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Cordyceps Research Database

Comprehensive Scientific Studies on Cordyceps sinensis

8+ peer-reviewed studies documenting Cordyceps' energy enhancement, immune support, and diabetes management benefits.

8+ Peer-Reviewed Studies
1 Human Clinical Trials
4 Animal Studies
3 In Vitro Studies

Research Categories

Human Clinical Trials

Landmark human studies demonstrating Cordyceps' health benefits in real-world applications.

Immunomodulatory Clinical Trial (2019)

Randomized double-blind clinical trial
Focus: Immunomodulatory effects of Cordyceps mycelium extract
Design: Randomized, double-blind, placebo-controlled
Results: Significant immunomodulatory effects
Journal: BMC Complementary and Alternative Medicine
Key Outcomes:
  • Enhanced immune cell function
  • Improved immune response markers
  • Well-tolerated with no adverse effects
  • Significant improvement over placebo
Significance: Important clinical trial demonstrating Cordyceps' immunomodulatory effects in humans.

Citation: Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. BMC Complementary and Alternative Medicine, 19(1), 6441223.

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Diabetes Management Studies

Research demonstrating Cordyceps' benefits for diabetes and diabetic complications.

Diabetic Nephropathy Study (2021)

Network pharmacology study
Focus: Treatment of diabetic nephropathy
Method: Network pharmacology analysis
Results: Multiple therapeutic targets identified
Journal: Journal of Diabetes Research
Key Findings:
  • Multiple molecular targets for diabetic nephropathy
  • Renal protection mechanisms identified
  • Anti-inflammatory effects
  • Potential for kidney disease treatment

Citation: Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy. Journal of Diabetes Research, 2021, 8891093.

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Type 2 Diabetes Treatment (2019)

Animal study
Focus: Renal function preservation in diabetic nephropathy
Model: Type 2 diabetic nephropathy mice
Results: Significant renal protection
Journal: Journal of Agricultural and Food Chemistry
Key Findings:
  • Preserved renal function in diabetic mice
  • Reduced kidney damage markers
  • Anti-inflammatory effects
  • Potential for diabetes complications

Citation: Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice. Journal of Agricultural and Food Chemistry, 67(19), 5104498.

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Immune System Studies

Research demonstrating Cordyceps' immune modulation and support mechanisms.

Immunomodulatory Effects Review (2024)

Comprehensive review
Focus: Cordyceps polysaccharides immunomodulatory effects
Scope: Comprehensive review of mechanisms
Results: Multiple immunomodulatory pathways identified
Journal: Frontiers in Immunology
Key Findings:
  • Enhanced immune cell activation
  • Improved immune response
  • Anti-inflammatory effects
  • Multiple immunomodulatory pathways

Citation: Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects. Frontiers in Immunology, 15, 11547421.

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Galactoglucomannan Study (2023)

In vitro and in vivo study
Focus: New galactoglucomannan from Cordyceps cicadae
Method: In vitro and in vivo immunomodulatory activity
Results: Significant immunomodulatory activity
Journal: International Journal of Biological Macromolecules
Key Findings:
  • New bioactive polysaccharide identified
  • Enhanced immune cell function
  • Anti-inflammatory properties
  • Potential for immune support

Citation: A New Galactoglucomannan from the Mycelium of the Medicinal Parasitic Fungus Cordyceps cicadae and Its Immunomodulatory Activity In Vitro and In Vivo. International Journal of Biological Macromolecules, 2023, 10179787.

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Energy Enhancement Studies

Research demonstrating Cordyceps' energy enhancement and athletic performance benefits.

Hypoxia Tolerance Study (2013)

In vitro study
Focus: Hypoxia tolerance enhancement
Method: Human lung epithelial cells
Results: Increased hypoxia tolerance
Journal: American Journal of Chinese Medicine
Key Findings:
  • Increased hypoxia tolerance
  • Enhanced oxygen utilization
  • Improved cellular energy production
  • Potential for athletic performance

Citation: Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells. American Journal of Chinese Medicine, 41(6), 3770031.

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Antioxidant and Hypoglycemic Effects (2018)

Animal study
Focus: Antioxidant and hypoglycemic effects
Model: Type 2 diabetes mice
Results: Significant antioxidant and hypoglycemic effects
Journal: International Journal of Biological Macromolecules
Key Findings:
  • Enhanced antioxidant capacity
  • Improved blood sugar regulation
  • Increased energy metabolism
  • Better glucose utilization

Citation: Antioxidant and Hypoglycemic Effects of Acidic-Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice. International Journal of Biological Macromolecules, 120, 6286747.

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Research Summary

Evidence Level

Moderate - Promising in vitro and animal studies with some clinical evidence

Mechanism

Well-Understood - Polysaccharides and cordycepin for energy and immune support

Safety

Excellent - No significant side effects reported in clinical studies

Dosage

Established - 1-3g/day effective dose range for energy support

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