al.

  Saudi J Biol Sci. 2021.

  PMCID: PMC8117109

  Medicinal mushrooms have been used in various treatments from a very long time, among which, Ganoderma lucidum is one of the most important medicinal mushroom. It is cultivated worldwide to meet its ever-increasing demand in the market. ...The farmers' field with em …

  Medicinal mushrooms have been used in various treatments from a very long time, among which, Ganoderma lucidum is one of the m …
• 367.

  Optimization of exopolysaccharides production from a novel strain of Ganoderma lucidum CAU5501 in submerged culture.

  • Yuan B, Chi X, Zhang R.
  • Braz J Microbiol. 2012 Jun 1;43(2):490-7. doi: 10.1590/S1517-83822012000200009.
  • PMCID: PMC3768814

  Yuan B, et al.

  Braz J Microbiol. 2012.

  PMCID: PMC3768814

  This study aimed at optimizing the medium of a new Ganoderma lucidum strain CAU5501 to enhance the yield of exopolysaccharides (EPS) and mycelial growth. ...Results obtained in this study are beneficial to further study for enhancing the production of Ganoderma …

  This study aimed at optimizing the medium of a new Ganoderma lucidum strain CAU5501 to enhance the yield of exopolysaccharides …
• 368.

  Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer.

  • Shin MJ, Chae HJ, Lee JW, Koo MH, Kim HJ, Seo JB, yanIllia S, Park SH, Lo HE, Kim SH, Youn UJ, Jeon YJ, Suh SS.
  • Evid Based Complement Alternat Med. 2022 Nov 8;2022:7404493. doi: 10.1155/2022/7404493.
  • PMCID: PMC9666013

  Shin MJ, et al.

  Evid Based Complement Alternat Med. 2022.

  PMCID: PMC9666013

  Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been r …

  Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages …
• 369.

  Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth.

  • Dogan MS, Yavas MC, Yavuz Y, Erdogan S, Yener İ, Simsek İ, Akkus Z, Eratilla V, Tanik A, Akdag MZ.
  • Drug Des Devel Ther. 2017 May 4;11:1393-1398. doi: 10.2147/DDDT.S132308.
  • PMCID: PMC5422323

  Dogan MS, et al.

  Drug Des Devel Ther. 2017.

  PMCID: PMC5422323

  The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-voltage source, on rat teeth in terms of changes in trace elements (TEs) and the effect of antioxidants (melatonin [MLT] and Ganoderma …

  The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-volta …
• 370.

  Degradation and Detoxification of Chlorophenols with Different Structure by LAC-4 Laccase Purified from White-Rot Fungus Ganoderma lucidum.

  • Deng W, Zhao W, Yang Y.
  • Int J Environ Res Public Health. 2022 Jul 2;19(13):8150. doi: 10.3390/ijerph19138150.
  • PMCID: PMC9266351

  Deng W, et al.

  Int J Environ Res Public Health. 2022.

  PMCID: PMC9266351

  A laccase named LAC-4 was purified from Ganoderma lucidum. Firstly, the enzymatic properties of purified LAC-4 laccase, and the degradation of three chlorophenol pollutants 2,6-dichlorophenol (2,6-DCP), 2,3,6-trichlorophenol (2,3,6-TCP) and 3-chlorophenol (3-CP) by …

  A laccase named LAC-4 was purified from Ganoderma lucidum. Firstly, the enzymatic properties of purified LAC-4 laccase, and th …

• 371.

  In Vitro Antimicrobial Efficacy Assessment of Ethanolic, Aqueous, and Dual Solvent Extracts of Mushroom Ganoderma lucidum: Genomic and Morphological Analysis.

  • Akamu E, Merrills L, Williams Z, Justice B, Iloghalu U, Williams V, Singh D.
  • Antibiotics (Basel). 2024 Nov 21;13(12):1109. doi: 10.3390/antibiotics13121109.
  • PMCID: PMC11672760

  Akamu E, et al.

  Antibiotics (Basel). 2024.

  PMCID: PMC11672760

  This work aimed to investigate the phytochemical constituents and antimicrobial potential of ethanolic, aqueous, and dual solvent extracts of mushroom Ganoderma lucidum. Methods: The antimicrobial studies were carried out by broth dilution against Gram-positive Stap …

  This work aimed to investigate the phytochemical constituents and antimicrobial potential of ethanolic, aqueous, and dual solvent extracts o …
• 372.

  Unraveling the Polysaccharide Biosynthesis Potential of Ganoderma lucidum: A Chromosome-Level Assembly Using Hi-C Sequencing.

  • Sonets IV, Dovidchenko NV, Ulianov SV, Yarina MS, Koshechkin SI, Razin SV, Krasnopolskaya LM, Tyakht AV.
  • J Fungi (Basel). 2023 Oct 16;9(10):1020. doi: 10.3390/jof9101020.
  • PMCID: PMC10608111

  Sonets IV, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10608111

  Ganoderma lucidum exhibits the ability to synthesize a diverse range of biologically active molecules with significant pharmaceutical potential, including xylomannan and fucogalactan, which have demonstrated antitumor activity. ...We employed high-throughput shotgun …

  Ganoderma lucidum exhibits the ability to synthesize a diverse range of biologically active molecules with significant pharmac …
• 373.

  Unveiling triterpenoid superiority in a newly developed Ganoderma lucidum variety through untargeted metabolomics approach.

  • Pan Z, Lin J, Luo G, Cheng W, Li Y, Wu C.
  • Front Nutr. 2025 Apr 10;12:1541162. doi: 10.3389/fnut.2025.1541162.
  • PMCID: PMC12018227

  Pan Z, et al.

  Front Nutr. 2025.

  PMCID: PMC12018227

  The fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid content. Variability in G. lucidum strains may influence the composition and abundance of triterpenoids. In this study, we explored the …

  The fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid co …
• 374.

  Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.

  • Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P.
  • Lipids Health Dis. 2004 Feb 18;3:2. doi: 10.1186/1476-511X-3-2.
  • PMCID: PMC385249

  Berger A, et al.

  Lipids Health Dis. 2004.

  PMCID: PMC385249

  We studied cholesterol lowering properties of Ganoderma lucidum (Gl), a renowned medicinal species. RESULTS: Organic fractions containing oxygenated lanosterol derivatives inhibited cholesterol synthesis in T9A4 hepatocytes. ...

  We studied cholesterol lowering properties of Ganoderma lucidum (Gl), a renowned medicinal species. RESULTS: Organic fractions …
• 375.

  Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.

  • Gao X, Homayoonfal M.
  • Cancer Cell Int. 2023 Dec 16;23(1):324. doi: 10.1186/s12935-023-03146-8.
  • PMCID: PMC10724890

  Gao X, et al.

  Cancer Cell Int. 2023.

  PMCID: PMC10724890

  There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma lucidum, a medicinal mushroom, has gained attention for its decadent array of therapeutic and pharmaceutical compounds. Notably, …

  There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma …
• 376.

  Comparative analysis of multifaceted properties of Agaricus bisporus and Ganoderma lucidum macro-fungi powder: Techno-functional and structural characterization, mineral uptake, and photocatalytic activity.

  • Singh V, Bains A, Goksen G, Capozzi V, Arjun AD, Ali N, Iqbal M, Chawla P.
  • Food Chem X. 2024 Oct 29;24:101937. doi: 10.1016/j.fochx.2024.101937.
  • PMCID: PMC11585834

  Singh V, et al.

  Food Chem X. 2024.

  PMCID: PMC11585834

  Macro-fungi are recognized for food, medicinal, and environmental applications, therefore, the study focuses on multifaceted nutritional, techno-functional, and bioremediation-related uses of Agaricus bisporus and Ganoderma lucidum powders. Herein, A. bisporus exhib …

  Macro-fungi are recognized for food, medicinal, and environmental applications, therefore, the study focuses on multifaceted nutritional, te …
• 377.

  Effects of Efficient Expression of Vitreoscilla Hemoglobin on Production, Monosaccharide Composition, and Antioxidant Activity of Exopolysaccharides in Ganoderma lucidum.

  • Wang ZX, Li N, Xu JW.
  • Microorganisms. 2021 Jul 21;9(8):1551. doi: 10.3390/microorganisms9081551.
  • PMCID: PMC8401987

  Wang ZX, et al.

  Microorganisms. 2021.

  PMCID: PMC8401987

  A Vitreoscilla hemoglobin (VHb) gene was efficiently expressed by the optimization of codons and intron addition in G. lucidum. Expression of the VHb gene was confirmed by genome PCR, quantitative real-time PCR and carbon monoxide (CO)-difference spectrum analysis in the t …

  A Vitreoscilla hemoglobin (VHb) gene was efficiently expressed by the optimization of codons and intron addition in G. lucidum. Expre …
• 378.

  Hepatoprotective Evaluation of Ganoderma lucidum Pharmacopuncture: In vivo Studies of Ethanol-induced Acute Liver Injury.

  • Jang SH, Cho SW, Yoon HM, Jang KJ, Song CH, Kim CH.
  • J Pharmacopuncture. 2014 Sep;17(3):16-24. doi: 10.3831/KPI.2014.17.022.
  • PMCID: PMC4332019

  Jang SH, et al.

  J Pharmacopuncture. 2014.

  PMCID: PMC4332019

  This study was aimed at investigating the protective effect of Ganoderma lucidum pharmacopuncture (GLP) against hepatotoxicity induced by acute ethanol (EtOH) intoxication in rats. ...The NP and the GLP groups were treated daily with injections of normal saline and …

  This study was aimed at investigating the protective effect of Ganoderma lucidum pharmacopuncture (GLP) against hepatotoxicity …
• 379.

  Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies.

  • Aref M, Khoshhali M, Ghasemi P, Adeli S, Heidari-Beni M, Kelishadi R.
  • J Res Med Sci. 2023 Sep 29;28:70. doi: 10.4103/jrms.jrms_175_23.
  • PMCID: PMC10729684

  Aref M, et al.

  J Res Med Sci. 2023.

  PMCID: PMC10729684

  BACKGROUND: Ganoderma lucidum (G. lucidum) is one of the most popular edible mushrooms in the world which has various pharmacological components. ...CONCLUSION: G. lucidum has favorable effects on TG, TC, LDL-C, HDL-C, and VLDL. Different doses of G. < …

  BACKGROUND: Ganoderma lucidum (G. lucidum) is one of the most popular edible mushrooms in the world which has various p …
• 380.

  Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum.

  • Ewunkem A, Merrills L, Williams Z, Maness L, Meixner J, Justice B, Iloghalu U, Williams V, Kiki L, Singh D.
  • Open J Med Microbiol. Author manuscript. 2025 Mar 5;15(1):11-35. doi: 10.4236/ojmm.2025.151002.
  • PMCID: PMC12094522

  Ewunkem A, et al.

  Open J Med Microbiol. Author manuscript. 2025.

  PMCID: PMC12094522

  Thus, this study also investigated anticandida activity of three solvent extracts of Ganoderma lucidum against the clinical isolate of Candida sp. The findings of this study provided evidence that Candida tropicalis MYA-3404 was the only strain present in the clinic …

  Thus, this study also investigated anticandida activity of three solvent extracts of Ganoderma lucidum against the clinical is …

• 381.

  Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway.

  • Zhu G, Liu Y, Luo S, Tang C, Zhao C, Lu X.
  • Biochem Biophys Rep. 2025 Jan 29;41:101926. doi: 10.1016/j.bbrep.2025.101926.
  • PMCID: PMC11815960

  Zhu G, et al.

  Biochem Biophys Rep. 2025.

  PMCID: PMC11815960

  In recent years, targeting the suppression of microglia-mediated neuroinflammation has emerged as a principal therapeutic strategy for RIR. Ganoderma lucidum polysaccharide (GLP), a pivotal bioactive extract of Ganoderma lucidum, has been demonstrated …

  In recent years, targeting the suppression of microglia-mediated neuroinflammation has emerged as a principal therapeutic strategy for RIR. …
• 382.

  GC-based chemoprofile of lipophilic compounds in Altaian Ganoderma lucidum sample.

  • Shevelev OB, Seryapina AA, Zavjalov EL, Gerlinskaya LA, Goryachkovskaya TN, Slynko NM, Kuibida LV, Peltek SE, Markel AL, Moshkin MP.
  • Data Brief. 2018 Mar 26;18:1054-1056. doi: 10.1016/j.dib.2018.03.098.
  • PMCID: PMC5996614

  Shevelev OB, et al.

  Data Brief. 2018.

  PMCID: PMC5996614

  The presented data contains information about component composition of lipophilic compounds in Ganoderma lucidum fungal body sample obtained using gas chromatography and subsequent mass spectrometry....

  The presented data contains information about component composition of lipophilic compounds in Ganoderma lucidum fungal body s …
• 383.

  Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.

  • Peng H, Zhong L, Cheng L, Chen L, Tong R, Shi J, Bai L.
  • Front Pharmacol. 2023 Jan 9;13:1094405. doi: 10.3389/fphar.2022.1094405.
  • PMCID: PMC9872944

  Peng H, et al.

  Front Pharmacol. 2023.

  PMCID: PMC9872944

  Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. ...Among them, the triterpenoids and polysaccharide components of G. lucidum have a wide range of anti-liver fibrotic effects. Currently, …

  Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. ...A …
• 384.

  Antifibrotic activity a fermentation filtrate of Ganoderma lucidum.

  • Kwon SC, Kim YB.
  • Lab Anim Res. 2011 Dec 19;27(4):369-71. doi: 10.5625/lar.2011.27.4.369.
  • PMCID: PMC3251772

  Kwon SC, et al.

  Lab Anim Res. 2011.

  PMCID: PMC3251772

  The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl(4))-induced hepatic fibrosis were investigated in rats. ...

  The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl(4))-induced hepatic fibrosis we …
• 385.

  WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.

  • Qiu WL, Hsu WH, Tsao SM, Tseng AJ, Lin ZH, Hua WJ, Yeh H, Lin TE, Chen CC, Chen LS, Lin TY.
  • Polymers (Basel). 2021 Dec 13;13(24):4353. doi: 10.3390/polym13244353.
  • PMCID: PMC8705874

  Qiu WL, et al.

  Polymers (Basel). 2021.

  PMCID: PMC8705874

  In this study, we investigated the effect of WSG, a glucose-rich, water soluble polysaccharide derived from Ganoderma lucidum, on cisplatin-based treatment for lung cancer. Murine Lewis lung carcinoma (LLC1) cells were injected into C57BL/6 mice subcutaneously and t …

  In this study, we investigated the effect of WSG, a glucose-rich, water soluble polysaccharide derived from Ganoderma lucidum, …
• 386.

  Recombinant Expression and Bioactivity Comparison of Four Typical Fungal Immunomodulatory Proteins from Three Main Ganoderma Species.

  • Qu ZW, Zhou SY, Guan SX, Gao R, Duan ZW, Zhang X, Sun WY, Fan WL, Chen SS, Chen LJ, Lin JW, Ruan YY.
  • BMC Biotechnol. 2018 Dec 14;18(1):80. doi: 10.1186/s12896-018-0488-0.
  • PMCID: PMC6295072

  Qu ZW, et al.

  BMC Biotechnol. 2018.

  PMCID: PMC6295072

  In the current study, two FIP genes termed FIP-gap1 and FIP-gap2 from G. applanatum, along with LZ-8 and FIP-gsi, another two representative Ganoderma FIP genes from G. lucidum and G. sinense were functionally expressed in Pichia. ...Both similarities and difference …

  In the current study, two FIP genes termed FIP-gap1 and FIP-gap2 from G. applanatum, along with LZ-8 and FIP-gsi, another two representative …
• 387.

  Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection.

  • Zhan L, Tang J, Lin S, Xu Y, Xu Y, Qin C.
  • Front Microbiol. 2016 Jan 8;6:1490. doi: 10.3389/fmicb.2015.01490.
  • PMCID: PMC4705449

  Zhan L, et al.

  Front Microbiol. 2016.

  PMCID: PMC4705449

  The model was used to demonstrate the comparative effects of prophylactic and therapeutic administration of Ganoderma lucidum extract (spores and spores lipid) in preventing H37Rv replication in both lung and spleen. H37Rv was inhibited with prophylactic use of G. < …

  The model was used to demonstrate the comparative effects of prophylactic and therapeutic administration of Ganoderma lucidum …
• 388.

  Inhibitory effects of Ganoderma lucidum triterpenoid on the growth and metastasis of hepatocellular carcinoma.

  • Ding Z, Zhou Z, Cheng X, Wang H, Liu J, Cai Y, Liu H, Lv M, Pan Y, Xiao E.
  • Am J Transl Res. 2023 May 15;15(5):3410-3423.
  • PMCID: PMC10251039

  Ding Z, et al.

  Am J Transl Res. 2023.

  PMCID: PMC10251039

  OBJECTIVE: To investigate the inhibitory effects and mechanisms of triterpenoids from Ganoderma lucidum (G. lucidum triterpenoids) on the growth and metastasis of hepatocellular carcinoma (HCC) both in vitro and in vivo. ...RESULTS: i. In in-vitro experiments …

  OBJECTIVE: To investigate the inhibitory effects and mechanisms of triterpenoids from Ganoderma lucidum (G. lucidum tri …
• 389.

  Characterizing novel anti-oncogenic triterpenoids from ganoderma.

  • Li X, Xie Y, Yang BB.
  • Cell Cycle. 2018;17(5):527-528. doi: 10.1080/15384101.2017.1315493.
  • PMCID: PMC5969549

  Li X, et al.

  Cell Cycle. 2018.

  PMCID: PMC5969549
• 390.

  Selective Antineoplastic Potential of Fractionated Caribbean Native Ganoderma Species Extracts on Triple-Negative Breast Cancer Cells.

  • Arroyo-Cruz LV, Sagardía-González S, Miller K, Ling T, Rivas F, Martínez-Montemayor MM.
  • Pharmaceuticals (Basel). 2024 Jul 1;17(7):864. doi: 10.3390/ph17070864.
  • PMCID: PMC11279663

  Arroyo-Cruz LV, et al.

  Pharmaceuticals (Basel). 2024.

  PMCID: PMC11279663

  Natural products derived from mushrooms have gained significant attention in neoplastic therapy due to their potential medicinal properties. The therapeutic potential of Ganoderma lucidum in breast cancer has been highlighted by our group, suggesting its use as an a …

  Natural products derived from mushrooms have gained significant attention in neoplastic therapy due to their potential medicinal properties. …

• 391.

  Dynamic succession of substrate-associated bacterial composition and function during Ganoderma lucidum growth.

  • Zhang B, Yan L, Li Q, Zou J, Tan H, Tan W, Peng W, Li X, Zhang X.
  • PeerJ. 2018 Jun 13;6:e4975. doi: 10.7717/peerj.4975.
  • PMCID: PMC6004108

  Zhang B, et al.

  PeerJ. 2018.

  PMCID: PMC6004108

  BACKGROUND: Ganoderma lucidum, a valuable medicinal fungus, is widely distributed in China. It grows alongside with a complex microbial ecosystem in the substrate. ...DISCUSSION: The changes in bacterial community composition, diversity and predicted functions were …

  BACKGROUND: Ganoderma lucidum, a valuable medicinal fungus, is widely distributed in China. It grows alongside with a complex …
• 392.

  Effects of Ganoderma lucidum polysaccharide peptide ameliorating cyclophosphamide-induced immune dysfunctions based on metabolomics analysis.

  • Xie J, Lin D, Li J, Zhou T, Lin S, Lin Z.
  • Front Nutr. 2023 May 25;10:1179749. doi: 10.3389/fnut.2023.1179749.
  • PMCID: PMC10248424

  Xie J, et al.

  Front Nutr. 2023.

  PMCID: PMC10248424

  Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents of Ganoderma lucidum (G. lucidum), with a wide range of functional activities. ...

  Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents of Ganoderma lucidum (G …
• 393.

  Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells.

  • Zheng S, Jia Y, Zhao J, Wei Q, Liu Y.
  • Oncol Lett. 2011 Dec 6;3(3):613-616. doi: 10.3892/ol.2011.515.
  • PMCID: PMC3362652

  Zheng S, et al.

  Oncol Lett. 2011.

  PMCID: PMC3362652

  However, NK cytotoxicity against tumor cells may be inhibited by a fibrinogen coat adhered to the surface of tumor cells. Ganoderma lucidum (G. lucidum) polysaccharides have been reported for their inhibitory ability on the adhesion of type I collagen, hyalur …

  However, NK cytotoxicity against tumor cells may be inhibited by a fibrinogen coat adhered to the surface of tumor cells. Ganoderma < …
• 394.

  Influence of cultivation substrate on antioxidant activities and triterpenoid profiles of the fruiting body of Ganoderma lucidum.

  • Luo G, Pan Z, Liu Z, Cheng W, Yu T.
  • Front Nutr. 2024 Feb 7;11:1329579. doi: 10.3389/fnut.2024.1329579.
  • PMCID: PMC10879320

  Luo G, et al.

  Front Nutr. 2024.

  PMCID: PMC10879320

  INTRODUCTION: The fruiting body of Ganoderma lucidum has been believed to possess a wide range of therapeutic effects. There are two main methods for artificial cultivation of G. lucidum to produce the fruiting body, namely wood log cultivation and substitute …

  INTRODUCTION: The fruiting body of Ganoderma lucidum has been believed to possess a wide range of therapeutic effects. There a …
• 395.

  Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble polysaccharide.

  • Fang L, Zhao Q, Guo C, Guo D, Li Z, Xu J, Guo C, Sang T, Wang Y, Chen J, Chen C, Chen R, Wu J, Wang X.
  • Front Nutr. 2022 Sep 16;9:1006127. doi: 10.3389/fnut.2022.1006127.
  • PMCID: PMC9524850

  Fang L, et al.

  Front Nutr. 2022.

  PMCID: PMC9524850

  The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm-removed spores of the medicinal mushroom Ganoderma lucidum (RSGLP), which removed the sporoderm completely, with polysacchari …

  The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm …
• 396.

  Generation and analysis of expressed sequence tags from a cDNA library of the fruiting body of Ganoderma lucidum.

  • Luo H, Sun C, Song J, Lan J, Li Y, Li X, Chen S.
  • Chin Med. 2010 Mar 16;5:9. doi: 10.1186/1749-8546-5-9.
  • PMCID: PMC2848221

  Luo H, et al.

  Chin Med. 2010.

  PMCID: PMC2848221

  BACKGROUND: Little genomic or trancriptomic information on Ganoderma lucidum (Lingzhi) is known. This study aims to discover the transcripts involved in secondary metabolite biosynthesis and developmental regulation of G. lucidum using an expressed sequence t …

  BACKGROUND: Little genomic or trancriptomic information on Ganoderma lucidum (Lingzhi) is known. This study aims to discover t …
• 397.

  Biochemical and Pharmacological aspects of Ganoderma lucidum: Exponent from the in vivo and computational investigations.

  • Hossen SMM, Yusuf ATM, Emon NU, Alam N, Sami SA, Polash SH, Nur MA, Mitra S, Uddin MH, Emran TB.
  • Biochem Biophys Rep. 2022 Nov 7;32:101371. doi: 10.1016/j.bbrep.2022.101371.
  • PMCID: PMC9650014

  Hossen SMM, et al.

  Biochem Biophys Rep. 2022.

  PMCID: PMC9650014

  Ganoderma lucidum is known as lingzhi mushroom, which is said to have medicinal properties by the local residents. ...The antidepressant, anxiolytic, and sedative properties of the methanol extracts of G. lucidum (MEGL) were assessed using the forced swim tes …

  Ganoderma lucidum is known as lingzhi mushroom, which is said to have medicinal properties by the local residents. ...The anti …
• 398.

  Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.

  • Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X.
  • J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494.
  • PMCID: PMC5985119

  Wei B, et al.

  J Immunol Res. 2018.

  PMCID: PMC5985119

  BACKGROUND: Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. ...

  BACKGROUND: Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects. ...
• 399.

  Exploring the Protective and Reparative Mechanisms of G. lucidum Polysaccharides Against H(2)O(2)-Induced Oxidative Stress in Human Skin Fibroblasts.

  • Shi X, Cheng W, Wang Q, Zhang J, Wang C, Li M, Zhao D, Wang D, An Q.
  • Clin Cosmet Investig Dermatol. 2021 Oct 14;14:1481-1496. doi: 10.2147/CCID.S334527.
  • PMCID: PMC8525518

  Shi X, et al.

  Clin Cosmet Investig Dermatol. 2021.

  PMCID: PMC8525518

  BACKGROUND: Ganoderma lucidum (G. lucidum) is one of China's traditional medicinal materials. G. lucidum polysaccharide has a wide range of promising pharmacological applications. However, there are many kinds of G. lucidum and they contain diff …

  BACKGROUND: Ganoderma lucidum (G. lucidum) is one of China's traditional medicinal materials. G. lucidum polysac …
• 400.

  Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial.

  • Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X.
  • Evid Based Complement Alternat Med. 2011 Dec 10;2012:809614. doi: 10.1155/2012/809614.
  • PMCID: PMC3236089

  Zhao H, et al.

  Evid Based Complement Alternat Med. 2011.

  PMCID: PMC3236089

  The aim of this study was to investigate the effectiveness of spore powder of Ganoderma lucidum for cancer-related fatigue in breast cancer patients undergoing endocrine therapy. ...This pilot study suggests that spore powder of Ganoderma lucidum may h …

  The aim of this study was to investigate the effectiveness of spore powder of Ganoderma lucidum for cancer-related fatigue in …

• 401.

  Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis.

  • Kaewjai C, Tonsomboon A, Pawiwongchai J, Prommano AO.
  • Vet World. 2023 Jan 28;16(1):187-193. doi: 10.14202/vetworld.2023.187-193.
  • PMCID: PMC9967722

  Kaewjai C, et al.

  Vet World. 2023.

  PMCID: PMC9967722

  This study aimed to determine the antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against B. hominis. MATERIALS AND METHODS: Antiprotozoal activity of B. rotunda and G. lucidum extracts against B. hominis su …

  This study aimed to determine the antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart e …
• 402.

  The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta.

  • Szydłowska-Tutaj M, Szymanowska U, Tutaj K, Domagała D, Złotek U.
  • Antioxidants (Basel). 2023 Mar 17;12(3):738. doi: 10.3390/antiox12030738.
  • PMCID: PMC10044984

  Szydłowska-Tutaj M, et al.

  Antioxidants (Basel). 2023.

  PMCID: PMC10044984

  The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied. ...In conclusion, the results suggest that Reishi and Lion's Mane mushroom powder can be used …

  The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro- …
• 403.

  Antifungal-demelanizing properties and RAW264.7 macrophages stimulation of glucan sulfate from the mycelium of the mushroom Ganoderma lucidum.

  • Wan-Mohtar WAAQI, Viegelmann C, Klaus A, Lim SAH.
  • Food Sci Biotechnol. 2017 Feb 28;26(1):159-165. doi: 10.1007/s10068-017-0021-6.
  • PMCID: PMC6049470

  Wan-Mohtar WAAQI, et al.

  Food Sci Biotechnol. 2017.

  PMCID: PMC6049470

  Underutilized mycelium of Ganoderma lucidum BCCM 31549 has been a significant source of a glucan sulfate (GS) possessing therapeutic activities. ...The results highlight a novel bifunctional property of mycelial GS from G. lucidum....

  Underutilized mycelium of Ganoderma lucidum BCCM 31549 has been a significant source of a glucan sulfate (GS) possessing thera …
• 404.

  Microbial communities and soil chemical features associated with commercial production of the medicinal mushroom Ganoderma lingzhi in soil.

  • Ke LQ, Li PD, Xu JP, Wang QS, Wang LL, Wen HP.
  • Sci Rep. 2019 Nov 1;9(1):15839. doi: 10.1038/s41598-019-52368-2.
  • PMCID: PMC6825212

  Ke LQ, et al.

  Sci Rep. 2019.

  PMCID: PMC6825212

  Here in this study, we analyzed the production of the medicinal mushroom Ganoderma lingzhi and the associated soil microbial communities and soil chemical features over 24 months from April 2015 to April 2017. ...

  Here in this study, we analyzed the production of the medicinal mushroom Ganoderma lingzhi and the associated soil microbial communit …
• 405.

  Ganoderma spore powder contains little triterpenoids.

  • Liu MT, Chen LX, Zhao J, Li SP.
  • Chin Med. 2020 Oct 12;15:111. doi: 10.1186/s13020-020-00391-1.
  • PMCID: PMC7552346

  Liu MT, et al.

  Chin Med. 2020.

  PMCID: PMC7552346

  BACKGROUND: Ganoderma spore is a minuscule germ cell ejected from Ganoderma gills during its growth maturity period, it has been considered with high exploitable potential in health-care products manufacture. METHODS: After testing sporoderm-broken rate, the triterp …

  BACKGROUND: Ganoderma spore is a minuscule germ cell ejected from Ganoderma gills during its growth maturity period, it has be …
• 406.

  Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis.

  • Ma Y, Han J, Wang K, Han H, Hu Y, Li H, Wu S, Zhang L.
  • Heliyon. 2024 Jun 19;10(12):e33307. doi: 10.1016/j.heliyon.2024.e33307.
  • PMCID: PMC11253544

  Ma Y, et al.

  Heliyon. 2024.

  PMCID: PMC11253544

  As such, traditional Chinese medicine (TCM) has been widely used recently due to its stable therapeutic effect and high safety. Ganoderma lucidum polysaccharides (GLP) are the main active ingredients of Ganoderma lucidum, a Chinese herbal medicine. ...

  As such, traditional Chinese medicine (TCM) has been widely used recently due to its stable therapeutic effect and high safety. Ganoderma …
• 407.

  Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.

  • Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF.
  • Evid Based Complement Alternat Med. 2011 Jan 4;2011:358717. doi: 10.1093/ecam/nep107.
  • PMCID: PMC3135330

  Hsu JW, et al.

  Evid Based Complement Alternat Med. 2011.

  PMCID: PMC3135330

  In our previous study, we found that fucose-containing polysaccharide fraction F3 extracted from Ganoderma lucidum can bring about cytokine secretion and cell death in human leukemia THP-1 cells. ...

  In our previous study, we found that fucose-containing polysaccharide fraction F3 extracted from Ganoderma lucidum can bring a …
• 408.

  Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway.

  • Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM.
  • Oncotarget. 2018 Nov 13;9(89):35907-35921. doi: 10.18632/oncotarget.26294.
  • PMCID: PMC6267592

  Rios-Fuller TJ, et al.

  Oncotarget. 2018.

  PMCID: PMC6267592

  The signal transducer and activator of transcription 3 (STAT3) pathway participates in the development and progression of BCSCs, but its role in TNBC remains unclear. Here, we report that Ganoderma lucidum extract (GLE), a medicinal mushroom with anticancer activity …

  The signal transducer and activator of transcription 3 (STAT3) pathway participates in the development and progression of BCSCs, but its rol …
• 409.

  Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts.

  • Veljović S, Veljović M, Nikićević N, Despotović S, Radulović S, Nikšić M, Filipović L.
  • J Food Sci Technol. 2017 Mar 10;54(5):1312-1320. doi: 10.1007/s13197-017-2559-y.
  • PMCID: PMC5380636

  Veljović S, et al.

  J Food Sci Technol. 2017.

  PMCID: PMC5380636

  The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) …

  The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of different …
• 410.

  Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.

  • Guggenheim AG, Wright KM, Zwickey HL.
  • Integr Med (Encinitas). 2014 Feb;13(1):32-44.
  • PMCID: PMC4684115

  Guggenheim AG, et al.

  Integr Med (Encinitas). 2014.

  PMCID: PMC4684115

  This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immun …

  This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ga …

• 411.

  Polysaccharides from sporoderm-removed spores of Ganoderma lucidum induce apoptosis in human gastric cancer cells via disruption of autophagic flux.

  • Zhong J, Fang L, Chen R, Xu J, Guo D, Guo C, Guo C, Chen J, Chen C, Wang X.
  • Oncol Lett. 2021 Mar 29;21(5):425. doi: 10.3892/ol.2021.12686.
  • PMCID: PMC8025153

  Zhong J, et al.

  Oncol Lett. 2021.

  PMCID: PMC8025153

  The sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from t …

  The sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit …
• 412.

  Novel Insights into the Mechanism Underlying High Polysaccharide Yield in Submerged Culture of Ganoderma lucidum Revealed by Transcriptome and Proteome Analyses.

  • Wang Q, Xu M, Zhao L, Chen L, Ding Z.
  • Microorganisms. 2023 Mar 17;11(3):772. doi: 10.3390/microorganisms11030772.
  • PMCID: PMC10055881

  Wang Q, et al.

  Microorganisms. 2023.

  PMCID: PMC10055881

  Polysaccharides are crucial dietary supplements and traditional pharmacological components of Ganoderma lucidum; however, the mechanisms responsible for high polysaccharide yields in G. lucidum remain unclear. ...Our findings provide new insights into the mec …

  Polysaccharides are crucial dietary supplements and traditional pharmacological components of Ganoderma lucidum; however, the …
• 413.

  Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays.

  • Li Z, Shi Y, Zhang X, Xu J, Wang H, Zhao L, Wang Y.
  • Front Pharmacol. 2020 Mar 18;11:287. doi: 10.3389/fphar.2020.00287.
  • PMCID: PMC7093641

  Li Z, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7093641

  Ganoderma lucidum is a well-known herbal remedy widely used for treating various chronic diseases. Traditionally, the fruiting body is regarded as the medicinal part of this fungus, while recently, the therapeutic potentials of Ganoderma lucidum spore …

  Ganoderma lucidum is a well-known herbal remedy widely used for treating various chronic diseases. Traditionally, the fruiting …
• 414.

  Breeding a new Ganoderma lucidum strain with increased contents of individual ganoderic acids by mono-mono crossing of genetically modified monokaryons.

  • Zhou DX, Kong XM, Huang XM, Li N, Feng N, Xu JW.
  • Front Microbiol. 2024 May 30;15:1410368. doi: 10.3389/fmicb.2024.1410368.
  • PMCID: PMC11169689

  Zhou DX, et al.

  Front Microbiol. 2024.

  PMCID: PMC11169689

  Ganoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G. lucidum strain with increased contents of individual GAs. ...In summary, we developed a new G. lucidum strain with higher contents of individu …

  Ganoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G. lucidum s …
• 415.

  Green Synthesis of Ganoderma Lucidum-Mediated Silver Nanoparticles and its Microbial Activity against Oral Pathogenic Microbes: An In Vitro Study.

  • Parameswari BD, Rajakumar M, Hariharan A, Kumar S, Mohamed K, Ballal S.
  • J Pharm Bioallied Sci. 2024 Apr 16;16(Suppl 2):S1456-S1460. doi: 10.4103/jpbs.jpbs_933_23.
  • PMCID: PMC11174218

  Parameswari BD, et al.

  J Pharm Bioallied Sci. 2024.

  PMCID: PMC11174218

  More than 200 active ingredients, including water-soluble, organic-soluble, and volatile chemicals, are found in Ganoderma. The main components are polysaccharides, adenosine, and terpenoids, each of which has exceptional therapeutic properties. This article explains the s …

  More than 200 active ingredients, including water-soluble, organic-soluble, and volatile chemicals, are found in Ganoderma. The main …
• 416.

  CD8(+) T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum.

  • Takaku S, Shimizu M, Morita R.
  • Evid Based Complement Alternat Med. 2023 Apr 28;2023:9630816. doi: 10.1155/2023/9630816.
  • PMCID: PMC10162866

  Takaku S, et al.

  Evid Based Complement Alternat Med. 2023.

  PMCID: PMC10162866

  In this study, we determined whether oral administration of an herbal mixture containing Ganoderma lucidum (WTMCGEP; Wisteria floribunda, Trapae fructus, Myristica fragrans, Coicis semen, Ganoderma lucidum, Elfvingia applanata, and Punica granatum), an …

  In this study, we determined whether oral administration of an herbal mixture containing Ganoderma lucidum (WTMCGEP; Wisteria …
• 417.

  Polysaccharide peptide isolated from grass-cultured Ganoderma lucidum induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.

  • Wang C, Lin D, Chen Q, Lin S, Shi S, Chen C.
  • Oncol Lett. 2018 Jan 19;15(4):4330-4336. doi: 10.3892/ol.2018.7823.
  • PMCID: PMC5835855

  Wang C, et al.

  Oncol Lett. 2018.

  PMCID: PMC5835855

  The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic act …

  The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its nume …
• 418.

  Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum.

  • Oluba OM, Olusola AO, Eidangbe GO, Babatola LJ, Onyeneke EC.
  • Cholesterol. 2012 Jul 25;2012:536396. doi: 10.1155/2012/536396.
  • PMCID: PMC3410371

  Oluba OM, et al.

  Cholesterol. 2012.

  PMCID: PMC3410371

  In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 …

  In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial inf …
• 419.

  Effects of sporoderm-broken spores of Ganoderma lucidum on growth performance, antioxidant function and immune response of broilers.

  • Liu T, Zhou J, Li W, Rong X, Gao Y, Zhao L, Fan Y, Zhang J, Ji C, Ma Q.
  • Anim Nutr. 2019 Dec 23;6(1):39-46. doi: 10.1016/j.aninu.2019.11.005.
  • PMCID: PMC7082644

  Liu T, et al.

  Anim Nutr. 2019.

  PMCID: PMC7082644

  This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL), a traditional Chinese medicinal herb, on growth performance, antioxidant ability, and immunity of broilers. ...

  This study was conducted to evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL), a traditional Chinese …
• 420.

  Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress.

  • Özevren H, İrtegün S, Deveci E, Aşır F, Pektanç G, Deveci Ş.
  • Korean J Neurotrauma. 2017 Oct 31;13(2):76-84. doi: 10.13004/kjnt.2017.13.2.76.
  • PMCID: PMC5702762

  Özevren H, et al.

  Korean J Neurotrauma. 2017.

  PMCID: PMC5702762

  This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats. ...Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum …

  This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides ( …

• 421.

  Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst.

  • Ansari MHR, Khan W, Parveen R, Saher S, Ahmad S.
  • Metabolites. 2022 Jan 21;12(2):97. doi: 10.3390/metabo12020097.
  • PMCID: PMC8876931

  Ansari MHR, et al.

  Metabolites. 2022.

  PMCID: PMC8876931

  Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. ...Preparation of triterpenoid enriched fraction (TEF) from Ganoderma lucidum. (2). Major triterpenoid in TEF …

  Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major ph …
• 422.

  G. lucidum triterpenes restores intestinal flora balance in non-hepatitis B virus-related hepatocellular carcinoma: evidence of 16S rRNA sequencing and network pharmacology analysis.

  • Xiong W, Yang C, Xia J, Wang W, Li N.
  • Front Pharmacol. 2023 Sep 18;14:1197418. doi: 10.3389/fphar.2023.1197418.
  • PMCID: PMC10544910

  Xiong W, et al.

  Front Pharmacol. 2023.

  PMCID: PMC10544910

  Background: Ganoderma lucidum (G. lucidum) is a popular traditional remedy medicine used in Asia to promote health and longevity, which has also been highlighted for anti-cancer effects. ...Conclusion: Therefore, Ganosporelactone B, the active ingredient of G …

  Background: Ganoderma lucidum (G. lucidum) is a popular traditional remedy medicine used in Asia to promote health and …
• 423.

  Wild Mushrooms: A Potential Source of Nutritional and Antioxidant Attributes with Acceptable Toxicity.

  • Sharif S, Shahid M, Mushtaq M, Akram S, Rashid A.
  • Prev Nutr Food Sci. 2017 Jun 30;22(2):124-130. doi: 10.3746/pnf.2017.22.2.124.
  • PMCID: PMC5503421

  Sharif S, et al.

  Prev Nutr Food Sci. 2017.

  PMCID: PMC5503421

  This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate …

  This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial …
• 424.

  Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia.

  • Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D.
  • Healthcare (Basel). 2020 Nov 30;8(4):520. doi: 10.3390/healthcare8040520.
  • PMCID: PMC7712001

  Pazzi F, et al.

  Healthcare (Basel). 2020.

  PMCID: PMC7712001

  It is associated with several secondary symptoms such as psychological and pain-specific distress, which can directly impact daily functioning and quality of life, like anxiety and depression. The Ganoderma lucidum (GL) mushroom seems to be able to improve fibromyal …

  It is associated with several secondary symptoms such as psychological and pain-specific distress, which can directly impact daily functioni …
• 425.

  Alterations in Growth and Morphology of Ganoderma lucidum and Volvariella volvaceae in Response to Nanoparticle Supplementation.

  • Singh S, Kuca K, Kalia A.
  • Mycobiology. 2020 Aug 27;48(5):383-391. doi: 10.1080/12298093.2020.1809613.
  • PMCID: PMC7580762

  Singh S, et al.

  Mycobiology. 2020.

  PMCID: PMC7580762

  The present investigation explores the effect of in vitro supplementation of TiO(2), silica and silver NPs on radial growth and ultrastructural changes in the hyphae and spores of two mushroom genera, Ganoderma lucidum and Volvariella volvaceae. A concentration depe …

  The present investigation explores the effect of in vitro supplementation of TiO(2), silica and silver NPs on radial growth and ultrastructu …
• 426.

  Ganoderma lucidum-Mediated Green Synthesis of Silver Nanoparticles with Antimicrobial Activity.

  • Constantin M, Răut I, Suica-Bunghez R, Firinca C, Radu N, Gurban AM, Preda S, Alexandrescu E, Doni M, Jecu L.
  • Materials (Basel). 2023 Jun 8;16(12):4261. doi: 10.3390/ma16124261.
  • PMCID: PMC10302571

  Constantin M, et al.

  Materials (Basel). 2023.

  PMCID: PMC10302571

  Nanoparticles can be synthesized by algae, bacteria, fungi, and plant extracts. Ganoderma lucidum is a commonly used medicinal mushroom with distinctive biological properties, such as antibacterial, antifungal, antioxidant, anti-inflammatory, anticancer, etc. In thi …

  Nanoparticles can be synthesized by algae, bacteria, fungi, and plant extracts. Ganoderma lucidum is a commonly used medicinal …
• 427.

  Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation.

  • Rossi P, Buonocore D, Altobelli E, Brandalise F, Cesaroni V, Iozzi D, Savino E, Marzatico F.
  • Evid Based Complement Alternat Med. 2014 Apr 1;2014:979613. doi: 10.1155/2014/979613.
  • PMCID: PMC3995149

  Rossi P, et al.

  Evid Based Complement Alternat Med. 2014.

  PMCID: PMC3995149

  We report the effects of a brief 3-month trial of two fungal supplements, Ganoderma lucidum and Cordyceps sinensis (3 capsules of O. sinensis and 2 capsules of G. lucidum per day), in 7 healthy male volunteers, aged between 30 and 40 years, who are all amateu …

  We report the effects of a brief 3-month trial of two fungal supplements, Ganoderma lucidum and Cordyceps sinensis (3 capsules …
• 428.

  Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.

  • Suárez-Arroyo IJ, Acevedo-Díaz A, Ríos-Fuller TJ, Ortiz-Soto G, Vallejo-Calzada R, Reyes-Chea J, Maldonado-Martínez G, Schneider RJ, Martínez-Montemayor MM.
  • Am J Cancer Res. 2022 Mar 15;12(3):1282-1294.
  • PMCID: PMC8984902

  Suárez-Arroyo IJ, et al.

  Am J Cancer Res. 2022.

  PMCID: PMC8984902

  Because studies show that medicinal mushroom Ganoderma lucidum (GLE) sensitizes cancer cells to radiation and other drugs; herein, we aimed to investigate the therapeutic potential of GLE, alone or in combination with carboplatin in breast cancer models. ...

  Because studies show that medicinal mushroom Ganoderma lucidum (GLE) sensitizes cancer cells to radiation and other drugs; her …
• 429.

  Transcriptome and metabolome analyses reveal transcription factors regulating ganoderic acid biosynthesis in Ganoderma lucidum development.

  • Meng L, Zhou R, Lin J, Zang X, Wang Q, Wang P, Wang L, Li Z, Wang W.
  • Front Microbiol. 2022 Aug 4;13:956421. doi: 10.3389/fmicb.2022.956421.
  • PMCID: PMC9386254

  Meng L, et al.

  Front Microbiol. 2022.

  PMCID: PMC9386254

  Ganoderma lucidum is an important medicinal fungus in Asian countries. Ganoderic acid (GA) is the major variety of bioactive and medicative components in G. lucidum. ...The analysis of predicted occurrences of DNA-binding domains revealed a set of 53 potentia …

  Ganoderma lucidum is an important medicinal fungus in Asian countries. Ganoderic acid (GA) is the major variety of bioactive a …
• 430.

  Improved ganoderic acids production in Ganoderma lucidum by wood decaying components.

  • Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X.
  • Sci Rep. 2017 Apr 19;7:46623. doi: 10.1038/srep46623.
  • PMCID: PMC5395960

  Hu Y, et al.

  Sci Rep. 2017.

  PMCID: PMC5395960

  Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). ...Our data indicated that MCC and D-galactose might be further industrialized for higher GAs pro …

  Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major ac …

• 431.

  Ganoderma lucidum inspired silver nanoparticles and its biomedical applications with special reference to drug resistant Escherichia coli isolates from CAUTI.

  • Al-Ansari MM, Dhasarathan P, Ranjitsingh AJA, Al-Humaid LA.
  • Saudi J Biol Sci. 2020 Sep 10;27(11):2993-3002. doi: 10.1016/j.sjbs.2020.09.008.
  • PMCID: PMC7569111

  Al-Ansari MM, et al.

  Saudi J Biol Sci. 2020.

  PMCID: PMC7569111

  Fungal bioactive compounds and their nanoparticles were reported with the potential biomedical application. A medicinal mushroom Ganoderma lucidum was reported as a repository of rich medicinal properties. In the current study, silver nanoparticles were synthesized …

  Fungal bioactive compounds and their nanoparticles were reported with the potential biomedical application. A medicinal mushroom Ganoderm …
• 432.

  Apoptosis induced by 9,11-dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl-1 dependent.

  • Zheng L, Wong YS, Shao M, Huang S, Wang F, Chen J.
  • Mol Med Rep. 2018 May 17;18(1):938-944. doi: 10.3892/mmr.2018.9035.
  • PMCID: PMC6059726

  Zheng L, et al.

  Mol Med Rep. 2018.

  PMCID: PMC6059726

  In the present study, the steroid from Ganoderma lucidum was purified on a submerged culture, and its antitumor mechanisms on A375 human malignant melanoma cells was investigated by MTT, flow cytometry and western blotting. ...The present study also suggests that my …

  In the present study, the steroid from Ganoderma lucidum was purified on a submerged culture, and its antitumor mechanisms on …
• 433.

  From agro-waste to tool: biotechnological characterization and application of Ganoderma lucidum E47 laccase in dye decolorization.

  • Palazzolo MA, Postemsky PD, Kurina-Sanz M.
  • 3 Biotech. 2019 May 16;9(6):213. doi: 10.1007/s13205-019-1744-2.
  • PMCID: PMC6522593

  Palazzolo MA, et al.

  3 Biotech. 2019.

  PMCID: PMC6522593

  The culture of fungal species from agro-waste allows for the sustainable preparation of valuable biotechnological products and contributes to establish the Circular Economy concept. The Ganoderma lucidum species is well known as producer of laccases (EC 1.10.3.2), w …

  The culture of fungal species from agro-waste allows for the sustainable preparation of valuable biotechnological products and contributes t …
• 434.

  Green Synthesis of ZnO Nanoparticles via Ganoderma Lucidum Extract: Structural and Functional Analysis in Polymer Composites.

  • Can A, Kızılbey K.
  • Gels. 2024 Sep 4;10(9):576. doi: 10.3390/gels10090576.
  • PMCID: PMC11431147

  Can A, et al.

  Gels. 2024.

  PMCID: PMC11431147

  This study presents the green synthesis of zinc oxide (ZnO) nanoparticles (ZnNPs) using Ganoderma Lucidum mushroom extract, characterized by DLS, SEM, XRD, and FTIR spectroscopy analyses. ...This pioneering study demonstrates the potential of Ganoderma Luc …

  This study presents the green synthesis of zinc oxide (ZnO) nanoparticles (ZnNPs) using Ganoderma Lucidum mushroom extract, ch …
• 435.

  Ganoderma lucidum polysaccharides counteract inhibition on CD71 and FasL expression by culture supernatant of B16F10 cells upon lymphocyte activation.

  • Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li M, Xing EH, Lan TF, Jiang MM, Yang N, Li WD.
  • Exp Ther Med. 2013 Jan 29;5(4):1117-1122. doi: 10.3892/etm.2013.931.
  • PMCID: PMC3628224

  Sun LX, et al.

  Exp Ther Med. 2013.

  PMCID: PMC3628224

  A potential component with this effect is Ganoderma lucidum polysaccharides (Gl-PS). In this study, Gl-PS was used on lymphocytes incubating with culture supernatant of B16F10 melanoma cells (B16F10-CS) in the presence of phytohemagglutinin. ...

  A potential component with this effect is Ganoderma lucidum polysaccharides (Gl-PS). In this study, Gl-PS was used on lymphocy …
• 436.

  Manganese affects the growth and metabolism of Ganoderma lucidum based on LC-MS analysis.

  • Zhang B, Zhou J, Li Q, Gan B, Peng W, Zhang X, Tan W, Jiang L, Li X.
  • PeerJ. 2019 May 1;7:e6846. doi: 10.7717/peerj.6846.
  • PMCID: PMC6500383

  Zhang B, et al.

  PeerJ. 2019.

  PMCID: PMC6500383

  BACKGROUND: As a metal-enriched edible fungus, Ganoderma lucidum is capable of adsorbing manganese effectively. And the manganese ion is demonstrated to play an important role in the synthesis of manganese peroxidase (Mnp) and other physiological activities during G …

  BACKGROUND: As a metal-enriched edible fungus, Ganoderma lucidum is capable of adsorbing manganese effectively. And the mangan …
• 437.

  ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells.

  • Sohretoglu D, Zhang C, Luo J, Huang S.
  • Signal Transduct Target Ther. 2019 Jun 28;4:21. doi: 10.1038/s41392-019-0056-7.
  • PMCID: PMC6799808

  Sohretoglu D, et al.

  Signal Transduct Target Ther. 2019.

  PMCID: PMC6799808

  Ganoderma lucidum (G. lucidum) extracts, as dietary supplements, have been found to exert potent anticancer activity, which is attributed to the presence of polysaccharides and triterpenes. However, the molecular mechanism underlying the anticancer action of …

  Ganoderma lucidum (G. lucidum) extracts, as dietary supplements, have been found to exert potent anticancer activity, w …
• 438.

  Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.

  • Deepalakshmi K, Mirunalini S.
  • Pharmacogn Mag. 2013 Apr;9(34):167-75. doi: 10.4103/0973-1296.111286.
  • PMCID: PMC3680858

  Deepalakshmi K, et al.

  Pharmacogn Mag. 2013.

  PMCID: PMC3680858

  BACKGROUND: Mushrooms are an important natural source represents a major and untapped potent pharmaceutical product. Ganoderma lucidum (G. lucidum) an important medicinal mushroom has been shown to contain high amount of antioxidant. ...Therefore, the dietary …

  BACKGROUND: Mushrooms are an important natural source represents a major and untapped potent pharmaceutical product. Ganoderma luc …
• 439.

  Hyperproduction of exopolysaccharides by submerged mycelial culture of Ganoderma lucidum using a solid seed grown in fine-powder of wheat bran and in vitro evaluation of the antioxidant activity of the exopolysaccharides produced.

  • Liu SR, Zhang WR.
  • Food Sci Biotechnol. 2018 Feb 28;27(4):1129-1136. doi: 10.1007/s10068-018-0343-z.
  • PMCID: PMC6085248

  Liu SR, et al.

  Food Sci Biotechnol. 2018.

  PMCID: PMC6085248

  To facilitate Ganoderma lucidum submerged culture and obtain high productivity, a fine powder of wheat bran was used to grow the fungus for solid-state fermentation and as solid seed for its submerged cultures. ...The developed solid seed can serve as a ready-to-use …

  To facilitate Ganoderma lucidum submerged culture and obtain high productivity, a fine powder of wheat bran was used to grow t …
• 440.

  Reconstruction and Analysis of a Genome-Scale Metabolic Model of Ganoderma lucidum for Improved Extracellular Polysaccharide Production.

  • Ma Z, Ye C, Deng W, Xu M, Wang Q, Liu G, Wang F, Liu L, Xu Z, Shi G, Ding Z.
  • Front Microbiol. 2018 Dec 11;9:3076. doi: 10.3389/fmicb.2018.03076.
  • PMCID: PMC6298397

  Ma Z, et al.

  Front Microbiol. 2018.

  PMCID: PMC6298397

  In this study, we reconstructed for the first time a genome-scale metabolic model (GSMM) of Ganoderma lucidum strain CGMCC5.26, termed model iZBM1060, containing 1060 genes, 1202 metabolites, and 1404 reactions. ...Model iZBM1060 provides a useful platform for regul …

  In this study, we reconstructed for the first time a genome-scale metabolic model (GSMM) of Ganoderma lucidum strain CGMCC5.26 …

• 441.

  Acrylamide Content of Experimental Flatbreads Prepared from Potato, Quinoa, and Wheat Flours with Added Fruit and Vegetable Peels and Mushroom Powders.

  • Crawford LM, Kahlon TS, Wang SC, Friedman M.
  • Foods. 2019 Jun 26;8(7):228. doi: 10.3390/foods8070228.
  • PMCID: PMC6678822

  Crawford LM, et al.

  Foods. 2019.

  PMCID: PMC6678822

  To further enhance the functionality of flatbreads, we have developed, in this work, new experimental flatbreads using potato, quinoa, and wheat flours supplemented with peel powders prepared from commercial nonorganic and organic fruits and vegetables (apples, cherry tomatoes, m …

  To further enhance the functionality of flatbreads, we have developed, in this work, new experimental flatbreads using potato, quinoa, and w …
• 442.

  Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.

  • Zhong B, Li FL, Zhao JY, Fu Y, Peng C.
  • Food Nutr Res. 2022 Oct 12;66. doi: 10.29219/fnr.v66.8745.
  • PMCID: PMC9602201

  Zhong B, et al.

  Food Nutr Res. 2022.

  PMCID: PMC9602201

  OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidum (SSPL) against obese mice fed with a high-fat diet. METHODS: Four groups of C57BL/6J mice were randomly assigned to the following diet …

  OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidu …
• 443.

  Immunostimulatory effects of a subcritical water extract of Ganoderma.

  • Hattori K, Takagi H, Ogata Y, Yamada T, Horiba H, Fukata K, Sakaida T, Yashiro Y, Hasegawa S, Tanaka H.
  • Biomed Rep. 2022 Nov 9;18(1):1. doi: 10.3892/br.2022.1583.
  • PMCID: PMC9756285

  Hattori K, et al.

  Biomed Rep. 2022.

  PMCID: PMC9756285

  Ganoderma, a medicinal mushroom with various physiological activities, has been extensively investigated regarding its effectiveness. ...These results were not obtained in experiments using hot water extract of Ganoderma lucidum and Ganoderma sinense. …

  Ganoderma, a medicinal mushroom with various physiological activities, has been extensively investigated regarding its effectiveness. …
• 444.

  Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway.

  • Zhao X, Zhou D, Liu Y, Li C, Zhao X, Li Y, Li W.
  • Mol Med Rep. 2017 Oct 26;17(1):147-157. doi: 10.3892/mmr.2017.7904.
  • PMCID: PMC5780085

  Zhao X, et al.

  Mol Med Rep. 2017.

  PMCID: PMC5780085

  At present, the molecular mechanisms of growth and migration in human prostate cancer have not been completely elucidated. Studies have demonstrated that Ganoderma lucidum polysaccharides (GLP) can inhibit cancer. Therefore the present study investigated the effect …

  At present, the molecular mechanisms of growth and migration in human prostate cancer have not been completely elucidated. Studies have demo …
• 445.

  Polysaccharides of Sporoderm-Broken Spore of Ganoderma lucidum Modulate Adaptive Immune Function via Gut Microbiota Regulation.

  • Su L, Li D, Su J, Zhang E, Chen S, Zheng C, Luo T, Li M, Chen X, Huang G, Xie Y, Li S.
  • Evid Based Complement Alternat Med. 2021 Mar 23;2021:8842062. doi: 10.1155/2021/8842062.
  • PMCID: PMC8009716

  Su L, et al.

  Evid Based Complement Alternat Med. 2021.

  PMCID: PMC8009716

  Ganoderma lucidum (Leyss.Fr.) Karst is one of the well-known medicinal macrofungi all over the world, and mounting researches have focused on the polysaccharides derived from the spores of G. lucidum. In the present study, BALB/c mice (n = 8-10) were administ …

  Ganoderma lucidum (Leyss.Fr.) Karst is one of the well-known medicinal macrofungi all over the world, and mounting researches …
• 446.

  Optimization of submerged culture conditions involving a developed fine powder solid seed for exopolysaccharide production by the medicinal mushroom Ganoderma lucidum.

  • Liu SR, Zhang WR.
  • Food Sci Biotechnol. 2018 Dec 12;28(4):1135-1145. doi: 10.1007/s10068-018-0536-5.
  • PMCID: PMC6595012

  Liu SR, et al.

  Food Sci Biotechnol. 2018.

  PMCID: PMC6595012

  To facilitate Ganoderma lucidum submerged cultivation and achieve high productivity, four fine powder solid substrates incorporated with different nitrogen-rich supplements were utilized to grow the fungus and as solid seed for its submerged culture. ...The develope …

  To facilitate Ganoderma lucidum submerged cultivation and achieve high productivity, four fine powder solid substrates incorpo …
• 447.

  Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities.

  • Tajik A, Samadlouie HR, Salek Farrokhi A, Ghasemi A.
  • Front Microbiol. 2024 Jan 22;14:1280405. doi: 10.3389/fmicb.2023.1280405.
  • PMCID: PMC10839005

  Tajik A, et al.

  Front Microbiol. 2024.

  PMCID: PMC10839005

  Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiological effects on human health. ...In addition, the IC50 levels of shell and stem of G. lucidum were 465.3 and 485.7 mug/mL, respectiv …

  Ganoderma lucidum (G. lucidum) is a medicinal mushroom that is known for its ability to produce compounds with physiolo …
• 448.

  Development of an Efficient Strategy to Improve Extracellular Polysaccharide Production of Ganoderma lucidum Using L-Phenylalanine as an Enhancer.

  • Ma Z, Xu M, Wang Q, Wang F, Zheng H, Gu Z, Li Y, Shi G, Ding Z.
  • Front Microbiol. 2019 Oct 15;10:2306. doi: 10.3389/fmicb.2019.02306.
  • PMCID: PMC6804554

  Ma Z, et al.

  Front Microbiol. 2019.

  PMCID: PMC6804554

  Ganoderma lucidum has been a well-known species of basidiomycetes for a long time, and has been widely applied in the fields of food and medicine. Based on the simulation results of model iZBM1060 in our previous research, the effect of L-phenylalanine on G. luci …

  Ganoderma lucidum has been a well-known species of basidiomycetes for a long time, and has been widely applied in the fields o …
• 449.

  Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia.

  • Lei X, Zhi C, Huang W, Sun X, Gao W, Yin X, Zhang X, Liang C, Zhang H, Sun F.
  • Front Pharmacol. 2020 Jun 26;11:956. doi: 10.3389/fphar.2020.00956.
  • PMCID: PMC7333219

  Lei X, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7333219

  Ganoderma lucidum, also known as LINGZHI, has a long tradition of use in folk medicine of the Far East, which is documented in the oldest Chinese pharmacopoeia, declaring it a superior medicine. LINGZHI-8 (LZ-8) is an immunoregulatory fungal protein isolated from th …

  Ganoderma lucidum, also known as LINGZHI, has a long tradition of use in folk medicine of the Far East, which is documented in …
• 450.

  Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer.

  • Zhang H, Wang L, Chan YW, Cho WC, Zuo Z, To KKW.
  • Pharmaceutics. 2025 Jul 15;17(7):917. doi: 10.3390/pharmaceutics17070917.
  • PMCID: PMC12298319

  Zhang H, et al.

  Pharmaceutics. 2025.

  PMCID: PMC12298319

  In Asian countries, the concomitant use of Western medicine and traditional Chinese medicine (TCM) is very common. Ganoderma lucidum (Lingzhi) and Coriolus versicolor (Yunzhi) are popular TCMs that are widely consumed by cancer patients to enhance anticancer efficac …

  In Asian countries, the concomitant use of Western medicine and traditional Chinese medicine (TCM) is very common. Ganoderma lucid …

• 451.

  Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo.

  • Liu X, Xu Y, Li Y, Pan Y, Sun Z, Zhao S, Hou Y.
  • Am J Transl Res. 2020 Jun 15;12(6):2675-2684.
  • PMCID: PMC7344060

  Liu X, et al.

  Am J Transl Res. 2020.

  PMCID: PMC7344060

  Although previous studies have found that Ganoderma lucidum extracts have the ability to directly resist tumor proliferation and reduce metastasis and invasion, the effect of the extracts of Ganoderma lucidum fruiting body (GLE) on cancer is not clarif …

  Although previous studies have found that Ganoderma lucidum extracts have the ability to directly resist tumor proliferation a …
• 452.

  Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?

  • Rašeta M, Mišković J, Čapelja E, Zapora E, Petrović Fabijan A, Knežević P, Karaman M.
  • Molecules. 2023 Apr 6;28(7):3264. doi: 10.3390/molecules28073264.
  • PMCID: PMC10096548

  Rašeta M, et al.

  Molecules. 2023.

  PMCID: PMC10096548

  Ganoderma species have been recognized as potential antimicrobial (AM) agents and have been used in traditional Chinese medicine (TCM) for a long time. The aim of this study is to examine the AM potential of autochthonous Ganoderma species (G. applanatum, G. luci …

  Ganoderma species have been recognized as potential antimicrobial (AM) agents and have been used in traditional Chinese medicine (TCM …
• 453.

  Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice.

  • Zhonghui Z, Xiaowei Z, Fang F.
  • Saudi J Biol Sci. 2013 Apr 23;21(2):119-23. doi: 10.1016/j.sjbs.2013.04.004.
  • PMCID: PMC3942859

  Zhonghui Z, et al.

  Saudi J Biol Sci. 2013.

  PMCID: PMC3942859

  The present study was designed to determine the effects of Ganoderma lucidum polysaccharides (GL-PS) on exhaustive exercise-induced oxidative stress in skeletal muscle tissues of mice. ...

  The present study was designed to determine the effects of Ganoderma lucidum polysaccharides (GL-PS) on exhaustive exercise-in …
• 454.

  A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.

  • Thompson A, Hynicka LM, Shere-Wolfe KD.
  • Integr Med (Encinitas). 2023 Mar;22(1):30-38.
  • PMCID: PMC10124234

  Thompson A, et al.

  Integr Med (Encinitas). 2023.

  PMCID: PMC10124234

  The search used the keywords for 18 herbal compounds: (1) andrographis (Andrographis paniculate), (2) astragalus (Astragalus propinquus), (3) berberine, (4) cat's claw bark (Uncaria tomentosa), (5) cordyceps (Cordyceps sinensis), (6) cryptolepis (Cryptolepis sanguinolenta), (7) C …

  The search used the keywords for 18 herbal compounds: (1) andrographis (Andrographis paniculate), (2) astragalus (Astragalus propinquus), (3 …
• 455.

  Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress.

  • Kim S, Kim J, Kim JL, Park MR, Park KW, Chung KW.
  • Antioxidants (Basel). 2025 Mar 28;14(4):409. doi: 10.3390/antiox14040409.
  • PMCID: PMC12024243

  Kim S, et al.

  Antioxidants (Basel). 2025.

  PMCID: PMC12024243

  This study aimed to investigate the effects of a Ganoderma lucidum and Robinia pseudoacacia flower extract complex (NEPROBIN) through in vitro and in vivo experiments. ...

  This study aimed to investigate the effects of a Ganoderma lucidum and Robinia pseudoacacia flower extract complex (NEPROBIN) …
• 456.

  An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method.

  • Tan Y, Yu X, Zhang Z, Tian J, Feng N, Tang C, Zou G, Zhang J.
  • J Fungi (Basel). 2023 Dec 5;9(12):1170. doi: 10.3390/jof9121170.
  • PMCID: PMC10745038

  Tan Y, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10745038

  In this study, we developed and optimized an RNP-mediated CRISPR/Cas9 genome editing system for the monokaryotic strain L1 from the Ganoderma lucidum cultivar 'Hunong No. 1'. On selective media containing 5-fluoroorotic acid (5-FOA), the targeting efficiency of the …

  In this study, we developed and optimized an RNP-mediated CRISPR/Cas9 genome editing system for the monokaryotic strain L1 from the Ganod …
• 457.

  ZnO and Ag NP-decorated ZnO nanoflowers: green synthesis using Ganoderma lucidum aqueous extract and characterization.

  • Smirnov O, Dzhagan V, Kovalenko M, Gudymenko O, Dzhagan V, Mazur N, Isaieva O, Maksimenko Z, Kondratenko S, Skoryk M, Yukhymchuk V.
  • RSC Adv. 2023 Jan 3;13(1):756-763. doi: 10.1039/d2ra05834k.
  • PMCID: PMC9809204

  Smirnov O, et al.

  RSC Adv. 2023.

  PMCID: PMC9809204

  ZnO NPs with a flower-like morphology were synthesized by an affordable colloidal route, using an aqueous extract of Ganoderma lucidum as a reducing agent and stabilizer. Each individual "flower" has a large effective surface, which is preserved when the particles a …

  ZnO NPs with a flower-like morphology were synthesized by an affordable colloidal route, using an aqueous extract of Ganoderma luc …
• 458.

  Polysaccharide prediction in Ganoderma lucidum fruiting body by hyperspectral imaging.

  • Liu Y, Long Y, Liu H, Lan Y, Long T, Kuang R, Wang Y, Zhao J.
  • Food Chem X. 2021 Dec 29;13:100199. doi: 10.1016/j.fochx.2021.100199.
  • PMCID: PMC9039882

  Liu Y, et al.

  Food Chem X. 2021.

  PMCID: PMC9039882

  Ganoderma lucidum polysaccharide plays a vital role in improving human immunity and anti-oxidation. ...This study indicates that HSI can quickly and nondestructive detect the polysaccharide content of Ganoderma lucidum, provide guidance for the cultiva …

  Ganoderma lucidum polysaccharide plays a vital role in improving human immunity and anti-oxidation. ...This study indicates th …
• 459.

  Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress.

  • Guo SS, Cui XL, Rausch WD.
  • Am J Neurodegener Dis. 2016 Jun 1;5(2):131-44.
  • PMCID: PMC4913221

  Guo SS, et al.

  Am J Neurodegener Dis. 2016.

  PMCID: PMC4913221

  Polysaccharides are the main active constituents from Ganoderma lucidum which is characterized with anti-oxidant, antitumor and immunostimulant properties. In the present study, primary dopaminergic cell cultures prepared from embryonic mouse mesencephala were used …

  Polysaccharides are the main active constituents from Ganoderma lucidum which is characterized with anti-oxidant, antitumor an …
• 460.

  Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene.

  • Meng L, Zhou R, Lin J, Wang Q, Wang P, Wang W, Wang L, Li Z.
  • J Fungi (Basel). 2022 Apr 28;8(5):456. doi: 10.3390/jof8050456.
  • PMCID: PMC9146657

  Meng L, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9146657

  Ganoderic acid (GA) is an important secondary metabolite of Ganoderma lucidum with a diverse array of pharmacological properties. In this study, we found that exogenous ethylene increased the production of endogenous ethylene and ganoderic acid in G. lucidum. …

  Ganoderic acid (GA) is an important secondary metabolite of Ganoderma lucidum with a diverse array of pharmacological properti …

• 461.

  Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway.

  • Kuo HP, Hsu SC, Ou CC, Li JW, Tseng HH, Chuang TC, Liu JY, Chen SJ, Su MH, Cheng YC, Chou WY, Kao MC.
  • Evid Based Complement Alternat Med. 2013 Apr 7;2013:219472. doi: 10.1155/2013/219472.
  • PMCID: PMC3638576

  Kuo HP, et al.

  Evid Based Complement Alternat Med. 2013.

  PMCID: PMC3638576

  Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. ...In this study, we investigated the molecular mechanisms by which Ganoderma tsugae (GT), one of the most common species of Ganoderma, i …

  Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. ...In this …
• 462.

  Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic.

  • Xia QH, Lu CT, Tong MQ, Yue M, Chen R, Zhuge DL, Yao Q, Xu HL, Zhao YZ.
  • Front Pharmacol. 2021 Jul 6;12:648708. doi: 10.3389/fphar.2021.648708.
  • PMCID: PMC8290260

  Xia QH, et al.

  Front Pharmacol. 2021.

  PMCID: PMC8290260

  PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ...

  PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the …
• 463.

  Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.

  • Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G.
  • Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120.
  • PMCID: PMC10299416

  Gariboldi MB, et al.

  Int J Mol Sci. 2023.

  PMCID: PMC10299416

  In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus. We also report insights …

  In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris …
• 464.

  Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.

  • Mao FF, Gao SS, Huang YJ, Zhou N, Feng JK, Liu ZH, Zhang YQ, Yuan LY, Wei G, Cheng SQ.
  • Front Nutr. 2023 Feb 14;10:1076569. doi: 10.3389/fnut.2023.1076569.
  • PMCID: PMC9971728

  Mao FF, et al.

  Front Nutr. 2023.

  PMCID: PMC9971728

  BACKGROUND: Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma triterpenoids (GTs) have been verified as an alternative adjuvant for treating leukemia, cancer, hepatitis and diabetes. ...

  BACKGROUND: Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma tr …
• 465.

  Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.

  • Bryant JM, Bouchard M, Haque A.
  • J Clin Cell Immunol. Author manuscript. 2017 Dec 12;8(6):535. doi: 10.4172/2155-9899.1000535.
  • PMCID: PMC5795599

  Bryant JM, et al.

  J Clin Cell Immunol. Author manuscript. 2017.

  PMCID: PMC5795599

  Ganoderma lucidum is a mushroom that has a long history of medicinal use in the Far East countries as this mushroom is revered for its supposed miracle cures and life improving properties. ...The main category of biologically active compounds produced in the G. l …

  Ganoderma lucidum is a mushroom that has a long history of medicinal use in the Far East countries as this mushroom is revered …
• 466.

  Gllac7 Is Induced by Agricultural and Forestry Residues and Exhibits Allelic Expression Bias in Ganoderma lucidum.

  • Wang L, Ding X, Huang Q, Hu B, Liang L, Wang Q.
  • Front Microbiol. 2022 Jun 30;13:890686. doi: 10.3389/fmicb.2022.890686.
  • PMCID: PMC9279560

  Wang L, et al.

  Front Microbiol. 2022.

  PMCID: PMC9279560

  Ganoderma lucidum has a wide carbon spectrum, while the expression profile of key genes relevant to carbon metabolism on different carbon sources has been seldom studied. Here, the transcriptomes of G. lucidum mycelia cultured on each of 19 carbon sources wer …

  Ganoderma lucidum has a wide carbon spectrum, while the expression profile of key genes relevant to carbon metabolism on diffe …
• 467.

  Ethanol Extract of Ganoderma lucidum Augments Cellular Anti-oxidant Defense through Activation of Nrf2/HO-1.

  • Lee YH, Kim JH, Song CH, Jang KJ, Kim CH, Kang JS, Choi YH, Yoon HM.
  • J Pharmacopuncture. 2016 Mar;19(1):59-69. doi: 10.3831/KPI.2016.19.008.
  • PMCID: PMC4887753

  Lee YH, et al.

  J Pharmacopuncture. 2016.

  PMCID: PMC4887753

  OBJECTIVES: The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. ...The present study investigated the cytoprotective effect of ethanol extract of Ganoderma lucidum (EGL) against oxidative stress (hydroge …

  OBJECTIVES: The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. ...The presen …
• 468.

  Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression.

  • Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM.
  • J Cancer. 2016 Feb 5;7(5):500-11. doi: 10.7150/jca.13599.
  • PMCID: PMC4780125

  Suárez-Arroyo IJ, et al.

  J Cancer. 2016.

  PMCID: PMC4780125

  Here, we investigate the therapeutic potential of Ganoderma lucidum extract (GLE) in breast cancer, focusing on the regulation of the EGFR signaling cascade when treated with the EGFR TKI, Erlotinib. ...

  Here, we investigate the therapeutic potential of Ganoderma lucidum extract (GLE) in breast cancer, focusing on the regulation …
• 469.

  Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway.

  • Liang Z, Yuan Z, Guo J, Wu J, Yi J, Deng J, Shan Y.
  • Int J Mol Sci. 2019 Jan 23;20(3):478. doi: 10.3390/ijms20030478.
  • PMCID: PMC6387170

  Liang Z, et al.

  Int J Mol Sci. 2019.

  PMCID: PMC6387170

  Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) ...

  Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) ...
• 470.

  Root-Knot Disease Suppression in Eggplant Based on Three Growth Ages of Ganoderma lucidum.

  • Fatima S, Khan F, Asif M, Alotaibi SS, Islam K, Shariq M, Khan A, Ikram M, Ahmad F, Khan TA, Meena R, Siddiqui MA.
  • Microorganisms. 2022 May 23;10(5):1068. doi: 10.3390/microorganisms10051068.
  • PMCID: PMC9144836

  Fatima S, et al.

  Microorganisms. 2022.

  PMCID: PMC9144836

  This investigation presents a novel finding showing the effect of culture filtrates (CFs) of macrofungi, Ganoderma lucidum, against Meloidogyne incognita evaluated in vitro and in planta. To determine the nematicidal activity, juveniles of M. incognita were exposed …

  This investigation presents a novel finding showing the effect of culture filtrates (CFs) of macrofungi, Ganoderma lucidum, ag …

• 471.

  Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.

  • Phan CW, David P, Naidu M, Wong KH, Sabaratnam V.
  • BMC Complement Altern Med. 2013 Oct 11;13:261. doi: 10.1186/1472-6882-13-261.
  • PMCID: PMC3852280

  Phan CW, et al.

  BMC Complement Altern Med. 2013.

  PMCID: PMC3852280

  In vitro cytotoxicity was investigated by using mouse embryonic fibroblast (BALB/3T3) and N2a cells for any embryo- and neuro-toxic effects; respectively. RESULTS: Aqueous extracts of Ganoderma lucidum, Lignosus rhinocerotis, Pleurotus giganteus and Grifola frondosa …

  In vitro cytotoxicity was investigated by using mouse embryonic fibroblast (BALB/3T3) and N2a cells for any embryo- and neuro-toxic effects; …
• 472.

  Hypouricemic Effect of Submerged Culture of Ganoderma lucidum in Potassium Oxonate-Induced Hyperuricemic Rats.

  • Huang CH, Chen TY, Tsai GJ.
  • Metabolites. 2022 Jun 16;12(6):553. doi: 10.3390/metabo12060553.
  • PMCID: PMC9227023

  Huang CH, et al.

  Metabolites. 2022.

  PMCID: PMC9227023

  The objective of this study was to investigate the hypouricemic effects of submerged culture of Ganoderma lucidum. The lyophilized powder of mycelium (GM) and extracellular polysaccharides (GP) of the G. lucidum submerged culture were prepared. ...These resul …

  The objective of this study was to investigate the hypouricemic effects of submerged culture of Ganoderma lucidum. The lyophil …
• 473.

  Water Extract of Sporoderm-Broken Spores of Ganoderma lucidum Induces Osteosarcoma Apoptosis and Restricts Autophagic Flux.

  • Zhang W, Lei Z, Meng J, Li G, Zhang Y, He J, Yan W.
  • Onco Targets Ther. 2019 Dec 31;12:11651-11665. doi: 10.2147/OTT.S226850.
  • PMCID: PMC6942530

  Zhang W, et al.

  Onco Targets Ther. 2019.

  PMCID: PMC6942530

  PURPOSE: Osteosarcoma (OS) is a malignant bone tumor with easy metastasis and poor prognosis. Ganoderma lucidum (G. lucidum), a traditional Chinese medicine, was reported playing a critical role in suppressing multiple tumor progress. So we wanted to investig …

  PURPOSE: Osteosarcoma (OS) is a malignant bone tumor with easy metastasis and poor prognosis. Ganoderma lucidum (G. lucidum …
• 474.

  Indian medicinal mushrooms as a source of antioxidant and antitumor agents.

  • A Ajith T, K Janardhanan K.
  • J Clin Biochem Nutr. 2007 May;40(3):157-62. doi: 10.3164/jcbn.40.157.
  • PMCID: PMC2275760

  A Ajith T, et al.

  J Clin Biochem Nutr. 2007.

  PMCID: PMC2275760

  Medicinal mushrooms occurring in South India namely Ganoderma lucidum, Phellinus rimosus, Pleurotus florida and Pleurotus pulmonaris possessed profound antioxidant and antitumor activities. ...

  Medicinal mushrooms occurring in South India namely Ganoderma lucidum, Phellinus rimosus, Pleurotus florida and Pleurotus pulm …
• 475.

  Comparative Mitogenomics Provides Valuable Insights for the Phylogeny and New DNA Barcodes of Ganoderma.

  • Chen TQ, Yang C, Xu XL, Yang L, He HQ, Weng MT, Ying ZH, Shi XK, Ding MG.
  • J Fungi (Basel). 2024 Nov 5;10(11):769. doi: 10.3390/jof10110769.
  • PMCID: PMC11595954

  Chen TQ, et al.

  J Fungi (Basel). 2024.

  PMCID: PMC11595954

  Herein, four novel mitogenomes of commonly cultivated Ganoderma (G. leucocontextum H4, G. lucidum G6, G. sinense MZ96 and G. tsugae SS) were de novo assembled and given detail functional annotations. ...And finally, we found that the atp9 and nad4L were the most rel …

  Herein, four novel mitogenomes of commonly cultivated Ganoderma (G. leucocontextum H4, G. lucidum G6, G. sinense MZ96 and G. t …
• 476.

  Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice.

  • Zeng M, Qi L, Guo Y, Zhu X, Tang X, Yong T, Xie Y, Wu Q, Zhang M, Chen D.
  • Front Aging Neurosci. 2021 May 6;13:628860. doi: 10.3389/fnagi.2021.628860.
  • PMCID: PMC8134542

  Zeng M, et al.

  Front Aging Neurosci. 2021.

  PMCID: PMC8134542

  In this study, long-term administration of triterpenoids of Ganoderma lucidum (TGL) can mitigate brain physiological decline in normal aging mice. In addition, the age-associated pathological features, including cataract formation, hair loss, and skin relaxation, br …

  In this study, long-term administration of triterpenoids of Ganoderma lucidum (TGL) can mitigate brain physiological decline i …
• 477.

  Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-kappaB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells.

  • Yoon HM, Jang KJ, Han MS, Jeong JW, Kim GY, Lee JH, Choi YH.
  • Exp Ther Med. 2013 Jan 15;5(3):957-963. doi: 10.3892/etm.2013.895.
  • PMCID: PMC3570243

  Yoon HM, et al.

  Exp Ther Med. 2013.

  PMCID: PMC3570243

  Ganoderma lucidum is a traditional Oriental medicine that has been widely used as a tonic to promote longevity and health in Korea and other Asian countries. ...In this study, we evaluated the inhibitory effects of G. lucidum ethanol extract (EGL) on the prod …

  Ganoderma lucidum is a traditional Oriental medicine that has been widely used as a tonic to promote longevity and health in K …
• 478.

  Ganoderma tsuage promotes pain sensitivity in aging mice.

  • Yang KN, Lin CY, Li WN, Tang CM, Pradhan J, Chao MW, Tseng CY.
  • Sci Rep. 2024 May 21;14(1):11536. doi: 10.1038/s41598-024-61499-0.
  • PMCID: PMC11109092

  Yang KN, et al.

  Sci Rep. 2024.

  PMCID: PMC11109092

  Health food is a geriatric healthcare choice for the elderly with Ganoderma tsuage (GT), a Reishi type, as the main product in the market. GT contains polysaccharides, triterpenoids, adenosine, immunoregulatory proteins, and other components, including anticancer, b …

  Health food is a geriatric healthcare choice for the elderly with Ganoderma tsuage (GT), a Reishi type, as the main product in …
• 479.

  Mushroom beta-Glucan Recovered from Antler-Type Fruiting Body of Ganoderma lucidum by Enzymatic Process and Its Potential Biological Activities for Cosmeceutical Applications.

  • Vaithanomsat P, Boonlum N, Chaiyana W, Tima S, Anuchapreeda S, Trakunjae C, Apiwatanapiwat W, Janchai P, Boondaeng A, Nimitkeatkai H, Jarerat A.
  • Polymers (Basel). 2022 Oct 7;14(19):4202. doi: 10.3390/polym14194202.
  • PMCID: PMC9573635

  Vaithanomsat P, et al.

  Polymers (Basel). 2022.

  PMCID: PMC9573635

  This research applied a process for recovering beta-glucan (BG) from the antler-type fruiting body of Ganoderma lucidum as well as tested the biological activities related to cosmeceutical applications. ...These findings provided new insights into the potential appl …

  This research applied a process for recovering beta-glucan (BG) from the antler-type fruiting body of Ganoderma lucidum as wel …
• 480.

  Inter and intraspecific genetic diversity (RAPD) among three most frequent species of macrofungi (Ganoderma lucidum, Leucoagricus sp. and Lentinus sp.) of Tropical forest of Central India.

  • Dwivedi S, Singh S, Chauhan UK, Tiwari MK.
  • J Genet Eng Biotechnol. 2017 Dec 2;16(1):133-141. doi: 10.1016/j.jgeb.2017.11.008.
  • PMCID: PMC6296601

  Dwivedi S, et al.

  J Genet Eng Biotechnol. 2017.

  PMCID: PMC6296601

  In present study seven RAPD primers were used to access the diversity within and among twelve populations of three mushroom species Ganoderma lucidum, leucoagaricus sp. and Lentinus sp. Total of 111 bands were scored by 7 RAPD primers in 30 accessions of three mushr …

  In present study seven RAPD primers were used to access the diversity within and among twelve populations of three mushroom species Ganod …

• 481.

  Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

  • Sułkowska-Ziaja K, Zengin G, Gunia-Krzyżak A, Popiół J, Szewczyk A, Jaszek M, Rogalski J, Muszyńska B.
  • Molecules. 2022 Jan 3;27(1):275. doi: 10.3390/molecules27010275.
  • PMCID: PMC8746335

  Sułkowska-Ziaja K, et al.

  Molecules. 2022.

  PMCID: PMC8746335

  The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G.&nbsp;applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. ...The total content of indole compounds in the extracts ranged …

  The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G.&nbsp; …
• 482.

  Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.

  • Liu J, Shimizu K, Tanaka A, Shinobu W, Ohnuki K, Nakamura T, Kondo R.
  • Sci Rep. 2012 Nov 30;2:905. doi: 10.1038/srep00905.
  • PMCID: PMC3510465

  Liu J, et al.

  Sci Rep. 2012.

  PMCID: PMC3510465

  Ganoderma fungus (Ganodermataceae) is a multifunctional medicinal mushroom and has been traditionally used for the treatment of various types of disease. ...

  Ganoderma fungus (Ganodermataceae) is a multifunctional medicinal mushroom and has been traditionally used for the treatment of vario …
• 483.

  Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.

  • Qin Y, Zhao Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Zhang GL, Cui SY, Zhang YH.
  • Front Pharmacol. 2024 Apr 24;15:1390294. doi: 10.3389/fphar.2024.1390294.
  • PMCID: PMC11076761

  Qin Y, et al.

  Front Pharmacol. 2024.

  PMCID: PMC11076761

  Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to improve restlessness, insomnia, and forgetfulness. We previously reported that a rat model of sporadic Alzheimer's disease (sAD) that was induced …

  Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to impro …
• 484.

  Ganoderma: A Cancer Immunotherapy Review.

  • Cao Y, Xu X, Liu S, Huang L, Gu J.
  • Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217.
  • PMCID: PMC6209820

  Cao Y, et al.

  Front Pharmacol. 2018.

  PMCID: PMC6209820

  Ganoderma is a significant source of natural fungal medicines and has been used for the treatment of various diseases for many years. ...This review provides guidance for future research into the role of Ganoderma in cancer immunotherapy....

  Ganoderma is a significant source of natural fungal medicines and has been used for the treatment of various diseases for many years. …
• 485.

  Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.

  • Abdelmoaty AAA, Chen J, Zhang K, Wu C, Li Y, Li P, Xu J.
  • Front Pharmacol. 2024 Sep 19;15:1422363. doi: 10.3389/fphar.2024.1422363.
  • PMCID: PMC11447279

  Abdelmoaty AAA, et al.

  Front Pharmacol. 2024.

  PMCID: PMC11447279

  BACKGROUND: Ganoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a variety of diseases. Different extractions from G. lucidum have been used to manage age-related diseases, including cancer. Neverthe …

  BACKGROUND: Ganoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a …
• 486.

  Management of Combined Therapy (Ceritinib, A. cinnamomea, G. lucidum, and Photobiomodulation) in Advanced Non-Small-Cell Lung Cancer: A Case Report.

  • Su CT, Wu JH.
  • Life (Basel). 2022 Jun 9;12(6):862. doi: 10.3390/life12060862.
  • PMCID: PMC9228003

  Su CT, et al.

  Life (Basel). 2022.

  PMCID: PMC9228003

  Here, we report a patient with advanced NSCLC who received combined therapy, including ceritinib, photobiomodulation (PBM), ACGL (Antrodia cinnamomea (A. cinnamomea), and Ganoderma lucidum (G. lucidum)). Based on combined therapy, suitable doses of A. cinnamo …

  Here, we report a patient with advanced NSCLC who received combined therapy, including ceritinib, photobiomodulation (PBM), ACGL (Antrodia c …
• 487.

  The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.

  • Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y.
  • Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150.
  • PMCID: PMC10516555

  Shahid A, et al.

  Front Pharmacol. 2023.

  PMCID: PMC10516555

  Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activity. ...

  Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activ …
• 488.

  Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via TNF/NF-κB/MAPKs Signaling Pathway.

  • Deng S, Zhong D, Dong Y, Qian Y, Wang B, Hu M, Liu M, Tan K, Zhang C, Tang H.
  • Food Sci Nutr. 2025 Mar 25;13(4):e70123. doi: 10.1002/fsn3.70123.
  • PMCID: PMC11936839

  Deng S, et al.

  Food Sci Nutr. 2025.

  PMCID: PMC11936839

  Ganoderma lucidum (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for its medicinal properties, particularly in alleviating respiratory issues like cough and asthma. ...Despite its widespread use, the effectiv …

  Ganoderma lucidum (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for …
• 489.

  Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review.

  • Wang L, Li JQ, Zhang J, Li ZM, Liu HG, Wang YZ.
  • RSC Adv. 2020 Nov 18;10(69):42084-42097. doi: 10.1039/d0ra07219b.
  • PMCID: PMC9057998

  Wang L, et al.

  RSC Adv. 2020.

  PMCID: PMC9057998

  In recent years, some natural products isolated from the fungi of the genus Ganoderma have been found to have anti-tumor, liver protection, anti-inflammatory, immune regulation, anti-oxidation, anti-viral, anti-hyperglycemic and anti-hyperlipidemic effects. ...The triterpe …

  In recent years, some natural products isolated from the fungi of the genus Ganoderma have been found to have anti-tumor, liver prote …
• 490.

  Advancement of Microwave-Assisted Biosynthesis for Preparing Au Nanoparticles Using Ganoderma lucidum Extract and Evaluation of Their Catalytic Reduction of 4-Nitrophenol.

  • Nguyen VP, Le Trung H, Nguyen TH, Hoang D, Tran TH.
  • ACS Omega. 2021 Nov 17;6(47):32198-32207. doi: 10.1021/acsomega.1c05033.
  • PMCID: PMC8638019

  Nguyen VP, et al.

  ACS Omega. 2021.

  PMCID: PMC8638019

  This study describes the biosynthesis of gold nanoparticles (AuNPs) using the extract of Ganoderma lucidum in the buffer zone of Bach Ma National Park, Vietnam, as a reducing and protecting agent using microwave-assisted synthesis. ...

  This study describes the biosynthesis of gold nanoparticles (AuNPs) using the extract of Ganoderma lucidum in the buffer zone …

• 491.

  Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes.

  • Yue QX, Xie FB, Guan SH, Ma C, Yang M, Jiang BH, Liu X, Guo DA.
  • Cancer Sci. 2008 Apr 16;99(7):1461-70. doi: 10.1111/j.1349-7006.2008.00824.x.
  • PMCID: PMC11159042

  Yue QX, et al.

  Cancer Sci. 2008.

  PMCID: PMC11159042

  Triterpenes are the main components with cytotoxicity in Ganoderma lucidum, which is used popularly as a complementary treatment for cancer therapy in traditional Chinese medicine. To investigate the possible interaction between chemotherapeutic agents and triterpen …

  Triterpenes are the main components with cytotoxicity in Ganoderma lucidum, which is used popularly as a complementary treatme …
• 492.

  A Review of Ganoderma Triterpenoids and Their Bioactivities.

  • Galappaththi MCA, Patabendige NM, Premarathne BM, Hapuarachchi KK, Tibpromma S, Dai DQ, Suwannarach N, Rapior S, Karunarathna SC.
  • Biomolecules. 2022 Dec 22;13(1):24. doi: 10.3390/biom13010024.
  • PMCID: PMC9856212

  Galappaththi MCA, et al.

  Biomolecules. 2022.

  PMCID: PMC9856212

  For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous publications are stating that Ganoderma species have a variety of beneficial medicinal properties, and investigations on different met …

  For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous p …
• 493.

  Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus.

  • Zhang W, Zhang Q, Deng W, Li Y, Xing G, Shi X, Du Y.
  • Neural Regen Res. 2014 Aug 1;9(15):1446-52. doi: 10.4103/1673-5374.139461.
  • PMCID: PMC4192946

  Zhang W, et al.

  Neural Regen Res. 2014.

  PMCID: PMC4192946

  This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion injury in rats. ...These results suggest that pretreatment with ganoderma lucidum …

  This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric …
• 494.

  The Versatile Functions of G. Lucidum Polysaccharides and G. Lucidum Triterpenes in Cancer Radiotherapy and Chemotherapy.

  • Xu J, Chen F, Wang G, Liu B, Song H, Ma T.
  • Cancer Manag Res. 2021 Aug 17;13:6507-6516. doi: 10.2147/CMAR.S319732.
  • PMCID: PMC8380140

  Xu J, et al.

  Cancer Manag Res. 2021.

  PMCID: PMC8380140

  G. lucidum has a long history of thousands of years in China and is closely related with the lives of the Chinese people. ...At present, many cancer research studies have reported the G. lucidum polysaccharides (GLPs) and G. lucidum triterpenes (GLTs) as the …

  G. lucidum has a long history of thousands of years in China and is closely related with the lives of the Chinese people. ...At prese …
• 495.

  Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis.

  • Sun XZ, Liao Y, Li W, Guo LM.
  • Neural Regen Res. 2017 Jun;12(6):953-958. doi: 10.4103/1673-5374.208590.
  • PMCID: PMC5514871

  Sun XZ, et al.

  Neural Regen Res. 2017.

  PMCID: PMC5514871

  Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. ...In these cells, ganoderma lucidum polysaccharides remarkably suppressed H(2)O(2)-induced a …

  Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, …
• 496.

  Exploring the health benefits of Ganoderma: antimicrobial properties and mechanisms of action.

  • Karunarathna SC, Patabendige NM, Hapuarachchi KK, Promputtha I.
  • Front Cell Infect Microbiol. 2025 Jul 18;15:1535246. doi: 10.3389/fcimb.2025.1535246.
  • PMCID: PMC12313647

  Karunarathna SC, et al.

  Front Cell Infect Microbiol. 2025.

  PMCID: PMC12313647

  Ganoderma, a well-known medicinal mushroom, has garnered attention for its broad therapeutic properties, particularly its potent antimicrobial activities. This review focuses on the mechanisms of action and bioactive compounds responsible for the ability of Ganoderma …

  Ganoderma, a well-known medicinal mushroom, has garnered attention for its broad therapeutic properties, particularly its potent anti …
• 497.

  Study on Differences of Metabolites among Different Ganoderma Species with Comprehensive Metabolomics.

  • Khadbaatar S, Bao H, Gao X, Huo H.
  • J Fungi (Basel). 2024 Jul 27;10(8):524. doi: 10.3390/jof10080524.
  • PMCID: PMC11355880

  Khadbaatar S, et al.

  J Fungi (Basel). 2024.

  PMCID: PMC11355880

  In traditional Chinese medicine, Ganoderma is a kind of edible and medicinal mushroom, which is widely used because of its significant pharmacological activity. ...This study provides new insights and a theoretical basis for the development and utilization of the genus …

  In traditional Chinese medicine, Ganoderma is a kind of edible and medicinal mushroom, which is widely used because of its significan …
• 498.

  The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.

  • Li K, Liu W, Wu C, Wang L, Huang Y, Li Y, Zheng H, Shang Y, Zhang L, Chen Z.
  • Heliyon. 2024 May 8;10(10):e30907. doi: 10.1016/j.heliyon.2024.e30907.
  • PMCID: PMC11103526

  Li K, et al.

  Heliyon. 2024.

  PMCID: PMC11103526

  AIMS: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum extracts. MATERIALS AND METHODS: PGB [incorporating Ganoderma lucidum extract (GE), broken Ganoderma lucidum …

  AIMS: This study aims to delve into the anti-fatigue and sleep-aiding effects of various formulations containing Ganoderma lucidum …
• 499.

  Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer.

  • Suárez-Arroyo IJ, Loperena-Alvarez Y, Rosario-Acevedo R, Martínez-Montemayor MM.
  • Medicines (Basel). 2017 Mar 15;4(1):15. doi: 10.3390/medicines4010015.
  • PMCID: PMC5533290

  Suárez-Arroyo IJ, et al.

  Medicines (Basel). 2017.

  PMCID: PMC5533290

  Ganoderma anticancer effects are attributed to its efficacy in reducing cancer cell survival and growth, as well as by its chemosensitizing role. In vitro and in vivo studies have been conducted in various cancer cells and animal models; however, in this review, we focus o …

  Ganoderma anticancer effects are attributed to its efficacy in reducing cancer cell survival and growth, as well as by its chemosensi …
• 500.

  The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.

  • Xie L, Zhong X, Liu D, Liu L, Xia Z.
  • BMC Complement Altern Med. 2017 Dec 1;17(1):511. doi: 10.1186/s12906-017-2021-8.
  • PMCID: PMC5709989

  Xie L, et al.

  BMC Complement Altern Med. 2017.

  PMCID: PMC5709989

  BACKGROUND: Conventional scientific studies had supported the use of polysaccharides and beta-glucans from a number of fungi, including Ganoderma lucidum for the treatment of recurrent oral ulceration (ROU). Our aim of the present study was to evaluate whether freez …

  BACKGROUND: Conventional scientific studies had supported the use of polysaccharides and beta-glucans from a number of fungi, including G …

• 501.

  Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  • Zhong L, Yan P, Lam WC, Yao L, Bian Z.
  • Front Pharmacol. 2019 Jul 3;10:703. doi: 10.3389/fphar.2019.00703.
  • PMCID: PMC6616310

  Zhong L, et al.

  Front Pharmacol. 2019.

  PMCID: PMC6616310

  Background: Cancer incidence and mortality rates keep rising globally. Coriolus versicolor and Ganoderma lucidum related natural products are commonly applied as a complementary therapeutic option for different stages and types of cancers. ...Conclusion: In this met …

  Background: Cancer incidence and mortality rates keep rising globally. Coriolus versicolor and Ganoderma lucidum related natur …
• 502.

  Elucidating "lucidum": Distinguishing the diverse laccate Ganoderma species of the United States.

  • Loyd AL, Barnes CW, Held BW, Schink MJ, Smith ME, Smith JA, Blanchette RA.
  • PLoS One. 2018 Jul 18;13(7):e0199738. doi: 10.1371/journal.pone.0199738.
  • PMCID: PMC6051579

  Loyd AL, et al.

  PLoS One. 2018.

  PMCID: PMC6051579

  For the past century, many studies of Ganoderma in North America and other regions of the world have used the name G. lucidum sensu lato for any laccate (shiny or varnished) Ganoderma species growing on hardwood trees or substrates. ...These collections appea …

  For the past century, many studies of Ganoderma in North America and other regions of the world have used the name G. lucidum …
• 503.

  Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease.

  • Zhao Y, Qin Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Cui SY, Zhang YH.
  • Front Pharmacol. 2024 Apr 24;15:1406127. doi: 10.3389/fphar.2024.1406127.
  • PMCID: PMC11076787

  Zhao Y, et al.

  Front Pharmacol. 2024.

  PMCID: PMC11076787

  Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicine that is used to treat various diseases, including Alzheimer's disease and mood disorders. We previously reported that the sporoderm-remove …

  Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicin …
• 504.

  A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.

  • Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.
  • Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478.
  • PMCID: PMC6271249

  Xia Q, et al.

  Molecules. 2014.

  PMCID: PMC6271249

  Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, popularly used for complementary cancer therapy. ...This paper compiles 316 naturally occurring triterpenes from Ganoderma based on th …

  Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, p …
• 505.

  Extraction, Structural Characterization, and Immunomodulatory Activity of a High Molecular Weight Polysaccharide From Ganoderma lucidum.

  • Liu G, Zhang J, Kan Q, Song M, Hou T, An S, Lin H, Chen H, Hu L, Xiao J, Chen Y, Cao Y.
  • Front Nutr. 2022 Mar 25;9:846080. doi: 10.3389/fnut.2022.846080.
  • PMCID: PMC8990850

  Liu G, et al.

  Front Nutr. 2022.

  PMCID: PMC8990850

  Ganoderma lucidum polysaccharides (GLP) exhibited excellent immunomodulatory activity. Unfortunately, the structure and immunomodulatory activity of GLP are still unclear. ...

  Ganoderma lucidum polysaccharides (GLP) exhibited excellent immunomodulatory activity. Unfortunately, the structure and immuno …
• 506.

  Fortification of Chinese Steamed Bread Through Broken Ganoderma lucidum Spore Powder Incorporation: Effects on Physicochemical and Quality Properties.

  • Chen J, Cheng D, Luo S, Hu Y, Liu C, Guo X, Yu X, Zhang L, Wu J.
  • Foods. 2025 Apr 21;14(8):1433. doi: 10.3390/foods14081433.
  • PMCID: PMC12027355

  Chen J, et al.

  Foods. 2025.

  PMCID: PMC12027355

  Broken Ganoderma lucidum spore powder (BGLSP) is abundant in nutrients and bioactive compounds, rendering it a suitable functional raw material for food applications. ...

  Broken Ganoderma lucidum spore powder (BGLSP) is abundant in nutrients and bioactive compounds, rendering it a suitable functi …
• 507.

  Ganoderma lucidum Pharmacopuncture for the Treatment of Acute Gastric Ulcers in Rats.

  • Park JH, Jang KJ, Kim CH, Lee YH, Lee SJ, Kim BH, Yoon HM.
  • J Pharmacopuncture. 2014 Sep;17(3):40-9. doi: 10.3831/KPI.2014.17.025.
  • PMCID: PMC4332011

  Park JH, et al.

  J Pharmacopuncture. 2014.

  PMCID: PMC4332011

  The basic physiopathology of a gastric ulcer results from an imbalance between some endogenous aggressive and cytoprotective factors. This study examined whether Ganoderma lucidum pharmacopuncture (GLP) would provide protection against acute gastric ulcers in rats. …

  The basic physiopathology of a gastric ulcer results from an imbalance between some endogenous aggressive and cytoprotective factors. This s …
• 508.

  Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.

  • Ling-Sing Seow S, Naidu M, David P, Wong KH, Sabaratnam V.
  • BMC Complement Altern Med. 2013 Jul 4;13:157. doi: 10.1186/1472-6882-13-157.
  • PMCID: PMC3720279

  Ling-Sing Seow S, et al.

  BMC Complement Altern Med. 2013.

  PMCID: PMC3720279

  METHODS: Cytotoxic effects of aqueous extracts of three medicinal mushrooms basidiocarps, Ganoderma lucidum, Ganoderma neo-japonicum and Grifola frondosa towards rat pheochromocytoma (PC-12) cells were determined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltet …

  METHODS: Cytotoxic effects of aqueous extracts of three medicinal mushrooms basidiocarps, Ganoderma lucidum, Ganoderma …
• 509.

  Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal.

  • Thapa I, Pandey A, Tiwari S, Awal SC.
  • Curr Issues Mol Biol. 2025 Aug 5;47(8):624. doi: 10.3390/cimb47080624.
  • PMCID: PMC12384079

  Thapa I, et al.

  Curr Issues Mol Biol. 2025.

  PMCID: PMC12384079

  Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type-water, ethanol, methanol, and acetone-on extraction efficiency and biological activity. ...These findings demonstrate t …

  Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influ …
• 510.

  Synergistic Cytotoxic Effects of Ganoderma lucidum and Bacillus Calmette Guerin on Premalignant Urothelial HUC-PC Cells and Its Regulation on Proinflammatory Cytokine Secretion.

  • Yuen JW, Gohel MD, Ng CF.
  • Evid Based Complement Alternat Med. 2012 Aug 28;2012:147896. doi: 10.1155/2012/147896.
  • PMCID: PMC3434421

  Yuen JW, et al.

  Evid Based Complement Alternat Med. 2012.

  PMCID: PMC3434421

  To address the issues of efficacy and safety, an ethanol extract of Ganoderma lucidum (GLe) was evaluated for its interaction with BCG. In a model of premalignant human uroepithelial cells (HUC-PC), GLe exerted immediate cytotoxic effects while BCG showed a delayed …

  To address the issues of efficacy and safety, an ethanol extract of Ganoderma lucidum (GLe) was evaluated for its interaction …

• 511.

  Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.

  • Mi X, Ruan X, Lin R, Huang S, Cai P, Chen X, Liao J, Dai X.
  • Front Pharmacol. 2025 Jul 4;16:1572771. doi: 10.3389/fphar.2025.1572771.
  • PMCID: PMC12271231

  Mi X, et al.

  Front Pharmacol. 2025.

  PMCID: PMC12271231

  Currently, there is currently still a lack of effective therapeutic drugs for AD. Ganoderma lucidum (G. lucidum) is abundant in active ingredients that harbor anti-inflammatory properties in both central nervous system and the periphery. We attempted to deter …

  Currently, there is currently still a lack of effective therapeutic drugs for AD. Ganoderma lucidum (G. lucidum) is abu …
• 512.

  Apoptotic and Immune Restoration Effects of Ganoderic Acids Define a New Prospective for Complementary Treatment of Cancer.

  • Radwan FF, Perez JM, Haque A.
  • J Clin Cell Immunol. Author manuscript. 2011 Dec 11;S3:4. doi: 10.4172/2155-9899.S3-004.
  • PMCID: PMC3546526

  Radwan FF, et al.

  J Clin Cell Immunol. Author manuscript. 2011.

  PMCID: PMC3546526

  One attractive source of antitumor products is the Ganoderma lucidum mushroom, which has been used for centuries as an herbal medicine for the prevention and treatment of a variety of diseases, including cancer, and has been shown to improve immune function. ...

  One attractive source of antitumor products is the Ganoderma lucidum mushroom, which has been used for centuries as an herbal …
• 513.

  Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.

  • Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK.
  • Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837.
  • PMCID: PMC10058372

  Shamim MZ, et al.

  Molecules. 2023.

  PMCID: PMC10058372

  Hypoglycaemic effects have been observed in investigations on Agaricussu brufescens, Agaricus bisporus, Cordyceps sinensis, Inonotus obliqus, Coprinus comatus, Ganoderma lucidum, Phellinus linteus, Pleurotus spp., Poria cocos, and Sparassis crispa. ...

  Hypoglycaemic effects have been observed in investigations on Agaricussu brufescens, Agaricus bisporus, Cordyceps sinensis, Inonotus obliqus …
• 514.

  Anticancer activity of Amauroderma rude.

  • Jiao C, Xie YZ, Yang X, Li H, Li XM, Pan HH, Cai MH, Zhong HM, Yang BB.
  • PLoS One. 2013 Jun 20;8(6):e66504. doi: 10.1371/journal.pone.0066504.
  • PMCID: PMC3688780

  Jiao C, et al.

  PLoS One. 2013.

  PMCID: PMC3688780

  We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucid …

  We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with a …
• 515.

  Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review.

  • Lau MF, Phan CW, Sabaratnam V, Kuppusamy UR.
  • Mycology. 2024 Jan 21;15(3):360-373. doi: 10.1080/21501203.2024.2302028.
  • PMCID: PMC11376291

  Lau MF, et al.

  Mycology. 2024.

  PMCID: PMC11376291

  Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma neo-japonicum (synonym Ganoderma bambusicola), also known as purple Lingzhi, is a species that is currently underutilised when c …

  Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma …
• 516.

  Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats.

  • Hu L, Yu L, Cao Z, Wang Y, Zhu C, Li Y, Yin J, Ma Z, He X, Zhang Y, Huang W, Guan Y, Chen Y, Li X, Chen X.
  • J Pharm Anal. 2024 Sep 19;14(12):101105. doi: 10.1016/j.jpha.2024.101105.
  • PMCID: PMC11750267

  Hu L, et al.

  J Pharm Anal. 2024.

  PMCID: PMC11750267

  Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lacking curative therapy. Sporoderm-broken spores of Ganoderma lucidum (GLP), an herbal medicine, has been used for the treatment …

  Diabetes mellitus (DM) is a major metabolic disease endangering global health, with diabetic nephropathy (DN) as a primary complication lack …
• 517.

  Distributions of Lanostene-Derived Triterpenoids and Glucan Content in the Fruiting Bodies of the Australian Ganoderma Species.

  • De Oliveira Campos A, Harrison MD, Marshall DL, Strong PJ.
  • J Fungi (Basel). 2024 Oct 18;10(10):723. doi: 10.3390/jof10100723.
  • PMCID: PMC11509325

  De Oliveira Campos A, et al.

  J Fungi (Basel). 2024.

  PMCID: PMC11509325

  Lanostene-derived triterpenoids and beta-glucans are important metabolites in Ganoderma mushrooms associated with benefits to human health. The medicinal value of the Australian Ganoderma species remains unclear, with no data on triterpenoid distribution or glucan c …

  Lanostene-derived triterpenoids and beta-glucans are important metabolites in Ganoderma mushrooms associated with benefits to human h …
• 518.

  Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.

  • Liu Y, Xu W, Wang K, You Z, Chen X, Ti H, Liang X, Cao L, Cai H, Liu J, Yang Z.
  • Front Pharmacol. 2025 Jun 10;16:1612043. doi: 10.3389/fphar.2025.1612043.
  • PMCID: PMC12185471

  Liu Y, et al.

  Front Pharmacol. 2025.

  PMCID: PMC12185471

  Interventions based on medicinal plants approaches are pivotal for prevention and treatment. Ganoderma lucidum (GL) is a traditional botanical drug to treat inflammatory ailments. The spores of this fungus demonstrate distinct influences on immune response regulatio …

  Interventions based on medicinal plants approaches are pivotal for prevention and treatment. Ganoderma lucidum (GL) is a tradi …
• 519.

  Applied modern biotechnology for cultivation of Ganoderma and development of their products.

  • Zhou XW, Su KQ, Zhang YM.
  • Appl Microbiol Biotechnol. 2011 Dec 15;93(3):941-63. doi: 10.1007/s00253-011-3780-7.
  • PMCID: PMC7080118

  Zhou XW, et al.

  Appl Microbiol Biotechnol. 2011.

  PMCID: PMC7080118

  In order to analyze the current status of Ganoderma products, the detailed process of cultivation of Ganoderma spp. and development of their products are restated in this review article. These include the breeding, cultivating, extracting bioactive component, and pr …

  In order to analyze the current status of Ganoderma products, the detailed process of cultivation of Ganoderma spp. and develo …
• 520.

  In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.

  • Abu-Serie MM, Habashy NH, Attia WE.
  • BMC Complement Altern Med. 2018 May 10;18(1):154. doi: 10.1186/s12906-018-2218-5.
  • PMCID: PMC5946467

  Abu-Serie MM, et al.

  BMC Complement Altern Med. 2018.

  PMCID: PMC5946467

  METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma lucidum aqueous extract (GLE) and Egyptian Chlorella vulgaris ethanolic extract (CVE). ...

  METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma luc …

• 521.

  Antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hei dou) and astragalus membranaceus ( sheng huang qi).

  • Su ZY, Sun Hwang L, Chiang BH, Sheen LY.
  • J Tradit Complement Med. 2013 Apr;3(2):110-8. doi: 10.4103/2225-4110.110415.
  • PMCID: PMC3924974

  Su ZY, et al.

  J Tradit Complement Med. 2013.

  PMCID: PMC3924974

  The antihepatoma activity and liver protective function of the fermentation products (5 L fermenator) of Ganoderma lucidum (GL; Ling Zhi) cultivated in a medium containing black soybean (BS; Hei Dou) and Astragalus membranaceus (AM; Sheng Huang Qi) at different ferm …

  The antihepatoma activity and liver protective function of the fermentation products (5 L fermenator) of Ganoderma lucidum (GL …
• 522.

  Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T's Biosynthesis.

  • Yan MQ, Su XW, Liu YF, Tang CH, Tang QJ, Zhou S, Tan Y, Liu LP, Zhang JS, Feng J.
  • J Fungi (Basel). 2022 Jun 9;8(6):615. doi: 10.3390/jof8060615.
  • PMCID: PMC9225475

  Yan MQ, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9225475

  The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T's biosynthesis from Ganoderma lucidum were investigated. The results showed that adding filter-sterilized oleic acid in the process of submerged fermentation …

  The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T's biosynthesis from Ganoderma …
• 523.

  Identification of commercial Ganoderma (Lingzhi) species by ITS2 sequences.

  • Liao B, Chen X, Han J, Dan Y, Wang L, Jiao W, Song J, Chen S.
  • Chin Med. 2015 Aug 19;10:22. doi: 10.1186/s13020-015-0056-7.
  • PMCID: PMC4543481

  Liao B, et al.

  Chin Med. 2015.

  PMCID: PMC4543481

  SNP(s) and RNA secondary structure of ITS2 were analyzed and compared among closely related Ganoderma species. RESULTS: G. lucidum cultivated in China was different from those cultivated in Europe. "Chizhi" (G. lucidum) and "Zizhi" (G. sinense) were clustered …

  SNP(s) and RNA secondary structure of ITS2 were analyzed and compared among closely related Ganoderma species. RESULTS: G. lucidum …
• 524.

  Recent Advances in the Preparation, Structure, and Biological Activities of beta-Glucan from Ganoderma Species: A Review.

  • Zhang H, Zhang J, Liu Y, Tang C.
  • Foods. 2023 Aug 7;12(15):2975. doi: 10.3390/foods12152975.
  • PMCID: PMC10419088

  Zhang H, et al.

  Foods. 2023.

  PMCID: PMC10419088

  Ganoderma has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for human protection against chronic diseases. Modern pharmacology studies have proven that Ganoderma beta-d-glucan exhibits versatile bi …

  Ganoderma has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for …
• 525.

  Taxonomy of Ganoderma lucidum from Korea Based on rDNA and Partial beta-Tubulin Gene Sequence Analysis.

  • Park YJ, Kwon OC, Son ES, Yoon DE, Han W, Yoo YB, Lee CS.
  • Mycobiology. 2012 Mar 31;40(1):71-5. doi: 10.5941/MYCO.2012.40.1.071.
  • PMCID: PMC3385146

  Park YJ, et al.

  Mycobiology. 2012.

  PMCID: PMC3385146

  In the present study, a phylogenetic analysis was undertaken based on the internal transcribed spacer (ITS) rDNA and partial beta-tubulin gene sequence of the Ganoderma species. The size of the ITS rDNA regions from different Ganoderma species varied from 625 to 673 …

  In the present study, a phylogenetic analysis was undertaken based on the internal transcribed spacer (ITS) rDNA and partial beta-tubulin ge …
• 526.

  Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation.

  • Chen Z, Qin W, Lin H, Liu Y, Tian Y, Zhao X, Ding T, Wang Y, Mao T, Li J, Shen Y.
  • Heliyon. 2023 Jan 28;9(2):e13205. doi: 10.1016/j.heliyon.2023.e13205.
  • PMCID: PMC9939615

  Chen Z, et al.

  Heliyon. 2023.

  PMCID: PMC9939615

  As the main bioactive substance of Ganoderma lucidum, Ganoderma lucidum polysaccharide (GLP) has anti-inflammatory, antibacterial, and other biological activities. Studies have shown that GLP can regulate the expression of multiple inflammatory cytokin …

  As the main bioactive substance of Ganoderma lucidum, Ganoderma lucidum polysaccharide (GLP) has anti-inflammato …
• 527.

  Mechanistic and Functional Studies on the Microbial Induction of Wolfiporia cocos Liquid Fermentation Products.

  • Yang Z, Su C, Xu Z, Liu Y, Chen J, Wu X.
  • Foods. 2024 May 18;13(10):1578. doi: 10.3390/foods13101578.
  • PMCID: PMC11121235

  Yang Z, et al.

  Foods. 2024.

  PMCID: PMC11121235

  Three edible mushroom co-fermentation systems were established, among which the Wolfiporia cocos-Ganoderma lucidum co-fermentation system significantly increased the mycelial biomass of the system by 57.71% compared to Wolfiporia cocos alone and 91.22% compared to < …

  Three edible mushroom co-fermentation systems were established, among which the Wolfiporia cocos-Ganoderma lucidum co-fermenta …
• 528.

  Comparative Mitogenomic Analysis Reveals Intraspecific, Interspecific Variations and Genetic Diversity of Medical Fungus Ganoderma.

  • Li Q, Zhang T, Li L, Bao Z, Tu W, Xiang P, Wu Q, Li P, Cao M, Huang W.
  • J Fungi (Basel). 2022 Jul 26;8(8):781. doi: 10.3390/jof8080781.
  • PMCID: PMC9394262

  Li Q, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9394262

  In this study, we sequenced and assembled four Ganoderma complete mitogenomes, including G. subamboinense s118, G. lucidum s37, G. lingzhi s62, and G. lingzhi s74. ...Frequent intron loss/gain events were detected within and between Ganoderma species. The mit …

  In this study, we sequenced and assembled four Ganoderma complete mitogenomes, including G. subamboinense s118, G. lucidum s37 …
• 529.

  AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum.

  • Zhu R, Zhang L, Wu L, Liu J, Zhang J, Li J, Song K, Han P.
  • Foods. 2025 Feb 27;14(5):826. doi: 10.3390/foods14050826.
  • PMCID: PMC11898911

  Zhu R, et al.

  Foods. 2025.

  PMCID: PMC11898911

  These findings highlight the significant role of AOX-derived ROS in regulating polysaccharide synthesis and accumulation in Ganoderma lucidum....

  These findings highlight the significant role of AOX-derived ROS in regulating polysaccharide synthesis and accumulation in Ganoderma …
• 530.

  Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcgammaR-mediated macrophage phagocytosis.

  • Li DD, Li ZX, Zhou YF, Jin L, Liang WL, Xu WD, Luo X, Xiao GD, Chen QJ, Xie T, Xu H, Liu Y, Cai HF, Cao YF, Sun WY, Li YF, Liang L, Liu JY, Wu YP, He RR.
  • Chin Med. 2025 Jul 14;20(1):111. doi: 10.1186/s13020-025-01168-0.
  • PMCID: PMC12257750

  Li DD, et al.

  Chin Med. 2025.

  PMCID: PMC12257750

  BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially recognized in both Eastern and Western pharmacopeias. G. lucidum spore oil (GLSO), a lipid substance extracted from sporoderm-broken s …

  BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially r …

• 531.

  Volatile Composition and Sensory Profiles of a Shiraz Wine Product Made with Pre- and Post-Fermentation Additions of Ganoderma lucidum Extract.

  • Nguyen ANH, Capone DL, Johnson TE, Jeffery DW, Danner L, Bastian SEP.
  • Foods. 2019 Nov 1;8(11):538. doi: 10.3390/foods8110538.
  • PMCID: PMC6915547

  Nguyen ANH, et al.

  Foods. 2019.

  PMCID: PMC6915547

  Novel Shiraz red wine products enriched with Ganoderma lucidum (GL) extract, a traditional Asian medicinal mushroom, were developed and characterized. ...

  Novel Shiraz red wine products enriched with Ganoderma lucidum (GL) extract, a traditional Asian medicinal mushroom, were deve …
• 532.

  Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease.

  • Lee OYA, Wong ANN, Ho CY, Tse KW, Chan AZ, Leung GP, Kwan YW, Yeung MHY.
  • Antioxidants (Basel). 2024 Jun 20;13(6):751. doi: 10.3390/antiox13060751.
  • PMCID: PMC11201162

  Lee OYA, et al.

  Antioxidants (Basel). 2024.

  PMCID: PMC11201162

  Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, and Ganoderma lucidum are known for their anti-inflammatory and antioxidant properties and may support kidney function preservation. ...

  Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, and Ganoderma lucidum are known for their anti-inflammatory and …
• 533.

  Impact of Ganoderma lucidum fermentation on the nutritional composition, structural characterization, metabolites, and antioxidant activity of Soybean, sweet potato and Zanthoxylum pericarpium residues.

  • Cen Q, Fan J, Zhang R, Chen H, Hui F, Li J, Zeng X, Qin L.
  • Food Chem X. 2023 Dec 16;21:101078. doi: 10.1016/j.fochx.2023.101078.
  • PMCID: PMC10776642

  Cen Q, et al.

  Food Chem X. 2023.

  PMCID: PMC10776642

  This study aimed to investigate the effects of Ganoderma lucidum (GL) fermentation on the nutritional components, structural characterization, metabolites, and antioxidant activity of soybean residue (SR), sweet potato residue (SPR), and zanthoxylum pericarpium resi …

  This study aimed to investigate the effects of Ganoderma lucidum (GL) fermentation on the nutritional components, structural c …
• 534.

  Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis.

  • Zhang H, Li N, Zhang Y, Xu Y, Lu F, Lin D, Lin S, Li M, Yang B.
  • Biomedicines. 2024 Jul 23;12(8):1632. doi: 10.3390/biomedicines12081632.
  • PMCID: PMC11351902

  Zhang H, et al.

  Biomedicines. 2024.

  PMCID: PMC11351902

  It is crucial to discover safe and effective treatments to prevent male reproductive injury caused by chemotherapy. The Ganoderma lucidum polysaccharide peptide (GLPP) has multiple pharmacological activities. ...

  It is crucial to discover safe and effective treatments to prevent male reproductive injury caused by chemotherapy. The Ganoderma …
• 535.

  A flow-injection mass spectrometry fingerprinting scaffold for feature selection and quantitation of Cordyceps and Ganoderma extracts in beverage: a predictive artificial neural network modelling strategy.

  • Lim CW, Tai SH, Chan SH.
  • AMB Express. 2012 Aug 13;2(1):43. doi: 10.1186/2191-0855-2-43.
  • PMCID: PMC3442979

  Lim CW, et al.

  AMB Express. 2012.

  PMCID: PMC3442979

  In this study, we described a scaffold (proof-of-concept) adapted from spectroscopy to quantify Cordyceps sinensis and Ganoderma lucidum in a popular Cordyceps sinensis /Ganoderma lucidum -enriched health beverage by utilizing flow-injection/mass spect …

  In this study, we described a scaffold (proof-of-concept) adapted from spectroscopy to quantify Cordyceps sinensis and Ganoderma l …
• 536.

  The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.

  • Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.
  • PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040.
  • PMCID: PMC3976396

  Lin J, et al.

  PLoS One. 2014.

  PMCID: PMC3976396

  Finally, we observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide extract isolated from another popular Chinese herbal medicine, Ganoderma lucidum. These results indicated that DH-PS might have potential applications …

  Finally, we observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide extract isolated from ano …
• 537.

  Diversity and effects of competitive Trichoderma species in Ganoderma lucidum-cultivated soils.

  • Wang Y, Zeng L, Wu J, Jiang H, Mei L.
  • Front Microbiol. 2022 Dec 8;13:1067822. doi: 10.3389/fmicb.2022.1067822.
  • PMCID: PMC9772278

  Wang Y, et al.

  Front Microbiol. 2022.

  PMCID: PMC9772278

  Ganoderma lucidum (GL) is a well-known medicinal mushroom that has been extensively cultivated. ...

  Ganoderma lucidum (GL) is a well-known medicinal mushroom that has been extensively cultivated. ...
• 538.

  Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?

  • De Luca F, Roda E, Rossi P, Bottone MG.
  • Curr Issues Mol Biol. 2024 Jul 17;46(7):7577-7591. doi: 10.3390/cimb46070450.
  • PMCID: PMC11276109

  De Luca F, et al.

  Curr Issues Mol Biol. 2024.

  PMCID: PMC11276109

  Among the group of most promising MMs are Lentinula edodes, Grifola frondosa, Ganoderma lucidum, Ophiocordyceps sinensis and Agaricus blazei, which are already employed in conventional cancer protocols in Asia and China. ...

  Among the group of most promising MMs are Lentinula edodes, Grifola frondosa, Ganoderma lucidum, Ophiocordyceps sinensis and A …
• 539.

  Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins.

  • Lu J, Qin JZ, Chen P, Chen X, Zhang YZ, Zhao SJ.
  • Front Pharmacol. 2012 Apr 9;3:57. doi: 10.3389/fphar.2012.00057.
  • PMCID: PMC3321521

  Lu J, et al.

  Front Pharmacol. 2012.

  PMCID: PMC3321521

  The quality difference of six varieties Ganoderma lucidum with different origins was investigated in this study by comparing the contents of ganoderic acid A and B, polysaccharide, and triterpenoids. The contents of ganoderic acid A and B in G. lucidum were a …

  The quality difference of six varieties Ganoderma lucidum with different origins was investigated in this study by comparing t …
• 540.

  A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19.

  • Arunachalam K, Sasidharan SP, Yang X.
  • Food Chem Adv. 2022 Mar 2;1:100023. doi: 10.1016/j.focha.2022.100023.
  • PMCID: PMC8887958

  Arunachalam K, et al.

  Food Chem Adv. 2022.

  PMCID: PMC8887958

  In this review of the literature we foucsed popular mushrooms such as Agaricus subrufescens Peck, Agaricus blazei Murill, Cordyceps sinensis (Berk.) Sacc., Ganoderma lucidum (Curtis.) P. Karst., Grifola frondosa (Dicks.) Gray, Hericium erinaceus (Bull.) ...

  In this review of the literature we foucsed popular mushrooms such as Agaricus subrufescens Peck, Agaricus blazei Murill, Cordyceps sinensis …

• 541.

  Effects of Environmental and Nutritional Conditions on Mycelium Growth of Three Basidiomycota.

  • Schoder KA, Krümpel J, Müller J, Lemmer A.
  • Mycobiology. 2024 Apr 25;52(2):124-134. doi: 10.1080/12298093.2024.2341492.
  • PMCID: PMC11057518

  Schoder KA, et al.

  Mycobiology. 2024.

  PMCID: PMC11057518

  Further, the influence of the initial substrate characteristics on hyphae expansion was determined. Fungal isolates of Ganoderma lucidum, Pleurotus ostreatus, and Trametes versicolor were cultivated for seven days on substrate mixtures consisting of various proporti …

  Further, the influence of the initial substrate characteristics on hyphae expansion was determined. Fungal isolates of Ganoderma l …
• 542.

  Non-destructive analysis of Ganoderma lucidum composition using hyperspectral imaging and machine learning.

  • Ran J, Xu H, Wang Z, Zhang W, Bai X.
  • Front Chem. 2025 Feb 26;13:1534216. doi: 10.3389/fchem.2025.1534216.
  • PMCID: PMC11897918

  Ran J, et al.

  Front Chem. 2025.

  PMCID: PMC11897918

  BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging. ...CONCLUSION: This integration of hyperspectral imaging and machine l …

  BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditi …
• 543.

  Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum.

  • Wang PY, Zhu XL, Lin ZB.
  • Front Pharmacol. 2012 Jul 13;3:135. doi: 10.3389/fphar.2012.00135.
  • PMCID: PMC3395810

  Wang PY, et al.

  Front Pharmacol. 2012.

  PMCID: PMC3395810
• 544.

  Molecular Identification and Characterization of Five Ganoderma Species from the Lower Volta River Basin of Ghana Based on Nuclear Ribosomal DNA (nrDNA) Sequences.

  • Adotey G, Alolga RN, Quarcoo A, Yerenkyi P, Otu P, Anang AK, Okine LKN, Gbewonyo WSK, Holliday JC, Lombardi VC.
  • J Fungi (Basel). 2023 Dec 21;10(1):6. doi: 10.3390/jof10010006.
  • PMCID: PMC10817336

  Adotey G, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10817336

  Ganoderma is a genus of biomedical fungus that is used in the development of numerous health products throughout the world. ...Blastn search and sequence analysis revealed that the sample we coded as Ganoderma LVRB-2 belongs to G. mbrekobenum, whereas Ganoderma …

  Ganoderma is a genus of biomedical fungus that is used in the development of numerous health products throughout the world. ...Blastn …
• 545.

  Volatile Composition, Colour, and Sensory Quality of Spirit-Based Beverages Enriched with Medicinal Fungus Ganoderma lucidum and Herbal Extract.

  • Veljović SP, Tomić NS, Belović MM, Nikićević NJ, Vukosavljević PV, Nikšić MP, Tešević VV.
  • Food Technol Biotechnol. 2019 Sep;57(3):408-417. doi: 10.17113/ftb.57.03.19.6106.
  • PMCID: PMC6902298

  Veljović SP, et al.

  Food Technol Biotechnol. 2019.

  PMCID: PMC6902298

  The multicomponent mixtures consisting of herbs and fungi are commonly used for the production of alcoholic beverages with potential health-promoting effects in many Asian countries. The medicinal fungus Ganoderma lucidum is one of the most important fungi used for …

  The multicomponent mixtures consisting of herbs and fungi are commonly used for the production of alcoholic beverages with potential health- …
• 546.

  Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation.

  • Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X.
  • Diabetes Metab Syndr Obes. 2025 Apr 23;18:1263-1284. doi: 10.2147/DMSO.S500955.
  • PMCID: PMC12034255

  Guo S, et al.

  Diabetes Metab Syndr Obes. 2025.

  PMCID: PMC12034255

  PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum, a food-medicine homologous in China, has been used to treat diabetes. ...The predicted key targets were verified via qRT-PCR in PA-ind …

  PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum …
• 547.

  The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice.

  • Zhu S, Wang X, Liu G.
  • Toxics. 2024 May 22;12(6):378. doi: 10.3390/toxics12060378.
  • PMCID: PMC11209525

  Zhu S, et al.

  Toxics. 2024.

  PMCID: PMC11209525

  Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ganoderma lucidum. ...The findings suggest that GLP4 reduces cadmium-induced lung injury in mice by inhibiting the activation of th …

  Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ga …
• 548.

  Hypoglicemic and Hypolipedimic Effects of Ganoderma lucidum in Streptozotocin-Induced Diabetic Rats.

  • Bach EE, Hi EMB, Martins AMC, Nascimento PAM, Wadt NSY.
  • Medicines (Basel). 2018 Jul 28;5(3):78. doi: 10.3390/medicines5030078.
  • PMCID: PMC6163537

  Bach EE, et al.

  Medicines (Basel). 2018.

  PMCID: PMC6163537

  Background:Ganoderma lucidum (Leyss. Ex. Fr) Karst is a basidiomycete mushroom that has been used for many years as a food supplement and medicine. In Brazil, National Health Surveillance Agency (ANVISA) classified Ganoderma lucidum as a nutraceutical …

  Background:Ganoderma lucidum (Leyss. Ex. Fr) Karst is a basidiomycete mushroom that has been used for many years as a food sup …
• 549.

  Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus.

  • Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N.
  • World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187.
  • PMCID: PMC5437617

  Vitak T, et al.

  World J Diabetes. 2017.

  PMCID: PMC5437617

  Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis (A. brasiliensis) and Ganoderma lucidum (G. lucidum) on streptozotocin-induced DM in rats. Also, we sho …

  Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaric …
• 550.

  Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats.

  • Hossen MS, Billah Prince MM, Tanvir EM, Chowdhury MAZ, Rahman MA, Alam F, Paul S, Saha M, Ali MY, Bhoumik NC, Karim N, Gan SH, Khalil MI.
  • Evid Based Complement Alternat Med. 2018 May 15;2018:6254929. doi: 10.1155/2018/6254929.
  • PMCID: PMC5976964

  Hossen MS, et al.

  Evid Based Complement Alternat Med. 2018.

  PMCID: PMC5976964

  The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. ...

  The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricula …

• 551.

  Antioxidant and Anti-Inflammatory Activity and Cytotoxicity of Ethanol Extracts from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.

  • Park MH, Kim M.
  • Prev Nutr Food Sci. 2018 Dec 31;23(4):326-334. doi: 10.3746/pnf.2018.23.4.326.
  • PMCID: PMC6342532

  Park MH, et al.

  Prev Nutr Food Sci. 2018.

  PMCID: PMC6342532

  In this study, in order to verify the use of mycelium as a new functional material, Rhynchosia nulubilis was cultivated with Ganoderma lucidum mycelium, and the biological activity of the culture extract was evaluated. ...These results demonstrated that increased to …

  In this study, in order to verify the use of mycelium as a new functional material, Rhynchosia nulubilis was cultivated with Ganoderma …
• 552.

  Bioreactor-grown exo- and endo-beta-glucan from Malaysian Ganoderma lucidum: An in vitro and in vivo study for potential antidiabetic treatment.

  • Abdullah NR, Mohd Nasir MH, Azizan NH, Wan-Mohtar WAAQI, Sharif F.
  • Front Bioeng Biotechnol. 2022 Aug 25;10:960320. doi: 10.3389/fbioe.2022.960320.
  • PMCID: PMC9452895

  Abdullah NR, et al.

  Front Bioeng Biotechnol. 2022.

  PMCID: PMC9452895

  This study aims to identify the roles of exo-beta-glucan (EPS-BG) and endo-beta-glucan (ENS-BG) extracted from Ganoderma lucidum (GL) in inhibiting the alpha-glucosidase enzyme, a target mechanism for postprandial hyperglycaemia regulation. ...

  This study aims to identify the roles of exo-beta-glucan (EPS-BG) and endo-beta-glucan (ENS-BG) extracted from Ganoderma lucidum …
• 553.

  Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects.

  • He S, Liu Y, Zhang Z, Cai M, Hao Y, Hu H.
  • J Fungi (Basel). 2025 Apr 14;11(4):310. doi: 10.3390/jof11040310.
  • PMCID: PMC12029067

  He S, et al.

  J Fungi (Basel). 2025.

  PMCID: PMC12029067

  We mainly introduce the development of gene-editing technology, the application of clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) in Ganoderma lucidum breeding, the current challenges and optimization strategies in the use of gene-editin …

  We mainly introduce the development of gene-editing technology, the application of clustered regularly interspaced short palindromic repeat/ …
• 554.

  Amylase-assisted extraction alters nutritional and physicochemical properties of polysaccharides and saponins isolated from Ganoderma spp.

  • Chen BJ, Liu Y, Yang K, Li X, Dong X, Guan Y, Ismail A, Khoo HE.
  • Food Chem X. 2023 Sep 29;20:100913. doi: 10.1016/j.fochx.2023.100913.
  • PMCID: PMC10740064

  Chen BJ, et al.

  Food Chem X. 2023.

  PMCID: PMC10740064

  This study aimed to evaluate the efficacy of amylase in hydrolyzing complex carbohydrates of different parts of Ganoderma spp. The aqueous extracts of the Ganoderma samples were analyzed for their selected nutritional composition and physicochemical properties. ...T …

  This study aimed to evaluate the efficacy of amylase in hydrolyzing complex carbohydrates of different parts of Ganoderma spp. The aq …
• 555.

  Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties.

  • Šťastný J, Morellá-Aucejo Á, Skala T, Bernardos A, Maršík P, Lérida-Viso A, Matějka J, Mascellani Bergo A, Marcos MD, Martínez-Máñez R, Jablonský I, Klouček P.
  • Front Pharmacol. 2025 Jan 23;16:1526502. doi: 10.3389/fphar.2025.1526502.
  • PMCID: PMC11799868

  Šťastný J, et al.

  Front Pharmacol. 2025.

  PMCID: PMC11799868

  Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. ...This study investigated the cytotoxic properties of Ganoderma species methanolic extracts against the HeLa cancer cell line. Notably, …

  Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. ... …
• 556.

  Evaluation of the phytochemical, bioactive compounds and descriptive sensory of encapsulated lingzhi (Ganoderma lucidum) extracts with combined wall materials for masking effect on the perception of off-flavour and bitterness.

  • Chuensun T, Chewonarin T, Laopajon W, Samakradhamrongthai RS, Chaisan W, Utama-Ang N.
  • Heliyon. 2024 Nov 2;10(21):e40094. doi: 10.1016/j.heliyon.2024.e40094.
  • PMCID: PMC11570458

  Chuensun T, et al.

  Heliyon. 2024.

  PMCID: PMC11570458

  Lingzhi mushroom (Ganoderma lucidum) is known as a medicinal mushroom that can be utilized in various functional foods available in the market, including powders, dietary supplements, and tea. ...

  Lingzhi mushroom (Ganoderma lucidum) is known as a medicinal mushroom that can be utilized in various functional foods availab …
• 557.

  Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes.

  • Zuo Z, Wen R, Jing S, Chen X, Liu R, Xue J, Zhang L, Li Q.
  • Pharmaceuticals (Basel). 2024 Dec 16;17(12):1695. doi: 10.3390/ph17121695.
  • PMCID: PMC11677753

  Zuo Z, et al.

  Pharmaceuticals (Basel). 2024.

  PMCID: PMC11677753

  Although luminal A breast cancer (LumA) has a relatively better prognosis, it still has a persistent pattern of recurrence. Ganoderma lucidum (Curtis) P. Karst. is a kind of traditional Chinese medicine and has antitumor effects. In this study, we aimed to identify …

  Although luminal A breast cancer (LumA) has a relatively better prognosis, it still has a persistent pattern of recurrence. Ganoderma …
• 558.

  Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia.

  • Preciado Iñiga G, Martínez-Carrera D, Meneses ME, Sánchez M, Argumedo A, Bonilla M, Castillo I, Petlacalco B, Morales A, Fernández N, Martínez W, Antonio-Bautista J, Sánchez-Tapia M, Coutiño-Hernández D, Torres N, Tovar AR, Leal-Lara H.
  • Int J Food Sci. 2025 Jul 29;2025:8096060. doi: 10.1155/ijfo/8096060.
  • PMCID: PMC12324917

  Preciado Iñiga G, et al.

  Int J Food Sci. 2025.

  PMCID: PMC12324917

  We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the medicinal mushroom Ganoderma lucidum (Gl) from Mexico. These products were characterised through physicochemical and sensory pr …

  We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the m …
• 559.

  Production of Ganodiesel from the biomass of Ganoderma lucidum in air-L-shaped bioreactor (ALSB).

  • Lim TC, Ilham Z, Wan-Mohtar WAAQI.
  • Heliyon. 2024 Jul 29;10(15):e35170. doi: 10.1016/j.heliyon.2024.e35170.
  • PMCID: PMC11334811

  Lim TC, et al.

  Heliyon. 2024.

  PMCID: PMC11334811

  Shake flask results showed 8.33 g/L of biomass and 2.17 % of lipid, while the ALSB system produced 5.32 g/L of biomass and 2.35 % lipid. The obtained Ganoderma lucidum mycelial lipid underwent acid-catalysed transesterification to produce biodiesel, which was subjec …

  Shake flask results showed 8.33 g/L of biomass and 2.17 % of lipid, while the ALSB system produced 5.32 g/L of biomass and 2.35 % lipid. The …
• 560.

  Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis.

  • Tsao SM, Hsu HY.
  • Sci Rep. 2016 Nov 10;6:36563. doi: 10.1038/srep36563.
  • PMCID: PMC5103195

  Tsao SM, et al.

  Sci Rep. 2016.

  PMCID: PMC5103195

  Ganoderma lucidum exerts antitumor activity, but the mechanism of G. lucidum polysaccharides on cancer is unclear. ...

  Ganoderma lucidum exerts antitumor activity, but the mechanism of G. lucidum polysaccharides on cancer is unclear. ...

• 561.

  Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer.

  • Zhao X, Xiu J, Yang H, Han W, Jin Y.
  • Int J Mol Sci. 2025 Jan 23;26(3):930. doi: 10.3390/ijms26030930.
  • PMCID: PMC11817456

  Zhao X, et al.

  Int J Mol Sci. 2025.

  PMCID: PMC11817456

  Integrating network pharmacological analysis and bioinformatic techniques, this study systematically investigated the molecular mechanisms of six medicinal food homologous plants (Astragalus membranaceus, Ganoderma lucidum, Dioscorea opposite, Curcuma longa, Glycyrr …

  Integrating network pharmacological analysis and bioinformatic techniques, this study systematically investigated the molecular mechanisms o …
• 562.

  Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo.

  • Liu YH, Lin YS, Lin KL, Lu YL, Chen CH, Chien MY, Shang HF, Lin SY, Hou WC.
  • Bot Stud. 2015 Jul 4;56(1):17. doi: 10.1186/s40529-015-0097-3.
  • PMCID: PMC5432903

  Liu YH, et al.

  Bot Stud. 2015.

  PMCID: PMC5432903

  BACKGROUND: Large amounts of Ganoderma lucidum (GL) commercial products are provided in the worldwide market such as powders, tea bags, or capsules as dietary supplements which contained triterpenoids and/or polysaccharides. ...

  BACKGROUND: Large amounts of Ganoderma lucidum (GL) commercial products are provided in the worldwide market such as powders, …
• 563.

  Anticancer effect of triterpenes from Ganoderma lucidum in human prostate cancer cells.

  • Qu L, Li S, Zhuo Y, Chen J, Qin X, Guo G.
  • Oncol Lett. 2017 Oct 9;14(6):7467-7472. doi: 10.3892/ol.2017.7153.
  • PMCID: PMC5755215

  Qu L, et al.

  Oncol Lett. 2017.

  PMCID: PMC5755215

  Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant and liver protective effects. …

  Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to p …
• 564.

  Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential.

  • Bentharavithana J, Islam T, Xu B.
  • Int J Mol Sci. 2025 May 31;26(11):5304. doi: 10.3390/ijms26115304.
  • PMCID: PMC12154085

  Bentharavithana J, et al.

  Int J Mol Sci. 2025.

  PMCID: PMC12154085

  Medicinal mushrooms such as Lentinus edodes, Phellinus linteus, Ganoderma lucidum, Inonotus obliquus, Pleurotus ostreatus, Hericium erinaceus, Pleurotus eryngii, Gloeostereum incarnatum, and Termitomyces heimii are emerging as promising candidates, not only because …

  Medicinal mushrooms such as Lentinus edodes, Phellinus linteus, Ganoderma lucidum, Inonotus obliquus, Pleurotus ostreatus, Her …
• 565.

  Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores.

  • Chang WT, Gao ZH, Lo YC, Wu SN.
  • Molecules. 2019 Nov 22;24(23):4256. doi: 10.3390/molecules24234256.
  • PMCID: PMC6930560

  Chang WT, et al.

  Molecules. 2019.

  PMCID: PMC6930560

  The triterpenoid fraction of Ganoderma (Ganoderma triterpenoids, GTs) has been increasingly demonstrated to provide effective antioxidant, neuroprotective or cardioprotective activities. ...

  The triterpenoid fraction of Ganoderma (Ganoderma triterpenoids, GTs) has been increasingly demonstrated to provide effective …
• 566.

  A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application.

  • Zhong Y, Tan P, Lin H, Zhang D, Chen X, Pang J, Mu R.
  • Foods. 2024 Aug 24;13(17):2665. doi: 10.3390/foods13172665.
  • PMCID: PMC11395056

  Zhong Y, et al.

  Foods. 2024.

  PMCID: PMC11395056

  Ganoderma lucidum (GL) is a kind of edible fungus with various functions and a precious medicinal material with a long history. Ganoderma lucidum polysaccharide (GLP) is one of the main bioactive substances in GL, with anti-tumor, anti-oxidation, anti- …

  Ganoderma lucidum (GL) is a kind of edible fungus with various functions and a precious medicinal material with a long history …
• 567.

  Ganoderma tuberculosum Liquid Culture With Vineyard Pruning Extracts for Bioactive Composite Production With Antiproliferative Activity.

  • Angulo-Sanchez LT, Cruz-Félix MC, Vidal-Gutiérrez M, Torres-Moreno H, Muñoz-Bernal ÓA, Álvarez-Parrilla E, Robles-Zepeda RE, Álvarez-Bajo O, Gutiérrez A, Esqueda M.
  • Adv Pharmacol Pharm Sci. 2024 Oct 24;2024:5245451. doi: 10.1155/2024/5245451.
  • PMCID: PMC11527534

  Angulo-Sanchez LT, et al.

  Adv Pharmacol Pharm Sci. 2024.

  PMCID: PMC11527534

  Elicitors are used to increase Ganoderma bioactive composite production. This study aims to evaluate the antiproliferative activity of ethanolic extracts from mycelium of Ganoderma tuberculosum (G. tuberculosum) grown in a liquid medium with vineyard pruning waste ( …

  Elicitors are used to increase Ganoderma bioactive composite production. This study aims to evaluate the antiproliferative activity o …
• 568.

  Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum.

  • Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P.
  • Oncol Lett. 2020 Nov 12;21(1):34. doi: 10.3892/ol.2020.12295.
  • PMCID: PMC7693130

  Wu X, et al.

  Oncol Lett. 2020.

  PMCID: PMC7693130

  The Traditional Chinese Medicine, Ganoderma lucidum, has been widely used for its immunity-related and anti-cancer effects. Fudan-Yueyang-Ganoderma lucidum (FYGL) is a proteoglycan, extracted from Ganoderma lucidum, that has shown safe an …

  The Traditional Chinese Medicine, Ganoderma lucidum, has been widely used for its immunity-related and anti-cancer effects. Fu …
• 569.

  Sensory and Chemical Drivers of Wine Consumers' Preference for a New Shiraz Wine Product Containing Ganoderma lucidum Extract as a Novel Ingredient.

  • Nguyen ANH, Johnson TE, Jeffery DW, Capone DL, Danner L, Bastian SEP.
  • Foods. 2020 Feb 20;9(2):224. doi: 10.3390/foods9020224.
  • PMCID: PMC7074515

  Nguyen ANH, et al.

  Foods. 2020.

  PMCID: PMC7074515

  This study explored wine consumers' preferences towards a novel Australian Shiraz wine product containing Ganoderma lucidum (GL). Wine consumers (n = 124) were asked to complete a questionnaire and participate in a blind tasting of six GL wine products (differing in …

  This study explored wine consumers' preferences towards a novel Australian Shiraz wine product containing Ganoderma lucidum (G …
• 570.

  Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans.

  • Rokos T, Pribulova T, Kozubik E, Biringer K, Holubekova V, Kudela E.
  • Life (Basel). 2023 Jan 16;13(1):244. doi: 10.3390/life13010244.
  • PMCID: PMC9861011

  Rokos T, et al.

  Life (Basel). 2023.

  PMCID: PMC9861011

  Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to improved HPV clearance in HPV cervical or oral-positive patients. ...

  Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to impr …

• 571.

  Anti-Staphylococcus aureus potential of compounds from Ganoderma sp.: A comprehensive molecular docking and simulation approaches.

  • Nguyen TTT, Nguyen TTT, Nguyen HD, Nguyen TK, Pham PTV, Tran LTT, Pham HKT, Truong PCH, Tran LT, Tran MH.
  • Heliyon. 2024 Mar 26;10(7):e28118. doi: 10.1016/j.heliyon.2024.e28118.
  • PMCID: PMC11002548

  Nguyen TTT, et al.

  Heliyon. 2024.

  PMCID: PMC11002548

  Interestingly, ganosinoside A showed the greatest affinity for the protein clumping factor A, a result validated by molecular dynamic simulation. Additionally, three natural Ganoderma sp. Strains as Ganoderma lingzhi VNKKK1903, Ganoderma lingzhi VNKK1905A2, a …

  Interestingly, ganosinoside A showed the greatest affinity for the protein clumping factor A, a result validated by molecular dynamic simula …
• 572.

  Extracts of Polypore Mushroom Mycelia Reduce Viruses in Honey Bees.

  • Stamets PE, Naeger NL, Evans JD, Han JO, Hopkins BK, Lopez D, Moershel HM, Nally R, Sumerlin D, Taylor AW, Carris LM, Sheppard WS.
  • Sci Rep. 2018 Oct 4;8(1):13936. doi: 10.1038/s41598-018-32194-8.
  • PMCID: PMC6172205

  Stamets PE, et al.

  Sci Rep. 2018.

  PMCID: PMC6172205

  We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) and reishi (Ganoderma) fungi reduced the levels of honey bee deformed wing virus (DWV) and Lake Sinai virus (LSV) in a dose-depe …

  We tested extracts from the mycelium of multiple polypore fungal species known to have antiviral properties. Extracts from amadou (Fomes) an …
• 573.

  Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update.

  • Basnet BB, Liu L, Bao L, Liu H.
  • Mycology. 2017 May 24;8(2):111-124. doi: 10.1080/21501203.2017.1324529.
  • PMCID: PMC6059132

  Basnet BB, et al.

  Mycology. 2017.

  PMCID: PMC6059132

  Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. ...In this review, we aim to summarise all the antimicrobial and anti-parasitic works on Ganoderma sp. displayed on web of science, google scholar and endnote …

  Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. ...In this review, we aim …
• 574.

  Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.

  • Zhen C, Wu X, Zhang J, Liu D, Li G, Yan Y, He X, Miao J, Song H, Yan Y, Zhang Y.
  • Front Pharmacol. 2023 Mar 23;14:1127123. doi: 10.3389/fphar.2023.1127123.
  • PMCID: PMC10076566

  Zhen C, et al.

  Front Pharmacol. 2023.

  PMCID: PMC10076566

  However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum polysaccharides (GLPs) are one of the main active components of G. lucidum (Ganoderma lucidum), and they have various phar …

  However, drug therapies that can reverse the maladaptive process and restore heart function are limited. Ganoderma lucidum pol …
• 575.

  Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years.

  • Górska-Jakubowska S, Wu Y, Turło J, Xu B.
  • Nutrients. 2025 May 30;17(11):1887. doi: 10.3390/nu17111887.
  • PMCID: PMC12157108

  Górska-Jakubowska S, et al.

  Nutrients. 2025.

  PMCID: PMC12157108

  In this review, we aim to analyze the anti-cancer effects of edible/medicinal mushrooms, including Schizophyllum commune, Trametes versicolor, Grifola frondosa, Ganoderma lucidum, Lentinula edodes, Laetiporus sulphureus, Boletus edulis, and Phellinus igniarius, as w …

  In this review, we aim to analyze the anti-cancer effects of edible/medicinal mushrooms, including Schizophyllum commune, Trametes versicolo …
• 576.

  Mid-Infrared Spectroscopic Study of Cultivating Medicinal Fungi Ganoderma: Composition, Development, and Strain Variability of Basidiocarps.

  • Synytsya A, Bleha R, Skrynnikova A, Babayeva T, Čopíková J, Kvasnička F, Jablonsky I, Klouček P.
  • J Fungi (Basel). 2023 Dec 28;10(1):23. doi: 10.3390/jof10010023.
  • PMCID: PMC10817577

  Synytsya A, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10817577

  Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was proposed for rapid, versatile, and non-invasive screening of Ganoderma basidiocarps to assess their potential for specific applications. Fifteen species and strains of this fungus were selec …

  Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was proposed for rapid, versatile, and non-invasive screening …
• 577.

  UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.

  • Wei-Ye L, Hong-Bo G, Rui-Heng Y, Ai-Guo X, Jia-Chen Z, Zhao-Qian Y, Wen-Jun H, Xiao-Dan Y.
  • Front Nutr. 2024 Mar 18;11:1335538. doi: 10.3389/fnut.2024.1335538.
  • PMCID: PMC10982346

  Wei-Ye L, et al.

  Front Nutr. 2024.

  PMCID: PMC10982346

  The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma species are often used interchangeably since the differences in their composition are not known. ...Our findings contribute to more target …

  The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma …
• 578.

  An improved HPLC-DAD method for quantitative comparisons of triterpenes in Ganoderma lucidum and its five related species originating from Vietnam.

  • Ha do T, Loan le T, Hung TM, Han le VN, Khoi NM, Dung le V, Min BS, Nguyen NP.
  • Molecules. 2015 Jan 9;20(1):1059-77. doi: 10.3390/molecules20011059.
  • PMCID: PMC6272446

  Ha do T, et al.

  Molecules. 2015.

  PMCID: PMC6272446

  An HPLC-DAD method for the quality control of wild and cultivated Ganoderma lucidum (Linhzhi) and related species samples was developed and validated. The quantitative determination of G. lucidum and its related species using 14 triterpene constituents, inclu …

  An HPLC-DAD method for the quality control of wild and cultivated Ganoderma lucidum (Linhzhi) and related species samples was …
• 579.

  Development of a rapid and confirmatory method to identify ganoderic acids in ganoderma mushrooms.

  • Qi Y, Zhao L, Sun HH.
  • Front Pharmacol. 2012 May 7;3:85. doi: 10.3389/fphar.2012.00085.
  • PMCID: PMC3345583

  Qi Y, et al.

  Front Pharmacol. 2012.

  PMCID: PMC3345583

  To examine the composition of lanostanoids in Ganoderma lucidum, we have developed a liquid chromatography-mass spectrometry (LC-MS) method by using the ganoderic acids isolated in our laboratory as reference standards. ...Subsequently, only the HPLC-UV method would …

  To examine the composition of lanostanoids in Ganoderma lucidum, we have developed a liquid chromatography-mass spectrometry ( …
• 580.

  Effect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets.

  • Shafiee-Nick R, Parizadeh SM, Zokaei N, Ghorbani A.
  • Avicenna J Phytomed. 2012 Fall;2(4):206-11.
  • PMCID: PMC4075681

  Shafiee-Nick R, et al.

  Avicenna J Phytomed. 2012.

  PMCID: PMC4075681

  OBJECTIVE: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level. This study was undertaken to investigate its direct effect on the islets of Langerhans. ...CONCLUSION: Our results demonstrate that G. lucidum acts directly o …

  OBJECTIVE: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level. This study was undertaken …

• 581.

  Feed-forward neural network assisted by discriminant analysis for the spectroscopic discriminantion of cracked spores Ganoderma lucidum: A prospective biotechnology production tool.

  • Lim CW, Chan SH, Visconti A.
  • AMB Express. 2011 Nov 15;1(1):40. doi: 10.1186/2191-0855-1-40.
  • PMCID: PMC3240128

  Lim CW, et al.

  AMB Express. 2011.

  PMCID: PMC3240128

  A major problem for manufacturers of cracked spores Ganoderma lucidum, a traditional functional food/Chinese medicine (TCM), is to ensure that raw materials are consistent as received from the producer. To address this, a feed-forward artificial neural network (ANN) …

  A major problem for manufacturers of cracked spores Ganoderma lucidum, a traditional functional food/Chinese medicine (TCM), i …
• 582.

  Safety Considerations for Natural Products with Adaptogenic and Immunomodulating Activities.

  • Liang CJW, Woerdenbag HJ, Ekhart C, Vitalone A, van Hunsel FPAM.
  • Pharmaceuticals (Basel). 2025 Aug 15;18(8):1208. doi: 10.3390/ph18081208.
  • PMCID: PMC12389708

  Liang CJW, et al.

  Pharmaceuticals (Basel). 2025.

  PMCID: PMC12389708

  These include herbal remedies (e.g., Panax ginseng), fungi (e.g., Ganoderma lucidum), and animal-derived substances (e.g., propolis from Apis mellifera). ...However, the causality remained unclear due to insufficient data. Ganoderma lucidum, Viscum alb …

  These include herbal remedies (e.g., Panax ginseng), fungi (e.g., Ganoderma lucidum), and animal-derived substances (e.g., pro …
• 583.

  Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced Colitis Recovery and Modulation in Microbiota.

  • Li M, Yu L, Zhai Q, Liu B, Zhao J, Chen W, Tian F.
  • Foods. 2022 Dec 13;11(24):4023. doi: 10.3390/foods11244023.
  • PMCID: PMC9778072

  Li M, et al.

  Foods. 2022.

  PMCID: PMC9778072

  Popular edible mushrooms Ganoderma lucidum and Gloeostereum incarnatum can improve physical health as a prebiotic and positively alter intestinal microbiota. Our research investigated the prebiotic effects of Ganoderma lucidum and Gloeostereum incarnat …

  Popular edible mushrooms Ganoderma lucidum and Gloeostereum incarnatum can improve physical health as a prebiotic and positive …
• 584.

  Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats.

  • Cheng PG, Phan CW, Sabaratnam V, Abdullah N, Abdulla MA, Kuppusamy UR.
  • Evid Based Complement Alternat Med. 2013 Nov 24;2013:671252. doi: 10.1155/2013/671252.
  • PMCID: PMC3857811

  Cheng PG, et al.

  Evid Based Complement Alternat Med. 2013.

  PMCID: PMC3857811

  Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. ...In this study, we evaluated the wound healing activi …

  Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound heal …
• 585.

  Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling.

  • Khanal S, Kumar A, Kumar P, Thakur P, Chander AM, Verma R, Tapwal A, Chauhan V, Kumar D, Kumar D.
  • Chin Herb Med. 2025 May 19;17(3):414-427. doi: 10.1016/j.chmed.2025.05.003.
  • PMCID: PMC12301918

  Khanal S, et al.

  Chin Herb Med. 2025.

  PMCID: PMC12301918

  Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics. ...Recent advances in omics tech …

  Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmaco …
• 586.

  Hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against carbon tetrachloride-induced liver injury in mice.

  • Susilo RJK, Winarni D, Husen SA, Hayaza S, Punnapayak H, Wahyuningsih SPA, Sajidah ES, Darmanto W.
  • Vet World. 2019 Dec 17;12(12):1987-1991. doi: 10.14202/vetworld.2019.1987-1991.
  • PMCID: PMC6989327

  Susilo RJK, et al.

  Vet World. 2019.

  PMCID: PMC6989327

  The study aimed to determine the hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against liver injury induced by carbon tetrachloride (CCl(4)). MATERIALS AND METHODS: Twenty-four male BALB/C mice were randomly divided into six group …

  The study aimed to determine the hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against liv …
• 587.

  Novel therapeutic role of Ganoderma Polysaccharides in a septic mouse model - The key role of macrophages.

  • Xiong W, Xia J, Peng X, Tan Y, Chen W, Zhou M, Yang C, Wang W.
  • Heliyon. 2024 Feb 20;10(5):e26732. doi: 10.1016/j.heliyon.2024.e26732.
  • PMCID: PMC10915390

  Xiong W, et al.

  Heliyon. 2024.

  PMCID: PMC10915390

  Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties. ...

  Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties. ...
• 588.

  The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species.

  • Poniedziałek B, Siwulski M, Wiater A, Komaniecka I, Komosa A, Gąsecka M, Magdziak Z, Mleczek M, Niedzielski P, Proch J, Ropacka-Lesiak M, Lesiak M, Henao E, Rzymski P.
  • Nutrients. 2019 Dec 12;11(12):3040. doi: 10.3390/nu11123040.
  • PMCID: PMC6950045

  Poniedziałek B, et al.

  Nutrients. 2019.

  PMCID: PMC6950045

  This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus, Auricularia auricularia-judae, Coprinus comatus, Ganoderma lucidum, Hericium erinaceus, Lentinula edodes, Pleurotus …

  This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus …
• 589.

  Metabolite profiling, antioxidant and anti-glycemic activities of Tartary buckwheat processed by solid-state fermentation(SSF)with Ganoderma lucidum.

  • Zhang R, Cen Q, Hu W, Chen H, Hui F, Li J, Zeng X, Qin L.
  • Food Chem X. 2024 Apr 10;22:101376. doi: 10.1016/j.fochx.2024.101376.
  • PMCID: PMC11043823

  Zhang R, et al.

  Food Chem X. 2024.

  PMCID: PMC11043823

  The aim of this study was to investigate the effect of Ganoderma lucidum fermentation on antioxidant and anti-glycemic activities of Tartary buckwheat. ...This study demonstrates that the fermentation of Ganoderma lucidum provides a new idea to enhance …

  The aim of this study was to investigate the effect of Ganoderma lucidum fermentation on antioxidant and anti-glycemic activit …
• 590.

  Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.

  • Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT.
  • PLoS One. 2013 Oct 29;8(10):e76620. doi: 10.1371/journal.pone.0076620.
  • PMCID: PMC3812178

  Wu GS, et al.

  PLoS One. 2013.

  PMCID: PMC3812178

  Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties …

  Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also cal …

• 591.

  The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis.

  • Son HU, Lee S, Heo JC, Lee SH.
  • Int J Mol Med. 2017 Apr 7;39(5):1233-1241. doi: 10.3892/ijmm.2017.2945.
  • PMCID: PMC5403521

  Son HU, et al.

  Int J Mol Med. 2017.

  PMCID: PMC5403521

  In this study, in order to enhance the bioactivity potential of the leaves of Artemisia by Ganoderma lucidum mycelium, we prepared aqueous samples of Artemisia capillaris (Ac) leaves, Ganoderma lucidum (Gl) and aqueous fractions produced by the solid f …

  In this study, in order to enhance the bioactivity potential of the leaves of Artemisia by Ganoderma lucidum mycelium, we prep …
• 592.

  Antimetastatic Effects of Ganoderma lucidum Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation.

  • Xian H, Li J, Zhang Y, Li D, Zhu Y, Li S, Tan Z, Lin Z, Li X, Pan Y.
  • Front Pharmacol. 2021 Jul 8;12:650216. doi: 10.3389/fphar.2021.650216.
  • PMCID: PMC8296642

  Xian H, et al.

  Front Pharmacol. 2021.

  PMCID: PMC8296642

  Ganoderma lucidum (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese medicine Ganoderma lucidum; Ganoderma lucidum is known for its sedative, hypnotic, immune regulatory, antitumor, an …

  Ganoderma lucidum (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese med …
• 593.

  The morphology of Ganoderma lucidum mycelium in a repeated-batch fermentation for exopolysaccharide production.

  • Wan-Mohtar WA, Ab Kadir S, Saari N.
  • Biotechnol Rep (Amst). 2016 May 17;11:2-11. doi: 10.1016/j.btre.2016.05.005.
  • PMCID: PMC5042302

  Wan-Mohtar WA, et al.

  Biotechnol Rep (Amst). 2016.

  PMCID: PMC5042302

  The morphology of Ganoderma lucidum BCCM 31549 mycelium in a repeated-batch fermentation (RBF) was studied for exopolysaccharide (EPS) production. ...The proposed strategy showed that the morphology of G. lucidum mycelium can withstand extended fermentation c …

  The morphology of Ganoderma lucidum BCCM 31549 mycelium in a repeated-batch fermentation (RBF) was studied for exopolysacchari …
• 594.

  How Different Molecular Markers Estimate the Diversity of European Species of the Ganoderma Genus.

  • Pristas P, Beck T, Nosalova L, Gaperova S, Gaper J.
  • J Fungi (Basel). 2023 Oct 17;9(10):1023. doi: 10.3390/jof9101023.
  • PMCID: PMC10608015

  Pristas P, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10608015

  Based on published anatomical-morphological and ecological characteristics and phylogenetic evidence, six species of the Ganoderma genus are known to occur in Europe, namely, G. applanatum (Pers.) Pat., G. adspersum (Schulzer) Donk, G. pfeifferi Bres., G. resinaceum Boud., …

  Based on published anatomical-morphological and ecological characteristics and phylogenetic evidence, six species of the Ganoderma ge …
• 595.

  Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity.

  • Salahuddin M, Balan V, Stamps KG, Abdel-Wareth AAA, Mohammadi M, Kim WK, Zhu W, Lohakare J.
  • Poult Sci. 2025 Apr 28;104(8):105223. doi: 10.1016/j.psj.2025.105223.
  • PMCID: PMC12166808

  Salahuddin M, et al.

  Poult Sci. 2025.

  PMCID: PMC12166808

  Medicinal mushrooms such as Lentinula edodes, Ganoderma lucidum, and Trametes versicolor further enhance antioxidant defense and gut microbial balance. ...

  Medicinal mushrooms such as Lentinula edodes, Ganoderma lucidum, and Trametes versicolor further enhance antioxidant defense a …
• 596.

  Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.

  • Li D, Lin Y, Lv X, Wu Y, Han C, Cao P, Zhang G, Leng A, Zhou J, Wang C.
  • Front Pharmacol. 2024 Nov 15;15:1485209. doi: 10.3389/fphar.2024.1485209.
  • PMCID: PMC11605156

  Li D, et al.

  Front Pharmacol. 2024.

  PMCID: PMC11605156

  BACKGROUND: Ganoderma lucidum (G. lucidum), which possesses various biological effects, has been widely used as traditional medicine and functional food in Asian countries, especially China. ...METHODS: Using the in vivo activity assay of CYPs, the inhibitory …

  BACKGROUND: Ganoderma lucidum (G. lucidum), which possesses various biological effects, has been widely used as traditi …
• 597.

  Transcriptome profiling of transcription factors in Ganoderma lucidum in response to methyl jasmonate.

  • Xu X, Zhu F, Zhu Y, Li Y, Zhou H, Chen S, Ruan J.
  • Front Microbiol. 2022 Nov 24;13:1052377. doi: 10.3389/fmicb.2022.1052377.
  • PMCID: PMC9730249

  Xu X, et al.

  Front Microbiol. 2022.

  PMCID: PMC9730249

  Ganoderma lucidum is a traditional Chinese medicine and its major active ingredients are ganoderma triterpenoids (GTs). ...This study provided useful information for a better understanding of the regulation of TFs involved in GT biosynthesis and fungal growth …

  Ganoderma lucidum is a traditional Chinese medicine and its major active ingredients are ganoderma triterpenoids (GTs). …
• 598.

  Practical Application of "About Herbs" Website: Herbs and Dietary Supplement Use in Oncology Settings.

  • Hou YN, Deng G, Mao JJ.
  • Cancer J. Author manuscript. 2019 Sep/Oct;25(5):357-366. doi: 10.1097/PPO.0000000000000403.
  • PMCID: PMC6777855

  Hou YN, et al.

  Cancer J. Author manuscript. 2019.

  PMCID: PMC6777855

  The 10 most searched-for herbs/supplements of 2018 are chaga mushroom, turmeric, ashwagandha, reishi mushroom, graviola, Active Hexose-Correlated Compound, boswellia, dandelion, green tea, and Coriolus versicolor. ...

  The 10 most searched-for herbs/supplements of 2018 are chaga mushroom, turmeric, ashwagandha, reishi mushroom, graviola, Active Hexos …
• 599.

  ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.

  • Thyagarajan-Sahu A, Lane B, Sliva D.
  • BMC Complement Altern Med. 2011 Sep 19;11:74. doi: 10.1186/1472-6882-11-74.
  • PMCID: PMC3224355

  Thyagarajan-Sahu A, et al.

  BMC Complement Altern Med. 2011.

  PMCID: PMC3224355

  In the present study, we evaluated whether a dietary supplement ReishiMax (RM), containing triterpenes and polysaccharides extracted from medicinal mushroom Ganoderma lucidum, affects adipocyte differentiation and glucose uptake in 3T3-L1 cells. ...

  In the present study, we evaluated whether a dietary supplement ReishiMax (RM), containing triterpenes and polysaccharides extracted from me …
• 600.

  Bioactive Compounds of Ganoderma boninense Inhibited Methicillin-Resistant Staphylococcus aureus Growth by Affecting Their Cell Membrane Permeability and Integrity.

  • Chan YS, Chong KP.
  • Molecules. 2022 Jan 27;27(3):838. doi: 10.3390/molecules27030838.
  • PMCID: PMC8840476

  Chan YS, et al.

  Molecules. 2022.

  PMCID: PMC8840476

  Some species of Ganoderma, such as G. lucidum, are well-known as traditional Chinese medicine (TCM), and their pharmacological value was scientifically proven in modern days. ...

  Some species of Ganoderma, such as G. lucidum, are well-known as traditional Chinese medicine (TCM), and their pharmacological …

• 601.

  Whole-genome assembly of Ganoderma leucocontextum (Ganodermataceae, Fungi) discovered from the Tibetan Plateau of China.

  • Liu Y, Huang L, Hu H, Cai M, Liang X, Li X, Zhang Z, Xie Y, Xiao C, Chen S, Chen D, Yong T, Pan H, Gao X, Wu Q.
  • G3 (Bethesda). 2021 Dec 8;11(12):jkab337. doi: 10.1093/g3journal/jkab337.
  • PMCID: PMC8664445

  Liu Y, et al.

  G3 (Bethesda). 2021.

  PMCID: PMC8664445

  Ganoderma leucocontextum, a newly discovered species of Ganodermataceae in China, has diverse pharmacological activities. ...Furthermore, differences in functional genes of secondary metabolites (terpenoids) were analyzed between G. leucocontextum and Ganoderma l …

  Ganoderma leucocontextum, a newly discovered species of Ganodermataceae in China, has diverse pharmacological activities. ...Furtherm …
• 602.

  Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.

  • Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S.
  • iScience. 2022 Sep 26;25(11):105214. doi: 10.1016/j.isci.2022.105214.
  • PMCID: PMC9586985

  Li H, et al.

  iScience. 2022.

  PMCID: PMC9586985

  Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering and anti-atherosclerotic effects. ...Here, we evaluated the anti-hyperlipidemic effect of the adenosine extract from Ganoderma luci …

  Ganoderma lucidum is a traditional Chinese medicine with a variety of active compounds and possesses adequate lipid-lowering a …
• 603.

  Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.

  • Zhang JJ, Wang DW, Cai D, Lu Q, Cheng YX.
  • Front Chem. 2021 Nov 3;9:772740. doi: 10.3389/fchem.2021.772740.
  • PMCID: PMC8595597

  Zhang JJ, et al.

  Front Chem. 2021.

  PMCID: PMC8595597

  Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (1-5), were characterized from Ganod …

  Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs o …
• 604.

  Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents.

  • Lai G, Guo Y, Chen D, Tang X, Shuai O, Yong T, Wang D, Xiao C, Zhou G, Xie Y, Yang BB, Wu Q.
  • Front Pharmacol. 2019 Mar 26;10:272. doi: 10.3389/fphar.2019.00272.
  • PMCID: PMC6444160

  Lai G, et al.

  Front Pharmacol. 2019.

  PMCID: PMC6444160

  In this study, the AD model rats were used to screen the main active extracts from the mushroom, Ganoderma lucidum, for anti-aging properties, and their effects on DNA methylation were evaluated. The results of evaluation of rats treated with 100 mg/kg/day of D-gala …

  In this study, the AD model rats were used to screen the main active extracts from the mushroom, Ganoderma lucidum, for anti-a …
• 605.

  Ganoderma (Ganodermataceae, Basidiomycota) Species from the Greater Mekong Subregion.

  • Luangharn T, Karunarathna SC, Dutta AK, Paloi S, Promputtha I, Hyde KD, Xu J, Mortimer PE.
  • J Fungi (Basel). 2021 Sep 30;7(10):819. doi: 10.3390/jof7100819.
  • PMCID: PMC8541142

  Luangharn T, et al.

  J Fungi (Basel). 2021.

  PMCID: PMC8541142

  The cosmopolitan fungal genus Ganoderma is an important pathogen on arboreal plant hosts, particularly in tropical and temperate regions. ...Comprehensive descriptions, color photographs of macro- and micro-characteristics, the distribution of Ganoderma within the G …

  The cosmopolitan fungal genus Ganoderma is an important pathogen on arboreal plant hosts, particularly in tropical and temperate regi …
• 606.

  GlSwi6 Positively Regulates Cellulase and Xylanase Activities through Intracellular Ca(2+) Signaling in Ganoderma lucidum.

  • Lian LD, Shi LY, Zhu J, Liu R, Shi L, Ren A, Yu HS, Zhao MW.
  • J Fungi (Basel). 2022 Feb 14;8(2):187. doi: 10.3390/jof8020187.
  • PMCID: PMC8877461

  Lian LD, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC8877461

  Ganoderma lucidum is a white-rot fungus that produces a range of lignocellulolytic enzymes to decompose lignin and cellulose. ...As the downstream transcription factor of Slt2-MAPK, the function of Swi6 in G. lucidum has not been fully studied. In this study, …

  Ganoderma lucidum is a white-rot fungus that produces a range of lignocellulolytic enzymes to decompose lignin and cellulose. …
• 607.

  Ganoderma lucidum polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota.

  • Zhang XT, Yang Y, Ji C, Fu Y, Pu X, Xu G.
  • Heliyon. 2024 Aug 2;10(15):e35559. doi: 10.1016/j.heliyon.2024.e35559.
  • PMCID: PMC11336721

  Zhang XT, et al.

  Heliyon. 2024.

  PMCID: PMC11336721

  Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between intestine and liver plays an important role in ALI, and natural polysaccharides can participate in the regulation of ALI by regulating the …

  Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between …
• 608.

  Triterpenoids from the spores of Ganoderma lucidum.

  • Ma B, Ren W, Zhou Y, Ma J, Ruan Y, Wen CN.
  • N Am J Med Sci. 2011 Nov;3(11):495-8. doi: 10.4297/najms.2011.3495.
  • PMCID: PMC3271404

  Ma B, et al.

  N Am J Med Sci. 2011.

  PMCID: PMC3271404

  Recently a series of triterpenoids were isolated from ganoderma spores and have drawn the attention of chemists and pharmacists. The aim of this review is to summarize the triterpenoids and their bioactivities of ganoderma spores. ...Triterpenoids isolated from g …

  Recently a series of triterpenoids were isolated from ganoderma spores and have drawn the attention of chemists and pharmacists. The …
• 609.

  Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities.

  • Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF.
  • Evid Based Complement Alternat Med. 2011 Jun 18;2012:464238. doi: 10.1155/2012/464238.
  • PMCID: PMC3118607

  Abdullah N, et al.

  Evid Based Complement Alternat Med. 2011.

  PMCID: PMC3118607

  Antioxidant potential of each mushroom species was calculated based on the average percentages relative to quercetin and summarized as Antioxidant Index (AI). Ganoderma lucidum (30.1%), Schizophyllum commune (27.6%), and Hericium erinaceus (17.7%) showed relatively …

  Antioxidant potential of each mushroom species was calculated based on the average percentages relative to quercetin and summarized as Antio …
• 610.

  Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors.

  • Zheng DS, Chen LS.
  • Exp Ther Med. 2017 Aug 3;14(4):3273-3278. doi: 10.3892/etm.2017.4883.
  • PMCID: PMC5585879

  Zheng DS, et al.

  Exp Ther Med. 2017.

  PMCID: PMC5585879

  To find effective agents for the inhibition of Epstein-Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigation of Ganoderma lucidum was carried out in the present study. Five triterpenoids were identified, including ganoderic acid A ( …

  To find effective agents for the inhibition of Epstein-Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigati …

• 611.

  Determination of selenium-containing species, including nanoparticles, in selenium-enriched Lingzhi mushrooms.

  • LeBlanc KL, Kumlung T, Suárez Priede A, Kumkrong P, Junvee T, Deawtong S, Bettmer J, Montes-Bayón M, Mester Z.
  • Anal Bioanal Chem. 2023 Nov 21;416(11):2761-2772. doi: 10.1007/s00216-023-05031-9.
  • PMCID: PMC11009765

  LeBlanc KL, et al.

  Anal Bioanal Chem. 2023.

  PMCID: PMC11009765
• 612.

  Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities.

  • Chen ML, Hsieh CC, Chiang BL, Lin BF.
  • Evid Based Complement Alternat Med. 2015 Apr 19;2015:754836. doi: 10.1155/2015/754836.
  • PMCID: PMC4417579

  Chen ML, et al.

  Evid Based Complement Alternat Med. 2015.

  PMCID: PMC4417579

  This study was to investigate antiallergic effects of triterpenoids (Gt-TRE) and polysaccharide (Gt-PS) extracts from Ganoderma tsugae, using mast cell line RBL-2H3, T cell line EL4, primary T cells, and transfected RAW264.7 macrophage cells. ...These data suggested that t …

  This study was to investigate antiallergic effects of triterpenoids (Gt-TRE) and polysaccharide (Gt-PS) extracts from Ganoderma tsuga …
• 613.

  Influence of Food Waste Compost on the Yield and Mineral Content of Ganoderma lucidum, Lentinula edodes, and Pholiota adipose Fruiting Bodies.

  • Jo EY, Choi JY, Choi JW, Ahn JH.
  • Mycobiology. 2013 Dec 19;41(4):210-3. doi: 10.5941/MYCO.2013.41.4.210.
  • PMCID: PMC3905124

  Jo EY, et al.

  Mycobiology. 2013.

  PMCID: PMC3905124

  The objectives of this study were to evaluate applicability of food waste compost (FWC) as a substrate for cultivation of Ganoderma lucidum, Lentinula edodes, and Pholiota adipose, and to determine contents of Ca, Mg, Na, and K in fruiting bodies (FB). FB yield per …

  The objectives of this study were to evaluate applicability of food waste compost (FWC) as a substrate for cultivation of Ganoderma < …
• 614.

  A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells.

  • Lin CC, Yu YL, Shih CC, Liu KJ, Ou KL, Hong LZ, Chen JD, Chu CL.
  • Cancer Immunol Immunother. 2011 Apr 17;60(7):1019-27. doi: 10.1007/s00262-011-1016-4.
  • PMCID: PMC11029078

  Lin CC, et al.

  Cancer Immunol Immunother. 2011.

  PMCID: PMC11029078

  The immunostimulatory effect of a fungal immunomodulatory protein Ling Zhi-8 (LZ-8) isolated from Ganoderma lucidum has been reported. In this study, we tested the adjuvanticity of LZ-8 for HER-2/neu DNA vaccine against p185(neu) expressing tumor MBT-2 in mice. ...

  The immunostimulatory effect of a fungal immunomodulatory protein Ling Zhi-8 (LZ-8) isolated from Ganoderma lucidum has been r …
• 615.

  Whole-Genome Sequencing and Transcriptome Analysis of Ganoderma lucidum Strain Yw-1-5 Provides New Insights into the Enhanced Effect of Tween80 on Exopolysaccharide Production.

  • Wu T, Cai M, Hu H, Jiao C, Zhang Z, Liu Y, Chen J, Xiao C, Li X, Gao X, Chen S, Wu Q, Xie Y.
  • J Fungi (Basel). 2022 Oct 14;8(10):1081. doi: 10.3390/jof8101081.
  • PMCID: PMC9605614

  Wu T, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9605614

  Ganoderma lucidum is an important medicinal mushroom widely cultured in Asian countries. Exopolysaccharides are bioactive compounds of G. lucidum with health benefits. Limited exopolysaccharide content hinders its extraction from G. lucidum. ...

  Ganoderma lucidum is an important medicinal mushroom widely cultured in Asian countries. Exopolysaccharides are bioactive comp …
• 616.

  Influence of Selenium Biofortification on the Growth and Bioactive Metabolites of Ganoderma lucidum.

  • Xu M, Zhu S, Wang L, Wei Z, Zhao L, Shi G, Ding Z.
  • Foods. 2021 Aug 12;10(8):1860. doi: 10.3390/foods10081860.
  • PMCID: PMC8391904

  Xu M, et al.

  Foods. 2021.

  PMCID: PMC8391904

  Selenium biofortification of edible and medicinal mushrooms is an effective way to produce selenium-enriched food supplements. Ganoderma lucidum is the typical one with excellent biological activity. This study investigated G. lucidum growth and bioactive met …

  Selenium biofortification of edible and medicinal mushrooms is an effective way to produce selenium-enriched food supplements. Ganoderma< …
• 617.

  The Performance and Evolutionary Mechanism of Ganoderma lucidum in Enhancing Selenite Tolerance and Bioaccumulation.

  • Xu M, Meng Q, Zhu S, Yu R, Chen L, Shi G, Wong KH, Fan D, Ding Z.
  • J Fungi (Basel). 2024 Jun 8;10(6):415. doi: 10.3390/jof10060415.
  • PMCID: PMC11205109

  Xu M, et al.

  J Fungi (Basel). 2024.

  PMCID: PMC11205109

  To obtain Se-accumulating fungi, we isolated selenite-tolerance-enhanced Ganoderma lucidum JNUSE-200 through adaptive evolution. METHODS: The molecular mechanism responsible for selenite tolerance and accumulation was explored in G. lucidum JNUSE-200 by compa …

  To obtain Se-accumulating fungi, we isolated selenite-tolerance-enhanced Ganoderma lucidum JNUSE-200 through adaptive evolutio …
• 618.

  Gel-Based Purification and Biochemical Study of Laccase Isozymes from Ganoderma sp. and Its Role in Enhanced Cotton Callogenesis.

  • Kumar A, Singh D, Sharma KK, Arora S, Singh AK, Gill SS, Singhal B.
  • Front Microbiol. 2017 Apr 20;8:674. doi: 10.3389/fmicb.2017.00674.
  • PMCID: PMC5397484

  Kumar A, et al.

  Front Microbiol. 2017.

  PMCID: PMC5397484

  Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse growth condition. Aromatic compounds and metal salts were also found to regulate the differential expression of laccase isozymes from both …

  Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse …
• 619.

  Regulatory Effects of Ganoderma lucidum, Grifola frondosa, and American ginseng Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.

  • Zhang F, Huang W, Zhao L.
  • Foods. 2023 Oct 17;12(20):3804. doi: 10.3390/foods12203804.
  • PMCID: PMC10606397

  Zhang F, et al.

  Foods. 2023.

  PMCID: PMC10606397

  The bioactivities of Ganoderma lucidum, Grifola frondosa, and American ginseng have been extensively studied and documented. ...In this study, an immunocompromised mouse model was induced using cyclophosphamide, and Ganoderma lucidum, Grifola frondosa, …

  The bioactivities of Ganoderma lucidum, Grifola frondosa, and American ginseng have been extensively studied and documented. . …
• 620.

  Investigation of lignocellulolytic enzymes during different growth phases of Ganoderma lucidum strain G0119 using genomic, transcriptomic and secretomic analyses.

  • Zhou S, Zhang J, Ma F, Tang C, Tang Q, Zhang X.
  • PLoS One. 2018 May 31;13(5):e0198404. doi: 10.1371/journal.pone.0198404.
  • PMCID: PMC5979026

  Zhou S, et al.

  PLoS One. 2018.

  PMCID: PMC5979026

  Ganoderma lucidum is a medicinal mushroom that is well known for its ability to enhance human health, and products made from this fungus have been highly profitable. ...This study provides insight into the changes in the lignocellulose degradation ability of G. l …

  Ganoderma lucidum is a medicinal mushroom that is well known for its ability to enhance human health, and products made from t …

• 621.

  Macromycete Edible Fungi as a Functional Poultry Feed Additive: Influence on Health, Welfare, Eggs, and Meat Quality-Review.

  • Duda D, Jaszcza K, Bernaś E.
  • Molecules. 2025 Aug 1;30(15):3241. doi: 10.3390/molecules30153241.
  • PMCID: PMC12348625

  Duda D, et al.

  Molecules. 2025.

  PMCID: PMC12348625

  Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus ostreatus, Flammulina velutipes, and Inonotus obliquus. These species contain many bioactive compounds, including beta-glucans, endo- and exo …

  Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus o …
• 622.

  Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) Combined with Chemometrics Methods for the Classification of Lingzhi Species.

  • Wang YY, Li JQ, Liu HG, Wang YZ.
  • Molecules. 2019 Jun 13;24(12):2210. doi: 10.3390/molecules24122210.
  • PMCID: PMC6631843

  Wang YY, et al.

  Molecules. 2019.

  PMCID: PMC6631843
• 623.

  Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum.

  • Xu X, Li C, Wu F, Zhao S, Chen T, You H, Lin Y, Zou X.
  • J Fungi (Basel). 2025 Jan 13;11(1):57. doi: 10.3390/jof11010057.
  • PMCID: PMC11767136

  Xu X, et al.

  J Fungi (Basel). 2025.

  PMCID: PMC11767136

  Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. ...In addition, interestingly, some flavonoids and phenolic compounds, which have been reported in plants, were also detect …

  Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioa …
• 624.

  Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats.

  • Özden H, Şahin Y, Kilitçi A, Karaca G, Gömeç M, Yildiz A, Uçar C.
  • Ann Surg Treat Res. 2022 Jan 3;102(1):29-35. doi: 10.4174/astr.2022.102.1.29.
  • PMCID: PMC8753384

  Özden H, et al.

  Ann Surg Treat Res. 2022.

  PMCID: PMC8753384

  Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA)-induced colitis in rats. METHODS: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine …

  Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA)-induced colitis in r …
• 625.

  Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats.

  • Huang CH, Lin WK, Chang SH, Tsai GJ.
  • Mycology. 2020 Mar 1;12(2):82-93. doi: 10.1080/21501203.2020.1733119.
  • PMCID: PMC8128183

  Huang CH, et al.

  Mycology. 2020.

  PMCID: PMC8128183

  We aim to investigate the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures and elucidate the potential mechanisms behind these effects using a type 2 diabetic rat model. ...Based on the hypoglycaemic and antioxidant effects of G. luci …

  We aim to investigate the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures and elucidate the pote …
• 626.

  GGV formula attenuates CCl₄-induced hepatic injury in mice by modulating the gut microbiota and metabolites.

  • Wang Y, Zhang Y, He Y, Zhang S, Huang B, Wang Y, Lin W, Xiao W, Zou Z, Cui G.
  • Front Nutr. 2025 May 27;12:1564177. doi: 10.3389/fnut.2025.1564177.
  • PMCID: PMC12148870

  Wang Y, et al.

  Front Nutr. 2025.

  PMCID: PMC12148870

  Although the individual hepatoprotective properties of glutathione, Ganoderma lucidum extract, and vitamin C are well-documented, their combined effects remain to be elucidated. ...

  Although the individual hepatoprotective properties of glutathione, Ganoderma lucidum extract, and vitamin C are well-document …
• 627.

  Two-dimensional code enables visibly mapping herbal medicine chemome: an application in Ganoderma lucidum.

  • Wang Q, Liu W, Peng B, Gong X, Shi J, Zhang K, Li B, Tu P, Li J, Jiang J, Zhao Y, Song Y.
  • Chin Med. 2023 Jan 12;18(1):6. doi: 10.1186/s13020-022-00702-8.
  • PMCID: PMC9837956

  Wang Q, et al.

  Chin Med. 2023.

  PMCID: PMC9837956

  METHODS: We here attempted to denote both MS[Formula: see text] and MS[Formula: see text] dataset of HM with a single 2D-code chart. Measurement of Ganoderma lucidum that is one of the most famous HMs with LC-MS/MS was employed to illustrate the "coding-decoding" wo …

  METHODS: We here attempted to denote both MS[Formula: see text] and MS[Formula: see text] dataset of HM with a single 2D-code chart. Measure …
• 628.

  Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts.

  • Chafouz R, Karavergou S, Tsiftsoglou OS, Maskovic P, Lazari D.
  • Int J Mol Sci. 2023 Dec 30;25(1):516. doi: 10.3390/ijms25010516.
  • PMCID: PMC10779304

  Chafouz R, et al.

  Int J Mol Sci. 2023.

  PMCID: PMC10779304

  Ganoderma is a genus of wood-degrading mushrooms with medicinal importance. Most Ganoderma species have been studied extensively for their secondary metabolites, biological activities, and ecological value. ...

  Ganoderma is a genus of wood-degrading mushrooms with medicinal importance. Most Ganoderma species have been studied extensive …
• 629.

  Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3.

  • Ji Z, Tang Q, Hao R, Zhang J, Pan Y.
  • Oncol Lett. 2011 Mar 21;2(3):565-570. doi: 10.3892/ol.2011.275.
  • PMCID: PMC3410455

  Ji Z, et al.

  Oncol Lett. 2011.

  PMCID: PMC3410455

  The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known for the immune-enhancing activity of its polysaccharide. ...These findings suggest that the triterpenes contained in G. lucidum are …

  The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known …
• 630.

  Genome-Wide Characterization and Comparative Analysis of MYB Transcription Factors in Ganoderma Species.

  • Wang L, Huang Q, Zhang L, Wang Q, Liang L, Liao B.
  • G3 (Bethesda). 2020 Aug 5;10(8):2653-2660. doi: 10.1534/g3.120.401372.
  • PMCID: PMC7407476

  Wang L, et al.

  G3 (Bethesda). 2020.

  PMCID: PMC7407476

  However, less is known about the functions of MYBs in Ganoderma In this study, five medicinal macrofungi of genus Ganoderma were subjected to a genome-wide comparative analysis of MYB genes. ...This comprehensive and systematic study of MYB family members provides a …

  However, less is known about the functions of MYBs in Ganoderma In this study, five medicinal macrofungi of genus Ganoderma we …

• 631.

  Analysis of Antioxidant and Anti-Inflammatory Activities of Solvent Fractions from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.

  • Park M, Kim M.
  • Prev Nutr Food Sci. 2017 Dec 31;22(4):365-371. doi: 10.3746/pnf.2017.22.4.365.
  • PMCID: PMC5758102

  Park M, et al.

  Prev Nutr Food Sci. 2017.

  PMCID: PMC5758102

  In this study, the crude ethanol Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium (RNGM) extract was solvent fractionated with organic solvents such as n-hexane, chloroform, ethyl acetate, and water. ...Therefore, it is suggested that the ethyl acetat …

  In this study, the crude ethanol Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium (RNGM) extract was solvent fr …
• 632.

  The Importance of Nitric Oxide as the Molecular Basis of the Hydrogen Gas Fumigation-Induced Alleviation of Cd Stress on Ganoderma lucidum.

  • Abdalmegeed D, Zhao G, Cheng P, Bhat JA, Khattak WA, Ali MG, Alnadari F, Ali I, Ali Q, Korma SA, Mahmoud YA, Abd Elnabi MK, Cui W, Shen W.
  • J Fungi (Basel). 2021 Dec 23;8(1):10. doi: 10.3390/jof8010010.
  • PMCID: PMC8780922

  Abdalmegeed D, et al.

  J Fungi (Basel). 2021.

  PMCID: PMC8780922

  Whether or not hydrogen gas (H(2)) can reduce cadmium (Cd) toxicity in Ganoderma lucidum has remained largely unknown. Here, we report that Cd-induced growth inhibition in G. lucidum was significantly alleviated by H(2) fumigation or hydrogen-rich water (HRW) …

  Whether or not hydrogen gas (H(2)) can reduce cadmium (Cd) toxicity in Ganoderma lucidum has remained largely unknown. Here, w …
• 633.

  Oral Administration of Ganoderma lucidum to Lead-Exposed Rats Protects Erythrocytes against Hemolysis: Implicates to Anti-Anemia.

  • Hossain S, Bhowmick S, Islam S, Rozario L, Jahan S, Hassan M, Sarkar M, Choudhury BK, Ahmed S, Shahjalal H.
  • Evid Based Complement Alternat Med. 2015 Aug 2;2015:463703. doi: 10.1155/2015/463703.
  • PMCID: PMC4537730

  Hossain S, et al.

  Evid Based Complement Alternat Med. 2015.

  PMCID: PMC4537730

  We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity could be decreased by feeding the rats with extract of medicinal mushroom Ganoderma lucidum. Three groups of rats, control, PbA-ex …

  We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity coul …
• 634.

  Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance.

  • Wińska K, Mączka W, Gabryelska K, Grabarczyk M.
  • Molecules. 2019 Nov 11;24(22):4075. doi: 10.3390/molecules24224075.
  • PMCID: PMC6891282

  Wińska K, et al.

  Molecules. 2019.

  PMCID: PMC6891282

  This minireview summarizes the perspectives, recent advances, and major challenges of medicinal mushrooms from Ganoderma genus with reference to their antidiabetic activity. The most active ingredients of those mushrooms are polysaccharides and triterpenoids. ...

  This minireview summarizes the perspectives, recent advances, and major challenges of medicinal mushrooms from Ganoderma genus with r …
• 635.

  Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety.

  • Shaito A, Thuan DTB, Phu HT, Nguyen THD, Hasan H, Halabi S, Abdelhady S, Nasrallah GK, Eid AH, Pintus G.
  • Front Pharmacol. 2020 Apr 7;11:422. doi: 10.3389/fphar.2020.00422.
  • PMCID: PMC7155419

  Shaito A, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7155419

  Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment …

  Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Gi …
• 636.

  Ornithine Decarboxylase-Mediated Production of Putrescine Influences Ganoderic Acid Biosynthesis by Regulating Reactive Oxygen Species in Ganoderma lucidum.

  • Wu CG, Tian JL, Liu R, Cao PF, Zhang TJ, Ren A, Shi L, Zhao MW.
  • Appl Environ Microbiol. 2017 Sep 29;83(20):e01289-17. doi: 10.1128/AEM.01289-17.
  • PMCID: PMC5627001

  Wu CG, et al.

  Appl Environ Microbiol. 2017.

  PMCID: PMC5627001

  A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the ODC gene and the putrescine content were significantly decreased. ...In this study, a homolog of the gene encoding ODC was cloned in Gan …

  A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the …
• 637.

  Anti-tumor and Anti-angiogenic Ergosterols from Ganoderma lucidum.

  • Chen S, Yong T, Zhang Y, Su J, Jiao C, Xie Y.
  • Front Chem. 2017 Oct 30;5:85. doi: 10.3389/fchem.2017.00085.
  • PMCID: PMC5670154

  Chen S, et al.

  Front Chem. 2017.

  PMCID: PMC5670154

  This study was carried out to isolate chemical constituents from the lipid enriched fraction of Ganoderma lucidum extract and to evaluate their anti-proliferative effect on tumor cells and human umbilical vein endothelial cells (HUVECs). Ergosterol derivatives (1-14 …

  This study was carried out to isolate chemical constituents from the lipid enriched fraction of Ganoderma lucidum extract and …
• 638.

  Ganoderma lucidum Immobilized on Wood Demonstrates High Persistence During the Removal of OPFRs in a Trickle-Bed Bioreactor.

  • Tayar S, Villagra J, Gaju N, Martínez-Alonso M, Beltrán-Flores E, Sarrà M.
  • J Fungi (Basel). 2025 Jan 22;11(2):85. doi: 10.3390/jof11020085.
  • PMCID: PMC11856180

  Tayar S, et al.

  J Fungi (Basel). 2025.

  PMCID: PMC11856180

  This study addresses this issue by evaluating the bioremediation potential of white-rot fungi for the removal of two OPFRs: tris(2-chloroethyl) phosphate (TCEP) and tributyl phosphate (TBP). Three fungal species-Ganoderma lucidum, Trametes versicolor, and Phanerocha …

  This study addresses this issue by evaluating the bioremediation potential of white-rot fungi for the removal of two OPFRs: tris(2-chloroeth …
• 639.

  Evaluation of anti-microbial activity of spore powder of Ganoderma lucidum on clinical isolates of Prevotella intermedia: A pilot study.

  • Nayak RN, Dixitraj PT, Nayak A, Bhat K.
  • Contemp Clin Dent. 2015 Sep;6(Suppl 1):S248-52. doi: 10.4103/0976-237X.166834.
  • PMCID: PMC4632230

  Nayak RN, et al.

  Contemp Clin Dent. 2015.

  PMCID: PMC4632230

  AIM: This study aimed at evaluating the anti-microbial activity of spore powder of Ganoderma lucidum on Prevotella intermedia isolated from subgingival plaque from chronic periodontitis patients. ...Eleven samples showed sensitivity at 4 mcg/ml, 8 samples showed sen …

  AIM: This study aimed at evaluating the anti-microbial activity of spore powder of Ganoderma lucidum on Prevotella intermedia …
• 640.

  Evaluation of Two Different Treatments for Larch Logs as Substrates to Cultivate Ganoderma tsugae in the Forest.

  • Xia L, Tan X, Wang P, Yang D, Zhang Y, Cui Y, Yu Y, Zhang W, Huang X, Wen J.
  • Life (Basel). 2024 Dec 31;15(1):39. doi: 10.3390/life15010039.
  • PMCID: PMC11766503

  Xia L, et al.

  Life (Basel). 2024.

  PMCID: PMC11766503

  Larch wood, a prevalent cultivation medium for Ganoderma tsugae, has yet to be scrutinized concerning the differential impacts of sterilized and non-sterilized substrates on the growth and development of this fungus. ...

  Larch wood, a prevalent cultivation medium for Ganoderma tsugae, has yet to be scrutinized concerning the differential impacts of ste …

• 641.

  Differentiation and grouping of isolates of the Ganoderma lucidum complex by random amplified polymorphic DNA-PCR compared with grouping on the basis of internal transcribed spacer sequences.

  • Hseu RS, Wang HH, Wang HF, Moncalvo JM.
  • Appl Environ Microbiol. 1996 Apr;62(4):1354-63. doi: 10.1128/aem.62.4.1354-1363.1996.
  • PMCID: PMC167902

  Hseu RS, et al.

  Appl Environ Microbiol. 1996.

  PMCID: PMC167902

  Laccate polypores of the Ganoderma lucidum species complex are widespread white rot fungi of economic importance, but isolates cannot be identified by traditional taxonomic methods. ...The conclusion of this study is that ITS sequences can be used to identify isolat …

  Laccate polypores of the Ganoderma lucidum species complex are widespread white rot fungi of economic importance, but isolates …
• 642.

  Detection of Extracellular Enzyme Activities in Ganoderma neo-japonicum.

  • Jo WS, Park HN, Cho DH, Yoo YB, Park SC.
  • Mycobiology. 2011 Jun 16;39(2):118-20. doi: 10.4489/MYCO.2011.39.2.118.
  • PMCID: PMC3385105

  Jo WS, et al.

  Mycobiology. 2011.

  PMCID: PMC3385105

  Two Ganoderma lucidum isolates showed moderate activity for avicelase; however, Ganoderma neo-japonicum showed the strongest activity. Moderate ligninase activity was only observed in Ganoderma neo-japonicum. In contrast, pectinase, amylase, protease, …

  Two Ganoderma lucidum isolates showed moderate activity for avicelase; however, Ganoderma neo-japonicum showed the stro …
• 643.

  Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast.

  • Wang Q, Li Y, Zhang S, Yuan W, Du Z, Shi T, Chang Z, Zhai X, Lu Y, Wang M, Guo J, Zhong JJ, Xiao H.
  • Cell Discov. 2025 Jul 8;11(1):61. doi: 10.1038/s41421-025-00812-1.
  • PMCID: PMC12234687

  Wang Q, et al.

  Cell Discov. 2025.

  PMCID: PMC12234687

  Mushroom's specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is extremely challenging, not to mention reprogramming of their biosynthetic networks to target metabolites. By taking Ganoderma lucidum …

  Mushroom's specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is ext …
• 644.

  Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets.

  • Mohd Hanafiah Z, Hafsari AR, Elango M, Ilham Z, Doni F, Wan Mohtar WHM, Gafforov Y, Wong YJ, Abdul Maulud KN, Ismail NH, Putera Mohd Yusof MY, Wan-Mohtar WAAQI.
  • Heliyon. 2024 Dec 15;11(1):e41205. doi: 10.1016/j.heliyon.2024.e41205.
  • PMCID: PMC11730225

  Mohd Hanafiah Z, et al.

  Heliyon. 2024.

  PMCID: PMC11730225

  This study investigated the effectiveness of the bio-flocculation approach using the Ganoderma lucidum fungus strain BGF4A1 to remove these harmful blooms, specifically targeting cyanobacterial species like Microcystis PCC-7914. ...Morphological analysis using field …

  This study investigated the effectiveness of the bio-flocculation approach using the Ganoderma lucidum fungus strain BGF4A1 to …
• 645.

  Structural characterization and hepatoprotective activity of an acidic polysaccharide from Ganoderma lucidum.

  • Chen S, Guan X, Yong T, Gao X, Xiao C, Xie Y, Chen D, Hu H, Wu Q.
  • Food Chem X. 2022 Jan 3;13:100204. doi: 10.1016/j.fochx.2022.100204.
  • PMCID: PMC9039936

  Chen S, et al.

  Food Chem X. 2022.

  PMCID: PMC9039936

  In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have protective effect on liver damage in mice caused by restraint stress through improving oxidative status. ...The findings provided a theoretical basis for the potential application of G. …

  In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have protective effect on liver damage in mice caused …
• 646.

  Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis.

  • Pushparajah V, Fatima A, Chong CH, Gambule TZ, Chan CJ, Ng ST, Tan CS, Fung SY, Lee SS, Tan NH, Lim RL.
  • Sci Rep. 2016 Jul 27;6:30010. doi: 10.1038/srep30010.
  • PMCID: PMC4962085

  Pushparajah V, et al.

  Sci Rep. 2016.

  PMCID: PMC4962085

  Here we report the cDNA of this new member (FIP-Lrh) with a homology range of 54-64% to FIPs from other mushroom species, the closest is with FIP-glu (LZ-8) (64%) from Ganoderma lucidum. The FIP-Lrh of 112 amino acids (12.59 kDa) has a relatively hydrophobic N-termi …

  Here we report the cDNA of this new member (FIP-Lrh) with a homology range of 54-64% to FIPs from other mushroom species, the closest is wit …
• 647.

  Effect of Food Waste Compost on the Antler-Type Fruiting Body Yield of Ganoderma lucidum.

  • Jo EY, Cheon JL, Ahn JH.
  • Mycobiology. 2013 Mar 28;41(1):42-6. doi: 10.5941/MYCO.2013.41.1.42.
  • PMCID: PMC3627969

  Jo EY, et al.

  Mycobiology. 2013.

  PMCID: PMC3627969

  The effects of the composition of a mixture containing food waste compost (FWC), rice bran (RB), and oak sawdust (SD) on the antler-type fruiting body (FB) yield of Ganoderma lucidum were studied. Experiments were performed using 0 (control), 5, 10, 15, 20, 25, 30, …

  The effects of the composition of a mixture containing food waste compost (FWC), rice bran (RB), and oak sawdust (SD) on the antler-type fru …
• 648.

  LingZhi oligopeptides amino acid sequence analysis and anticancer potency evaluation.

  • Liu J, Wang H, Luo Q, Qiu S, He Z, Liu Z, Yang L, Liu X, Sun X.
  • RSC Adv. 2020 Feb 27;10(14):8377-8384. doi: 10.1039/c9ra10400c.
  • PMCID: PMC9049989

  Liu J, et al.

  RSC Adv. 2020.

  PMCID: PMC9049989

  LingZhi (Ganoderma lucidum) has been used as a therapeutic agent for decades, but the antitumor potency of LingZhi oligopeptides (LZOs) was not well explored. ...

  LingZhi (Ganoderma lucidum) has been used as a therapeutic agent for decades, but the antitumor potency of LingZhi oligopeptid …
• 649.

  Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study.

  • Tawasri P, Ampasavate C, Tharatha S, Chiranthanut N, Teekachunhatean S.
  • Biomed Res Int. 2016 Sep 25;2016:2819862. doi: 10.1155/2016/2819862.
  • PMCID: PMC5055913

  Tawasri P, et al.

  Biomed Res Int. 2016.

  PMCID: PMC5055913
• 650.

  Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.

  • Ling T, Arroyo-Cruz LV, Smither WR, Seighman EK, Martínez-Montemayor MM, Rivas F.
  • ACS Omega. 2024 Aug 19;9(35):37117-37127. doi: 10.1021/acsomega.4c04350.
  • PMCID: PMC11375702

  Ling T, et al.

  ACS Omega. 2024.

  PMCID: PMC11375702

  Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol peroxide (EP), which is attributed to its anticancer effects. The current study focuses …

  Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bi …

• 651.

  A novel Ganoderma lucidum G0119 fermentation strategy for enhanced triterpenes production by statistical process optimization and addition of oleic acid.

  • Feng J, Zhang JS, Feng N, Yan MQ, Yang Y, Jia W, Lin CC.
  • Eng Life Sci. 2016 Nov 2;17(4):430-439. doi: 10.1002/elsc.201600071.
  • PMCID: PMC6999601

  Feng J, et al.

  Eng Life Sci. 2016.

  PMCID: PMC6999601

  A novel enhanced triterpenes fermentation production process by Ganoderma lucidum G0119 with the addition of oleic acid in the medium has been developed and optimized. All of the six exogenous additives tested were found to exhibit stimulatory effect on mycelial gro …

  A novel enhanced triterpenes fermentation production process by Ganoderma lucidum G0119 with the addition of oleic acid in the …
• 652.

  Optimizing a culture medium for biomass and phenolic compounds production using Ganoderma lucidum.

  • Zárate-Chaves CA, Romero-Rodríguez MC, Niño-Arias FC, Robles-Camargo J, Linares-Linares M, Rodríguez-Bocanegra MX, Gutiérrez-Rojas I.
  • Braz J Microbiol. 2013 May 17;44(1):215-23. doi: 10.1590/S1517-83822013005000032.
  • PMCID: PMC3804202

  Zárate-Chaves CA, et al.

  Braz J Microbiol. 2013.

  PMCID: PMC3804202

  The present work was aimed at optimizing a culture medium for biomass production and phenolic compounds by using Ganoderma lucidum. The culture was optimized in two stages; a Plackett-Burman design was used in the first one for identifying key components in the medi …

  The present work was aimed at optimizing a culture medium for biomass production and phenolic compounds by using Ganoderma lucidum …
• 653.

  Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats.

  • Huang CH, Lin WK, Chang SH, Tsai GJ.
  • Mycology. 2020 Mar 23;12(2):94-104. doi: 10.1080/21501203.2020.1740409.
  • PMCID: PMC8128174

  Huang CH, et al.

  Mycology. 2020.

  PMCID: PMC8128174

  Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its mycelia for 5 weeks. Body weight, adipose tissue weight and plasma triglyceride levels were reduced, while high-density lipoprotein-choleste …

  Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its …
• 654.

  The Effect of Mitochondria on Ganoderma lucidum Growth and Bioactive Components Based on Transcriptomics.

  • Ye L, He X, Su C, Feng H, Meng G, Chen B, Wu X.
  • J Fungi (Basel). 2022 Nov 9;8(11):1182. doi: 10.3390/jof8111182.
  • PMCID: PMC9692720

  Ye L, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9692720

  In this study, the effect of mitochondria on Ganoderma lucidum morphology, yield, and main primary bioactive components was analyzed via structuring and comparing isonuclear alloplasmic strains. ...The above results further proved that mitochondria could affect the …

  In this study, the effect of mitochondria on Ganoderma lucidum morphology, yield, and main primary bioactive components was an …
• 655.

  Fungal beta glucan protects radiation induced DNA damage in human lymphocytes.

  • Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK.
  • Ann Transl Med. 2014 Feb;2(2):13. doi: 10.3978/j.issn.2305-5839.2014.02.02.
  • PMCID: PMC4202477

  Pillai TG, et al.

  Ann Transl Med. 2014.

  PMCID: PMC4202477

  BACKGROUND: Ganoderma lucidum (Ling Zhi), a basidiomycete white rot macrofungus has been used extensively for therapeutic use in China, Japan, Korea and other Asian countries for 2,000 years. ...The radioprotective properties of BG isolated from the macro fungi G …

  BACKGROUND: Ganoderma lucidum (Ling Zhi), a basidiomycete white rot macrofungus has been used extensively for therapeutic use …
• 656.

  Ganoderma lucidum Immune Modulator Protein rLZ-8 Could Prevent and Reverse Bone Loss in Glucocorticoids-Induced Osteoporosis Rat Model.

  • Yang Y, Yu T, Tang H, Ren Z, Li Q, Jia J, Chen H, Fu J, Ding S, Hao Q, Xu D, Song L, Sun B, Sun F, Pei J.
  • Front Pharmacol. 2020 May 19;11:731. doi: 10.3389/fphar.2020.00731.
  • PMCID: PMC7248554

  Yang Y, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7248554
• 657.

  In vitro prebiotic activities of oligosaccharides from the by-products in Ganoderma lucidum spore polysaccharide extraction.

  • Yang K, Zhang Y, Cai M, Guan R, Neng J, Pi X, Sun P.
  • RSC Adv. 2020 Apr 14;10(25):14794-14802. doi: 10.1039/c9ra10798c.
  • PMCID: PMC9052122

  Yang K, et al.

  RSC Adv. 2020.

  PMCID: PMC9052122

  Until recently, a variety of oligosaccharides from fruits, vegetables and mushrooms have demonstrated positive prebiotic effects. Ganoderma lucidum, a well-known traditional medicine and tonic in East Asia, has been utilized in the prevention and treatment of a broa …

  Until recently, a variety of oligosaccharides from fruits, vegetables and mushrooms have demonstrated positive prebiotic effects. Ganoder …
• 658.

  A global meta-analysis of ITS rDNA sequences from material belonging to the genus Ganoderma (Basidiomycota, Polyporales) including new data from selected taxa.

  • Fryssouli V, Zervakis GI, Polemis E, Typas MA.
  • MycoKeys. 2020 Dec 1;75:71-143. doi: 10.3897/mycokeys.75.59872.
  • PMCID: PMC7723883

  Fryssouli V, et al.

  MycoKeys. 2020.

  PMCID: PMC7723883

  Ganoderma taxa segregated into five main lineages (Clades A to E). Clade A corresponds to the core of laccate species and includes G. shanxiense and three major well-supported clusters: Cluster A.1 ('G. lucidum sensu lato') consists of taxa from Eurasia and North Am …

  Ganoderma taxa segregated into five main lineages (Clades A to E). Clade A corresponds to the core of laccate species and includes G. …
• 659.

  Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts.

  • Abdelkader ME, Mediatrice H, Lin D, Lin Z, Aggag SA.
  • Foods. 2024 Dec 13;13(24):4028. doi: 10.3390/foods13244028.
  • PMCID: PMC11727512

  Abdelkader ME, et al.

  Foods. 2024.

  PMCID: PMC11727512

  This study investigated the antioxidant and anti-aging properties of four medicinal and edible mushrooms: Ganoderma lucidum, Hericium erinaceus, Pleurotus ostreatus, and Agaricus bisporus. The antioxidant activity of mushroom extracts was evaluated using (DPPH-ABTS- …

  This study investigated the antioxidant and anti-aging properties of four medicinal and edible mushrooms: Ganoderma lucidum, H …
• 660.

  Characterization of gamma-Cadinene Enzymes in Ganoderma lucidum and Ganoderma sinensis from Basidiomycetes Provides Insight into the Identification of Terpenoid Synthases.

  • Cao R, Wu X, Wang Q, Qi P, Zhang Y, Wang L, Sun C.
  • ACS Omega. 2022 Feb 16;7(8):7229-7239. doi: 10.1021/acsomega.1c06792.
  • PMCID: PMC8892675

  Cao R, et al.

  ACS Omega. 2022.

  PMCID: PMC8892675

  Aided by bioinformatics analysis, three gamma-cadinene enzymes from Ganoderma lucidum and Ganoderma sinensis were accurately predicted and identified experimentally. ...

  Aided by bioinformatics analysis, three gamma-cadinene enzymes from Ganoderma lucidum and Ganoderma sinensis were accur …

• 661.

  Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum.

  • Sa-Ard P, Sarnthima R, Khammuang S, Kanchanarach W.
  • J Food Sci Technol. 2014 Apr 21;52(5):2966-73. doi: 10.1007/s13197-014-1343-5.
  • PMCID: PMC4397306

  Sa-Ard P, et al.

  J Food Sci Technol. 2014.

  PMCID: PMC4397306

  Crude proteins of cultured mycelia and fruiting bodies of Ganoderma lucidum were investigated for antioxidant, antibacterial and DNA protective activities. ...This protein extract was partial purified by Diethyl amino ethyl (DEAE)-Sepharose column and Sulfopropyl (S …

  Crude proteins of cultured mycelia and fruiting bodies of Ganoderma lucidum were investigated for antioxidant, antibacterial a …
• 662.

  Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria.

  • Fang H, Lin D, Li X, Wang L, Yang T.
  • Front Pharmacol. 2023 Sep 29;14:1287908. doi: 10.3389/fphar.2023.1287908.
  • PMCID: PMC10570435

  Fang H, et al.

  Front Pharmacol. 2023.

  PMCID: PMC10570435

  To reduce renal RAS activation and proteinuria caused by DOX, this study evaluated the effectiveness of Ganoderma lucidum polysaccharide peptide (GL-PP), a new glycopeptide produced from Ganoderma lucidum grown on grass. ...

  To reduce renal RAS activation and proteinuria caused by DOX, this study evaluated the effectiveness of Ganoderma lucidum poly …
• 663.

  Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima.

  • Li R, Zhang Z, Su X, Yu J, Lu L, Liu T.
  • Front Pharmacol. 2022 Oct 26;13:1012063. doi: 10.3389/fphar.2022.1012063.
  • PMCID: PMC9643841

  Li R, et al.

  Front Pharmacol. 2022.

  PMCID: PMC9643841

  This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of Ganoderma lucidum. Non-targeted metabolomics analysis was carried out on the fermentation products after the optimization proces …

  This study aims to produce biotransformation products rich in pungent saponins by using Marsdenia tenacissima as a fermentation medium of …
• 664.

  Use of Herbal Drugs in Cardiovascular Disease- A Review.

  • Kaur A, Kumar R.
  • Curr Cardiol Rev. 2025;21(1):e1573403X323724. doi: 10.2174/011573403X323724240830075719.
  • PMCID: PMC12060911

  Kaur A, et al.

  Curr Cardiol Rev. 2025.

  PMCID: PMC12060911

  Medicinal plants that are widely known for treating CVD include ginseng, Ginkgo biloba, ganoderma lucidum, gynostemma pentaphyllum, viridis amaranthus, etc. Plant sterol, flavonoids, polyphenols, sulphur compound and terpenoid are the active phytochemicals present i …

  Medicinal plants that are widely known for treating CVD include ginseng, Ginkgo biloba, ganoderma lucidum, gynostemma pentaphy …
• 665.

  Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota.

  • Wang J, Pu J, Zhang Z, Feng Z, Han J, Su X, Shi L.
  • Heliyon. 2023 Jun 7;9(6):e16682. doi: 10.1016/j.heliyon.2023.e16682.
  • PMCID: PMC10360580

  Wang J, et al.

  Heliyon. 2023.

  PMCID: PMC10360580

  The study assessed the antitumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice. A triterpene compound, 2alpha, 3alpha, 23-trihydroxy-urs-12-en-28-oic acid, was successfully isolated and purified from G. lucidum. ...

  The study assessed the antitumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice. A trit …
• 666.

  Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy.

  • Ma Y, He H, Wu J, Wang C, Chao K, Huang Q.
  • Sci Rep. 2018 Jan 8;8(1):10. doi: 10.1038/s41598-017-18422-7.
  • PMCID: PMC5758644

  Ma Y, et al.

  Sci Rep. 2018.

  PMCID: PMC5758644

  Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which contain rich polysaccharides valuable for nutrition and positive medicinal effects. In order to evaluate polysaccharide content in Ganoderma …

  Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which con …
• 667.

  Inhibitory effect of plant essential oils on α-glucosidase.

  • You Z, Li Y, Zhang K, Zheng X, Wong VKW, Liu W.
  • Food Sci Biotechnol. 2022 Aug 9;31(12):1593-1602. doi: 10.1007/s10068-022-01145-5.
  • PMCID: PMC9582169

  You Z, et al.

  Food Sci Biotechnol. 2022.

  PMCID: PMC9582169

  The further study revealed that the most potent EOs against alpha-glucosidase were chuan-xiong, fructus cnidii, sacha inchi, aloe, ganoderma lucidum spore and ginger with IC(50) values of 3.02, 2.88, 7.37, 5.06, 5.32 and 7.40 mug/mL. Moreover, the inhibitory mechani …

  The further study revealed that the most potent EOs against alpha-glucosidase were chuan-xiong, fructus cnidii, sacha inchi, aloe, ganode …
• 668.

  Water Quality Assessment and Decolourisation of Contaminated Ex-Mining Lake Water Using Bioreactor Dye-Eating Fungus (BioDeF) System: A Real Case Study.

  • Hanafiah ZM, Azmi AR, Wan-Mohtar WAAQI, Olivito F, Golemme G, Ilham Z, Jamaludin AA, Razali N, Halim-Lim SA, Wan Mohtar WHM.
  • Toxics. 2024 Jan 11;12(1):60. doi: 10.3390/toxics12010060.
  • PMCID: PMC10818540

  Hanafiah ZM, et al.

  Toxics. 2024.

  PMCID: PMC10818540

  Due to population growth and development limits, former mining lakes are being converted to more lucrative land uses like those of recreational zones, agriculture, and livestock. The fungus Ganoderma lucidum has the potential to be utilised as a substitute or to per …

  Due to population growth and development limits, former mining lakes are being converted to more lucrative land uses like those of recreatio …
• 669.

  Dynamic changes of nutrients, isoflavone composition and antioxidant activities during liquid-state fermentation of soybean embryo homogenate by Ganoderma lucidum.

  • Kim GY, Kwon YS, Gebru YA, Kim YH, Kang DH, Kim MK, Choi HS.
  • Food Chem X. 2025 Feb 14;26:102283. doi: 10.1016/j.fochx.2025.102283.
  • PMCID: PMC11880717

  Kim GY, et al.

  Food Chem X. 2025.

  PMCID: PMC11880717

  This study aims to explore compositional changes of oligosaccharides, amino-type nitrogen, free amino acids volatile compounds, isoflavones, total phenol, total flavonoid, and antioxidant capacities during liquid-state fermentation (LSF) of soybean embryo homogenate (SEH) by G …

  This study aims to explore compositional changes of oligosaccharides, amino-type nitrogen, free amino acids volatile compounds, isoflavones, …
• 670.

  Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors.

  • Wang CL, Lu CY, Pi CC, Zhuang YJ, Chu CL, Liu WH, Chen CJ.
  • BMC Complement Altern Med. 2012 Aug 10;12:119. doi: 10.1186/1472-6882-12-119.
  • PMCID: PMC3495220

  Wang CL, et al.

  BMC Complement Altern Med. 2012.

  PMCID: PMC3495220

  BACKGROUND: The fungus of Ganoderma is a traditional medicine in Asia with a variety of pharmacological functions including anti-cancer activities. ...

  BACKGROUND: The fungus of Ganoderma is a traditional medicine in Asia with a variety of pharmacological functions including anti-canc …

• 671.

  Effects of fermentation by Ganoderma lucidum and Saccharomyces cerevisiae on rape pollen morphology and its wall.

  • Zhang Z, Cao H, Chen C, Chen X, Wei Q, Zhao F.
  • J Food Sci Technol. 2017 Sep 19;54(12):4026-4034. doi: 10.1007/s13197-017-2868-1.
  • PMCID: PMC5643820

  Zhang Z, et al.

  J Food Sci Technol. 2017.

  PMCID: PMC5643820

  This study investigated the mechanism of wall rupture fermentation of the rape bee pollen by Ganoderma lucidum and Saccharomyces cerevisiae. The enzymatic activities and broken-wall ratios were determined, and the results suggested the involvement of cellulase, prot …

  This study investigated the mechanism of wall rupture fermentation of the rape bee pollen by Ganoderma lucidum and Saccharomyc …
• 672.

  Biodegradation and decolourization of textile dye wastewater using Ganoderma lucidum.

  • Selvakumar S, Manivasagan R, Chinnappan K.
  • 3 Biotech. 2012 Jun 13;3(1):71-79. doi: 10.1007/s13205-012-0073-5.
  • PMCID: PMC3563749

  Selvakumar S, et al.

  3 Biotech. 2012.

  PMCID: PMC3563749

  In this work, treatment of textile dye wastewater was carried in a batch reactor using Ganoderma lucidum. The characteristics of textile dye wastewater were studied. The effect of process parameters like pH, temperature, agitation speed and dye wastewater concentrat …

  In this work, treatment of textile dye wastewater was carried in a batch reactor using Ganoderma lucidum. The characteristics …
• 673.

  Evaluation of Total Phenolic Content, HPLC Analysis, and Antioxidant Potential of Three Local Varieties of Mushroom: A Comparative Study.

  • Bristy AT, Islam T, Ahmed R, Hossain J, Reza HM, Jain P.
  • Int J Food Sci. 2022 Oct 19;2022:3834936. doi: 10.1155/2022/3834936.
  • PMCID: PMC9605836

  Bristy AT, et al.

  Int J Food Sci. 2022.

  PMCID: PMC9605836

  The present study is aimed to investigate the ethanolic extracts of three varieties of mushrooms, namely, G. lucidum, G. tropicum, and C. indica grown in Bangladesh for phenolic and flavonoid content and their antioxidant properties. ...The alpha-amylase inhibitory and ant …

  The present study is aimed to investigate the ethanolic extracts of three varieties of mushrooms, namely, G. lucidum, G. tropicum, an …
• 674.

  Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.

  • Li J, Zhang Y, Yu F, Pan Y, Zhang Z, He Y, Yang H, Zhou P.
  • ACS Omega. 2023 Aug 8;8(33):30359-30373. doi: 10.1021/acsomega.3c03513.
  • PMCID: PMC10448640

  Li J, et al.

  ACS Omega. 2023.

  PMCID: PMC10448640

  In this study, we demonstrated that FYGL (Fudan-Yueyang-G. lucidum), a proteoglycan extracted from Ganoderma lucidum, ameliorated muscle atrophy in rat and mouse models of diabetes. ...

  In this study, we demonstrated that FYGL (Fudan-Yueyang-G. lucidum), a proteoglycan extracted from Ganoderma lucidum, a …
• 675.

  Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the beta-1,3-Glucosyltransferase Gene gl20535.

  • Liu J, Xu M, Shen M, Li J, Chen L, Gu Z, Shi G, Ding Z.
  • J Fungi (Basel). 2025 Jul 17;11(7):532. doi: 10.3390/jof11070532.
  • PMCID: PMC12295571

  Liu J, et al.

  J Fungi (Basel). 2025.

  PMCID: PMC12295571

  Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. beta-1,3-glucosyltransferase (GL20535) plays an important role in polysaccharide synthesis by catalyzing the transfer of UDP-glucose to extend sugar chains …

  Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. beta-1,3-glucos …
• 676.

  Antitumor effects and mechanisms of Ganoderma extracts and spores oil.

  • Chen C, Li P, Li Y, Yao G, Xu JH.
  • Oncol Lett. 2016 Aug 29;12(5):3571-3578. doi: 10.3892/ol.2016.5059.
  • PMCID: PMC5104053

  Chen C, et al.

  Oncol Lett. 2016.

  PMCID: PMC5104053

  Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active ingredients of Ganoderma can exhibit several effects, including antitumor effects and immunomodulation. ...The half maximal inhibitor …

  Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active …
• 677.

  Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets.

  • Yu F, Teng Y, Li J, Yang S, Zhang Z, He Y, Yang H, Ding CF, Zhou P.
  • ACS Omega. 2023 May 5;8(19):17304-17316. doi: 10.1021/acsomega.3c02200.
  • PMCID: PMC10193549

  Yu F, et al.

  ACS Omega. 2023.

  PMCID: PMC10193549

  A natural proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating insulin resistance in previous work. ...

  A natural proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to be capable of ameliorating ins …
• 678.

  The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia.

  • Wihastuti TA, Heriansyah T.
  • Heart Int. 2017 Apr 12;12(1):e1-e7. doi: 10.5301/heartint.5000234.
  • PMCID: PMC5460693

  Wihastuti TA, et al.

  Heart Int. 2017.

  PMCID: PMC5460693

  OBJECTIVES: This study aims to report Ganoderma lucidum polysaccharide peptide (PsP) effects in atherogenic process by measuring H(2)O(2) level, IL-10 level, and EPC number in blood serum, and also intima-media thickness of aorta in dyslipidemia Wistar rat model by …

  OBJECTIVES: This study aims to report Ganoderma lucidum polysaccharide peptide (PsP) effects in atherogenic process by measuri …
• 679.

  Ganoderma lucidum driven fermentation of Rosa roxburghii pomace: Effects on noodle physicochemical properties, digestion, and gut microbiota.

  • Liu M, Yan K, Yu S, Tan F, Hu W, Dai Z, Tie H, Zeng X.
  • Food Chem X. 2024 Nov 17;24:102014. doi: 10.1016/j.fochx.2024.102014.
  • PMCID: PMC11617704

  Liu M, et al.

  Food Chem X. 2024.

  PMCID: PMC11617704

  This study investigated the effects of Ganoderma lucidum fermented Rosa roxburghii pomace (FRRP) on noodle cooking characteristics, texture, structure, in vitro digestion, and fermentation. ...

  This study investigated the effects of Ganoderma lucidum fermented Rosa roxburghii pomace (FRRP) on noodle cooking characteris …
• 680.

  Experimental mixture design as a tool to optimize the growth of various Ganoderma species cultivated on media with different sugars.

  • Goh YK, Marzuki NF, Tan SY, Tan SS, Tung HJ, Goh YK, Goh KJ.
  • Mycology. 2016 Feb 16;7(1):36-44. doi: 10.1080/21501203.2015.1137985.
  • PMCID: PMC6059077

  Goh YK, et al.

  Mycology. 2016.

  PMCID: PMC6059077

  The media were adjusted to either pH 5 or 8. Ganoderma isolates (two G. boninense from oil palm, one Ganoderma species from coconut palm, G. lingzhi, and G. australe from tower tree) grew faster at pH 8. Ganoderma lingzhi proliferated at the slowest rate comp …

  The media were adjusted to either pH 5 or 8. Ganoderma isolates (two G. boninense from oil palm, one Ganoderma species from co …

• 681.

  Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production.

  • Fang Z, Liu X, Chen L, Shen Y, Zhang X, Fang W, Wang X, Bao X, Xiao Y.
  • Biotechnol Biofuels. 2015 Mar 31;8:54. doi: 10.1186/s13068-015-0235-x.
  • PMCID: PMC4399389

  Fang Z, et al.

  Biotechnol Biofuels. 2015.

  PMCID: PMC4399389

  Therefore, it is necessary to identify new laccases with lower cost but higher activity to detoxify lignocellulosic hydrolysates and better efficiency to produce biofuels such as bioethanol. Laccases from Ganoderma lucidum represent proper candidates in processing o …

  Therefore, it is necessary to identify new laccases with lower cost but higher activity to detoxify lignocellulosic hydrolysates and better …
• 682.

  A Gene from Ganoderma lucidum with Similarity to nmrA of Filamentous Ascomycetes Contributes to Regulating AreA.

  • Liu H, Qiao J, Shangguan J, Guo X, Xing Z, Zhou X, Zhao M, Zhu J.
  • J Fungi (Basel). 2023 Apr 26;9(5):516. doi: 10.3390/jof9050516.
  • PMCID: PMC10219401

  Liu H, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10219401

  Studies have shown that there are different ways to regulate AreA activity in yeast and filamentous ascomycetes, but in Basidiomycota, how AreA is regulated is unknown. Here, a gene from Ganoderma lucidum with similarity to nmrA of filamentous ascomycetes was identi …

  Studies have shown that there are different ways to regulate AreA activity in yeast and filamentous ascomycetes, but in Basidiomycota, how A …
• 683.

  Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.

  • Zhao J, Fan Y, Li H, Wang C, Fan S, Sun H, Liu M.
  • Food Sci Nutr. 2025 Apr 14;13(4):e70177. doi: 10.1002/fsn3.70177.
  • PMCID: PMC11997014

  Zhao J, et al.

  Food Sci Nutr. 2025.

  PMCID: PMC11997014

  Osteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum has been reported to have a variety of pharmacological activities, including immune regulation, anti-inflammation, antioxidation, sedative …

  Osteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum …
• 684.

  Re-Examination of the Holotype of Ganoderma sichuanense (Ganodermataceae, Polyporales) and a Clarification of the Identity of Chinese Cultivated Lingzhi.

  • Du Z, Li Y, Wang XC, Wang K, Yao YJ.
  • J Fungi (Basel). 2023 Mar 5;9(3):323. doi: 10.3390/jof9030323.
  • PMCID: PMC10051598

  Du Z, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10051598

  The widely cultivated Chinese Lingzhi is a famous fungus with significant medicinal and economic value, which has commonly been misidentified as Ganoderma lucidum for a long period of time. The scientific binomial of the fungus is always a hotly debated question tha …

  The widely cultivated Chinese Lingzhi is a famous fungus with significant medicinal and economic value, which has commonly been misidentifie …
• 685.

  Determination of nucleosides in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method.

  • Khan MS, Parveen R, Mishra K, Tulsawani R, Ahmad S.
  • J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):264-6. doi: 10.4103/0975-7406.168022.
  • PMCID: PMC4678991

  Khan MS, et al.

  J Pharm Bioallied Sci. 2015.

  PMCID: PMC4678991

  BACKGROUND: Nucleosides are supportive in the regulation and modulation of various physiological processes in body, they acts as precursors in nucleic acid synthesis, enhance immune response, help in absorption of iron and influence the metabolism of fatty acids. Cordyceps sinens …

  BACKGROUND: Nucleosides are supportive in the regulation and modulation of various physiological processes in body, they acts as precursors …
• 686.

  Culture broth of Ganoderma lucidum exhibited antioxidant, antibacterial and alpha-amylase inhibitory activities.

  • Sarnthima R, Khammaung S, Sa-Ard P.
  • J Food Sci Technol. 2017 Sep 7;54(11):3724-3730. doi: 10.1007/s13197-017-2839-6.
  • PMCID: PMC5629183

  Sarnthima R, et al.

  J Food Sci Technol. 2017.

  PMCID: PMC5629183

  Culture broth of Ganoderma lucidum was determined for antioxidant, antibacterial and alpha-amylase inhibitory activities. ...This study suggested that apart from the fruiting bodies and the mycelial of G. lucidum, its culture broth also had potential applicat …

  Culture broth of Ganoderma lucidum was determined for antioxidant, antibacterial and alpha-amylase inhibitory activities. ...T …
• 687.

  Profiling of phytochemical and antioxidant activity of wild mushrooms: Evidence from the in vitro study and phytoconstituent's binding affinity to the human erythrocyte catalase and human glutathione reductase.

  • Hossen SMM, Hossain MS, Yusuf ATM, Chaudhary P, Emon NU, Janmeda P.
  • Food Sci Nutr. 2021 Nov 2;10(1):88-102. doi: 10.1002/fsn3.2650.
  • PMCID: PMC8751451

  Hossen SMM, et al.

  Food Sci Nutr. 2021.

  PMCID: PMC8751451

  Again, the absorption, distribution, metabolism, elimination and toxicity (ADME/T) analysis has been determined by using online tools. Both Ganoderma lucidum (Curtis) Karst. and Ganoderma applanatum (Pers.) Pat. showed a significant (p < .001) increase in

  …

  Again, the absorption, distribution, metabolism, elimination and toxicity (ADME/T) analysis has been determined by using online tools. Both …
• 688.

  Understanding the characteristic changes of retrogradation behavior and edible quality of brown rice modified with inhibiting retrogradation enzymes of Ganoderma lucidum.

  • Cui M, Qiu K, Ma Y, Wang J, Zhao W, Zhang X.
  • Curr Res Food Sci. 2024 Nov 15;9:100927. doi: 10.1016/j.crfs.2024.100927.
  • PMCID: PMC11617885

  Cui M, et al.

  Curr Res Food Sci. 2024.

  PMCID: PMC11617885

  Enzymatic modification is considered as an effective manner to retard starch retrogradation by degrading starch to an appropriate extent. Ganoderma lucidum can secrete various hydrolytic enzymes related to starch hydrolysis, providing a theoretical basis and feasibi …

  Enzymatic modification is considered as an effective manner to retard starch retrogradation by degrading starch to an appropriate extent. …
• 689.

  Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity.

  • Cen K, Chen M, He M, Li Z, Song Y, Liu P, Jiang Q, Xu S, Jia Y, Shen P.
  • Front Pharmacol. 2022 Feb 21;13:826716. doi: 10.3389/fphar.2022.826716.
  • PMCID: PMC8900012

  Cen K, et al.

  Front Pharmacol. 2022.

  PMCID: PMC8900012

  Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application is profoundly limited due to chemoresistance and severe adverse effects. Sporoderm-broken spores of Ganoderma lucidum (SBSGL) …

  Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application …
• 690.

  Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats.

  • Jiang Y, Zhang N, Zhou Y, Zhou Z, Bai Y, Strappe P, Blanchard C.
  • Food Sci Biotechnol. 2021 Apr 24;30(5):755-764. doi: 10.1007/s10068-021-00908-w.
  • PMCID: PMC8144259

  Jiang Y, et al.

  Food Sci Biotechnol. 2021.

  PMCID: PMC8144259

  Our team previously demonstrated that Ganoderma lucidum spores (GLS) and resistant starch (RS) had hypoglycemic effects separately on type 2 diabetic mellitus (T2DM) rats. ...

  Our team previously demonstrated that Ganoderma lucidum spores (GLS) and resistant starch (RS) had hypoglycemic effects separa …

• 691.

  Interaction and Inhibition of a Ganoderma lucidum Proteoglycan on PTP1B Activity for Anti-diabetes.

  • Yu F, Wang Y, Teng Y, Yang S, He Y, Zhang Z, Yang H, Ding CF, Zhou P.
  • ACS Omega. 2021 Oct 27;6(44):29804-29813. doi: 10.1021/acsomega.1c04244.
  • PMCID: PMC8582033

  Yu F, et al.

  ACS Omega. 2021.

  PMCID: PMC8582033

  A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, Fudan-Yueyang G. Lucidum (FYGL), was demonstrated capable of inhibiting the activity of PTP1B. ...

  A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, Fudan-Yueyang G. Lucidum (FYGL), was dem …
• 692.

  Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model.

  • Roda E, Luca F, Iorio CD, Ratto D, Siciliani S, Ferrari B, Cobelli F, Borsci G, Priori EC, Chinosi S, Ronchi A, Franco R, Di Francia R, Berretta M, Locatelli CA, Gregori A, Savino E, Bottone MG, Rossi P.
  • Int J Mol Sci. 2020 May 14;21(10):3479. doi: 10.3390/ijms21103479.
  • PMCID: PMC7279026

  Roda E, et al.

  Int J Mol Sci. 2020.

  PMCID: PMC7279026

  Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice were generated by injecting 4T1 cells in both supp …

  Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma …
• 693.

  A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi.

  • Luo Q, Li N, Xu JW.
  • Front Microbiol. 2022 Oct 14;13:1025983. doi: 10.3389/fmicb.2022.1025983.
  • PMCID: PMC9614229

  Luo Q, et al.

  Front Microbiol. 2022.

  PMCID: PMC9614229

  In this study, the laeA gene was identified in the basidiomycete Ganoderma lingzhi and its function in regulating the biosynthesis of anti-tumor ganoderic acids was evaluated. ...These results demonstrate an essential role of LaeA in the regulation of ganoderic acid biosyn …

  In this study, the laeA gene was identified in the basidiomycete Ganoderma lingzhi and its function in regulating the biosynthesis of …
• 694.

  Study on the Structure and Bioactivity of Ganoderma lucidum Polysaccharides under Cassava Stalk Stress.

  • Liu Y, Mai B, Li Z, Feng X, Chen Y, Lin L, Xia Q.
  • J Fungi (Basel). 2023 Apr 26;9(5):514. doi: 10.3390/jof9050514.
  • PMCID: PMC10219112

  Liu Y, et al.

  J Fungi (Basel). 2023.

  PMCID: PMC10219112

  Various carbon sources affect the growth of the G. lucidum fruiting body, and the cassava stalk is considered a promising carbon source for G. lucidum. ...This study provided essential data support for cassava stalk as a carbon source in G. lucidum cultivatio …

  Various carbon sources affect the growth of the G. lucidum fruiting body, and the cassava stalk is considered a promising carbon sour …
• 695.

  Physicochemical characteristics of Ganoderma lucidum oligosaccharide and its regulatory effect on intestinal flora in vitro fermentation.

  • Xia Q, Zhao Q, Zhu H, Cao Y, Yang K, Sun P, Cai M.
  • Food Chem X. 2022 Aug 9;15:100421. doi: 10.1016/j.fochx.2022.100421.
  • PMCID: PMC9532794

  Xia Q, et al.

  Food Chem X. 2022.

  PMCID: PMC9532794

  This study explored the structure characteristics of an oligosaccharide from Ganoderma lucidum (GLO) and its regulatory functions on intestinal flora fermentation in vitro. ...

  This study explored the structure characteristics of an oligosaccharide from Ganoderma lucidum (GLO) and its regulatory functi …
• 696.

  Bioconversion of ginsenosides in the american ginseng ( xi yang shen) extraction residue by fermentation with lingzhi ( ling zhi, ganoderma lucidum).

  • Yang Hsu B, Hui Chen C, Jang Lu T, Sun Hwang L.
  • J Tradit Complement Med. 2013 Apr;3(2):95-101. doi: 10.4103/2225-4110.110416.
  • PMCID: PMC3924966

  Yang Hsu B, et al.

  J Tradit Complement Med. 2013.

  PMCID: PMC3924966

  The objective of this research was to convert ginsenosides in American ginseng ( Xi Yang Shen) extraction residue (AmR) by fermentation with lingzhi ( Ling Zhi, Ganoderma lucidum) and the fermentation products will be used for further hypoglycemic activity research. …

  The objective of this research was to convert ginsenosides in American ginseng ( Xi Yang Shen) extraction residue (AmR) by fermentation with …
• 697.

  Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats.

  • Choi YJ, Yang HS, Jo JH, Lee SC, Park TY, Choi BS, Seo KS, Huh CK.
  • Prev Nutr Food Sci. 2015 Jun 30;20(2):126-32. doi: 10.3746/pnf.2015.20.2.126.
  • PMCID: PMC4500515

  Choi YJ, et al.

  Prev Nutr Food Sci. 2015.

  PMCID: PMC4500515

  This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine-induced memory impairment in rats. ...

  This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine-induced memo …
• 698.

  Humoral responses of broiler chickens challenged with NDV following supplemental treatment with extracts of Aloe vera, Alma millsoni, Ganoderma lucidum and Archachatina marginata.

  • Ojiezeh TI, Eghafona N.
  • Cent Eur J Immunol. 2015 Oct 15;40(3):300-6. doi: 10.5114/ceji.2015.54590.
  • PMCID: PMC4655379

  Ojiezeh TI, et al.

  Cent Eur J Immunol. 2015.

  PMCID: PMC4655379

  Group A was supplemented with Aloe vera (AV) extract, group B was given Alma millsoni (AM) extract, group C was given Archachatina marginata (AMS) extract and group D was given Ganoderma lucidum (GL) extract, and group E was the control group. Extract concentrations …

  Group A was supplemented with Aloe vera (AV) extract, group B was given Alma millsoni (AM) extract, group C was given Archachatina marginata …
• 699.

  Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases.

  • Wu JY, Ding HY, Wang TY, Zhang YR, Chang TS.
  • Int J Mol Sci. 2021 Sep 9;22(18):9744. doi: 10.3390/ijms22189744.
  • PMCID: PMC8468440

  Wu JY, et al.

  Int J Mol Sci. 2021.

  PMCID: PMC8468440

  Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Ganoderma triterpenoids have already been identified, rare Ganoderma triterpenoid saponins were recently discovered. ...

  Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Gano …
• 700.

  Ganoderma lucidum polysaccharide enhances radiosensitivity of hepatocellular carcinoma cell line HepG2 through Akt signaling pathway.

  • Yu Y, Qian L, Du N, Liu Y, Zhao X, Zhang X.
  • Exp Ther Med. 2017 Oct 18;14(6):5903-5907. doi: 10.3892/etm.2017.5340.
  • PMCID: PMC5740818

  Yu Y, et al.

  Exp Ther Med. 2017.

  PMCID: PMC5740818

  Ganoderma lucidum polysaccharide (GLP) is a well-known traditional Chinese medicine, known for its anti-cancer and immunomodulatory properties. ...

  Ganoderma lucidum polysaccharide (GLP) is a well-known traditional Chinese medicine, known for its anti-cancer and immunomodul …

• 701.

  Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma.

  • Wu X, Wu Q, Wang Y, Liu Y, Li Z, Liu Q, Huang Z, Li M, Zhang B, Zhan Q.
  • Chin J Cancer Res. 2023 Apr 30;35(2):176-190. doi: 10.21147/j.issn.1000-9604.2023.02.07.
  • PMCID: PMC10167607

  Wu X, et al.

  Chin J Cancer Res. 2023.

  PMCID: PMC10167607

  Here we explored the tumor inhibition effects of Ganoderma lucidum (G. lucidum) on oral squamous cell carcinoma (OSCC). Specifically, we aimed to clarify the biological mechanism of components in the dietary, aqueous-soluble sporoderm-removed G. lucidum …

  Here we explored the tumor inhibition effects of Ganoderma lucidum (G. lucidum) on oral squamous cell carcinoma (OSCC). …
• 702.

  Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids.

  • Tong A, Wu W, Chen Z, Wen J, Jia R, Liu B, Cao H, Zhao C.
  • Curr Res Food Sci. 2022 Dec 27;6:100427. doi: 10.1016/j.crfs.2022.100427.
  • PMCID: PMC9826932

  Tong A, et al.

  Curr Res Food Sci. 2022.

  PMCID: PMC9826932

  Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. ...

  Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. ...
• 703.

  Lanostane Triterpenoids and Ergostane Steroids from Ganoderma luteomarginatum and Their Cytotoxicity.

  • Ma Q, Zhang S, Yang L, Xie Q, Dai H, Yu Z, Zhao Y.
  • Molecules. 2022 Oct 18;27(20):6989. doi: 10.3390/molecules27206989.
  • PMCID: PMC9611895

  Ma Q, et al.

  Molecules. 2022.

  PMCID: PMC9611895

  Macrofungus Ganoderma luteomarginatum is one of the main species of Ganoderma fungi distributed in Hainan province of China, the fruiting bodies of which have been widely used in folk as a healthy food to prevent tumors. ...

  Macrofungus Ganoderma luteomarginatum is one of the main species of Ganoderma fungi distributed in Hainan province of China, t …
• 704.

  Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease.

  • Areesanan A, Wasilewicz A, Nicolay S, Grienke U, Zimmermann-Klemd AM, Rollinger JM, Gründemann C.
  • Front Pharmacol. 2025 Mar 5;16:1557359. doi: 10.3389/fphar.2025.1557359.
  • PMCID: PMC11920184

  Areesanan A, et al.

  Front Pharmacol. 2025.

  PMCID: PMC11920184

  In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies of Fomes fomentarius (L.) Fr. (FF), Ganoderma lucidum (Fr.) P. Karst. (GL), Ganoderma tsugae Murrill (GT), Gloeophyllum …

  In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies …
• 705.

  Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy.

  • Ma Y, Zhang Q, Zhang Q, He H, Chen Z, Zhao Y, Wei D, Kong M, Huang Q.
  • PLoS One. 2018 Sep 21;13(9):e0204266. doi: 10.1371/journal.pone.0204266.
  • PMCID: PMC6150529

  Ma Y, et al.

  PLoS One. 2018.

  PMCID: PMC6150529

  As a traditional Chinese medicine, Ganoderma lingzhi has attracted increasing attention for both scientific research and medical application. In this work, in order to improve the production of polysaccharides from an original wide-type (WT) strain (named "RWY-0") of Ga …

  As a traditional Chinese medicine, Ganoderma lingzhi has attracted increasing attention for both scientific research and medical appl …
• 706.

  Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.

  • Mei X, Zhang J, Chen L, Wang F.
  • Discov Oncol. 2025 Aug 4;16(1):1467. doi: 10.1007/s12672-025-03280-x.
  • PMCID: PMC12321698

  Mei X, et al.

  Discov Oncol. 2025.

  PMCID: PMC12321698

  Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases. Ganoderma lucidum (Lingzhi), a well-known medicinal fungus, has shown anti-tumor effects in several malignancies, but its molecular mechanisms …

  Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases. Ganoderma …
• 707.

  Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.

  • Zhou Y, Chen S, Ding R, Yao W, Gao X.
  • Mediators Inflamm. 2014 May 22;2014:691285. doi: 10.1155/2014/691285.
  • PMCID: PMC4055584

  Zhou Y, et al.

  Mediators Inflamm. 2014.

  PMCID: PMC4055584

  Glycopeptide from Ganoderma capense (Lloyd) Teng (GCGP) injection is widely used in kinds of immune disorders, but little is known about the molecular mechanisms of how GCGP could interfere with immune cell function. ...

  Glycopeptide from Ganoderma capense (Lloyd) Teng (GCGP) injection is widely used in kinds of immune disorders, but little is known ab …
• 708.

  Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy.

  • Muthoosamy K, Bai RG, Abubakar IB, Sudheer SM, Lim HN, Loh HS, Huang NM, Chia CH, Manickam S.
  • Int J Nanomedicine. 2015 Feb 20;10:1505-19. doi: 10.2147/IJN.S75213.
  • PMCID: PMC4345939

  Muthoosamy K, et al.

  Int J Nanomedicine. 2015.

  PMCID: PMC4345939

  PURPOSE: A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the-counter medicinal and edible mushroom, Ganoderma lucidum. METHODS: The mushroom was boiled in hot water to liberate the polys …

  PURPOSE: A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the …
• 709.

  Use of sawdust for production of ligninolytic enzymes by white-rot fungi and pharmaceutical removal.

  • Hultberg M, Golovko O.
  • Bioprocess Biosyst Eng. 2024 Mar 14;47(4):475-482. doi: 10.1007/s00449-024-02976-8.
  • PMCID: PMC11003897

  Hultberg M, et al.

  Bioprocess Biosyst Eng. 2024.

  PMCID: PMC11003897

  We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolytic enzymes in aqueous suspension. Crude enzyme suspensions of the three fungi, with laccase activity range 12-43 U/L and manganese peroxidas …

  We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolyt …
• 710.

  An update on plant derived anti-androgens.

  • Grant P, Ramasamy S.
  • Int J Endocrinol Metab. 2012 Apr 20;10(2):497-502. doi: 10.5812/ijem.3644.
  • PMCID: PMC3693613

  Grant P, et al.

  Int J Endocrinol Metab. 2012.

  PMCID: PMC3693613

  We provide an overview and discussion of the use of anti-androgen medications in clinical practice and explore the increasing recognition of the benefits of plant-derived anti-androgens, for example, spearmint tea in the management of PCOS, for which some evidence about efficacy …

  We provide an overview and discussion of the use of anti-androgen medications in clinical practice and explore the increasing recognition of …

• 711.

  Ganoderma lucidum extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells.

  • Lee S, Kim SY, Lee S, Jang S, Hwang ST, Kwon Y, Choi J, Kwon O.
  • iScience. 2024 Apr 6;27(5):109675. doi: 10.1016/j.isci.2024.109675.
  • PMCID: PMC11068553

  Lee S, et al.

  iScience. 2024.

  PMCID: PMC11068553

  Here, we investigated the impact of stress-induced senescence and evaluated the potential of Ganoderma lucidum (GL) extract in mitigating CRH-induced senescence in human hair follicle cells (hHFCs). ...

  Here, we investigated the impact of stress-induced senescence and evaluated the potential of Ganoderma lucidum (GL) extract in …
• 712.

  Modulation of energy metabolism and mitochondrial biogenesis by a novel proteoglycan from Ganoderma lucidum.

  • Yang Z, Zhang Z, Zhao J, He Y, Yang H, Zhou P.
  • RSC Adv. 2019 Jan 18;9(5):2591-2598. doi: 10.1039/c8ra09482a.
  • PMCID: PMC9059857

  Yang Z, et al.

  RSC Adv. 2019.

  PMCID: PMC9059857

  In this study we first focused on the effects of a novel proteoglycan extracted from Ganoderma lucidum (FYGL) on mitochondrial biogenesis, because mitochondrial dysfunction is highly related to insulin resistance. ...

  In this study we first focused on the effects of a novel proteoglycan extracted from Ganoderma lucidum (FYGL) on mitochondrial …
• 713.

  Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma.

  • Wang M, Yu F.
  • Front Pharmacol. 2022 Jul 5;13:891171. doi: 10.3389/fphar.2022.891171.
  • PMCID: PMC9294232

  Wang M, et al.

  Front Pharmacol. 2022.

  PMCID: PMC9294232

  Accumulating evidence has verified the prominent anticancer properties of Ganoderma polysaccharides, suggesting that Ganoderma polysaccharides may be effective chemopreventive agents of natural origin. ...A more sophisticated understanding of the anticancer benefits …

  Accumulating evidence has verified the prominent anticancer properties of Ganoderma polysaccharides, suggesting that Ganoderma …
• 714.

  Effects of molecular weight on intestinal anti-inflammatory activities of beta-D-glucan from Ganoderma lucidum.

  • Liu Y, Tang Q, Feng J, Liu J, Tang C, Yan M, Zhou S, Liu L, Zhou J, Zhang J.
  • Front Nutr. 2022 Sep 29;9:1028727. doi: 10.3389/fnut.2022.1028727.
  • PMCID: PMC9557179

  Liu Y, et al.

  Front Nutr. 2022.

  PMCID: PMC9557179

  To investigate the influence of molecular weight (M (w)) on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum, ultrasonic irradiation was applied to treat the beta-D-glucan (GLP, 2.42 10(6) g/mol) solution to obtain two degraded fractions with m …

  To investigate the influence of molecular weight (M (w)) on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum …
• 715.

  Enhanced active extracellular polysaccharide production from Ganoderma formosanum using computational modeling.

  • Hsu KD, Wu SP, Lin SP, Lum CC, Cheng KC.
  • J Food Drug Anal. 2017 Feb 16;25(4):804-811. doi: 10.1016/j.jfda.2016.12.006.
  • PMCID: PMC9328880

  Hsu KD, et al.

  J Food Drug Anal. 2017.

  PMCID: PMC9328880

  Extracellular polysaccharide (EPS) is one of the major bioactive ingredients contributing to the health benefits of Ganoderma spp. In this study, response surface methodology was applied to determine the optimal culture conditions for EPS production of Ganoderma for …

  Extracellular polysaccharide (EPS) is one of the major bioactive ingredients contributing to the health benefits of Ganoderma spp. In …
• 716.

  Study of Optimal Conditions to Grow Thai Ganoderma, Fruiting Test, Proximate and Their Alpha Glucosidase Inhibitory Activity.

  • Wannasawang N, Luangharn T, Thawthong A, Charoensup R, Jaidee W, Tongdeesoontorn W, Hyde KD, Thongklang N.
  • Life (Basel). 2023 Sep 9;13(9):1887. doi: 10.3390/life13091887.
  • PMCID: PMC10532565

  Wannasawang N, et al.

  Life (Basel). 2023.

  PMCID: PMC10532565

  Ganoderma (Ganodermataceae) has a worldwide distribution and has been widely used in traditional medicines. ...All types of cereal grains can be used to promote the growth of the mycelia of Ganoderma species. Fruiting tests were performed. All strains of Ganoderm …

  Ganoderma (Ganodermataceae) has a worldwide distribution and has been widely used in traditional medicines. ...All types of cereal gr …
• 717.

  An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery.

  • Lin HJ, Chang YS, Lin LH, Haung CF, Wu CY, Ou KL.
  • Evid Based Complement Alternat Med. 2014 May 5;2014:916531. doi: 10.1155/2014/916531.
  • PMCID: PMC4026841

  Lin HJ, et al.

  Evid Based Complement Alternat Med. 2014.

  PMCID: PMC4026841
• 718.

  Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans.

  • Kozarski M, Klaus A, Špirović-Trifunović B, Miletić S, Lazić V, Žižak Ž, Vunduk J.
  • Molecules. 2024 Jan 8;29(2):314. doi: 10.3390/molecules29020314.
  • PMCID: PMC10819588

  Kozarski M, et al.

  Molecules. 2024.

  PMCID: PMC10819588

  Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumor effect in comparison to normal cells. ...

  Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumo …
• 719.

  Effects of replacing fat by betaglucans from Ganoderma lucidum on batter and cake properties.

  • Lindarte Artunduaga J, Gutiérrez LF.
  • J Food Sci Technol. 2018 Dec 4;56(1):451-461. doi: 10.1007/s13197-018-3507-1.
  • PMCID: PMC6342768

  Lindarte Artunduaga J, et al.

  J Food Sci Technol. 2018.

  PMCID: PMC6342768

  The aim of this study was to investigate the effects of replacing vegetable fat at different concentrations (20, 30, 40 and 50%) by betaglucans from Ganoderma lucidum (betaGGL), on the physical properties of cake batters, and on the quality of the resultant cakes. . …

  The aim of this study was to investigate the effects of replacing vegetable fat at different concentrations (20, 30, 40 and 50%) by betagluc …
• 720.

  Antrodia cinnamomea Formula Suppresses Prostate Cancer Progression via Immune Modulation and PD-1/PD-L1 Pathway Inhibition.

  • Tsai MY, Lu CK, Shu LH, Liu HT, Wu YH, Lin YS, Yang YH, Shih WT, Lee IY, Wu YH, Wu CY.
  • Int J Mol Sci. 2025 Mar 17;26(6):2684. doi: 10.3390/ijms26062684.
  • PMCID: PMC11942070

  Tsai MY, et al.

  Int J Mol Sci. 2025.

  PMCID: PMC11942070

  This study investigated the therapeutic potential of the Antrodia cinnamomea formula (XIANZHIFANG formula, XZF), comprising Antrodia cinnamomea, Sanghuangporus sanghuang, Ganoderma lucidum, Ganoderma sinense, and Inonotus obliquus, in prostate cancer treatmen …

  This study investigated the therapeutic potential of the Antrodia cinnamomea formula (XIANZHIFANG formula, XZF), comprising Antrodia cinnamo …

• 721.

  Convenient synthesis of uncovered imprinted microspheres by Ganoderma lucidum spore-stabilized pickering emulsion polymerization and their enhanced recognition of spiramycin.

  • Zhu Y, Teng H, Sun D, Jiang D, Yan Y.
  • RSC Adv. 2019 Oct 29;9(60):34772-34783. doi: 10.1039/c9ra07745f.
  • PMCID: PMC9074138

  Zhu Y, et al.

  RSC Adv. 2019.

  PMCID: PMC9074138

  And surprisingly the solid particles were absent on the surface of imprinted microspheres, which can be ascribed to the Ganoderma lucidum spores (GLS): they were firstly selected to be the stabilizers for the Pickering emulsion in this new strategy. ...

  And surprisingly the solid particles were absent on the surface of imprinted microspheres, which can be ascribed to the Ganoderma …
• 722.

  The innovation research on the extraction technology of ganoderma lucidum.

  • Liang C.
  • Front Pharmacol. 2012 Jun 18;3:79. doi: 10.3389/fphar.2012.00079.
  • PMCID: PMC3376421

  Liang C.

  Front Pharmacol. 2012.

  PMCID: PMC3376421
• 723.

  Molecular Pharmacological Interventions for Endometrial Cancer: A Comprehensive Review.

  • Qin W, Qi Y, Li Q, Wang B, Wang J, Ge X, Li Y, Zhang X, Liu K.
  • Drug Des Devel Ther. 2025 Aug 27;19:7381-7392. doi: 10.2147/DDDT.S524181.
  • PMCID: PMC12399865

  Qin W, et al.

  Drug Des Devel Ther. 2025.

  PMCID: PMC12399865

  Additionally, we highlight the potential of natural compounds like curcumin, paclitaxel, and Ganoderma lucidum polysaccharides as adjunctive therapies, demonstrating efficacy in preclinical studies and early-phase clinical trials. ...

  Additionally, we highlight the potential of natural compounds like curcumin, paclitaxel, and Ganoderma lucidum polysaccharides …
• 724.

  Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells.

  • Liu L, Yu Z, Chen J, Liu B, Wu C, Li Y, Xu J, Li P.
  • Pharm Biol. 2023 Dec;61(1):918-926. doi: 10.1080/13880209.2023.2220754.
  • PMCID: PMC10281419

  Liu L, et al.

  Pharm Biol. 2023.

  PMCID: PMC10281419

  CONTEXT: Lucialdehyde B (LB), an effective triterpenoid isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyproraceae), exerts cytotoxic activity against nasopharyngeal carcinoma CNE2 cells. ...

  CONTEXT: Lucialdehyde B (LB), an effective triterpenoid isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyproraceae) …
• 725.

  Linzhi (Ganoderma lucidum); evidence of its clinical usefulness in renal diseases.

  • Joob B, Wiwanitkit V.
  • J Nephropharmacol. 2015 Dec 27;5(1):9-10.
  • PMCID: PMC5297513

  Joob B, et al.

  J Nephropharmacol. 2015.

  PMCID: PMC5297513
• 726.

  Green synthesis of nanoparticles with extracellular and intracellular extracts of basidiomycetes.

  • Vetchinkina E, Loshchinina E, Kupryashina M, Burov A, Pylaev T, Nikitina V.
  • PeerJ. 2018 Jul 20;6:e5237. doi: 10.7717/peerj.5237.
  • PMCID: PMC6055591

  Vetchinkina E, et al.

  PeerJ. 2018.

  PMCID: PMC6055591

  Au, Ag, Se, and Si nanoparticles were synthesized from aqueous solutions of HAuCl(4), AgNO(3), Na(2)SeO(3), and Na(2)SiO(3) with extra- and intracellular extracts from the xylotrophic basidiomycetes Pleurotus ostreatus, Lentinus edodes, Ganoderma lucidum, and Grifol …

  Au, Ag, Se, and Si nanoparticles were synthesized from aqueous solutions of HAuCl(4), AgNO(3), Na(2)SeO(3), and Na(2)SiO(3) with extra- and …
• 727.

  Pellet diameter of Ganoderma lucidum in a repeated-batch fermentation for the trio total production of biomass-exopolysaccharide-endopolysaccharide and its anti-oral cancer beta-glucan response.

  • Abdullah NR, Sharif F, Azizan NH, Hafidz IFM, Supramani S, Usuldin SRA, Ahmad R, Wan-Mohtar WAAQI.
  • AIMS Microbiol. 2020 Oct 22;6(4):379-400. doi: 10.3934/microbiol.2020023.
  • PMCID: PMC7755588

  Abdullah NR, et al.

  AIMS Microbiol. 2020.

  PMCID: PMC7755588

  The pellet morphology and diameter range (DR) of Ganoderma lucidum were observed in a repeated-batch fermentation (RBF) for the trio total production of biomass, exopolysaccharide (EPS) and endopolysaccharide (ENS). ...Meanwhile, 4 mg/L of BG gave negative cytotoxic …

  The pellet morphology and diameter range (DR) of Ganoderma lucidum were observed in a repeated-batch fermentation (RBF) for th …
• 728.

  The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis.

  • Chen SN, Chang CS, Hung MH, Chen S, Wang W, Tai CJ, Lu CL.
  • Evid Based Complement Alternat Med. 2014 Apr 1;2014:252171. doi: 10.1155/2014/252171.
  • PMCID: PMC3995106

  Chen SN, et al.

  Evid Based Complement Alternat Med. 2014.

  PMCID: PMC3995106

  This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhibition by examining size of the primary tumor and rate of metastasis in Lewis lung carcinoma (LLC) bearing mice (C57BL/6), given oral adminis …

  This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhib …
• 729.

  Structure-function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications.

  • Wu ZW, Zhao XF, Quan CX, Liu XC, Tao XY, Li YJ, Peng XR, Qiu MH.
  • Nat Prod Bioprospect. 2025 Mar 4;15(1):15. doi: 10.1007/s13659-025-00496-w.
  • PMCID: PMC11880470

  Wu ZW, et al.

  Nat Prod Bioprospect. 2025.

  PMCID: PMC11880470

  Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, including immune modulation, anti-tumor effects, and gut microbiota regulation. ...

  Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, including …
• 730.

  Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.

  • Zhang Y, Zhou J, Yang L, Xiao H, Liu D, Kang X.
  • Antioxidants (Basel). 2024 Dec 9;13(12):1501. doi: 10.3390/antiox13121501.
  • PMCID: PMC11673792

  Zhang Y, et al.

  Antioxidants (Basel). 2024.

  PMCID: PMC11673792

  Lipid accumulation and oxidative stress, which could be improved by autophagy, are the "hits" of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has the effect of improving liver function. However, there are few reports about …

  Lipid accumulation and oxidative stress, which could be improved by autophagy, are the "hits" of metabolic-associated fatty liver disease (M …

• 731.

  Carbonized Ganoderma Lucidum/V(2)O(3) Composites as a Superior Cathode for High-Performance Aqueous Zinc-Ion Batteries.

  • Zeng G, Li Z, Jiang S, Zhou W.
  • Molecules. 2024 Aug 4;29(15):3688. doi: 10.3390/molecules29153688.
  • PMCID: PMC11314629

  Zeng G, et al.

  Molecules. 2024.

  PMCID: PMC11314629

  In response to the suboptimal electrochemical performance of low-valence vanadium oxides, Ganoderma lucidum biomass-derived carbon@V(2)O(3) (V(2)O(3)@CGL) composites were prepared by evaporative self-assembly technology and high-temperature calcination. ...

  In response to the suboptimal electrochemical performance of low-valence vanadium oxides, Ganoderma lucidum biomass-derived ca …
• 732.

  Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum.

  • Cui ML, Yang HY, He GQ.
  • J Zhejiang Univ Sci B. 2017 Dec.;18(12):1101-1112. doi: 10.1631/jzus.B1700189.
  • PMCID: PMC5742293

  Cui ML, et al.

  J Zhejiang Univ Sci B. 2017.

  PMCID: PMC5742293

  In this paper, we first studied the transformation of soybean isoflavones with the homogenized slurry of Ganoderma lucidum. The resultant transformed products (TSI) contained (703.21 4.35) mg/g of genistein, with transformed rates of 96.63% and 87.82% of daidzein an …

  In this paper, we first studied the transformation of soybean isoflavones with the homogenized slurry of Ganoderma lucidum. Th …
• 733.

  Characterizations of Ganoderma species causing basal stem rot disease in coconut tree.

  • Sajjan U, Hubballi M, Pandey AK, Devappa V, Maheswarappa HP.
  • 3 Biotech. 2024 Mar 8;14(4):104. doi: 10.1007/s13205-023-03872-w.
  • PMCID: PMC10923766

  Sajjan U, et al.

  3 Biotech. 2024.

  PMCID: PMC10923766

  The basal stem rot disease incidence ranged from 0 to 5% in Karnataka India during the year 2019-20. Twenty pathogenic isolates of Ganoderma sp varied with cultural characteristics and virulence on coconut seedlings of the variety Tipatur Tall. ...Two isolates viz., G(4) a …

  The basal stem rot disease incidence ranged from 0 to 5% in Karnataka India during the year 2019-20. Twenty pathogenic isolates of Ganode …
• 734.

  Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice.

  • Oluba OM.
  • Lipids Health Dis. 2019 Jan 12;18(1):12. doi: 10.1186/s12944-018-0951-x.
  • PMCID: PMC6330487

  Oluba OM.

  Lipids Health Dis. 2019.

  PMCID: PMC6330487

  Bioactive components of Ganoderma lucidum has recently gained intense research attention due to their acclaimed nutritional and medicinal properties. Thus, the terpenoid extract from the fruit bodies of G. lucidum (GT) was evaluated for activity against Plasm …

  Bioactive components of Ganoderma lucidum has recently gained intense research attention due to their acclaimed nutritional an …
• 735.

  Proteomic Research on the Antitumor Properties of Medicinal Mushrooms.

  • Jakopovic B, Oršolić N, Jakopovich I.
  • Molecules. 2021 Nov 5;26(21):6708. doi: 10.3390/molecules26216708.
  • PMCID: PMC8588050

  Jakopovic B, et al.

  Molecules. 2021.

  PMCID: PMC8588050

  This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including Phellinus linteus, Ganoderma lucidum, Auricularia auricula, Agrocybe aegerita, Grifola frondosa, and Lent …

  This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroo …
• 736.

  Study of the Metabolite Changes in Ganoderma lucidum under Pineapple Leaf Residue Stress via LC-MS/MS Coupled with a Non-Targeted Metabolomics Approach.

  • Liu Y, Qian Y, Wang C, He Y, Zhu C, Chen G, Lin L, Chen Y.
  • Metabolites. 2023 Mar 28;13(4):487. doi: 10.3390/metabo13040487.
  • PMCID: PMC10144527

  Liu Y, et al.

  Metabolites. 2023.

  PMCID: PMC10144527

  The effects of fermentation metabolites of G. lucidum under different pineapple leaf residue additions were separated and identified using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). ...These study results are considered instrumental in substant …

  The effects of fermentation metabolites of G. lucidum under different pineapple leaf residue additions were separated and identified …
• 737.

  Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation.

  • Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan P.
  • Evid Based Complement Alternat Med. 2011 Jun 18;2011:156810. doi: 10.1093/ecam/nep075.
  • PMCID: PMC3136196

  Zhang R, et al.

  Evid Based Complement Alternat Med. 2011.

  PMCID: PMC3136196

  The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising therapeutic target. Ganoderma lucidum (GL), a traditional Chinese medicinal herb, has been shown potential neuroprotective effec …

  The emerging evidence has supported that microglia may play key roles in the progressive neurodegeneration in PD and might be a promising th …
• 738.

  Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection.

  • Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C, Hung SC, Wong CH.
  • Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2021579118. doi: 10.1073/pnas.2021579118.
  • PMCID: PMC7865145

  Jan JT, et al.

  Proc Natl Acad Sci U S A. 2021.

  PMCID: PMC7865145

  Some of the active compounds identified in the screen were further tested in vivo, and it was found that mefloquine, nelfinavir, and extracts of Ganoderma lucidum (RF3), Perilla frutescens, and Mentha haplocalyx were effective in a challenge study using hamsters as …

  Some of the active compounds identified in the screen were further tested in vivo, and it was found that mefloquine, nelfinavir, and extract …
• 739.

  Efficacy of complementary medicine for nonsteroidal anti-inflammatory drug-induced small intestinal injuries: A narrative review.

  • Cho M, Bu Y, Park JW, Rahman H, Ko SJ.
  • Medicine (Baltimore). 2021 Dec 3;100(48):e28005. doi: 10.1097/MD.0000000000028005.
  • PMCID: PMC9191556

  Cho M, et al.

  Medicine (Baltimore). 2021.

  PMCID: PMC9191556

  Clinical and experimental studies on the effect of CAMs on NSIs were performed using 10 databases.Twenty-two studies (3 clinical and 19 in vivo experimental studies) were included in the final analysis involving 10 kinds of CAMs: bovine colostrum, Orengedokuto (coptis), muscovite …

  Clinical and experimental studies on the effect of CAMs on NSIs were performed using 10 databases.Twenty-two studies (3 clinical and 19 in v …
• 740.

  Lignin-modifying enzymes of the white rot basidiomycete Ganoderma lucidum.

  • D'Souza TM, Merritt CS, Reddy CA.
  • Appl Environ Microbiol. 1999 Dec;65(12):5307-13. doi: 10.1128/AEM.65.12.5307-5313.1999.
  • PMCID: PMC91721

  D'Souza TM, et al.

  Appl Environ Microbiol. 1999.

  PMCID: PMC91721

  Ganoderma lucidum, a white rot basidiomycete widely distributed worldwide, was studied for the production of the lignin-modifying enzymes laccase, manganese-dependent peroxidase (MnP), and lignin peroxidase (LiP). ...No LiP activity was seen in any of the media test …

  Ganoderma lucidum, a white rot basidiomycete widely distributed worldwide, was studied for the production of the lignin-modify …

• 741.

  Spore Oil enhances the effect of cyclophosphamide inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice.

  • Zhaojian J, Hongfei C, Cheng Y, Lin C, Wendong XU, Yaming H, Qin Z, Jing LI, Qin W, Juyan L.
  • J Tradit Chin Med. 2024 Aug;44(4):652-659. doi: 10.19852/j.cnki.jtcm.2024.04.003.
  • PMCID: PMC11337259

  Zhaojian J, et al.

  J Tradit Chin Med. 2024.

  PMCID: PMC11337259

  OBJECTIVE: To investigate the effect of Ganoderma Lucidum Spore Oil (GLSO) on the tumor growth and survival of H22 tumor-bearing mice treated with cyclophosphamide (CTX), and explore the underlying mechanism. ...

  OBJECTIVE: To investigate the effect of Ganoderma Lucidum Spore Oil (GLSO) on the tumor growth and survival of H22 tumor-beari …
• 742.

  Pan-genomic characterization and structural variant analysis reveal insights into spore development and species diversity in Ganoderma.

  • Yu H, Wang S, Wang L, Wu W, Xu W, Wu S, Li X, Xu W, Huang Z, Lin Y, Wang H.
  • Microb Genom. 2024 Nov;10(11):001328. doi: 10.1099/mgen.0.001328.
  • PMCID: PMC11897173

  Yu H, et al.

  Microb Genom. 2024.

  PMCID: PMC11897173

  Understanding the genomic diversity and functional implications of Ganoderma species is crucial for elucidating their evolutionary history and biotechnological potential. Here, we present the first pan-genomic analysis of Ganoderma spp., combining five newly sequenc …

  Understanding the genomic diversity and functional implications of Ganoderma species is crucial for elucidating their evolutionary hi …
• 743.

  Preparation and Characterization of Multilayer pH-Responsive Hydrogel Loaded Ganoderma lucidum Peptides.

  • Liu R, Gan J, Du M, Kong X, Xu C, Lü Y, Cao S, Meng T, Wang B, Yu T.
  • Foods. 2023 Mar 31;12(7):1481. doi: 10.3390/foods12071481.
  • PMCID: PMC10094239

  Liu R, et al.

  Foods. 2023.

  PMCID: PMC10094239

  The composite hydrogels exhibited excellent pH sensitivity and Ganoderma lucidum peptides (GLP) loading capacity. The prepared hydrogels were characterized and evaluated. ...

  The composite hydrogels exhibited excellent pH sensitivity and Ganoderma lucidum peptides (GLP) loading capacity. The prepared …
• 744.

  Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation.

  • Qu D, He J, Liu C, Zhou J, Chen Y.
  • Int J Nanomedicine. 2013 Dec 19;9:109-19. doi: 10.2147/IJN.S54796.
  • PMCID: PMC3872217

  Qu D, et al.

  Int J Nanomedicine. 2013.

  PMCID: PMC3872217

  Ganoderma lucidum triterpene-loaded microemulsions (TMEs) using Coix lacryma-jobi (adlay) seed oil as oil phase were prepared, characterized, and evaluated for enhanced antitumor activity. ...

  Ganoderma lucidum triterpene-loaded microemulsions (TMEs) using Coix lacryma-jobi (adlay) seed oil as oil phase were prepared, …
• 745.

  Impact of the fermentation broth of Ganoderma lucidum on the quality of Chinese steamed bread.

  • Guowei Z, Lili W, Yufeng L, Hailei W.
  • AMB Express. 2019 Aug 27;9(1):133. doi: 10.1186/s13568-019-0859-5.
  • PMCID: PMC6712117

  Guowei Z, et al.

  AMB Express. 2019.

  PMCID: PMC6712117

  The potential of fermentation broth of Ganoderma lucidum (FB(G)) in improving the quality of Chinese steamed bread (CSB) was firstly evaluated. ...

  The potential of fermentation broth of Ganoderma lucidum (FB(G)) in improving the quality of Chinese steamed bread (CSB) was f …
• 746.

  Mushroom-Derived Novel Selenium Nanocomposites' Effects on Potato Plant Growth and Tuber Germination.

  • Tsivileva OM, Perfileva AI.
  • Molecules. 2022 Jul 11;27(14):4438. doi: 10.3390/molecules27144438.
  • PMCID: PMC9321743

  Tsivileva OM, et al.

  Molecules. 2022.

  PMCID: PMC9321743

  Potato plants exposed to Se-bio-composite from Ganoderma lucidum SIE1303 experienced an increase in the potato vegetative biomass by up to 55% versus the control. ...

  Potato plants exposed to Se-bio-composite from Ganoderma lucidum SIE1303 experienced an increase in the potato vegetative biom …
• 747.

  Ganoderma lucidum and Professor Zhi-Bin Lin.

  • Su DF, Zhu XL.
  • Front Pharmacol. 2012 Mar 28;3:51. doi: 10.3389/fphar.2012.00051.
  • PMCID: PMC3314231

  Su DF, et al.

  Front Pharmacol. 2012.

  PMCID: PMC3314231
• 748.

  Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.

  • Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
  • J Clin Med. 2018 Jun 15;7(6):152. doi: 10.3390/jcm7060152.
  • PMCID: PMC6025418

  Jung S, et al.

  J Clin Med. 2018.

  PMCID: PMC6025418

  In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. ...

  In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcohol …
• 749.

  Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes.

  • Ogidi OC, Oyetayo VO.
  • Mycology. 2016 Feb 22;7(1):9-14. doi: 10.1080/21501203.2016.1145608.
  • PMCID: PMC6059083

  Ogidi OC, et al.

  Mycology. 2016.

  PMCID: PMC6059083

  The phytochemical property and inhibitory potential of petroleum ether and ethanol extracts of Lenzites quercina, Ganoderma lucidum and Rigidoporus ulmarius were assessed. Standard method was adopted to quantify the phytochemicals in the mushroom extracts. ...Extrac …

  The phytochemical property and inhibitory potential of petroleum ether and ethanol extracts of Lenzites quercina, Ganoderma lucidu …
• 750.

  Anti-lung cancer activity through enhancement of immunomodulation and induction of cell apoptosis of total triterpenes extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst.

  • Feng L, Yuan L, Du M, Chen Y, Zhang MH, Gu JF, He JJ, Wang Y, Cao W.
  • Molecules. 2013 Aug 19;18(8):9966-81. doi: 10.3390/molecules18089966.
  • PMCID: PMC6270046

  Feng L, et al.

  Molecules. 2013.

  PMCID: PMC6270046

  Ganoderma luncidum (Leyss. ex Fr.) Karst. (GLK) has been used traditionally for the prevention and treatment of cancers or tumors for a long time in Traditional Chinese Medicine. ...

  Ganoderma luncidum (Leyss. ex Fr.) Karst. (GLK) has been used traditionally for the prevention and treatment of cancers or tumors for …

• 751.

  Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi.

  • Wang XL, Ding ZY, Liu GQ, Yang H, Zhou GY.
  • Molecules. 2016 Oct 20;21(10):1395. doi: 10.3390/molecules21101395.
  • PMCID: PMC6273529

  Wang XL, et al.

  Molecules. 2016.

  PMCID: PMC6273529

  Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G. lingzhi submerged culture mycelia possess antitumo …

  Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative producti …
• 752.

  Polysaccharides from Basidiocarps of the Polypore Fungus Ganoderma resinaceum: Isolation and Structure.

  • Bleha R, Třešnáková L, Sushytskyi L, Capek P, Čopíková J, Klouček P, Jablonský I, Synytsya A.
  • Polymers (Basel). 2022 Jan 8;14(2):255. doi: 10.3390/polym14020255.
  • PMCID: PMC8778809

  Bleha R, et al.

  Polymers (Basel). 2022.

  PMCID: PMC8778809

  In this study, we focused on the isolation and structural characterization of polysaccharides from a basidiocarp of polypore fungus Ganoderma resinaceum. Polysaccharide fractions were obtained by successive extractions with cold water at room temperature (20 C), hot water …

  In this study, we focused on the isolation and structural characterization of polysaccharides from a basidiocarp of polypore fungus Ganod …
• 753.

  Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C-HSF1-CAM signaling pathway.

  • Pan R, Lou J, Wei L.
  • Exp Ther Med. 2021 Jun 2;22(2):820. doi: 10.3892/etm.2021.10252.
  • PMCID: PMC8193219

  Pan R, et al.

  Exp Ther Med. 2021.

  PMCID: PMC8193219

  Type 2 diabetes (T2DM), one of the two main types of diabetes, is a long-term metabolic disease caused by heredity and environmental factors. It has been reported that Ganoderma lucidum polysaccharide (GLP) significantly decreased the concentration of blood glucose, …

  Type 2 diabetes (T2DM), one of the two main types of diabetes, is a long-term metabolic disease caused by heredity and environmental factors …
• 754.

  In vitro antitumor effects of methanolic extracts of three Ganoderema mushrooms.

  • Toson EA, El-Fallal AA, Oransa MA, El-Gharabawy HM.
  • Sci Rep. 2025 Jan 17;15(1):2274. doi: 10.1038/s41598-025-86162-0.
  • PMCID: PMC11748650

  Toson EA, et al.

  Sci Rep. 2025.

  PMCID: PMC11748650

  Ganoderma mushrooms have a variety of pharmacological activities and may have antitumor effects. ...Additionally, Ganoderma australe and Ganoderma mbrekobenum decreased the viability of OEC cell line at an IC(50) of 328.29 and 271.56 g/ mL, respectively. ...

  Ganoderma mushrooms have a variety of pharmacological activities and may have antitumor effects. ...Additionally, Ganoderma au …
• 755.

  Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b.

  • Li A, Shuai X, Jia Z, Li H, Liang X, Su D, Guo W.
  • J Transl Med. 2015 Mar 26;13:100. doi: 10.1186/s12967-015-0465-5.
  • PMCID: PMC4379953

  Li A, et al.

  J Transl Med. 2015.

  PMCID: PMC4379953

  BACKGROUND: Ganoderma lucidum polysaccharides (GLPS) have been used as traditional Chinese medicine for their properties of cancer prevention and immunomodulation. ...

  BACKGROUND: Ganoderma lucidum polysaccharides (GLPS) have been used as traditional Chinese medicine for their properties of ca …
• 756.

  Comparative studies of delignification caused by ganoderma species.

  • Adaskaveg JE, Gilbertson RL, Blanchette RA.
  • Appl Environ Microbiol. 1990 Jun;56(6):1932-43. doi: 10.1128/aem.56.6.1932-1943.1990.
  • PMCID: PMC184533

  Adaskaveg JE, et al.

  Appl Environ Microbiol. 1990.

  PMCID: PMC184533

  Isolates of six species of Ganoderma in the G. lucidum complex were evaluated for their ability to decay wood of Quercus hypoleucoides A. ...Only Ganoderma sp. isolates JEA615 and JEA625 caused delignification, with JEA615 causing a lignin-to-glucose gram los …

  Isolates of six species of Ganoderma in the G. lucidum complex were evaluated for their ability to decay wood of Quercus hypol …
• 757.

  The Effects of the Substrate Length and Cultivation Time on the Physical and Mechanical Properties of Mycelium-Based Cushioning Materials from Salix psammophila and Peanut Straw.

  • Song X, Chen S, Wu J, Cai Z, Zhang Y, Na R, Lv H, He C, Wu T, Wang X.
  • Biomimetics (Basel). 2025 Jun 5;10(6):371. doi: 10.3390/biomimetics10060371.
  • PMCID: PMC12191277

  Song X, et al.

  Biomimetics (Basel). 2025.

  PMCID: PMC12191277

  This study investigated the potential of using Salix psammophila and peanut straw as substrates for cultivating Pleurotus ostreatus and Ganoderma lucidum, respectively, to fabricate mycelium-based cushioning materials. The results demonstrated that the Pleurotus ost …

  This study investigated the potential of using Salix psammophila and peanut straw as substrates for cultivating Pleurotus ostreatus and G …
• 758.

  Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain.

  • Xuan M, Okazaki M, Iwata N, Asano S, Kamiuchi S, Matsuzaki H, Sakamoto T, Miyano Y, Iizuka H, Hibino Y.
  • Evid Based Complement Alternat Med. 2015 Apr 6;2015:865986. doi: 10.1155/2015/865986.
  • PMCID: PMC4402482

  Xuan M, et al.

  Evid Based Complement Alternat Med. 2015.

  PMCID: PMC4402482

  On the basis of our previous study regarding a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (designed as MAK), which exerts antioxidative and neuroprotective effects, the present study was conducted to evaluate the preventive effects of …

  On the basis of our previous study regarding a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (des …
• 759.

  An In-Depth Study of Phytopathogenic Ganoderma: Pathogenicity, Advanced Detection Techniques, Control Strategies, and Sustainable Management.

  • Karunarathna SC, Patabendige NM, Lu W, Asad S, Hapuarachchi KK.
  • J Fungi (Basel). 2024 Jun 7;10(6):414. doi: 10.3390/jof10060414.
  • PMCID: PMC11204718

  Karunarathna SC, et al.

  J Fungi (Basel). 2024.

  PMCID: PMC11204718

  Recent studies have quantified the economic impact of Ganoderma infections, revealing staggering yield losses ranging from 20% to 80% across various crops. ...This comprehensive analysis underscores the imperative for adopting an integrated approach to Ganoderma dis …

  Recent studies have quantified the economic impact of Ganoderma infections, revealing staggering yield losses ranging from 20% to 80% …
• 760.

  The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake.

  • Cao YJ, Huang ZR, You SZ, Guo WL, Zhang F, Liu B, Lv XC, Lin ZX, Liu PH.
  • Foods. 2022 Mar 25;11(7):949. doi: 10.3390/foods11070949.
  • PMCID: PMC8997615

  Cao YJ, et al.

  Foods. 2022.

  PMCID: PMC8997615

  This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. ...

  This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and …

• 761.

  Development and Characterization of Mycelium-Based Composite Using Agro-Industrial Waste and Ganoderma lucidum as Insulating Material.

  • Jiménez-Obando G, Arcila JS, Tolosa-Correa RA, Valencia-Cardona YL, Montoya S.
  • J Fungi (Basel). 2025 Jun 17;11(6):460. doi: 10.3390/jof11060460.
  • PMCID: PMC12194127

  Jiménez-Obando G, et al.

  J Fungi (Basel). 2025.

  PMCID: PMC12194127

  This study focuses on developing an MBC based on abundant waste in Colombia, pith Arboloco (A) (Montanoa quadrangularis), a plant endemic to the Colombian-Venezuelan Andes with outstanding insulating properties, and natural fiber of Kikuyu grass (G) (Cenchrus clandestinus), utili …

  This study focuses on developing an MBC based on abundant waste in Colombia, pith Arboloco (A) (Montanoa quadrangularis), a plant endemic to …
• 762.

  Impact of malt concentration in solid substrate on mycelial growth and network connectivity in Ganoderma species.

  • Nussbaum N, von Wyl T, Gandia A, Romanens E, Rühs PA, Fischer P.
  • Sci Rep. 2023 Nov 29;13(1):21051. doi: 10.1038/s41598-023-48203-4.
  • PMCID: PMC10687231

  Nussbaum N, et al.

  Sci Rep. 2023.

  PMCID: PMC10687231

  The effect of malt extract concentration in the growth medium on radial growth kinetics, morphology, mycelium network connectivity, and mechanical characteristics of mycelium from two Ganoderma species were investigated. While an evident pattern of radial growth rate enhan …

  The effect of malt extract concentration in the growth medium on radial growth kinetics, morphology, mycelium network connectivity, and mech …
• 763.

  Whole-genome sequencing and comparative genomic analyses of the medicinal fungus Sanguinoderma infundibulare in Ganodermataceae.

  • Fang Y, Wu D, Gao N, Lv M, Zhou M, Ma C, Sun Y, Cui B.
  • G3 (Bethesda). 2024 Apr 3;14(4):jkae005. doi: 10.1093/g3journal/jkae005.
  • PMCID: PMC10989896

  Fang Y, et al.

  G3 (Bethesda). 2024.

  PMCID: PMC10989896

  Comparative genomic analyses were conducted among S. infundibulare, Sanguinoderma rugosum, Ganoderma lucidum, and Ganoderma sinense to determine their intergeneric differences. The 4 species were found to share 4,011 orthogroups, and 24 specific gene families …

  Comparative genomic analyses were conducted among S. infundibulare, Sanguinoderma rugosum, Ganoderma lucidum, and Ganoderma …
• 764.

  Evaluation of Conditions to Improve Biomass Production by Submerged Culture of Ganoderma sp.

  • Rosales-López C, Vargas-López A, Monge-Artavia M, Rojas-Chaves M.
  • Microorganisms. 2022 Jul 12;10(7):1404. doi: 10.3390/microorganisms10071404.
  • PMCID: PMC9322093

  Rosales-López C, et al.

  Microorganisms. 2022.

  PMCID: PMC9322093

  In the present investigation, the conditions for in vitro submerged culture of a native strain of Ganoderma sp. were evaluated. Different culture medium ingredients, inoculum concentrations, inoculation methods, configuration, and airflows were evaluated to improve biomass …

  In the present investigation, the conditions for in vitro submerged culture of a native strain of Ganoderma sp. were evaluated. Diffe …
• 765.

  Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.

  • Su J, Li D, Chen Q, Li M, Su L, Luo T, Liang D, Lai G, Shuai O, Jiao C, Wu Q, Xie Y, Zhou X.
  • Front Microbiol. 2018 Dec 17;9:3099. doi: 10.3389/fmicb.2018.03099.
  • PMCID: PMC6304348

  Su J, et al.

  Front Microbiol. 2018.

  PMCID: PMC6304348

  The present work explored the enhancement of a polysaccharide derived from spore of Ganoderma lucidum (SGP) with PTX in a murine 4T1-breast cancer model. Results showed that the combination of PTX and SGP displayed an improved tumor control, in which mRNA expression …

  The present work explored the enhancement of a polysaccharide derived from spore of Ganoderma lucidum (SGP) with PTX in a muri …
• 766.

  Extracellular expression of a functional recombinant Ganoderma lucidium immunomodulatory protein by Bacillus subtilis and Lactococcus lactis.

  • Yeh CM, Yeh CK, Hsu XY, Luo QM, Lin MY.
  • Appl Environ Microbiol. 2007 Dec 21;74(4):1039-49. doi: 10.1128/AEM.01547-07.
  • PMCID: PMC2258568

  Yeh CM, et al.

  Appl Environ Microbiol. 2007.

  PMCID: PMC2258568

  Bacillus subtilis and Lactococcus lactis are ideal hosts for the production of extracellular heterologous proteins of major commercial importance. A recombinant gene for the novel Ganoderma lucidium immunomodulatory protein LZ-8, recombinant LZ-8, was designed encoding the …

  Bacillus subtilis and Lactococcus lactis are ideal hosts for the production of extracellular heterologous proteins of major commercial impor …
• 767.

  Ganoderma Lucidum Pharmacopuncture for Teating Ethanol-induced Chronic Gastric Ulcers in Rats.

  • Park JH, Jang KJ, Kim CH, Kim JH, Kim YK, Yoon HM.
  • J Pharmacopuncture. 2015 Mar;18(1):72-8. doi: 10.3831/KPI.2015.18.008.
  • PMCID: PMC4379478

  Park JH, et al.

  J Pharmacopuncture. 2015.

  PMCID: PMC4379478

  This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in rats. METHODS: The rats were divided into 4 groups of 8 animals each: the normal, the control, the normal saline (NP) and the GLP groups. . …

  This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in …
• 768.

  Competitive antagonistic action of laccase between Trichoderma species and the newly identified wood pathogenic Ganoderma camelum.

  • Umar A, Elshikh MS, Aljowaie RM, Hussein JM, Dufossé L, Wu C, Lu J.
  • Front Microbiol. 2024 Sep 25;15:1408521. doi: 10.3389/fmicb.2024.1408521.
  • PMCID: PMC11461316

  Umar A, et al.

  Front Microbiol. 2024.

  PMCID: PMC11461316

  Ganoderma, a well-known genus in the Ganodermataceae family, has caused the extinction of several tree species due to its pathogenicity. This study explored the pathogenic effect of a newly identified Ganoderma species on trees and its competitive efficiency against …

  Ganoderma, a well-known genus in the Ganodermataceae family, has caused the extinction of several tree species due to its pathogenici …
• 769.

  Synthesis, Application and Prospects of Carbon Dots as A Medicine Food Homology.

  • Huang S, Ren H, Chen H, Wen N, Du L, Song C, Lv Y.
  • Nanomaterials (Basel). 2025 Jun 11;15(12):906. doi: 10.3390/nano15120906.
  • PMCID: PMC12196279

  Huang S, et al.

  Nanomaterials (Basel). 2025.

  PMCID: PMC12196279

  This review used ChatGPT 4.0 to collect background information related to carbon dots, focusing on the common rich medicinal and food resources such as Lycium barbarum, Chinese yam, honeysuckle, and Ganoderma lucidum. These carbon dots are synthesized by hydrotherma …

  This review used ChatGPT 4.0 to collect background information related to carbon dots, focusing on the common rich medicinal and food resour …
• 770.

  Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.

  • Singh A, Saini RK, Kumar A, Chawla P, Kaushik R.
  • Foods. 2025 Feb 22;14(5):741. doi: 10.3390/foods14050741.
  • PMCID: PMC11899115

  Singh A, et al.

  Foods. 2025.

  PMCID: PMC11899115

  Edible mushroom varieties such as Hericium erinaceus, Ganoderma sp., and Lentinula edodes are recognized as functional foods due to their remarkable potential for disease prevention and promotion of overall health and well-being. ...

  Edible mushroom varieties such as Hericium erinaceus, Ganoderma sp., and Lentinula edodes are recognized as functional foods due to t …

• 771.

  Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation.

  • Hsu PL, Lin YC, Ni H, Mo FE.
  • Oxid Med Cell Longev. 2018 Apr 11;2018:3491703. doi: 10.1155/2018/3491703.
  • PMCID: PMC5924996

  Hsu PL, et al.

  Oxid Med Cell Longev. 2018.

  PMCID: PMC5924996

  Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditi …

  Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supp …
• 772.

  The Protective Effect of Ganoderma lucidum Extract in Ultraviolet B-Induced Human Dermal Fibroblasts and Skin Equivalent Models.

  • Lee SH, Lee ES, Bae IH, Kim SH, Park NH, Shim JS, Lee CS, Lee J.
  • Ann Dermatol. 2020 Apr 24;32(3):251-254. doi: 10.5021/ad.2020.32.3.251.
  • PMCID: PMC7992618

  Lee SH, et al.

  Ann Dermatol. 2020.

  PMCID: PMC7992618
• 773.

  Development of efficient strain of Ganoderma lucidum for biological stripping of cotton fabric dyed Reactive Blue 21.

  • Latif Z, Shafique J, Summuna B, Lone B, Ur Rehman M, El-Sheikh MA, Hashim MJ, Vladulescu C, Shafique T.
  • Saudi J Biol Sci. 2021 Sep 17;28(12):7550-7560. doi: 10.1016/j.sjbs.2021.09.038.
  • PMCID: PMC8626342

  Latif Z, et al.

  Saudi J Biol Sci. 2021.

  PMCID: PMC8626342

  In this research work reactive blue 21 dye with 0.5, 2 and 4% shade strengths was used to dye cotton fabric. The Ganoderma lucidum fungal strains were mutated by UV mutagen, and five were selected for further processing. ...

  In this research work reactive blue 21 dye with 0.5, 2 and 4% shade strengths was used to dye cotton fabric. The Ganoderma lucidum …
• 774.

  Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.

  • Jeitler M, Michalsen A, Frings D, Hübner M, Fischer M, Koppold-Liebscher DA, Murthy V, Kessler CS.
  • Front Pharmacol. 2020 Nov 11;11:580656. doi: 10.3389/fphar.2020.580656.
  • PMCID: PMC7794004

  Jeitler M, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7794004

  The medicinal mushrooms investigated were Agaricus sylvaticus (two trials), Agaricus blazei murill (two trials), Antrodia cinnamomea (one trial), Coriolus versicolor (one trial) and Ganoderma lucidum (three trials); all were compared to placebo and administered oral …

  The medicinal mushrooms investigated were Agaricus sylvaticus (two trials), Agaricus blazei murill (two trials), Antrodia cinnamomea (one tr …
• 775.

  Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum.

  • Cui J, Wang D, Liu Y, Zhang T, Liu Y, Cheng Y, Liu X.
  • Ultrason Sonochem. 2025 Aug 25;121:107528. doi: 10.1016/j.ultsonch.2025.107528. Online ahead of print.
  • PMCID: PMC12410444

  Cui J, et al.

  Ultrason Sonochem. 2025.

  PMCID: PMC12410444

  Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properties. ...

  Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properti …
• 776.

  Improvement of Saccharification and Delignification Efficiency of Trichoderma reesei Rut-C30 by Genetic Bioengineering.

  • Gopalakrishnan RM, Manavalan T, Ramesh J, Thangavelu KP, Heese K.
  • Microorganisms. 2020 Jan 23;8(2):159. doi: 10.3390/microorganisms8020159.
  • PMCID: PMC7074786

  Gopalakrishnan RM, et al.

  Microorganisms. 2020.

  PMCID: PMC7074786

  In this study, we heterologously expressed the Ganoderma lucidum RMK1 versatile peroxidase gene (vp1) in the Rut-C30 strain of T. reesei. The expression of purified 6 His-tag-containing recombinant G. lucidum-derived protein (rVP1) was confirmed through weste …

  In this study, we heterologously expressed the Ganoderma lucidum RMK1 versatile peroxidase gene (vp1) in the Rut-C30 strain of …
• 777.

  Ganoderic acid C2 exerts the pharmacological effects against cyclophosphamide-induced immunosuppression: a study involving molecular docking and experimental validation.

  • Liu Y, Tan D, Cui H, Wang J.
  • Sci Rep. 2023 Oct 18;13(1):17745. doi: 10.1038/s41598-023-44394-y.
  • PMCID: PMC10584852

  Liu Y, et al.

  Sci Rep. 2023.

  PMCID: PMC10584852

  Triterpenoids, as the main active ingredient of Ganoderma lucidum fermented extract, exert multiple pharmacological activities, including immunomodulatory properties. ...Our findings lay a theoretical foundation for the in-depth development and utilization of Gan …

  Triterpenoids, as the main active ingredient of Ganoderma lucidum fermented extract, exert multiple pharmacological activities …
• 778.

  Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo.

  • Wang W, Gou X, Xue H, Liu K.
  • Onco Targets Ther. 2019 Oct 25;12:8821-8832. doi: 10.2147/OTT.S221161.
  • PMCID: PMC6821078

  Wang W, et al.

  Onco Targets Ther. 2019.

  PMCID: PMC6821078

  Ganoderan (GDN) is one of the components of Ganoderma lucidum polysaccharides. Ganoderan A (GDNA), Ganoderan B (GDNB) and Ganoderan C (GDNC) were three polysaccharides isolated from the Ganoderma lucidum fruiting body. ...

  Ganoderan (GDN) is one of the components of Ganoderma lucidum polysaccharides. Ganoderan A (GDNA), Ganoderan B (GDNB) and Gano …
• 779.

  Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity.

  • Sinaeve S, Husson C, Antoine MH, Welti S, Stévigny C, Nortier J.
  • J Fungi (Basel). 2022 Sep 24;8(10):1002. doi: 10.3390/jof8101002.
  • PMCID: PMC9605180

  Sinaeve S, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9605180

  This study aims to identify new prophylactic properties with respect to medicinal mushrooms. Among five Ganoderma species, the methanolic extracts of Ganoderma tuberculosum Murill., Ganoderma parvigibbosum Welti & Courtec. (10 g/mL), and their association …

  This study aims to identify new prophylactic properties with respect to medicinal mushrooms. Among five Ganoderma species, the methan …
• 780.

  Synthesis of Ganoderic Acids Loaded Zein-Chitosan Nanoparticles and Evaluation of Their Hepatoprotective Effect on Mice Given Excessive Alcohol.

  • Cao Y, Yang Y, Liang Z, Guo W, Lv X, Ni L, Chen Y.
  • Foods. 2024 Aug 29;13(17):2760. doi: 10.3390/foods13172760.
  • PMCID: PMC11394847

  Cao Y, et al.

  Foods. 2024.

  PMCID: PMC11394847

  Ganoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological activities but are limited by poor water solubility and low oral bioaccessibility. ...

  Ganoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological …

• 781.

  Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake.

  • Guo WL, Cao YJ, You SZ, Wu Q, Zhang F, Han JZ, Lv XC, Rao PF, Ai LZ, Ni L.
  • Curr Res Food Sci. 2022 Feb 24;5:515-530. doi: 10.1016/j.crfs.2022.02.013.
  • PMCID: PMC8913248

  Guo WL, et al.

  Curr Res Food Sci. 2022.

  PMCID: PMC8913248

  Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human health. It is well known that Ganoderma lucidum possesses various excellent beneficial effects on liver function and lipid metabo …

  Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human hea …
• 782.

  The reduction of aorta histopathological images through inhibition of reactive oxygen species formation in hypercholesterolemia rattus norvegicus treated with polysaccharide peptide of Ganoderma lucidum.

  • Andri Wihastuti T, Sargowo D, Heriansyah T, Eka Aziza Y, Puspitarini D, Nur Iwana A, Astrida Evitasari L.
  • Iran J Basic Med Sci. 2015 May;18(5):514-9.
  • PMCID: PMC4475661

  Andri Wihastuti T, et al.

  Iran J Basic Med Sci. 2015.

  PMCID: PMC4475661

  One source of antioxidant, which has potential to be developed, is PsP from Ganoderma lucidum. This study aims to prove the effect of PsP in decreasing H2O2, PVAT, foam cells and atherosclerotic plaque. ...

  One source of antioxidant, which has potential to be developed, is PsP from Ganoderma lucidum. This study aims to prove the ef …
• 783.

  Mycelium-based biomaterials as smart devices for skin wound healing.

  • Ruggeri M, Miele D, Contardi M, Vigani B, Boselli C, Icaro Cornaglia A, Rossi S, Suarato G, Athanassiou A, Sandri G.
  • Front Bioeng Biotechnol. 2023 Aug 15;11:1225722. doi: 10.3389/fbioe.2023.1225722.
  • PMCID: PMC10465301

  Ruggeri M, et al.

  Front Bioeng Biotechnol. 2023.

  PMCID: PMC10465301

  Introduction: Recently, mycelia of Ganoderma lucidum and Pleurotus ostreatus, edible fungi, have been characterized in vitro as self-growing biomaterials for tissue engineering since they are constituted of interconnected fibrous networks resembling the dermal colla …

  Introduction: Recently, mycelia of Ganoderma lucidum and Pleurotus ostreatus, edible fungi, have been characterized in vitro a …
• 784.

  Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner.

  • Huang D, Shen S, Zhuang Q, Ye X, Qian Y, Dong Z, Wan X.
  • Chin Med. 2024 Jan 24;19(1):16. doi: 10.1186/s13020-024-00889-y.
  • PMCID: PMC10809463

  Huang D, et al.

  Chin Med. 2024.

  PMCID: PMC10809463

  BACKGROUND: Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders. .. …

  BACKGROUND: Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bil …
• 785.

  Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis.

  • Hossain MS, Barua A, Tanim MAH, Hasan MS, Islam MJ, Hossain MR, Emon NU, Hossen SMM.
  • Food Sci Nutr. 2021 Jun 24;9(8):4364-4374. doi: 10.1002/fsn3.2407.
  • PMCID: PMC8358375

  Hossain MS, et al.

  Food Sci Nutr. 2021.

  PMCID: PMC8358375

  Besides, in silico screening of the compounds of Ganoderma applanatum has been incorporated thus to check the binding affinity of compounds and enzymes affinity. ...Nine days of oral feeding of MEGA and AEGA of Ganoderma applanatum resulted in a significant (p < …

  Besides, in silico screening of the compounds of Ganoderma applanatum has been incorporated thus to check the binding affinity of com …
• 786.

  Anti-glycated and antiradical activities in vitro of polysaccharides from Ganoderma capense.

  • Yan C, Kong F, Zhang D, Cui J.
  • Pharmacogn Mag. 2013 Jan;9(33):23-7. doi: 10.4103/0973-1296.108132.
  • PMCID: PMC3647389

  Yan C, et al.

  Pharmacogn Mag. 2013.

  PMCID: PMC3647389

  BACKGROUND: Ganoderma capense is a Ganoderma species and is widely used, especially in Asia, as a well-known medicinal mushroom for health-promoting effect and for treatment of chronic diseases, such as diabetes, aging, etc. ...

  BACKGROUND: Ganoderma capense is a Ganoderma species and is widely used, especially in Asia, as a well-known medicinal mushroo …
• 787.

  Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.

  • Xie J, Liu Y, Chen B, Zhang G, Ou S, Luo J, Peng X.
  • Food Nutr Res. 2019 Feb 12;63. doi: 10.29219/fnr.v63.1559.
  • PMCID: PMC6387425

  Xie J, et al.

  Food Nutr Res. 2019.

  PMCID: PMC6387425

  As a result, it is still unclear whether there is an anti-colitis effect in Ganoderma lucidum polysaccharide (GLP), which is mainly composed of beta-glucan. Moreover, the association between GLP function and gut microbiota remains to be elucidated. ...

  As a result, it is still unclear whether there is an anti-colitis effect in Ganoderma lucidum polysaccharide (GLP), which is m …
• 788.

  Evaluation of the Use of Elicitors for the Production of Antioxidant Compounds in Liquid Cultures of Ganoderma curtisii from Costa Rica.

  • Rosales-López C, Arce-Torres F, Monge-Artavia M, Rojas-Chaves M.
  • Molecules. 2022 Jul 2;27(13):4265. doi: 10.3390/molecules27134265.
  • PMCID: PMC9268739

  Rosales-López C, et al.

  Molecules. 2022.

  PMCID: PMC9268739

  In this research, the effects of different elicitors on the production of antioxidant secondary metabolites were evaluated in a strain of Ganoderma sp. The elicitors tested were pH changes in different growth phases of the fungus (pH 3, 5.5 and 8), different concentrations …

  In this research, the effects of different elicitors on the production of antioxidant secondary metabolites were evaluated in a strain of …
• 789.

  Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib.

  • Rodseeda C, Yamanont P, Pinthong D, Korprasertthaworn P.
  • Toxicol Rep. 2022 Oct 4;9:1846-1852. doi: 10.1016/j.toxrep.2022.10.004.
  • PMCID: PMC9742957

  Rodseeda C, et al.

  Toxicol Rep. 2022.

  PMCID: PMC9742957

  The aim of this study was to determine the inhibitory effects of Andrographis paniculata, Curcuma zedoaria, Ganoderma lucidum, Murdannia loriformis and Ventilago denticulata extracts on the metabolism of gefitinib, lapatinib and sorafenib. ...Curcuma zedoaria extrac …

  The aim of this study was to determine the inhibitory effects of Andrographis paniculata, Curcuma zedoaria, Ganoderma lucidum, …
• 790.

  Growth Characteristics of Polyporales Mushrooms for the Mycelial Mat Formation.

  • Bae B, Kim M, Kim S, Ro HS.
  • Mycobiology. 2021 Apr 26;49(3):280-284. doi: 10.1080/12298093.2021.1911401.
  • PMCID: PMC8259868

  Bae B, et al.

  Mycobiology. 2021.

  PMCID: PMC8259868

  Among the 64 strains of Polyporales, G. lucidum LBS5496GL was selected as the best candidate because it showed fast mycelial growth with high mycelial strength in both the sawdust-based solid medium and the potato dextrose liquid plate medium. ...The higher physical streng …

  Among the 64 strains of Polyporales, G. lucidum LBS5496GL was selected as the best candidate because it showed fast mycelial growth w …

• 791.

  Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.

  • Shaher F, Wang S, Qiu H, Hu Y, Zhang Y, Wang W, Al-Ward H, Abdulghani MAM, Baldi S, Zhou S.
  • Diabetes Metab Syndr Obes. 2020 Dec 7;13:4809-4822. doi: 10.2147/DMSO.S281527.
  • PMCID: PMC7736836

  Shaher F, et al.

  Diabetes Metab Syndr Obes. 2020.

  PMCID: PMC7736836

  BACKGROUND: Ganoderma lucidum spores (GLS) exhibit disease prevention properties, but no study has been carried out on the anti-diabetic cardiomyopathy property of GLS. ...

  BACKGROUND: Ganoderma lucidum spores (GLS) exhibit disease prevention properties, but no study has been carried out on the ant …
• 792.

  Evaluation of cosmetic efficacy of lychee seed fermentation liquid.

  • Yan Y, Fu H, Tang Y, Huang T, Zou X, Su N, Wang D, Wang C, Li M.
  • Bioresour Bioprocess. 2024 Oct 31;11(1):104. doi: 10.1186/s40643-024-00818-9.
  • PMCID: PMC11527852

  Yan Y, et al.

  Bioresour Bioprocess. 2024.

  PMCID: PMC11527852

  BACKGROUND: Lychee seeds were fermented by three kinds of bacteria (Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma lucidum mycelium), and two effective strains were selected by two indexes of activity content and antioxidant, so as to further verify …

  BACKGROUND: Lychee seeds were fermented by three kinds of bacteria (Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma < …
• 793.

  Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.

  • Jeong JH, Hong GL, Jeong YG, Lee NS, Kim DK, Park JY, Park M, Kim HM, Kim YE, Yoo YC, Han SY.
  • Curr Issues Mol Biol. 2023 Aug 15;45(8):6775-6789. doi: 10.3390/cimb45080428.
  • PMCID: PMC10453438

  Jeong JH, et al.

  Curr Issues Mol Biol. 2023.

  PMCID: PMC10453438

  Here, the aqueous extract of mixed medicinal mushroom mycelia (MMMM)-Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus-cultivated on a barley medium was assessed for its anti-AD effects. ...

  Here, the aqueous extract of mixed medicinal mushroom mycelia (MMMM)-Phellinus linteus, Ganoderma lucidum, and Inonotus obliqu …
• 794.

  Erratum: Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.

  • Frontiers Production Office.
  • Front Chem. 2021 Dec 23;9:817898. doi: 10.3389/fchem.2021.817898.
  • PMCID: PMC8753409

  Frontiers Production Office.

  Front Chem. 2021.

  PMCID: PMC8753409
• 795.

  Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway.

  • Yao X, Yuan Y, Jing T, Ye S, Wang S, Xia D.
  • Transl Androl Urol. 2022 Jul;11(7):982-995. doi: 10.21037/tau-22-428.
  • PMCID: PMC9360518

  Yao X, et al.

  Transl Androl Urol. 2022.

  PMCID: PMC9360518

  This study aimed to explore the role and mechanism of Ganoderma lucidum polysaccharide (GLP) on DMED. METHODS: DMED was induced in the experimental rats [male 12-week-old Sprague-Dawley (SD) rats] by treatment with streptozotocin (60 mg/kg) and apomorphine (APO). .. …

  This study aimed to explore the role and mechanism of Ganoderma lucidum polysaccharide (GLP) on DMED. METHODS: DMED was induce …
• 796.

  Effect of Pd-Sensitization on Poisonous Chlorine Gas Detection Ability of TiO₂: Green Synthesis and Low-Temperature Operation.

  • Ekar S, Nakate UT, Khollam YB, Shaikh SF, Mane RS, Rana AUHS, Palaniswami M.
  • Sensors (Basel). 2022 May 31;22(11):4200. doi: 10.3390/s22114200.
  • PMCID: PMC9185264

  Ekar S, et al.

  Sensors (Basel). 2022.

  PMCID: PMC9185264

  Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO(2)) is explored via a low-temperature ( 70 C) wet chemical method. The role of Ganoderma lucidum mushroom extract in the reaction is to release the ganoderic a …

  Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO(2)) is explored via a low-tempera …
• 797.

  The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers.

  • Gao YY, Liu XP, Zhou YH, He JY, Di B, Zheng XY, Guo PT, Zhang J, Wang CK, Jin L.
  • Animals (Basel). 2024 Oct 11;14(20):2926. doi: 10.3390/ani14202926.
  • PMCID: PMC11503797

  Gao YY, et al.

  Animals (Basel). 2024.

  PMCID: PMC11503797

  The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers. ...

  The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Resid …
• 798.

  Preparation of Ganoderma Lucidum Bran-Based Biological Activated Carbon for Dual-Functional Adsorption and Detection of Copper Ions.

  • Wang B, Lan J, Bo C, Gong B, Ou J.
  • Materials (Basel). 2023 Jan 10;16(2):689. doi: 10.3390/ma16020689.
  • PMCID: PMC9866797

  Wang B, et al.

  Materials (Basel). 2023.

  PMCID: PMC9866797

  In this paper, Ganoderma lucidum bran was explored as the precursor to fabricate biomass activated carbon. ...

  In this paper, Ganoderma lucidum bran was explored as the precursor to fabricate biomass activated carbon. ...
• 799.

  New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish.

  • Chang TS, Chiang CM, Wang TY, Lee CH, Lee YW, Wu JY.
  • Molecules. 2018 Sep 13;23(9):2345. doi: 10.3390/molecules23092345.
  • PMCID: PMC6225395

  Chang TS, et al.

  Molecules. 2018.

  PMCID: PMC6225395

  Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum. In studying the microbial biotransformation of GAA, dozens of intestinal bacteria were isolated from the excreta of zebrafish. ...The present study is the first to report the …

  Ganoderic acid A (GAA) is a major triterpenoid from the medicinal fungus Ganoderma lucidum. In studying the microbial biotrans …
• 800.

  Widely Targeted Metabolomics Decodes Metabolic Remodeling and Functional Shifts in Ganoderma lucidum-Fermented Green Tea Infusion.

  • Liu X, Ju Y, Wen S, Zeng H, Wang C, Jiang M, Tian B, Huang J, Liu Z.
  • Foods. 2025 Aug 18;14(16):2855. doi: 10.3390/foods14162855.
  • PMCID: PMC12385791

  Liu X, et al.

  Foods. 2025.

  PMCID: PMC12385791

  This study used a targeted metabolomics approach to examine changes in metabolites within green tea infusions fermented by G. lucidum (TFG) and evaluate the in vitro antioxidant and lipid-lowering properties of TFG. ...

  This study used a targeted metabolomics approach to examine changes in metabolites within green tea infusions fermented by G. lucidum …

• 801.

  Ganoderma tsugae prevents cognitive impairment and attenuates oxidative damage in d-galactose-induced aging in the rat brain.

  • Kuo HC, Tong SY, Chao MW, Tseng CY.
  • PLoS One. 2022 Apr 7;17(4):e0266331. doi: 10.1371/journal.pone.0266331.
  • PMCID: PMC8989198

  Kuo HC, et al.

  PLoS One. 2022.

  PMCID: PMC8989198

  The D-galactose (D-gal, 100 mg/kg/day)-induced aging Long-Evans rats were simultaneously orally administered a DMSO extract of Ganoderma tsugae (GTDE, 200 mug/kg/day) for 25 weeks to investigate the effects of GTDE on oxidative stress and memory deficits in the D-galactose …

  The D-galactose (D-gal, 100 mg/kg/day)-induced aging Long-Evans rats were simultaneously orally administered a DMSO extract of Ganoderma< …
• 802.

  Ganoderma lucidum extract, Lycopene, Sulforaphane, Royal Jelly and Resveratrol as a combination demonstrate antioxidant and anti-inflammatory effects in COVID-19.

  • Emilija A, Marija P, Dragica Z, Kristina P, Katerina S, Kosta K, Dejan J.
  • Free Radic Biol Med. 2022 Aug 11;189:29. doi: 10.1016/j.freeradbiomed.2022.06.129.
  • PMCID: PMC9386034

  Emilija A, et al.

  Free Radic Biol Med. 2022.

  PMCID: PMC9386034
• 803.

  Cytotoxic activity of Ganoderma weberianum-sichuanese isolated from the Lower Volta River Basin of Ghana against human prostate carcinoma (PC-3), leukemic T cell (Jurkat), and plasmacytoid dendritic cell (pDC)-derived acute leukemia (PMDC05) cell lines.

  • Adotey G, Alolga RN, Quarcoo A, Gedel MA, Yerenkyi P, Otu P, Anang AK, Okine LKN, Gbewonyo WSK, Holliday JC, Lombardi VC.
  • PLoS One. 2025 Jul 11;20(7):e0327087. doi: 10.1371/journal.pone.0327087.
  • PMCID: PMC12250544

  Adotey G, et al.

  PLoS One. 2025.

  PMCID: PMC12250544

  Ganoderma is a genus of medically important fungus that contains at least 80 species, many of which have not been properly evaluated for their anticancer potential. This study was conducted to assess the cytotoxic activity of the mycelial biomass of Ganoderma weberi …

  Ganoderma is a genus of medically important fungus that contains at least 80 species, many of which have not been properly evaluated …
• 804.

  Ganoderma lucidum and Hypericum perforatum Exhibit Anti-Inflammatory, Antioxidant, and Anti-Androgen Effect in Rat Model of Experimental Polycystic Ovarian Syndrome.

  • Okay G, Kırıcı P, Mavral N, Utkan Korun ZE, Annac E, Kaplan S.
  • Med Princ Pract. 2024 Apr 10;33(4):1-7. doi: 10.1159/000538595. Online ahead of print.
  • PMCID: PMC11324204

  Okay G, et al.

  Med Princ Pract. 2024.

  PMCID: PMC11324204

  OBJECTIVE: Chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS). Ganoderma lucidum polysaccharide (GLP) and Hypericum perforatum (HP) have been reported to have anti-inflammatory and antioxidant activit …

  OBJECTIVE: Chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS). Ganoderm …
• 805.

  A review of botany, phytochemistry, pharmacology, and applications of the herb with the homology of medicine and food: Ligustrum lucidum W.T. Aiton.

  • Chen L, Huang D, Jiang L, Yang J, Shi X, Wang R, Li W.
  • Front Pharmacol. 2024 Jun 12;15:1330732. doi: 10.3389/fphar.2024.1330732.
  • PMCID: PMC11199554

  Chen L, et al.

  Front Pharmacol. 2024.

  PMCID: PMC11199554

  Ligustrum lucidum W.T. Aiton is rich in nutritional components and a variety of bioactive ingredients. ...Ligustrum lucidum W.T. Aiton has rich plant resources. However, the application potential of it has not been fully exploited. ...

  Ligustrum lucidum W.T. Aiton is rich in nutritional components and a variety of bioactive ingredients. ...Ligustrum lucidum W. …
• 806.

  Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties.

  • Rašeta M, Kebert M, Mišković J, Kostić S, Kaišarević S, Stilinović N, Vukmirović S, Karaman M.
  • J Fungi (Basel). 2024 Jul 19;10(7):501. doi: 10.3390/jof10070501.
  • PMCID: PMC11277669

  Rašeta M, et al.

  J Fungi (Basel). 2024.

  PMCID: PMC11277669

  Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds with various effects. ...Further research and dietary assessments could help determine the full potential and applications of the two underexpl …

  Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds wit …
• 807.

  Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.

  • Yang J, Pan H, Wang M, Li A, Zhang G, Fan X, Li Z.
  • Front Pharmacol. 2024 Aug 16;15:1419881. doi: 10.3389/fphar.2024.1419881.
  • PMCID: PMC11361955

  Yang J, et al.

  Front Pharmacol. 2024.

  PMCID: PMC11361955

  Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T cell development. However, the precise mechanisms underlying this regulation remain elusive. ...

  Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T c …
• 808.

  Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.

  • Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ.
  • Springerplus. 2014 Jun 12;3:297. doi: 10.1186/2193-1801-3-297.
  • PMCID: PMC4072879

  Pi CC, et al.

  Springerplus. 2014.

  PMCID: PMC4072879

  Allergic asthma is an inflammatory disease of the airways mediated by Th2 immune responses and characterized by airway hyperresponsiveness (AHR). Fungi of the genus Ganoderma are basidiomycetes that have been used in traditional Asian medicine for centuries. We recently fo …

  Allergic asthma is an inflammatory disease of the airways mediated by Th2 immune responses and characterized by airway hyperresponsiveness ( …
• 809.

  Correction: Generation and Analysis of the Expressed Sequence Tags from the Mycelium of Ganoderma lucidum.

  • Huang YH, Wu HY, Wu KM, Liu TT, Liou RF, Tsai SF, Shiao MS, Ho LT, Tzean SS, Yang UC.
  • PLoS One. 2013 Sep 9;8(9):10.1371/annotation/d3ee6fb1-5239-4a09-b197-379d22f27163. doi: 10.1371/annotation/d3ee6fb1-5239-4a09-b197-379d22f27163.
  • PMCID: PMC3776884

  Huang YH, et al.

  PLoS One. 2013.

  PMCID: PMC3776884
• 810.

  Correction: Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII alpha in Epileptic Hippocampal Neurons.

  • The PLOS ONE Staff.
  • PLoS One. 2014 Oct 10;9(10):e111295. doi: 10.1371/journal.pone.0111295.
  • PMCID: PMC4193866

  The PLOS ONE Staff.

  PLoS One. 2014.

  PMCID: PMC4193866

• 811.

  Oral Presentation Award Winner: Polysaccharide Peptide of Ganoderma lucidum Reduces Endothelial Injury in Stable Angina and High-risk Patients.

  • Susilowati E, Sargowo D, Ovianti N.
  • Eur Cardiol. 2021 Dec 14;16:e59. doi: 10.15420/ecr.2021.16.PO3.
  • PMCID: PMC8785058

  Susilowati E, et al.

  Eur Cardiol. 2021.

  PMCID: PMC8785058
• 812.

  Erratum: Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs.

  • Frontiers Production Office.
  • Front Pharmacol. 2024 Dec 19;15:1539089. doi: 10.3389/fphar.2024.1539089.
  • PMCID: PMC11693988

  Frontiers Production Office.

  Front Pharmacol. 2024.

  PMCID: PMC11693988
• 813.

  Optimization of mycelial growth and cultivation of wild Ganoderma sinense.

  • Nguyen LT, Van Le V, Nguyen BTT, Nguyen HTT, Tran AD, Ngo NX.
  • BioTechnologia (Pozn). 2023 Mar 27;104(1):65-74. doi: 10.5114/bta.2023.125087.
  • PMCID: PMC10091450

  Nguyen LT, et al.

  BioTechnologia (Pozn). 2023.

  PMCID: PMC10091450

  Ganoderma sinense, a well-known medicinal macrofungus of Basidiomycetes, is widely used in traditional medicine for promoting health and longevity in East Asia. ...

  Ganoderma sinense, a well-known medicinal macrofungus of Basidiomycetes, is widely used in traditional medicine for promoting health …
• 814.

  Corrigendum: Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.

  • Su J, Li D, Chen Q, Li M, Su L, Luo T, Liang D, Lai G, Shuai O, Jiao C, Wu Q, Xie Y, Zhou X.
  • Front Microbiol. 2019 May 31;10:1224. doi: 10.3389/fmicb.2019.01224.
  • PMCID: PMC6555303

  Su J, et al.

  Front Microbiol. 2019.

  PMCID: PMC6555303
• 815.

  The comparative protective effects of ganoderma spores lipid and fish oil on N-methyl-N-nitrosourea-induced photoreceptor cell lesion in rats.

  • Yang G, Xin-Guo D, Na L, Guang-Wei L, Chung PC.
  • Evid Based Complement Alternat Med. 2011 May 18;2011:903261. doi: 10.1155/2011/903261.
  • PMCID: PMC3108162

  Yang G, et al.

  Evid Based Complement Alternat Med. 2011.

  PMCID: PMC3108162

  Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats. ...

  Purpose. To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-meth …
• 816.

  Protective Effects of Amauroderma rugosum on Doxorubicin-Induced Cardiotoxicity through Suppressing Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Activating Akt/mTOR and Nrf2/HO-1 Signaling Pathways.

  • Li J, Cheng Y, Li R, Wu X, Zheng C, Shiu PH, Chan JC, Rangsinth P, Liu C, Leung SW, Lee SM, Zhang C, Fu C, Zhang J, Cheung TM, Leung GP.
  • Oxid Med Cell Longev. 2022 Jun 1;2022:9266178. doi: 10.1155/2022/9266178.
  • PMCID: PMC9177334
  • • Retraction in: Oxid Med Cell Longev. 2023 Dec 29;2023:9861059. doi: 10.1155/2023/9861059. PubMed Abstract

  Li J, et al.

  Oxid Med Cell Longev. 2022.

  PMCID: PMC9177334

  Retracted.

  Natural products provide abundant resources to search for novel cardioprotective agents. Ganoderma lucidum (GL) is the most well-known edible mushroom within the Ganodermataceae family. ...

  Natural products provide abundant resources to search for novel cardioprotective agents. Ganoderma lucidum (GL) is the most we …
• 817.

  The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi.

  • Liu YN, Wu FY, Tian RY, Shi YX, Xu ZQ, Liu JY, Huang J, Xue FF, Liu BY, Liu GQ.
  • Commun Biol. 2023 Jan 3;6(1):1. doi: 10.1038/s42003-022-04154-6.
  • PMCID: PMC9810662

  Liu YN, et al.

  Commun Biol. 2023.

  PMCID: PMC9810662

  Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. H …

  Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete ge …
• 818.

  Ganoderma lucidum bran-derived blue-emissive and green-emissive carbon dots for detection of copper ions.

  • Wang B, Lan J, Ou J, Bo C, Gong B.
  • RSC Adv. 2023 May 12;13(21):14506-14516. doi: 10.1039/d3ra02168h.
  • PMCID: PMC10176043

  Wang B, et al.

  RSC Adv. 2023.

  PMCID: PMC10176043

  Ganoderma lucidum bran (GB) has a broad application prospect in the preparation of activated carbon, livestock feed, and biogas, but the preparation of carbon dots (CDs) from GB has never been reported. ...

  Ganoderma lucidum bran (GB) has a broad application prospect in the preparation of activated carbon, livestock feed, and bioga …
• 819.

  A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2.

  • Wang H, Peng X, Ge Y, Zhang S, Wang Z, Fan Y, Huang W, Qiu M, Ye RD.
  • Front Pharmacol. 2020 Mar 24;11:337. doi: 10.3389/fphar.2020.00337.
  • PMCID: PMC7105723

  Wang H, et al.

  Front Pharmacol. 2020.

  PMCID: PMC7105723

  In order to search for potentially novel anti-inflammatory agents, we examined Ganoderma (Lingzhi), a Chinese medicinal herbs known for its anti-inflammatory effects, and found that compound 18 (C18) derived from Ganoderma cochlear could limit the inflammatory respo …

  In order to search for potentially novel anti-inflammatory agents, we examined Ganoderma (Lingzhi), a Chinese medicinal herbs known f …
• 820.

  Insoluble Dietary Fibers From By-Products of Edible Fungi Industry: Basic Structure, Physicochemical Properties, and Their Effects on Energy Intake.

  • Tian B, Pan Y, Wang J, Cai M, Ye B, Yang K, Sun P.
  • Front Nutr. 2022 Mar 10;9:851228. doi: 10.3389/fnut.2022.851228.
  • PMCID: PMC8961438

  Tian B, et al.

  Front Nutr. 2022.

  PMCID: PMC8961438

  Among them, Hericium erinaceus is the softest without obvious granular texture, following Lentinus edodes, while Ganoderma lucidum and Grifola frondosa have a relatively hard texture. The yield of four kinds of IDF from high to low came from Ganoderma luci …

  Among them, Hericium erinaceus is the softest without obvious granular texture, following Lentinus edodes, while Ganoderma lucidum …

• 821.

  Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats.

  • Fu HY, Hseu RS.
  • Toxicol Rep. 2022 May 26;9:1240-1254. doi: 10.1016/j.toxrep.2022.05.013.
  • PMCID: PMC9742912

  Fu HY, et al.

  Toxicol Rep. 2022.

  PMCID: PMC9742912

  The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. This study assessed the safety of GMI derived from engineered Pichia pastoris in Sprague-Dawley rats as a dietary supplement and food ingredient by evaluatin …

  The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. This study assess …
• 822.

  202 Functional Properties of Ganoderma Lucidum (GL) Supplementation in Canine Nutrition.

  • Kayser E, Osorio LMGM, de Godoy MRC.
  • J Anim Sci. 2023 Nov 6;101(Suppl 3):107. doi: 10.1093/jas/skad281.130.
  • PMCID: PMC10632978

  Kayser E, et al.

  J Anim Sci. 2023.

  PMCID: PMC10632978

  Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory and anti-inflammatory capacity. ...

  Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory and anti-inflammatory capacity …
• 823.

  Insight into plant cell wall degradation and pathogenesis of Ganoderma boninense via comparative genome analysis.

  • Ramzi AB, Che Me ML, Ruslan US, Baharum SN, Nor Muhammad NA.
  • PeerJ. 2019 Dec 18;7:e8065. doi: 10.7717/peerj.8065.
  • PMCID: PMC6927665

  Ramzi AB, et al.

  PeerJ. 2019.

  PMCID: PMC6927665

  Comparison of CAZymes from G. boninense NJ3 was made against G. lucidum, a well-studied model Ganoderma sp. and five selected pathogenic fungi for CAZymes characterization. ...RESULTS: G. boninense was enriched with CAZymes and CWDEs in a similar fashion to G. lu …

  Comparison of CAZymes from G. boninense NJ3 was made against G. lucidum, a well-studied model Ganoderma sp. and five selected …
• 824.

  Natural Compounds and Health Benefits of Ganoderma capense.

  • Liu L, Shi X, Jia L, Wang R, Liu C.
  • Molecules. 2025 May 21;30(10):2250. doi: 10.3390/molecules30102250.
  • PMCID: PMC12114035

  Liu L, et al.

  Molecules. 2025.

  PMCID: PMC12114035

  Ganoderma capense, a member of the Ganoderma genus within the Polyporaceae family, has long been recognized for its high nutritional value and extensive use in traditional medicine. ...

  Ganoderma capense, a member of the Ganoderma genus within the Polyporaceae family, has long been recognized for its high nutri …
• 825.

  [20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe.

  • Zhou L, Guo LL, Isaka M, Li ZH, Chen HP.
  • J Fungi (Basel). 2022 May 12;8(5):503. doi: 10.3390/jof8050503.
  • PMCID: PMC9145439

  Zhou L, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9145439

  Twelve new lanostane triterpenoids (1-5, 7-13) were isolated from the fruiting bodies of the fungus Ganoderma australe. The structures of the new compounds were elucidated by extensive 1D and 2D NMR, and HRESIMS spectroscopic analysis. All the triterpenes are featured by 2 …

  Twelve new lanostane triterpenoids (1-5, 7-13) were isolated from the fruiting bodies of the fungus Ganoderma australe. The structure …
• 826.

  Historical and current perspectives on therapeutic potential of higher basidiomycetes: an overview.

  • Varghese R, Dalvi YB, Lamrood PY, Shinde BP, Nair CKK.
  • 3 Biotech. 2019 Sep 17;9(10):362. doi: 10.1007/s13205-019-1886-2.
  • PMCID: PMC6749005

  Varghese R, et al.

  3 Biotech. 2019.

  PMCID: PMC6749005

  The present review provides historical importance as well as an updated information on pharmacologically relevant higher basidiomycetes belong to the genus Agaricus, Auricularia, Phellinus, Ganoderma, Pleurotus, Trametes and Lentinus and their biologically active secondary …

  The present review provides historical importance as well as an updated information on pharmacologically relevant higher basidiomycetes belo …
• 827.

  A New Species of Ganoderma (Ganodermataceae, Polyporales) from Southern China and Optimum Condition for Mycelia Production.

  • Wei QL, Zheng HF, Shao YY, Rasheed U, Lin JT, Huang FC, Liu B.
  • Mycobiology. 2024 Feb 21;52(1):58-67. doi: 10.1080/12298093.2024.2306012.
  • PMCID: PMC10896125

  Wei QL, et al.

  Mycobiology. 2024.

  PMCID: PMC10896125

  The present study sought to propose Ganoderma guixiense sp. nov. as a new species based on phenotypic and genotypic evidence. ...

  The present study sought to propose Ganoderma guixiense sp. nov. as a new species based on phenotypic and genotypic evidence. ...
• 828.

  Degradation of three aromatic dyes by white rot fungi and the production of ligninolytic enzymes.

  • Jayasinghe C, Imtiaj A, Lee GW, Im KH, Hur H, Lee MW, Yang HS, Lee TS.
  • Mycobiology. 2008 Jun 30;36(2):114-20. doi: 10.4489/MYCO.2008.36.2.114.
  • PMCID: PMC3755234

  Jayasinghe C, et al.

  Mycobiology. 2008.

  PMCID: PMC3755234

  The results of this study revealed that Pycnoporus cinnabarinus, Pleurotus pulmonarius, Ganoderma lucidum, Trametes suaveolens, Stereum ostrea and Fomes fomentarius have the ability to efficiently degrade congo red on solid media. ...In addition, P. cinnabarinus, G. …

  The results of this study revealed that Pycnoporus cinnabarinus, Pleurotus pulmonarius, Ganoderma lucidum, Trametes suaveolens …
• 829.

  Use of Zebrafish Embryo Assay to Evaluate Toxicity and Safety of Bioreactor-Grown Exopolysaccharides and Endopolysaccharides from European Ganoderma applanatum Mycelium for Future Aquaculture Applications.

  • Wan-Mohtar WAAQI, Ilham Z, Jamaludin AA, Rowan N.
  • Int J Mol Sci. 2021 Feb 7;22(4):1675. doi: 10.3390/ijms22041675.
  • PMCID: PMC7914815

  Wan-Mohtar WAAQI, et al.

  Int J Mol Sci. 2021.

  PMCID: PMC7914815

  Natural mycelial exopolysaccharide (EPS) and endopolysaccharide (ENS) extracted from bioreactor-cultivated European Ganoderma applanatum mushrooms are of potential high commercial value for both food and adjacent biopharmaceutical industries. ...

  Natural mycelial exopolysaccharide (EPS) and endopolysaccharide (ENS) extracted from bioreactor-cultivated European Ganoderma applana …
• 830.

  113 Immunological Effects of Ganoderma Lucidum Supplementation in Canine Nutrition.

  • Kayser E, He F, Gomez LM, de Godoy MR.
  • J Anim Sci. 2022 Sep 21;100(Suppl 3):53. doi: 10.1093/jas/skac247.103.
  • PMCID: PMC9493504

  Kayser E, et al.

  J Anim Sci. 2022.

  PMCID: PMC9493504

  Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory, anti-inflammatory and anti-tumor capacity in humans. ...

  Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunomodulatory, anti-inflammatory and anti-tu …

• 831.

  Two Laminaria japonica Fermentation Broths Alleviate Oxidative Stress and Inflammatory Response Caused by UVB Damage: Photoprotective and Reparative Effects.

  • Sun Q, Fang J, Wang Z, Song Z, Geng J, Wang D, Wang C, Li M.
  • Mar Drugs. 2022 Oct 20;20(10):650. doi: 10.3390/md20100650.
  • PMCID: PMC9605345

  Sun Q, et al.

  Mar Drugs. 2022.

  PMCID: PMC9605345

  We establish a UVB-induced damage model of human immortalized epidermal keratinocytes (HaCaT) to explore the protective and reparative effects of Laminaria japonica on UVB-damaged epidermal inflammation after fermentation by white Ganoderma lucidum (Curtis) P. Karst …

  We establish a UVB-induced damage model of human immortalized epidermal keratinocytes (HaCaT) to explore the protective and reparative effec …
• 832.

  Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.

  • Zhu Q, Bang TH, Ohnuki K, Sawai T, Sawai K, Shimizu K.
  • Sci Rep. 2015 Aug 26;5:13194. doi: 10.1038/srep13194.
  • PMCID: PMC4549708

  Zhu Q, et al.

  Sci Rep. 2015.

  PMCID: PMC4549708

  Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. ...

  Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to t …
• 833.

  Green synthesis and antimicrobial activity of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India.

  • Mohanta YK, Singdevsachan SK, Parida UK, Panda SK, Mohanta TK, Bae H.
  • IET Nanobiotechnol. 2016 Aug;10(4):184-9. doi: 10.1049/iet-nbt.2015.0059.
  • PMCID: PMC8675986

  Mohanta YK, et al.

  IET Nanobiotechnol. 2016.

  PMCID: PMC8675986

  In the present study, green synthesis and cost effective approach of silver nanoparticles using wild medicinal mushroom Ganoderma applanatum (Pers.) Pat. from Similipal Biosphere Reserve, Odisha, India is reported. ...

  In the present study, green synthesis and cost effective approach of silver nanoparticles using wild medicinal mushroom Ganoderma app …
• 834.

  Effects of Ganoderma lucidum Powder on the Growth Performance, Immune Organ Weights, Cecal Microbiology, Serum Immunoglobulins, and Tibia Minerals of Broiler Chickens.

  • Avain A, Azad MAK, García Y, García Y, Martínez Y.
  • Vet Sci. 2024 Dec 22;11(12):675. doi: 10.3390/vetsci11120675.
  • PMCID: PMC11680373

  Avain A, et al.

  Vet Sci. 2024.

  PMCID: PMC11680373

  The treatments consisted of a basal diet (control group), basal diet + 0.02% zinc bacitracin (AGP group), basal diet + 0.2% G. lucidum powder (GLP; 0.2% GLP group), and basal diet + 0.3% GLP (0.3% GLP group). The results showed that dietary 0.2% GLP supplementation increas …

  The treatments consisted of a basal diet (control group), basal diet + 0.02% zinc bacitracin (AGP group), basal diet + 0.2% G. lucidum …
• 835.

  Ganoderic acid T improves the radiosensitivity of HeLa cells via converting apoptosis to necroptosis.

  • Shao CS, Feng N, Zhou S, Zheng XX, Wang P, Zhang JS, Huang Q.
  • Toxicol Res (Camb). 2021 May 13;10(3):531-541. doi: 10.1093/toxres/tfab030.
  • PMCID: PMC8201584

  Shao CS, et al.

  Toxicol Res (Camb). 2021.

  PMCID: PMC8201584

  The use of natural substances derived from traditional Chinese medicine and natural plants as safe radiosensitizing adjuvants is a new trend for cancer radiotherapy. Ganoderma lucidum has been used as a traditional Chinese medicine with a history of more than 2000 y …

  The use of natural substances derived from traditional Chinese medicine and natural plants as safe radiosensitizing adjuvants is a new trend …
• 836.

  Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.

  • Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YM, Young JD, Lai HC.
  • Nat Commun. 2017 Jul 11;8:16130. doi: 10.1038/ncomms16130.
  • PMCID: PMC5508223

  Chang CJ, et al.

  Nat Commun. 2017.

  PMCID: PMC5508223
• 837.

  Correction: Exploring the anti-cancer potential of Ganoderma Lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.

  • Gao X, Homayoonfal M.
  • Cancer Cell Int. 2024 May 22;24(1):178. doi: 10.1186/s12935-024-03284-7.
  • PMCID: PMC11112831

  Gao X, et al.

  Cancer Cell Int. 2024.

  PMCID: PMC11112831
• 838.

  Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats.

  • Mfopa A, Mediesse FK, Mvongo C, Nkoubatchoundjwen S, Lum AA, Sobngwi E, Kamgang R, Boudjeko T.
  • Evid Based Complement Alternat Med. 2021 Aug 18;2021:2452057. doi: 10.1155/2021/2452057.
  • PMCID: PMC8390130

  Mfopa A, et al.

  Evid Based Complement Alternat Med. 2021.

  PMCID: PMC8390130

  Increased consumption of high-calorie foods leads to obesity usually associated with metabolic disorders including diabetes, hyperglycemia, and dyslipidemia. Ganoderma applanatum is a nonedible mushroom traditionally used in West Cameroon for the treatment of many diseases …

  Increased consumption of high-calorie foods leads to obesity usually associated with metabolic disorders including diabetes, hyperglycemia, …
• 839.

  Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.

  • Grammatikopoulou MG, Gkiouras K, Papageorgiou SΤ, Myrogiannis I, Mykoniatis I, Papamitsou T, Bogdanos DP, Goulis DG.
  • Nutrients. 2020 Sep 29;12(10):2985. doi: 10.3390/nu12102985.
  • PMCID: PMC7600271

  Grammatikopoulou MG, et al.

  Nutrients. 2020.

  PMCID: PMC7600271

  Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palme …

  Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea …
• 840.

  Erratum: Polysaccharide Peptide (PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum].

  • [No authors listed]
  • Vasc Health Risk Manag. 2019 Nov 5;15:517. doi: 10.2147/VHRM.S234754.
  • PMCID: PMC6842898

  [No authors listed]

  Vasc Health Risk Manag. 2019.

  PMCID: PMC6842898

• 841.

  Features of the Formation of Sensitive Films Based on Mycelium of Higher Fungi for Surface and Plate Acoustic Waves Gas Sensors.

  • Smirnov A, Anisimkin V, Krasnopolskaya L, Guliy O, Sinev I, Simakov V, Golyshkin A, Almyasheva N, Ageykin N, Kuznetsova I.
  • Sensors (Basel). 2023 Feb 16;23(4):2216. doi: 10.3390/s23042216.
  • PMCID: PMC9962002

  Smirnov A, et al.

  Sensors (Basel). 2023.

  PMCID: PMC9962002

  Two types of films based on mycelium of higher fungus Ganoderma lucidum (Curtis) P. Karst (G. lucidum) prepared by various methods were used as sensitive coatings. These films were based on G. lucidum mycelium ethanolic (48% v/v) homogenizate (MEGl) an …

  Two types of films based on mycelium of higher fungus Ganoderma lucidum (Curtis) P. Karst (G. lucidum) prepared by vari …
• 842.

  Anticancer, antithrombotic, antityrosinase, and anti-α-glucosidase activities of selected wild and commercial mushrooms from Pakistan.

  • Sharif S, Atta A, Huma T, Shah AA, Afzal G, Rashid S, Shahid M, Mustafa G.
  • Food Sci Nutr. 2018 Sep 14;6(8):2170-2176. doi: 10.1002/fsn3.781.
  • PMCID: PMC6261167

  Sharif S, et al.

  Food Sci Nutr. 2018.

  PMCID: PMC6261167

  They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganoderma lucidum and four commercial mushrooms, that is, Pleurotus ostreatus, Volvariella volvacea, Hericium erinaceus, and Lentinus e …

  They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganode …
• 843.

  Two-stage cultivation strategies for optimal production of Ganoderma pellets with potential application in the vegan food industry.

  • Bibi S, Wang ZL, Lin C, Min SH, Cheng CY.
  • J Food Sci Technol. 2023 Mar 17;60(6):1793-1802. doi: 10.1007/s13197-023-05719-x.
  • PMCID: PMC10169959

  Bibi S, et al.

  J Food Sci Technol. 2023.

  PMCID: PMC10169959

  The vegan food industry is gaining popularity nowadays. Ganoderma sp. is mainly used in the health and food industries as a medicinal, edible mushroom with high nutritional potential. ...

  The vegan food industry is gaining popularity nowadays. Ganoderma sp. is mainly used in the health and food industries as a medicinal …
• 844.

  Two novel lanostane triterpenoids from Ganoderma sinense.

  • Qiao Y, Zhang XM, Qiu MH.
  • Molecules. 2007 Aug 23;12(8):2038-46. doi: 10.3390/12082038.
  • PMCID: PMC6149161

  Qiao Y, et al.

  Molecules. 2007.

  PMCID: PMC6149161
• 845.

  Neuronal health - can culinary and medicinal mushrooms help?

  • Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P.
  • J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549.
  • PMCID: PMC3924982

  Sabaratnam V, et al.

  J Tradit Complement Med. 2013.

  PMCID: PMC3924982

  Hericium erinaceus a culinary and medicinal mushroom is a well established candidate for brain and nerve health. Ganoderma lucidum, Grifola frondosa and Sarcodon scabrosus have been reported to have neurite outgrowth and neuronal health benefits. ...In the on-going …

  Hericium erinaceus a culinary and medicinal mushroom is a well established candidate for brain and nerve health. Ganoderma lucidum …
• 846.

  Ganoderma tsugae hepatoprotection against exhaustive exercise-induced liver injury in rats.

  • Huang CC, Huang WC, Yang SC, Chan CC, Lin WT.
  • Molecules. 2013 Jan 29;18(2):1741-54. doi: 10.3390/molecules18021741.
  • PMCID: PMC6270576

  Huang CC, et al.

  Molecules. 2013.

  PMCID: PMC6270576

  Several studies have been shown that accelerated apoptosis is involved in post-exercise lymphocytopenia and tissue damage after high-intensity exercise. Ganoderma tsugae (GT) is one of the well-known medicinal mushrooms that possess various pharmacological functions. ...

  Several studies have been shown that accelerated apoptosis is involved in post-exercise lymphocytopenia and tissue damage after high-intensi …
• 847.

  In silico Approach for Anti-Thrombosis Drug Discovery: P2Y₁R Structure-Based TCMs Screening.

  • Yi F, Sun L, Xu LJ, Peng Y, Liu HB, He CN, Xiao PG.
  • Front Pharmacol. 2017 Jan 9;7:531. doi: 10.3389/fphar.2016.00531.
  • PMCID: PMC5220089

  Yi F, et al.

  Front Pharmacol. 2017.

  PMCID: PMC5220089

  These computational results suggested that licorice (Glycyrrhiza uralensis Fisch), cimicifugae (Cimicifuga foetida L.), and ganoderma (Ganoderma lucidum Karst) and their chemical constituents, which have not previously been widely used for anti-thrombosis, ma …

  These computational results suggested that licorice (Glycyrrhiza uralensis Fisch), cimicifugae (Cimicifuga foetida L.), and ganoderma …
• 848.

  Investigating the cellular antioxidant and anti-inflammatory effects of the novel peptides in lingzhi mushrooms.

  • Aursuwanna T, Noitang S, Sangtanoo P, Srimongkol P, Saisavoey T, Puthong S, Reamtong O, Karnchanatat A.
  • Heliyon. 2022 Oct 13;8(10):e11067. doi: 10.1016/j.heliyon.2022.e11067.
  • PMCID: PMC9593296

  Aursuwanna T, et al.

  Heliyon. 2022.

  PMCID: PMC9593296

  The lingzhi mushroom (Ganoderma lucidum) is well known for its medicinal properties and has long played a role in traditional oriental medicine due to its health-giving benefits and potential to extend life expectancy. ...

  The lingzhi mushroom (Ganoderma lucidum) is well known for its medicinal properties and has long played a role in traditional …
• 849.

  Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities.

  • Dai R, Liu M, Nik Nabil WN, Xi Z, Xu H.
  • Molecules. 2021 Feb 19;26(4):1113. doi: 10.3390/molecules26041113.
  • PMCID: PMC7923288

  Dai R, et al.

  Molecules. 2021.

  PMCID: PMC7923288

  As medicinal fungi and fungal metabolites can induce apoptosis or autophagy, enhance the immune response, and reduce metastatic potential, several types of mushrooms, such as Ganoderma lucidum and Grifola frondosa, have been extensively investigated, and anti-cancer …

  As medicinal fungi and fungal metabolites can induce apoptosis or autophagy, enhance the immune response, and reduce metastatic potential, s …
• 850.

  Enzymatic extract containing lignin peroxidase immobilized on carbon nanotubes: Potential biocatalyst in dye decolourization.

  • Oliveira SF, da Luz JMR, Kasuya MCM, Ladeira LO, Correa Junior A.
  • Saudi J Biol Sci. 2016 Mar 10;25(4):651-659. doi: 10.1016/j.sjbs.2016.02.018.
  • PMCID: PMC5936880

  Oliveira SF, et al.

  Saudi J Biol Sci. 2016.

  PMCID: PMC5936880

  Two fungi isolates, Pleurotus ostreatus (PLO9) and Ganoderma lucidum (GRM117), produced the enzymatic extract by fermentation in the lignocellulosic residue, Jatropha curcas seed cake. ...

  Two fungi isolates, Pleurotus ostreatus (PLO9) and Ganoderma lucidum (GRM117), produced the enzymatic extract by fermentation …

• 851.

  Characterization and fungicide sensitivity of Trichoderma species causing green mold of Ganoderma sichuanense in China.

  • Li X, Sossah FL, Tuo Y, Hu J, Wei Q, Li S, Rong N, Wiafe-Kwagyan M, Li C, Zhang B, Li X, Li Y.
  • Front Microbiol. 2023 Oct 19;14:1264699. doi: 10.3389/fmicb.2023.1264699.
  • PMCID: PMC10620716

  Li X, et al.

  Front Microbiol. 2023.

  PMCID: PMC10620716
• 852.

  Screening of tropical wood-rotting mushrooms for copper biosorption.

  • Muraleedharan TR, Iyengar L, Venkobachar C.
  • Appl Environ Microbiol. 1995 Sep;61(9):3507-8. doi: 10.1128/aem.61.9.3507-3508.1995.
  • PMCID: PMC1388590

  Muraleedharan TR, et al.

  Appl Environ Microbiol. 1995.

  PMCID: PMC1388590

  Wide variation in Q(infmax) was observed among the species and ranged from 0.048 to 0.383 mmol per g of sorbent. The uptake capacity of Ganoderma lucidum, which exhibited the highest Q(infmax), was higher than those of other microbial biosorbents reported in the lit …

  Wide variation in Q(infmax) was observed among the species and ranged from 0.048 to 0.383 mmol per g of sorbent. The uptake capacity of G …
• 853.

  Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea.

  • Upadhyaya J, Kim MJ, Kim YH, Ko SR, Park HW, Kim MK.
  • J Ginseng Res. 2015 Jun 4;40(2):105-12. doi: 10.1016/j.jgr.2015.05.007.
  • PMCID: PMC4845050

  Upadhyaya J, et al.

  J Ginseng Res. 2015.

  PMCID: PMC4845050

  METHODS: Mycelia of Armillaria mellea, Ganoderma lucidum, Phellinus linteus, Elfvingia applanata, and Pleurotus ostreatus were cultivated in liquid media at 25 C for 2 wk. ...RESULTS: Among the mushrooms used in this study, the enzyme preparation from cultured mycel …

  METHODS: Mycelia of Armillaria mellea, Ganoderma lucidum, Phellinus linteus, Elfvingia applanata, and Pleurotus ostreatus were …
• 854.

  Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

  • Wang WJ, Wu YS, Chen S, Liu CF, Chen SN.
  • Biomed Res Int. 2015 Jun 17;2015:604385. doi: 10.1155/2015/604385.
  • PMCID: PMC4488085

  Wang WJ, et al.

  Biomed Res Int. 2015.

  PMCID: PMC4488085

  The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-gamma mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides tr …

  The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-gamma mRNA expression but significantly reduce …
• 855.

  Corrigendum to "Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake" [Curr. Res. Food Sci. 5(2022) 515-530].

  • Guo WL, Cao YJ, You SZ, Wu Q, Zhang F, Han JZ, Lv XC, Rao PF, Ai LZ, Ni L.
  • Curr Res Food Sci. 2022 Jul 14;5:1108-1109. doi: 10.1016/j.crfs.2022.07.001.
  • PMCID: PMC9294490

  Guo WL, et al.

  Curr Res Food Sci. 2022.

  PMCID: PMC9294490
• 856.

  Fungal Based Biopolymer Composites for Construction Materials.

  • Răut I, Călin M, Vuluga Z, Oancea F, Paceagiu J, Radu N, Doni M, Alexandrescu E, Purcar V, Gurban AM, Petre I, Jecu L.
  • Materials (Basel). 2021 May 28;14(11):2906. doi: 10.3390/ma14112906.
  • PMCID: PMC8198279

  Răut I, et al.

  Materials (Basel). 2021.

  PMCID: PMC8198279

  Fungal based biopolymer composite was obtained after cultivation of Ganoderma lucidum macromycetes on a mixture including wheat straws and polypropylene embedded with spores from Bacillus amyloliquefaciens. ...

  Fungal based biopolymer composite was obtained after cultivation of Ganoderma lucidum macromycetes on a mixture including whea …
• 857.

  Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.

  • Ko KM, Leung HY.
  • Chin Med. 2007 Mar 27;2:3. doi: 10.1186/1749-8546-2-3.
  • PMCID: PMC1847515

  Ko KM, et al.

  Chin Med. 2007.

  PMCID: PMC1847515

  Chinese tonifying herbs such as herba cistanche, ganoderma and cordyceps, which possess antioxidant and/or immunomodulatory activities, can be useful in the prevention and treatment of age-related diseases. ...

  Chinese tonifying herbs such as herba cistanche, ganoderma and cordyceps, which possess antioxidant and/or immunomodulatory activitie …
• 858.

  Comprehensive analysis of codon bias in 13 Ganoderma mitochondrial genomes.

  • Wu P, Xiao W, Luo Y, Xiong Z, Chen X, He J, Sha A, Gui M, Li Q.
  • Front Microbiol. 2023 May 4;14:1170790. doi: 10.3389/fmicb.2023.1170790.
  • PMCID: PMC10192751

  Wu P, et al.

  Front Microbiol. 2023.

  PMCID: PMC10192751

  However, the specific attributes of codon usage in the mitochondrial genome of Ganoderma species remain unknown. METHODS: In this study, we investigated the codon bias of 12 mitochondrial core protein-coding genes (PCGs) in 9 Ganoderma species, including 13 Ganod …

  However, the specific attributes of codon usage in the mitochondrial genome of Ganoderma species remain unknown. METHODS: In this stu …
• 859.

  Two cases of incidental Podostroma cornu-damae poisoning.

  • Kim HN, Do HH, Seo JS, Kim HY.
  • Clin Exp Emerg Med. 2016 Sep 30;3(3):186-189. doi: 10.15441/ceem.15.028.
  • PMCID: PMC5065333

  Kim HN, et al.

  Clin Exp Emerg Med. 2016.

  PMCID: PMC5065333

  However, it can be easily mistaken for antler Ganoderma lucidum. In this case report, two patients made tea with the fungus and drank it over a 2-week period. ...

  However, it can be easily mistaken for antler Ganoderma lucidum. In this case report, two patients made tea with the fungus an …
• 860.

  Structure elucidation and immunomodulatory activity of a beta glucan from the fruiting bodies of Ganoderma sinense.

  • Han XQ, Yue GL, Yue RQ, Dong CX, Chan CL, Ko CH, Cheung WS, Luo KW, Dai H, Wong CK, Leung PC, Han QB.
  • PLoS One. 2014 Jul 11;9(7):e100380. doi: 10.1371/journal.pone.0100380.
  • PMCID: PMC4094382

  Han XQ, et al.

  PLoS One. 2014.

  PMCID: PMC4094382

  A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structure was well elucidated, by a combined utilization of chemical and spectroscopic techniques, to be a beta-glucan with a backbone of (1 4)- and …

  A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structur …

• 861.

  Iron biofortification and availability in the mycelial biomass of edible and medicinal basidiomycetes cultivated in sugarcane molasses.

  • Scheid SS, Faria MGI, Velasquez LG, do Valle JS, Gonçalves AC Jr, Dragunski DC, Colauto NB, Linde GA.
  • Sci Rep. 2020 Jul 30;10(1):12875. doi: 10.1038/s41598-020-69699-0.
  • PMCID: PMC7393360

  Scheid SS, et al.

  Sci Rep. 2020.

  PMCID: PMC7393360

  This study aimed to evaluate the in vitro iron bioaccumulation and availability in the mycelial biomass of edible and medicinal basidiomycetes grown in two distinct culture media. Lentinus crinitus, Ganoderma lucidum, Schizophyllum commune, Pleurotus ostreatus, Pleu …

  This study aimed to evaluate the in vitro iron bioaccumulation and availability in the mycelial biomass of edible and medicinal basidiomycet …
• 862.

  Enzymatic Glycosylation of Ganoderma Terpenoid via Bacterial Glycosyltransferases and Glycoside Hydrolases.

  • Chang TS, Wu JY, Ding HY, Wang TY.
  • Biomolecules. 2025 May 1;15(5):655. doi: 10.3390/biom15050655.
  • PMCID: PMC12109177

  Chang TS, et al.

  Biomolecules. 2025.

  PMCID: PMC12109177

  This review explored the role of two primary enzyme classes-glycosyltransferases (GTs) and glycoside hydrolases (GHs, glycosidases)-in catalyzing the glycosylation of natural products, with a specific focus on Ganoderma triterpenoids. While GTs typically use activated suga …

  This review explored the role of two primary enzyme classes-glycosyltransferases (GTs) and glycoside hydrolases (GHs, glycosidases)-in catal …
• 863.

  GSP-2, a polysaccharide extracted from Ganoderma sinense, is a novel toll-like receptor 4 agonist.

  • Liu KS, Zhang C, Dong HL, Li KK, Han QB, Wan Y, Chen R, Yang F, Li HL, Ko CH, Han XQ.
  • PLoS One. 2019 Aug 23;14(8):e0221636. doi: 10.1371/journal.pone.0221636.
  • PMCID: PMC6707555

  Liu KS, et al.

  PLoS One. 2019.

  PMCID: PMC6707555

  Ganoderma sinense is a Chinese unique medicinal fungus that has been used in folk medicine for thousands of years. ...Previously we found that GSP-2, a new polysaccharide isolated from Ganoderma sinense, exerts an immunomodulatory effect in human peripheral blood mo …

  Ganoderma sinense is a Chinese unique medicinal fungus that has been used in folk medicine for thousands of years. ...Previously we f …
• 864.

  Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine.

  • Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H.
  • J Tradit Complement Med. 2012 Apr;2(2):84-95.
  • PMCID: PMC3942920

  Lee KH, et al.

  J Tradit Complement Med. 2012.

  PMCID: PMC3942920

  This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms ( ba xi mo gu; Agaricus blazei, yun zhi; Coriolus versicolor, ling zhi; Ganoderma lucidum, xiang xun; shiitake, Lentinus edodes, niu zhang zhi; Taiw …

  This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms ( ba xi mo gu; Agaricu …
• 865.

  Potato freeze-thaw solution enhances immune function and antitumor activity in vivo.

  • Xu G, Shen J, Sun P, Niu Y, Zhao P, Tang P, Zhang J, Fei C, Bu L, Yue Z, Liu H, Wang Z, Yang L, Sun D.
  • Oncol Lett. 2017 Sep 15;14(5):6129-6134. doi: 10.3892/ol.2017.6970.
  • PMCID: PMC5661393

  Xu G, et al.

  Oncol Lett. 2017.

  PMCID: PMC5661393

  While mice injected with cyclophosphamide exhibited decreased counts of peripheral WBCs, treatment of the cyclophosphamide-injected mice with PFTS for 10 days significantly increased the number of peripheral WBCs and reversed WBC counts to the normal level, a comparable effect to …

  While mice injected with cyclophosphamide exhibited decreased counts of peripheral WBCs, treatment of the cyclophosphamide-injected mice wit …
• 866.

  Optimized Synthesis of Small and Stable Silver Nanoparticles Using Intracellular and Extracellular Components of Fungi: An Alternative for Bacterial Inhibition.

  • Murillo-Rábago EI, Vilchis-Nestor AR, Juarez-Moreno K, Garcia-Marin LE, Quester K, Castro-Longoria E.
  • Antibiotics (Basel). 2022 Jun 14;11(6):800. doi: 10.3390/antibiotics11060800.
  • PMCID: PMC9220004

  Murillo-Rábago EI, et al.

  Antibiotics (Basel). 2022.

  PMCID: PMC9220004

  In this work, we report optimized protocols for the production of AgNPs using extracts and supernatants of Trichoderma harzianum and Ganoderma sessile. AgNPs were characterized using UV-Vis spectroscopy and transmission electron microscopy, and the hydrodynamic diameter an …

  In this work, we report optimized protocols for the production of AgNPs using extracts and supernatants of Trichoderma harzianum and Gano …
• 867.

  Colon targeting in rats, dogs and IBD patients with species-independent film coatings.

  • Ferraro F, Sonnleitner LM, Neut C, Mahieux S, Verin J, Siepmann J, Siepmann F.
  • Int J Pharm X. 2024 Feb 8;7:100233. doi: 10.1016/j.ijpx.2024.100233.
  • PMCID: PMC10876578

  Ferraro F, et al.

  Int J Pharm X. 2024.

  PMCID: PMC10876578

  Interestingly, extracts from aloe vera and reishi (a mushroom) showed a promising potential for colon targeting in all species....

  Interestingly, extracts from aloe vera and reishi (a mushroom) showed a promising potential for colon targeting in all species....
• 868.

  Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

  • Huang YL, Pai FS, Tsou YT, Mon HC, Hsu TL, Wu CY, Chou TY, Yang WB, Chen CH, Wong CH, Hsieh SL.
  • J Biol Chem. 2015 Jul 13;290(35):21252-63. doi: 10.1074/jbc.M115.649814.
  • PMCID: PMC4571857

  Huang YL, et al.

  J Biol Chem. 2015.

  PMCID: PMC4571857

  Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3). The Ser(339) (CLE …

  Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain cont …
• 869.

  The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction.

  • Yang N, Liang B, Srivastava K, Zeng J, Zhan J, Brown L, Sampson H, Goldfarb J, Emala C, Li XM.
  • Phytochemistry. Author manuscript. 2013 Aug 27;95:259-267. doi: 10.1016/j.phytochem.2013.07.023.
  • PMCID: PMC4118489

  Yang N, et al.

  Phytochemistry. Author manuscript. 2013.

  PMCID: PMC4118489

  ASHMI (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora flavescens Aiton (Ku Shen) and Glycyrrhiza uralensis Fisch. ex DC (Gan Cao). ...It was found that S. flavescens, but not G. lucidum …

  ASHMI (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora …
• 870.

  Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.

  • Li Y, Wang X, Ma X, Liu C, Wu J, Sun C.
  • Front Pharmacol. 2021 Apr 14;12:621813. doi: 10.3389/fphar.2021.621813.
  • PMCID: PMC8080043

  Li Y, et al.

  Front Pharmacol. 2021.

  PMCID: PMC8080043

  For a long time in the past, polysaccharides such as lentinan and Ganoderma lucidum glycopeptide have been used in clinic as adjuvant drugs to widely improve the immunity of the body. ...

  For a long time in the past, polysaccharides such as lentinan and Ganoderma lucidum glycopeptide have been used in clinic as a …

• 871.

  Phosphatidic acid directly activates mTOR and then regulates SREBP to promote ganoderic acid biosynthesis under heat stress in Ganoderma lingzhi.

  • Liu YN, Chen YL, Zhang ZJ, Wu FY, Wang HJ, Wang XL, Liu GQ.
  • Commun Biol. 2024 Nov 13;7(1):1503. doi: 10.1038/s42003-024-07225-y.
  • PMCID: PMC11560937

  Liu YN, et al.

  Commun Biol. 2024.

  PMCID: PMC11560937

  Ganoderic acids (GAs), a class of secondary metabolites produced by the traditional medicinal mushroom Ganoderma, are a group of triterpenoids with superior biological activities. Heat stress (HS) is one of the most important environmental abiotic stresses. ...

  Ganoderic acids (GAs), a class of secondary metabolites produced by the traditional medicinal mushroom Ganoderma, are a group of trit …
• 872.

  Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells.

  • Gurunathan S, Raman J, Abd Malek SN, John PA, Vikineswary S.
  • Int J Nanomedicine. 2013 Nov 15;8:4399-413. doi: 10.2147/IJN.S51881.
  • PMCID: PMC3833323

  Gurunathan S, et al.

  Int J Nanomedicine. 2013.

  PMCID: PMC3833323

  The aim of our study was to determine the cytotoxic effects of biologically synthesized AgNPs using hot aqueous extracts of the mycelia of Ganoderma neo-japonicum Imazeki on MDA-MB-231 human breast cancer cells. METHODS: We developed a green method for the synthesis of wat …

  The aim of our study was to determine the cytotoxic effects of biologically synthesized AgNPs using hot aqueous extracts of the mycelia of < …
• 873.

  Application progress of CRISPR/Cas9 genome-editing technology in edible fungi.

  • Zhang Y, Chen S, Yang L, Zhang Q.
  • Front Microbiol. 2023 May 25;14:1169884. doi: 10.3389/fmicb.2023.1169884.
  • PMCID: PMC10248459

  Zhang Y, et al.

  Front Microbiol. 2023.

  PMCID: PMC10248459

  In this review, we briefly summarized the working mechanism of the CRISPR/Cas9 system and highlighted the application progress of CRISPR/Cas9-mediated genome-editing technology in edible fungi, including Agaricus bisporus, Ganoderma lucidum, Flammulina filiformis, U …

  In this review, we briefly summarized the working mechanism of the CRISPR/Cas9 system and highlighted the application progress of CRISPR/Cas …
• 874.

  Microwave-Assisted Biogenic Synthesis of Metal-Decorated Reduced Graphene Oxide and their Electrochemical Properties.

  • Gannavarapu KP, Azizighannad S, Muthukumar V S, Mitra S, Dandamudi RB.
  • ChemistrySelect. Author manuscript. 2018 Dec 17;3(47):13438-13441. doi: 10.1002/slct.201803420.
  • PMCID: PMC6370324

  Gannavarapu KP, et al.

  ChemistrySelect. Author manuscript. 2018.

  PMCID: PMC6370324

  Herein we report a microwave assisted, fungal (Ganoderma lucidum) extract mediated synthesis of noble metal decorated reduced graphene oxide(r-GO). ...

  Herein we report a microwave assisted, fungal (Ganoderma lucidum) extract mediated synthesis of noble metal decorated reduced …
• 875.

  Plant polysaccharides influence tumor development based on epigenetics: a review.

  • Li C, Hu Y, Yang H.
  • Front Pharmacol. 2025 May 6;16:1588857. doi: 10.3389/fphar.2025.1588857.
  • PMCID: PMC12089089

  Li C, et al.

  Front Pharmacol. 2025.

  PMCID: PMC12089089

  This review integrates evidences from multi-database (PubMed, Web of Science and CNKI, 2010-2025) to elucidate three core epigenetic mechanisms of plant polysaccharides (e.g., Astragalus and Ganoderma lucidum): 1) TET2-mediated DNA demethylation; 2) inhibition of hi …

  This review integrates evidences from multi-database (PubMed, Web of Science and CNKI, 2010-2025) to elucidate three core epigenetic mechani …
• 876.

  LC/MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats.

  • Hussein A, Ghonimy A, Jiang H, Qin G, El-Ashram S, Hussein S, Abd El-Razek I, El-Afifi T, Farouk MH.
  • Food Sci Nutr. 2023 Jan 27;11(5):2321-2335. doi: 10.1002/fsn3.3236.
  • PMCID: PMC10171545

  Hussein A, et al.

  Food Sci Nutr. 2023.

  PMCID: PMC10171545

  The effects of five different mushroom species (Ganoderma lucidum, GLM; Pleurotus ostreatus, POM; Pleurotus citrinopileatus, PCM; Lentinus edodes, LEM; or Hypsizigus marmoreus, HMM) on alloxan-induced diabetic rats were investigated in this study. ...

  The effects of five different mushroom species (Ganoderma lucidum, GLM; Pleurotus ostreatus, POM; Pleurotus citrinopileatus, P …
• 877.

  Basic Research of Material Properties of Mycelium-Based Composites.

  • Vašatko H, Gosch L, Jauk J, Stavric M.
  • Biomimetics (Basel). 2022 Apr 21;7(2):51. doi: 10.3390/biomimetics7020051.
  • PMCID: PMC9150003

  Vašatko H, et al.

  Biomimetics (Basel). 2022.

  PMCID: PMC9150003

  The methodology includes evaluating several substrates, focused on beech sawdust, with two mycelium strains (Pleurotus ostreatus and Ganoderma lucidum), density calculations, compression tests, three-point flexural tests and capillary water absorption. ...

  The methodology includes evaluating several substrates, focused on beech sawdust, with two mycelium strains (Pleurotus ostreatus and Gano …
• 878.

  Mechanical properties of dense mycelium-bound composites under accelerated tropical weathering conditions.

  • Chan XY, Saeidi N, Javadian A, Hebel DE, Gupta M.
  • Sci Rep. 2021 Nov 11;11(1):22112. doi: 10.1038/s41598-021-01598-4.
  • PMCID: PMC8586338

  Chan XY, et al.

  Sci Rep. 2021.

  PMCID: PMC8586338

  Here, we show how weathering conditions affect the DMC stress and elastic modulus. DMC was made using Ganoderma lucidum mycelium grown on a substrate of sawdust and empty fruit bunch. The DMC was then subjected to weathering under tropical conditions over 35 days an …

  Here, we show how weathering conditions affect the DMC stress and elastic modulus. DMC was made using Ganoderma lucidum myceli …
• 879.

  Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.

  • Johnson BM, Doonan BP, Radwan FF, Haque A.
  • Open Prost Cancer J. Author manuscript. 2010 Jan 1;3:78-85. doi: 10.2174/1876822901003010078.
  • PMCID: PMC4002166

  Johnson BM, et al.

  Open Prost Cancer J. Author manuscript. 2010.

  PMCID: PMC4002166

  In this review, we discuss one potential candidate, ganoderic acid, an extract from the Ganoderma lucidum mushroom that has been tested in multiple cancer models. Interestingly, ganoderic acid DM (GA-DM) has shown toxicity to both androgen-dependent and independent …

  In this review, we discuss one potential candidate, ganoderic acid, an extract from the Ganoderma lucidum mushroom that has be …
• 880.

  Phylogenetic analysis and morphology of Ganoderma multipileum, a Ganoderma species associated with dieback of the metropolitan woody plant Delonix regia (Boj. ex Hook.) Raf. in Vietnam.

  • Nguyen TTT, Nguyen HD, Bui AT, Pham KHT, Van KTP, Tran LT, Tran MH.
  • Sci Prog. 2023 Jul-Sep;106(3):368504231195503. doi: 10.1177/00368504231195503.
  • PMCID: PMC10467396

  Nguyen TTT, et al.

  Sci Prog. 2023.

  PMCID: PMC10467396

  Ganoderma multipileum, a wood decay mushroom, was initially discovered and classified in Taiwan through the analysis of its morphology and the internal transcribed spacer (ITS) region of nuclear ribosomal DNA. ...Notably, scanning electron microscopy of the basidiospores r …

  Ganoderma multipileum, a wood decay mushroom, was initially discovered and classified in Taiwan through the analysis of its morpholog …

• 881.

  Single- and repeated-dose toxicities of aloe fermentation products in rats.

  • Cho JH, Kim HK, Baik SO, Choi SY, Lee JY.
  • Lab Anim Res. 2011 Sep 30;27(3):235-44. doi: 10.5625/lar.2011.27.3.235.
  • PMCID: PMC3188731

  Cho JH, et al.

  Lab Anim Res. 2011.

  PMCID: PMC3188731

  In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased with fermentation time. ...

  In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinace …
• 882.

  Species diversity of Ganoderma (Ganodermataceae, Polyporales) with three new species and a key to Ganoderma in Yunnan Province, China.

  • He J, Han X, Luo ZL, Li EX, Tang SM, Luo HM, Niu KY, Su XJ, Li SH.
  • Front Microbiol. 2022 Oct 14;13:1035434. doi: 10.3389/fmicb.2022.1035434.
  • PMCID: PMC9614375

  He J, et al.

  Front Microbiol. 2022.

  PMCID: PMC9614375

  Despite the importance of this fungus, the studies on the species diversity of Ganoderma in Yunnan Province, China (YPC) have poorly been carried out. During this study, opportunistic sampling was used to collect 21 specimens of Ganoderma from YPC. ...In addition, a …

  Despite the importance of this fungus, the studies on the species diversity of Ganoderma in Yunnan Province, China (YPC) have poorly …
• 883.

  Isolation of laccase gene-specific sequences from white rot and brown rot fungi by PCR.

  • D'Souza TM, Boominathan K, Reddy CA.
  • Appl Environ Microbiol. 1996 Oct;62(10):3739-44. doi: 10.1128/aem.62.10.3739-3744.1996.
  • PMCID: PMC168181

  D'Souza TM, et al.

  Appl Environ Microbiol. 1996.

  PMCID: PMC168181

  Computer searches of the databases identified the sequence of each of the PCR products analyzed as a laccase gene sequence, suggesting the specificity of the primers. PCR products of the white rot fungi Ganoderma lucidum, Phlebia brevispora, and Trametes versicolor …

  Computer searches of the databases identified the sequence of each of the PCR products analyzed as a laccase gene sequence, suggesting the s …
• 884.

  CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches.

  • Hossen SMM, Islam MJ, Hossain MR, Barua A, Uddin MG, Emon NU.
  • Biochem Biophys Rep. 2021 Jul 9;27:101062. doi: 10.1016/j.bbrep.2021.101062.
  • PMCID: PMC8278240

  Hossen SMM, et al.

  Biochem Biophys Rep. 2021.

  PMCID: PMC8278240

  This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma applanatum, a valuable medicinal fungus used in multiple disorders belongs to Ganodermataceae family. ...

  This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma …
• 885.

  Growth Propagation of Liquid Spawn on Non-Woven Hemp Mats to Inform Digital Biofabrication of Mycelium-Based Composites.

  • Biront A, Sillen M, Van Dijck P, Wurm J.
  • Biomimetics (Basel). 2025 Jan 8;10(1):33. doi: 10.3390/biomimetics10010033.
  • PMCID: PMC11762511

  Biront A, et al.

  Biomimetics (Basel). 2025.

  PMCID: PMC11762511

  This paper, part of a digital biofabrication framework, investigates the growth kinetics of Ganoderma lucidum and Pleurotus ostreatus on hemp non-woven mats, offering flexibility and mold-free fabrication using liquid inoculation. ...The experiment involved pre-cult …

  This paper, part of a digital biofabrication framework, investigates the growth kinetics of Ganoderma lucidum and Pleurotus os …
• 886.

  Anti-Adipogenic Lanostane-Type Triterpenoids from the Edible and Medicinal Mushroom Ganoderma applanatum.

  • Peng XR, Wang Q, Su HG, Zhou L, Xiong WY, Qiu MH.
  • J Fungi (Basel). 2022 Mar 22;8(4):331. doi: 10.3390/jof8040331.
  • PMCID: PMC9028577

  Peng XR, et al.

  J Fungi (Basel). 2022.

  PMCID: PMC9028577

  Our previous research has shown that lanostane triterpenoids from Ganoderma applanatum exhibit significant anti-adipogenesis effects. In order to obtain more structurally diverse lanostane triterpenoids to establish a structure-activity relationship, we continued the study …

  Our previous research has shown that lanostane triterpenoids from Ganoderma applanatum exhibit significant anti-adipogenesis effects. …
• 887.

  Additions to the knowledge of Ganoderma in Thailand: Ganoderma casuarinicola, a new record; and Ganoderma thailandicum sp. nov.

  • Luangharn T, Karunarathna SC, Mortimer PE, Hyde KD, Xu J.
  • MycoKeys. 2019 Oct 16;59:47-65. doi: 10.3897/mycokeys.59.36823.
  • PMCID: PMC6811390

  Luangharn T, et al.

  MycoKeys. 2019.

  PMCID: PMC6811390

  Ganoderma is a cosmopolitan genus of mushrooms, which can cause root and butt rot diseases on many tree species. ...In this study, three Ganoderma strains were collected in tropical southern Thailand. Phylogenetic analyses of combined ITS, LSU, TEF1alpha and RPB2 se …

  Ganoderma is a cosmopolitan genus of mushrooms, which can cause root and butt rot diseases on many tree species. ...In this study, th …
• 888.

  Potential of natural products and gut microbiome in tumor immunotherapy.

  • Cao L, Wang X, Ma X, Xu M, Li J.
  • Chin Med. 2024 Nov 20;19(1):161. doi: 10.1186/s13020-024-01032-7.
  • PMCID: PMC11580227

  Cao L, et al.

  Chin Med. 2024.

  PMCID: PMC11580227

  Karst, Icariside I, Safflower yellow, Ganoderma lucidum, and Ginsenoside Rk3, and other Chinese native medicinal compound prescriptions to boost their efficacy of anti-tumor immunotherapy through the regulation of microbiota and microbiota metabolites. ...

  Karst, Icariside I, Safflower yellow, Ganoderma lucidum, and Ginsenoside Rk3, and other Chinese native medicinal compound pres …
• 889.

  Natural Products in Renal-Associated Drug Discovery.

  • Wruck W, Genfi AKA, Adjaye J.
  • Antioxidants (Basel). 2023 Aug 11;12(8):1599. doi: 10.3390/antiox12081599.
  • PMCID: PMC10451693

  Wruck W, et al.

  Antioxidants (Basel). 2023.

  PMCID: PMC10451693

  Additionally, we conducted a meta-analysis to identify gene signatures and associated biological processes perturbed in human and mouse cells treated with antioxidants such as epigallocatechin gallate (EGCG), the active ingredient in green tea, and the mushroom Ganoderma < …

  Additionally, we conducted a meta-analysis to identify gene signatures and associated biological processes perturbed in human and mouse cell …
• 890.

  Phorbol ester degradation in Jatropha seedcake using white rot fungi.

  • Bose A, Keharia H.
  • 3 Biotech. 2013 Sep 26;4(4):447-450. doi: 10.1007/s13205-013-0174-9.
  • PMCID: PMC4145619

  Bose A, et al.

  3 Biotech. 2013.

  PMCID: PMC4145619

  All the white rot fungi tested exhibited degradation of phorbol ester during fermentation of JSC without adversely influencing the nutritional properties of the seedcake. Ganoderma lucidum and Trametes zonata were found to degrade phorbol ester in JSC to undetectabl …

  All the white rot fungi tested exhibited degradation of phorbol ester during fermentation of JSC without adversely influencing the nutrition …