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Reishi Research Database

Comprehensive Scientific Studies on Ganoderma lucidum

12+ peer-reviewed studies documenting Reishi's immune support, cardiovascular health, and cancer treatment adjunct benefits.

12+ Peer-Reviewed Studies
2 Human Clinical Trials
8 Animal Studies
2 In Vitro Studies

Research Categories

Human Clinical Trials

Landmark human studies demonstrating Reishi's health benefits in real-world applications.

Gulf War Illness Study (2021)

Placebo-controlled, pseudo-randomized, crossover trial
Participants: Gulf War veterans with chronic illness
Duration: Crossover trial design
Intervention: Reishi mushroom extract
Results: Significant improvements in symptoms
Key Outcomes:
  • Improved quality of life measures
  • Reduced fatigue and cognitive symptoms
  • Enhanced immune function markers
  • Well-tolerated with no adverse effects
Significance: First major clinical trial demonstrating Reishi's benefits for chronic illness management in veterans.

Citation: A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum). Journal of Alternative and Complementary Medicine, 2021.

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Cancer Treatment Studies

Research demonstrating Reishi's anti-cancer properties and potential as a treatment adjunct.

Cancer Cell Growth Inhibition (2011)

In vitro and in vivo study
Focus: Inflammatory breast cancer treatment
Model: In vitro and in vivo cancer models
Results: Significant inhibition of cancer cell growth
Journal: Nutrition and Cancer
Key Findings:
  • Inhibition of cancer cell proliferation
  • Reduced expression of key cancer molecules
  • Anti-inflammatory effects in cancer tissue
  • Potential for breast cancer treatment adjunct

Citation: Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. Nutrition and Cancer, 63(7), 1085-1094.

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Anti-Tumor Effects (2013)

In vivo and in vitro study
Focus: Inflammatory breast cancer models
Results: Significant anti-tumor effects
Journal: PLoS One
Key Findings:
  • Reduced tumor growth in animal models
  • Enhanced immune response against cancer
  • Anti-angiogenic effects
  • Potential for cancer treatment adjunct

Citation: Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One, 8(2), e57431.

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Cardiovascular Health Studies

Research demonstrating Reishi's benefits for heart health and metabolic disease risk.

Cardiovascular and Metabolic Benefits (2021)

Systematic review and meta-analysis
Focus: Cardiovascular and metabolic disease risk
Scope: Comprehensive review of clinical evidence
Journal: International Journal of Environmental Research and Public Health
Key Findings:
  • Reduced cardiovascular disease risk factors
  • Improved lipid profiles and cholesterol levels
  • Enhanced blood pressure regulation
  • Potential for metabolic syndrome management

Citation: The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. International Journal of Environmental Research and Public Health, 18(7), 3671.

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Immune System Studies

Research demonstrating Reishi's immune modulation and support mechanisms.

Quality Consistency Study (2017)

Quality assessment study
Focus: Quality consistency of Reishi supplements
Scope: United States dietary supplements
Results: Variable quality across products
Key Findings:
  • Significant variation in product quality
  • Importance of standardized extracts
  • Need for quality control in supplements
  • Consumer education on product selection

Citation: Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States. Scientific Reports, 7, 7792.

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Research Summary

Evidence Level

Moderate to Strong - Promising clinical trials with supporting in vitro and animal studies

Mechanism

Well-Understood - Triterpenes and polysaccharides modulate immune and cardiovascular function

Safety

Excellent - No significant side effects reported in clinical studies

Dosage

Established - 1-3g/day effective dose range for immune and cardiovascular support

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